Abcc8 (ATP binding cassette subfamily C member 8) - Rat Genome Database

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Gene: Abcc8 (ATP binding cassette subfamily C member 8) Rattus norvegicus
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Symbol: Abcc8
Name: ATP binding cassette subfamily C member 8
RGD ID: 3786
Description: Predicted to enable several functions, including ATPase-coupled transmembrane transporter activity; adenyl ribonucleotide binding activity; and transmembrane transporter binding activity. Involved in several processes, including learning or memory; negative regulation of blood-brain barrier permeability; and negative regulation of low-density lipoprotein particle clearance. Located in sarcolemma and synaptic vesicle membrane. Part of inward rectifying potassium channel. Is active in presynaptic membrane. Used to study brain edema; cardiac arrest; hypoglycemia; and middle cerebral artery infarction. Biomarker of Parkinsonism; epilepsy; sciatic neuropathy; and status epilepticus. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple) and hypertension. Orthologous to human ABCC8 (ATP binding cassette subfamily C member 8); PARTICIPATES IN diabetes mellitus pathway; acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATP-binding cassette sub-family C (CFTR/MRP) member 8; ATP-binding cassette sub-family C member 8; ATP-binding cassette subfamily C (CFTR/MRP) member 8; ATP-binding cassette transporter sub-family C member 8; ATP-binding cassette, sub-family C (CFTR/MRP), member 8; ATP-binding cassette, subfamily C (CFTR/MRP), member 8; sulfonylurea receptor; sulfonylurea receptor 1; sulphonylurea receptor 1; Sur; Sur1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Abcc8em1Cgen
Genetic Models: SD-Abcc8em1Cgen
Candidate Gene For: Niddm7
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,734,992 - 105,816,272 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1105,734,992 - 105,815,982 (-)EnsemblGRCr8
mRatBN7.2196,598,568 - 96,679,563 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,598,647 - 96,679,510 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1101,984,796 - 102,065,631 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,456,780 - 110,537,604 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,747,149 - 103,827,975 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01102,110,708 - 102,191,287 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,110,708 - 102,191,287 (-)Ensemblrn6Rnor6.0
Rnor_5.01103,194,473 - 103,275,508 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4196,622,574 - 96,703,723 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera190,849,685 - 90,928,224 (-)NCBICelera
RGSC_v3.1196,700,590 - 96,781,880 (-)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
atrial heart septal defect  (ISO)
brain edema  (IMP,ISO)
Brain Injuries  (IMP)
cardiac arrest  (IMP)
Colorectal Neoplasms  (ISO)
Congenital Hyperinsulinism  (ISO)
congestive heart failure  (ISO)
cryptorchidism  (ISO)
diabetes mellitus  (ISO)
Dwarfism  (ISO)
Endotoxemia  (IEP)
epilepsy  (IEP)
familial hyperinsulinemic hypoglycemia 1  (ISO)
gastroesophageal reflux disease  (ISO)
genetic disease  (ISO)
Growth Disorders  (ISO)
hyperinsulinemic hypoglycemia  (ISO,ISS)
hyperinsulinism  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
hypoglycemia  (IMP,ISO)
leucine-sensitive hypoglycemia of infancy  (ISO)
Macrocephaly  (ISO)
maturity-onset diabetes of the young  (ISO)
maturity-onset diabetes of the young type 1  (ISO)
maturity-onset diabetes of the young type 12  (ISO)
middle cerebral artery infarction  (IMP)
Muscle Hypotonia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Necrosis  (IMP)
neonatal diabetes mellitus  (ISO)
Neonatal Hypoglycemia, Simulating Foetopathia Diabetica  (ISO)
Neuraminidase Deficiency  (ISO)
newborn respiratory distress syndrome  (ISO)
Parkinsonism  (IEP)
permanent neonatal diabetes mellitus  (ISO)
Permanent Neonatal Diabetes Mellitus 3  (ISO)
polyhydramnios  (ISO)
Pulmonary Arterial Hypertension  (ISO)
Retrognathia  (ISO)
sciatic neuropathy  (IEP)
Spinal Cord Injuries  (IEP,IMP,ISO)
status epilepticus  (IEP)
stroke  (ISO)
