GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
NFE2L2 protein affects the reaction [[Acetaminophen co-treated with 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole] results in increased expression of GCLC mRNA]
[GCLC protein binds to GCLM protein] which results in decreased susceptibility to Acetaminophen
[IL4 gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of GCLC protein