GCLC (glutamate-cysteine ligase catalytic subunit) - Rat Genome Database

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Gene: GCLC (glutamate-cysteine ligase catalytic subunit) Chlorocebus sabaeus
Analyze
Symbol: GCLC
Name: glutamate-cysteine ligase catalytic subunit
RGD ID: 18726881
Description: ENCODES a protein that exhibits ADP binding (ortholog); glutamate binding (ortholog); glutamate-cysteine ligase activity (ortholog); INVOLVED IN blood vessel diameter maintenance (ortholog); cell redox homeostasis (ortholog); cellular response to fibroblast growth factor stimulus (ortholog); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; cysteine metabolic pathway; glutamic acid/glutamate metabolic pathway; ASSOCIATED WITH amino acid metabolic disorder (ortholog); cataract (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cytosol (ortholog); glutamate-cysteine ligase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: glutamate--cysteine ligase catalytic subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11719,012,994 - 19,060,617 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1719,013,026 - 19,060,659 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604453,368,286 - 53,415,900 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel diameter maintenance  (ISO)
cell redox homeostasis  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to thyroxine stimulus  (ISO)
cysteine metabolic process  (ISO)
glutamate metabolic process  (ISO)
glutathione biosynthetic process  (IEA,ISO)
glutathione metabolic process  (ISO)
L-ascorbic acid metabolic process  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of hepatic stellate cell activation  (ISO)
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of protein ubiquitination  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
regulation of mitochondrial depolarization  (ISO)
response to activity  (ISO)
response to arsenic-containing substance  (ISO)
response to auditory stimulus  (ISO)
response to cadmium ion  (ISO)
response to heat  (ISO)
response to hormone  (ISO)
response to human chorionic gonadotropin  (ISO)
response to interleukin-1  (ISO)
response to nitrosative stress  (ISO)
response to nutrient  (ISO)
response to oxidative stress  (ISO)
response to xenobiotic stimulus  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GCLC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11719,012,994 - 19,060,617 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1719,013,026 - 19,060,659 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604453,368,286 - 53,415,900 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
GCLC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38653,497,341 - 53,545,101 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl653,497,341 - 53,616,970 (-)EnsemblGRCh38hg38GRCh38
GRCh37653,362,139 - 53,409,899 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36653,470,098 - 53,517,790 (-)NCBINCBI36Build 36hg18NCBI36
Build 34653,470,097 - 53,517,790NCBI
Celera655,024,301 - 55,071,990 (-)NCBICelera
Cytogenetic Map6p12.1NCBI
HuRef653,193,712 - 53,241,391 (-)NCBIHuRef
CHM1_1653,363,932 - 53,411,726 (-)NCBICHM1_1
T2T-CHM13v2.0653,337,262 - 53,388,129 (-)NCBIT2T-CHM13v2.0
Gclc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39977,661,817 - 77,701,771 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl977,661,817 - 77,701,767 (+)EnsemblGRCm39 Ensembl
GRCm38977,754,535 - 77,794,489 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl977,754,535 - 77,794,485 (+)EnsemblGRCm38mm10GRCm38
MGSCv37977,602,617 - 77,641,458 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36977,540,494 - 77,579,335 (+)NCBIMGSCv36mm8
Celera974,927,826 - 74,966,687 (+)NCBICelera
Cytogenetic Map9E1NCBI
cM Map943.36NCBI
Gclc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8887,510,251 - 87,548,896 (+)NCBIGRCr8
mRatBN7.2878,629,899 - 78,668,547 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl878,630,127 - 78,668,544 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx884,117,437 - 84,155,850 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0882,394,078 - 82,432,491 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0880,216,769 - 80,255,182 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0885,059,051 - 85,097,471 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl885,059,051 - 85,097,468 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0884,627,768 - 84,666,188 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4882,724,429 - 82,762,848 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1882,743,482 - 82,781,899 (+)NCBI
Celera878,379,669 - 78,418,088 (+)NCBICelera
Cytogenetic Map8q31NCBI
Gclc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554112,593,541 - 2,616,539 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554112,593,523 - 2,617,553 (+)NCBIChiLan1.0ChiLan1.0
GCLC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2567,968,397 - 68,019,315 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1663,844,833 - 63,895,670 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0653,052,145 - 53,102,794 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1654,687,315 - 54,738,111 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl654,687,315 - 54,734,994 (-)Ensemblpanpan1.1panPan2
GCLC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11220,999,815 - 21,047,779 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1221,000,792 - 21,047,779 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1220,898,243 - 20,947,109 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01221,495,557 - 21,544,499 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1221,496,624 - 21,545,459 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11220,996,643 - 21,045,520 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01221,104,936 - 21,153,860 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01221,243,198 - 21,292,135 (-)NCBIUU_Cfam_GSD_1.0
Gclc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494656,541,439 - 56,588,950 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364767,371,149 - 7,418,958 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364767,371,270 - 7,418,756 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GCLC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl727,209,565 - 27,253,530 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1727,209,565 - 27,253,535 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2731,702,759 - 31,747,437 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Gclc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624850749,050 - 793,959 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624850749,046 - 793,654 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 46
Low 20 14
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000011257   ⟹   ENSCSAP00000009336
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1719,013,026 - 19,060,659 (+)Ensembl
RefSeq Acc Id: XM_007972225   ⟹   XP_007970416
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11719,013,381 - 19,060,617 (+)NCBI
Vero_WHO_p1.0NW_02366604453,368,286 - 53,415,900 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007972227   ⟹   XP_007970418
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11719,012,994 - 19,060,617 (+)NCBI
Vero_WHO_p1.0NW_02366604453,368,294 - 53,415,879 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007970416 (Get FASTA)   NCBI Sequence Viewer  
  XP_007970418 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000009336
  ENSCSAP00000009336.1
Reference Protein Sequences
RefSeq Acc Id: XP_007970418   ⟸   XM_007972227
- Peptide Label: isoform X2
RefSeq Acc Id: XP_007970416   ⟸   XM_007972225
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RL47 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000009336   ⟸   ENSCSAT00000011257


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000013162 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000011257.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.8.960 UniProtKB/TrEMBL
  3.30.590.50 UniProtKB/TrEMBL
InterPro GCS UniProtKB/TrEMBL
  Gln_synth/guanido_kin_cat_dom UniProtKB/TrEMBL
KEGG Report csab:103221339 UniProtKB/TrEMBL
NCBI Gene GCLC ENTREZGENE
PANTHER GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT UniProtKB/TrEMBL
  PTHR11164 UniProtKB/TrEMBL
Pfam GCS UniProtKB/TrEMBL
Superfamily-SCOP SSF55931 UniProtKB/TrEMBL
UniProt A0A0D9RL47 ENTREZGENE, UniProtKB/TrEMBL