Subarachnoid Hemorrhage  (IMP)
transient neonatal diabetes mellitus  (ISO,ISS)
transient neonatal diabetes mellitus 2  (ISO)
Traumatic Subarachnoid Hemorrhage  (IMP)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylcholine  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
ATP  (EXP)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beryllium difluoride  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
cadmium dichloride  (EXP)
CGP 52608  (ISO)
chlorpropamide  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
DDE  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (EXP)
endosulfan  (EXP)
estrone  (EXP)
ethanol  (ISO)
ethylparaben  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
gliclazide  (ISO)
glimepiride  (ISO)
glyburide  (EXP)
hydrogen cyanide  (ISO)
lipopolysaccharide  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercaptopurine  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
mifepristone  (ISO)
mitiglinide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (EXP)
oxidopamine  (EXP)
paracetamol  (EXP)
phenobarbital  (EXP)
picrotoxin  (EXP)
potassium atom  (EXP,ISO)
potassium cyanide  (ISO)
purine-6-thiol  (EXP)
resveratrol  (EXP,ISO)
riddelliine  (EXP)
rubidium atom  (EXP,ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
Terfenadine  (EXP)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolbutamide  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
troglitazone  (EXP)
uranium atom  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway   (ISO)
altered insulin secretion pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diabetes mellitus pathway  (IDA)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
forkhead class A signaling pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
gliclazide pharmacodynamics pathway  (ISO)
glyburide pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway   (ISO)
insulin secretion pathway  (TAS)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway   (ISO)
potassium channel inhibitors pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway   (ISO)
type 2 diabetes mellitus pathway  (IEA,ISO)
verapamil pharmacodynamics pathway  (ISO)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Antihyperglycemic and antihyperlipidemic effects of newly synthesized glibenclamide analogues on streptozotocin-diabetic rats. Ahmadi A, etal., Drug Res (Stuttg). 2013 Dec;63(12):614-9. doi: 10.1055/s-0033-1349128. Epub 2013 Jul 4.
2. Two SUR1-specific histidine residues mandatory for zinc-induced activation of the rat KATP channel. Bancila V, etal., J Biol Chem. 2005 Mar 11;280(10):8793-9. Epub 2004 Dec 21.
3. Molecular basis of ATP-sensitive K+ channels in rat vascular smooth muscles. Cao K, etal., Biochem Biophys Res Commun 2002 Aug 16;296(2):463-9.
4. Modulation of the trafficking efficiency and functional properties of ATP-sensitive potassium channels through a single amino acid in the sulfonylurea receptor. Cartier EA, etal., J Biol Chem 2003 Feb 28;278(9):7081-90.
5. Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel. Cooper PE, etal., J Biol Chem. 2017 Oct 20;292(42):17387-17398. doi: 10.1074/jbc.M117.804971. Epub 2017 Aug 23.
6. ABCC8 (SUR1) and KCNJ11 (KIR6.2) mutations in persistent hyperinsulinemic hypoglycemia of infancy and evaluation of different therapeutic measures. Darendeliler F, etal., J Pediatr Endocrinol Metab. 2002 Jul-Aug;15(7):993-1000.
7. Increased ATPase activity produced by mutations at arginine-1380 in nucleotide-binding domain 2 of ABCC8 causes neonatal diabetes. de Wet H, etal., Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):18988-92. Epub 2007 Nov 19.
8. Stoichiometry of sulfonylurea-induced ATP-sensitive potassium channel closure. Dorschner H, etal., Mol Pharmacol. 1999 Jun;55(6):1060-6.
9. Role of sulfonylurea receptor type 1 subunits of ATP-sensitive potassium channels in myocardial ischemia/reperfusion injury. Elrod JW, etal., Circulation. 2008 Mar 18;117(11):1405-13. Epub 2008 Mar 3.
10. Congenital hyperinsulinism: clinical and molecular analysis of a large Italian cohort. Faletra F, etal., Gene. 2013 May 25;521(1):160-5. doi: 10.1016/j.gene.2013.03.021. Epub 2013 Mar 16.
