Gene:	Abcc8 ( Rattus norvegicus ) ATP-binding cassette, sub-family C (CFTR/MRP), member 8
Description:	binds sulfonylurea; subunit of the ATP-sensitive potassium channel K(ATP), which is composed of Sur1 and the inwardly rectifying K(+) channel subunit, Kir6.2
Synonyms:	sulfonylurea receptor; Sur; ATP-binding cassette sub-family C (CFTR/MRP) member 8; ATP-binding cassette, subfamily C (CFTR/MRP), member 8; Sur1;
ArrayIDs:	6606044; A_43_P11674; 6253839; 6278951; 6049628; 5938002; 6473297; L40624_at; 6136587; 6439047; 5791180; 6163893; 6712482; 5850862; 6221908; 6624219; 6411207; 5975063; 5993992; 6712479; GE1183782; 1369632_a_at; 6059754; 6401149; 6204154; 6201421; 6738457; 6598619; 5672993; rc_AA799786_s_at; 6172074; 6035445; 5641437; 6364915; 5774602; 6642720; 5813109; 5920071; 6715775; 6019758; 6317271; 6492397; 5942665; 5883058; 6583569; 5725570;  (details...)
Gene Type:	protein-coding
Additional Data
Candidate gene for:	Niddm7 - Non-insulin dependent diabetes mellitus QTL 7
Homologs
Homo sapiens: ABCC8     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Abcc8     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Abcc8 genome assembly 3.1 1 96700590 - 96781880     Rat Celera Assembly 1 90849591 - 90928273     RGSC genome assembly v3.4 1 96622480 - 96703769     Cytogenetic 1 q22 Mus musculus Abcc8 Mouse genome assembly build 36.1 7 53359893 - 53435403     Cytogenetic 7 7 B4 Homo sapiens ABCC8 human genome assembly 11 17371008 - 17455025     Human genome assembly build 36.2 11 17371009 - 17455025     Cytogenetic 11 p15.1   View comparative maps:      NCBI MapViewer
Genome
View:
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Annotation
Molecular Function	Note Reference putative subunit of the beta-cell ATP-sensitive potassium channel (KATP) 724707 Gene Ontology potassium channel activity,  syntaxin binding,  sulfonylurea receptor activity ...  (details...)
Biological Process	Note Reference regulator of ATP-sensitive K+ channels and insulin release 724707 Gene Ontology response to drug,  response to lipopolysaccharide,  response to zinc ion ...  (details...)
Cellular Component	Gene Ontology ATP-sensitive potassium channel complex,  synaptic vesicle membrane,  sarcolemma ...  (details...)
Disease	Note Reference mutation of the human homolog is detected in patients with familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI) 728122 Ontology Myocardial Reperfusion Injury,  Hypertension,  Diabetes Mellitus ...  (details...)
Phenotype	Ontology increased circulating insulin level (details...)
Pathway	Ontology altered insulin secretion pathway,  type 2 diabetes mellitus pathway,  diabetes pathway ...  (details...)
External Links
Databases	DATABASE ID SOURCE SMART: AAA IPI PROSITE: ABC_TRANSPORTER_1 IPI PROSITE: ABC_TM1F IPI PROSITE: ABC_TRANSPORTER_2 IPI UNIPARC: UPI0000ED8F34 IPI UNIPARC: UPI0001B7BE35 IPI UNIPARC: UPI0000181E6D IPI UNIPARC: UPI0001B7BE37 IPI UNIPARC: UPI0000170675 IPI UNIPARC: UPI0000DC2084 IPI KEGG Report: rno:25559 ENTREZGENE HomoloGene Group ID: 68048 ENTREZGENE Germonline: 3786 Pfam: ABC_membrane IPI Pfam: ABC_tran IPI KEGG Pathway: 02010 ENTREZGENE KEGG Pathway: 04930 ENTREZGENE InterPro: ABC_transporter_CS. IPI InterPro: ATPase_AAA+_core. IPI InterPro: ABC_transporter-like. IPI InterPro: Surea_rcpt_1_N. IPI InterPro: ABC_TM_1. IPI InterPro: Sulphorea_rcpt_N. IPI InterPro: ABC_transporter_type1. IPI InterPro: ABC_TM_transpt. IPI IPI: IPI00208166 IPI IPI: IPI00851131 IPI IPI: IPI00287695 IPI IPI: IPI00392305 IPI IPI: IPI00204427 IPI IPI: IPI00476240 IPI Ensembl Protein: ENSRNOP00000035010 IPI Ensembl Protein: ENSRNOP00000024982 IPI Ensembl Protein: ENSRNOP00000028696 IPI Ensembl Protein: ENSRNOP00000028691 IPI Ensembl Protein: ENSRNOP00000041893 IPI Entrez Gene: Abcc8 ENTREZGENE UniProt: Q70X89_RAT IPI UniProt: ABCC8_RAT IPI UniProt: ABCC8_RAT IPI UniProt: Q70X90_RAT IPI UniProt: ABCC8_RAT IPI Ensembl Genes: ENSRNOG00000021130 IPI RatMap: 41444 ENTREZGENE Superfamily-SCOP: ABC_TM_1 IPI PRINTS: SULFNYLUREAR. IPI PRINTS: SULFNYLUR1. IPI
Sequences	Nucleotide: AB052294 Get FASTA Search GEO Profiles Nucleotide: AF039595 Get FASTA Search GEO Profiles Nucleotide: AJ511272 Get FASTA Search GEO Profiles Nucleotide: AJ511273 Get FASTA Search GEO Profiles Nucleotide: CH473979 Get FASTA Search GEO Profiles Nucleotide: X97279 Get FASTA Search GEO Profiles Nucleotide: NM_013039 Get FASTA Search GEO Profiles (View all 7 Nucleotide Accessions) Protein: NP_037171 Get FASTA Protein: CAA65934 Get FASTA Protein: Q09429 Get FASTA Protein: BAB19011 Get FASTA Protein: Q70X90 Get FASTA Protein: CAD54073 Get FASTA Protein: EDM07269 Get FASTA Protein: CAD54072 Get FASTA Protein: EDM07270 Get FASTA Protein: AAB96684 Get FASTA Protein: EDM07271 Get FASTA Protein: Q70X89 Get FASTA (View all 12 Protein Accessions)
Clusters	UniGene: 11187
References
Curated References	37 references in RGD related to Abcc8
Other References	30 other references at PubMed related to Abcc8
Database Information
RGD ID	3786
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 10-SEP-04: Abcc8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 ATP-binding cassette, subfamily C (CFTR/MRP), member 8 APPROVED Name updated 1299863 10-JUN-02: Abcc8 ATP-binding cassette, subfamily C (CFTR/MRP), member 8 APPROVED Symbol and Name status set to approved 70586 14-JAN-02: Abcc8 ATP-binding cassette, subfamily C (CFTR/MRP), member 8 APPROVED Symbol and Name updated to reflect Human and Mouse nomenclature 69665