RGD Gene Chemical Interaction Report

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Keyword

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	619868
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Gclc
Name:	glutamate-cysteine ligase, catalytic subunit

Acc ID:	CHEBI:46195
Term:	paracetamol
Definition:	A derivative of phenol which has an acetamido substituent located para to the phenolic -OH group.
CasRN:	103-90-2
Chemical ID:	MESH:D000082

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:10652	6480464	CTD	Acetaminophen results in increased expression of GCLC mRNA	PMID:18078705 PMID:17935745 PMID:10915739 PMID:20123758 PMID:19371629 PMID:18071297
increases expression	ISO	RGD:10652	6480464	CTD	Acetaminophen results in increased expression of GCLC protein	PMID:17935745 PMID:10915739 PMID:18468992
increases expression	EXP		6480464	CTD	Acetaminophen results in increased expression of GCLC mRNA	PMID:11779202 PMID:17202762 PMID:17202758 PMID:19103213 PMID:11245408
increases expression	ISO	RGD:10652	6480464	CTD	Acetaminophen results in increased expression of GCLC protein	PMID:10915739 PMID:18468992 PMID:17935745
increases expression	EXP		6480464	CTD	Acetaminophen results in increased expression of GCLC mRNA	PMID:11245408 PMID:19103213 PMID:17202762 PMID:11779202 PMID:17202758
increases expression	ISO	RGD:10652	6480464	CTD	Acetaminophen results in increased expression of GCLC mRNA	PMID:21672600 PMID:17935745 PMID:18071297 PMID:20123758 PMID:18078705 PMID:10915739 PMID:19371629
affects expression	ISO	RGD:10652	6480464	CTD	Acetaminophen affects the expression of GCLC mRNA	PMID:17562736 PMID:15606129
multiple interactions	ISO	RGD:10652	6480464	CTD	Acetaminophen promotes the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of GCLC mRNA] NFE2L2 protein affects the reaction [[Acetaminophen co-treated with 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole] results in increased expression of GCLC mRNA]	PMID:19371629
multiple interactions	ISO	RGD:10652	6480464	CTD	Acetaminophen promotes the reaction [Mifepristone results in increased activity of [GCLC protein binds to GCLM protein]] [GCLC protein binds to GCLM protein] which results in decreased susceptibility to Acetaminophen	PMID:16840778
decreases activity	ISO	RGD:10652	6480464	CTD	Acetaminophen results in decreased activity of GCLC protein	PMID:10915739
increases expression	ISO	RGD:10652	6480464	CTD	Acetaminophen results in increased expression of GCLC mRNA	PMID:10915739 PMID:18071297 PMID:19371629 PMID:20123758 PMID:18078705 PMID:17935745
increases expression	ISO	RGD:10652	6480464	CTD	Acetaminophen results in increased expression of GCLC protein	PMID:10915739 PMID:17935745 PMID:18468992
multiple interactions	ISO	RGD:10652	6480464	CTD	[Acetaminophen results in increased activity of and results in increased localization of NFE2L2 protein] which results in increased expression of GCLC mRNA	PMID:15122755
decreases response to substance	ISO	RGD:10652	6480464	CTD	GCLC protein results in decreased susceptibility to Acetaminophen	PMID:18642143
multiple interactions	ISO	RGD:10652	6480464	CTD	NFE2L2 protein affects the reaction [Acetaminophen results in increased expression of GCLC mRNA]	PMID:17935745 PMID:19371629
multiple interactions	ISO	RGD:10652	6480464	CTD	NFE2L2 protein affects the reaction [Acetaminophen results in increased expression of GCLC protein]	PMID:17935745
multiple interactions	ISO	RGD:10652	6480464	CTD	Prazosin inhibits the reaction [Acetaminophen results in increased expression of GCLC mRNA]	PMID:18071297
increases expression	EXP		6480464	CTD	Acetaminophen results in increased expression of GCLC mRNA	PMID:11779202 PMID:17202758 PMID:17202762 PMID:11245408 PMID:19103213
affects response to substance	EXP		6480464	CTD	GCLC protein affects the susceptibility to Acetaminophen	PMID:17573345
affects expression	ISO	RGD:10652	6480464	CTD	Acetaminophen affects the expression of GCLC mRNA	PMID:15606129 PMID:17562736
increases expression	ISO	RGD:10652	6480464	CTD	Acetaminophen results in increased expression of GCLC mRNA	PMID:10915739 PMID:17935745 PMID:18078705 PMID:20123758 PMID:18071297 PMID:19371629
increases expression	ISO	RGD:10652	6480464	CTD	Acetaminophen results in increased expression of GCLC protein	PMID:18468992 PMID:10915739 PMID:17935745
multiple interactions	ISO	RGD:10652	6480464	CTD	NFE2L2 protein affects the reaction [Acetaminophen results in increased expression of GCLC mRNA]	PMID:19371629 PMID:17935745
increases expression	EXP		6480464	CTD	Acetaminophen results in increased expression of GCLC mRNA	PMID:11779202 PMID:17202758 PMID:11245408 PMID:17202762 PMID:19103213
increases expression	EXP		6480464	CTD	Acetaminophen results in increased expression of GCLC mRNA	PMID:19103213 PMID:11245408 PMID:17202758 PMID:17202762 PMID:11779202
increases expression	ISO	RGD:10652	6480464	CTD	Acetaminophen results in increased expression of GCLC protein	PMID:17935745 PMID:18468992 PMID:10915739
increases expression	ISO	RGD:10652	6480464	CTD	Acetaminophen results in increased expression of GCLC mRNA	PMID:19371629 PMID:21672600 PMID:18078705 PMID:18071297 PMID:20123758 PMID:17935745 PMID:10915739
increases expression	ISO	RGD:10652	6480464	CTD	Acetaminophen results in increased expression of GCLC protein	PMID:18468992 PMID:17935745 PMID:10915739
increases expression	ISO	RGD:10652	6480464	CTD	Acetaminophen results in increased expression of GCLC mRNA	PMID:18071297 PMID:18078705 PMID:10915739 PMID:20123758 PMID:19371629 PMID:17935745 PMID:21672600
increases expression	EXP		6480464	CTD	Acetaminophen results in increased expression of GCLC mRNA	PMID:17202758 PMID:19103213 PMID:11779202 PMID:17202762 PMID:11245408
increases expression	ISO	RGD:736793	6480464	CTD	Acetaminophen results in increased expression of GCLC mRNA	PMID:21420995
increases expression	ISO	RGD:10652	6480464	CTD	Acetaminophen results in increased expression of GCLC mRNA	PMID:10915739 PMID:17935745 PMID:18071297 PMID:18078705 PMID:19371629 PMID:20123758 PMID:21672600
increases expression	ISO	RGD:10652	6480464	CTD	Acetaminophen results in increased expression of GCLC protein	PMID:10915739 PMID:17935745 PMID:18468992 PMID:22107450
multiple interactions	ISO	RGD:10652	6480464	CTD	[IL4 gene mutant form results in increased susceptibility to Acetaminophen] which affects the expression of GCLC mRNA [IL4 gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of GCLC protein	PMID:22107450
increases expression	EXP		6480464	CTD	Acetaminophen results in increased expression of GCLC mRNA	PMID:11245408 PMID:11779202 PMID:17202758 PMID:17202762 PMID:19103213

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