11. Amplified hormonal counterregulatory responses to hypoglycemia in rats following systemic delivery of a SUR-1-selective potassium channel opener? Fan X, etal., Diabetes. 2008 Sep 5.
12. Ser1369Ala variant in sulfonylurea receptor gene ABCC8 is associated with antidiabetic efficacy of gliclazide in Chinese type 2 diabetic patients. Feng Y, etal., Diabetes Care. 2008 Oct;31(10):1939-44. Epub 2008 Jul 3.
13. Mutation spectra of ABCC8 gene in Spanish patients with Hyperinsulinism of Infancy (HI). Fernandez-Marmiesse A, etal., Hum Mutat. 2006 Feb;27(2):214.
14. Dominantly acting ABCC8 mutations in patients with medically unresponsive hyperinsulinaemic hypoglycaemia. Flanagan SE, etal., Clin Genet. 2011 Jun;79(6):582-7. doi: 10.1111/j.1399-0004.2010.01476.x.
15. Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program. Florez JC, etal., Diabetes. 2007 Feb;56(2):531-6.
16. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. Mutations in the genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) in diabetes mellitus and hyperinsulinism. Gloyn AL, etal., Hum Mutat. 2006 Mar;27(3):220-31.
18. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
19. Characterization of two novel forms of the rat sulphonylurea receptor SUR1A2 and SUR1BDelta31. Gros L, etal., Br J Pharmacol 2002 Sep;137(1):98-106.
20. Association of KCNJ11 and ABCC8 genetic polymorphisms with response to repaglinide in Chinese diabetic patients. He YY, etal., Acta Pharmacol Sin. 2008 Aug;29(8):983-9.
21. Nitric oxide differentially regulates renal ATP-binding cassette transporters during endotoxemia. Heemskerk S, etal., Pflugers Arch. 2007 May;454(2):321-34. Epub 2007 Feb 7.
22. Channel regulation of glucose sensing in the pancreatic beta-cell. Hiriart M and Aguilar-Bryan L, Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1298-306. Epub 2008 Oct 21.
23. Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats. Hirohashi T, etal., Mol Pharmacol 1998 Jun;53(6):1068-75.
24. Glibenclamide Improves Survival and Neurologic Outcome After Cardiac Arrest in Rats. Huang K, etal., Crit Care Med. 2015 Sep;43(9):e341-9. doi: 10.1097/CCM.0000000000001093.
25. The pattern of ATP-sensitive K+ channel subunits, Kir6.2 and SUR1 mRNA expressions in DG region is different from those in CA1-3 regions of chronic epilepsy induced by picrotoxin in rats. Jiang K, etal., Neuropathology. 2007 Dec;27(6):531-8.
26. Sulfonylureas improve outcome in patients with type 2 diabetes and acute ischemic stroke. Kunte H, etal., Stroke. 2007 Sep;38(9):2526-30. Epub 2007 Aug 2.
27. Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish Diabetes Prevention Study. Laukkanen O, etal., J Clin Endocrinol Metab. 2004 Dec;89(12):6286-90.
28. 17ß-estradiol inhibits MMP-9 and SUR1/TrpM4 expression and activation and thereby attenuates BSCB disruption/hemorrhage after spinal cord injury in male rats. Lee JY, etal., Endocrinology. 2015 May;156(5):1838-50. doi: 10.1210/en.2014-1832. Epub 2015 Mar 12.
29. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Lohmueller KE, etal., Nat Genet 2003 Feb;33(2):177-82.
30. ATP-sensitive potassium channels modulate in vitro tocolytic effects of ß2-adrenergic receptor agonists on uterine muscle rings in rats in early but not in late pregnancy. Lovasz N, etal., Croat Med J. 2015 Apr;56(2):114-8.
31. Ontogeny of sulfonylurea-binding regulatory subunits of K(ATP) channels in the pregnant rat myometrium. Lovasz N, etal., Reproduction. 2011 Jul;142(1):175-81. doi: 10.1530/REP-10-0492. Epub 2011 Apr 28.
32. [Ontogeny of sulphonylurea-binding regulatory subunits of K(ATP) channels in the pregnant rat myometrium]. Lovász N, etal., Acta Pharm Hung. 2011;81(3):101-7.
33. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
34. Clinical and genetic evaluation of patients with KATP channel mutations from the German registry for congenital hyperinsulinism. Mohnike K, etal., Horm Res Paediatr. 2014;81(3):156-68. doi: 10.1159/000356905. Epub 2014 Jan 7.
35. Regulated expression of adenosine triphosphate-sensitive potassium channel subunits in pancreatic beta-cells. Moritz W, etal., Endocrinology 2001 Jan;142(1):129-38.
36. Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature. Morrissey A, etal., BMC Physiol. 2005 Jan 12;5(1):1.
37. Enhancement of liver regeneration by adenosine triphosphate-sensitive K¿ channel opener (diazoxide) after partial hepatectomy. Nakagawa Y, etal., Transplantation. 2012 Jun 15;93(11):1094-100. doi: 10.1097/TP.0b013e31824ef1d1.
38. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
39. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
40. Glibenclamide enhances neurogenesis and improves long-term functional recovery after transient focal cerebral ischemia. Ortega FJ, etal., J Cereb Blood Flow Metab. 2013 Mar;33(3):356-64. doi: 10.1038/jcbfm.2012.166. Epub 2012 Nov 14.
41. Risperidone reduces mRNA expression levels of Sulfonylurea Receptor 1 and TASK1 in PC12 cells. Ota M, etal., Neurosci Lett. 2007 Feb 2;412(3):254-8. Epub 2006 Dec 15.
42. Characterization of ABCC8 and KCNJ11 gene mutations and phenotypes in Korean patients with congenital hyperinsulinism. Park SE, etal., Eur J Endocrinol. 2011 Jun;164(6):919-26. doi: 10.1530/EJE-11-0160. Epub 2011 Mar 21.
43. Syntaxin-1A binds the nucleotide-binding folds of sulphonylurea receptor 1 to regulate the KATP channel. Pasyk EA, etal., J Biol Chem 2004 Feb 6;279(6):4234-40. Epub 2003 Nov 25.
44. Glibenclamide reduces hippocampal injury and preserves rapid spatial learning in a model of traumatic brain injury. Patel AD, etal., J Neuropathol Exp Neurol. 2010 Dec;69(12):1177-90. doi: 10.1097/NEN.0b013e3181fbf6d6.
45. Clinical characteristics and biochemical mechanisms of congenital hyperinsulinism associated with dominant KATP channel mutations. Pinney SE, etal., J Clin Invest. 2008 Aug;118(8):2877-86. doi: 10.1172/JCI35414.
46. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
47. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
48. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
49. Association of a variant in exon 31 of the sulfonylurea receptor 1 (SUR1) gene with type 2 diabetes mellitus in French Caucasians. Reis AF, etal., Hum Genet 2000 Aug;107(2):138-44.
50. GOA pipeline RGD automated data pipeline
51. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
52. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
53. Metabolic gene expression changes in the hippocampus of obese epileptic male rats in the pilocarpine model of temporal lobe epilepsy. Ruiz N, etal., Brain Res. 2011 Dec 2;1426:86-95. Epub 2011 Oct 8.
54. Glibenclamide reduces inflammation, vasogenic edema, and caspase-3 activation after subarachnoid hemorrhage. Simard JM, etal., J Cereb Blood Flow Metab. 2009 Feb;29(2):317-30. Epub 2008 Oct 15.
55. Endothelial sulfonylurea receptor 1-regulated NC Ca-ATP channels mediate progressive hemorrhagic necrosis following spinal cord injury. Simard JM, etal., J Clin Invest. 2007 Aug;117(8):2105-13.
56. Newly expressed SUR1-regulated NC(Ca-ATP) channel mediates cerebral edema after ischemic stroke. Simard JM, etal., Nat Med. 2006 Apr;12(4):433-40. Epub 2006 Mar 19.
57. Brief suppression of Abcc8 prevents autodestruction of spinal cord after trauma. Simard JM, etal., Sci Transl Med. 2010 Apr 21;2(28):28ra29. doi: 10.1126/scitranslmed.3000522.
58. Genetic analysis of Italian patients with congenital hyperinsulinism of infancy. Sogno Valin P, etal., Horm Res Paediatr. 2013;79(4):236-42. doi: 10.1159/000350827. Epub 2013 May 1.
59. Arylcyanoguanidines as activators of Kir6.2/SUR1K ATP channels and inhibitors of insulin release. Tagmose TM, etal., J Med Chem. 2004 Jun 3;47(12):3202-11.
60. Kir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2-SUR1 interactions. Tammaro P, etal., EMBO J. 2005 Jul 6;24(13):2318-30. Epub 2005 Jun 16.
61. Protective effect of treatment with low-dose gliclazide in a model of middle cerebral artery occlusion and reperfusion in rats. Tan F, etal., Brain Res. 2014 Apr 29;1560:83-90. doi: 10.1016/j.brainres.2014.02.044. Epub 2014 Mar 3.
62. A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults. Tarasov AI, etal., Diabetes. 2008 Jun;57(6):1595-604. Epub 2008 Mar 17.
63. Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy. Thomas PM, etal., Science 1995 Apr 21;268(5209):426-9.
64. Inhibition of SUR1 decreases the vascular permeability of cerebral metastases. Thompson EM, etal., Neoplasia. 2013 May;15(5):535-43.
65. Inhibition of the Sur1-Trpm4 channel reduces neuroinflammation and cognitive impairment in subarachnoid hemorrhage. Tosun C, etal., Stroke. 2013 Dec;44(12):3522-8. doi: 10.1161/STROKEAHA.113.002904. Epub 2013 Oct 10.
66. Effects of caudal fourth ventricular lactate infusion on hypoglycemia-associated MCT2, GLUT3, GLUT4, GCK, and sulfonylurea receptor-1 gene expression in the ovariectomized female rat LHA and VMH: impact of estradiol. Vavaiya KV and Briski KP, J Mol Neurosci. 2008 Feb;34(2):121-9. Epub 2007 Dec 15.
67. Paternal mutation of the sulfonylurea receptor (SUR1) gene and maternal loss of 11p15 imprinted genes lead to persistent hyperinsulinism in focal adenomatous hyperplasia. Verkarre V, etal., J Clin Invest. 1998 Oct 1;102(7):1286-91.
68. Studies of ATP-sensitive potassium channels on 6-hydroxydopamine and haloperidol rat models of Parkinson's disease: implications for treating Parkinson's disease? Wang S, etal., Neuropharmacology. 2005 Jun;48(7):984-92.
69. Reopening of ATP-sensitive potassium channels reduces neuropathic pain and regulates astroglial gap junctions in the rat spinal cord. Wu XF, etal., Pain. 2011 Nov;152(11):2605-15. doi: 10.1016/j.pain.2011.08.003. Epub 2011 Sep 9.
70. The characteristics of glucose metabolism in the sulfonylurea receptor 1 knockout rat model. Zhou X, etal., Mol Med. 2019 Jan 7;25(1):2. doi: 10.1186/s10020-018-0067-9.
Additional References at PubMed
PMID:7716547   PMID:8942641   PMID:12627323   PMID:15485808   PMID:16085792   PMID:16308567   PMID:17311891   PMID:17395632   PMID:17561960   PMID:17584766   PMID:17593344   PMID:17656102  
PMID:17889836   PMID:19151370   PMID:19604096   PMID:19933268   PMID:20456845   PMID:20598356   PMID:20610380   PMID:21173146   PMID:21540180   PMID:22144717   PMID:22802590   PMID:23032400  
PMID:23255597   PMID:24035941   PMID:24429282   PMID:24814349   PMID:25261791   PMID:25720052   PMID:26172285   PMID:26181369   PMID:27560494   PMID:28092267   PMID:30868916  


Genomics

Comparative Map Data
Abcc8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,734,992 - 105,816,272 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1105,734,992 - 105,815,982 (-)EnsemblGRCr8
mRatBN7.2196,598,568 - 96,679,563 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,598,647 - 96,679,510 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1101,984,796 - 102,065,631 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,456,780 - 110,537,604 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,747,149 - 103,827,975 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01102,110,708 - 102,191,287 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,110,708 - 102,191,287 (-)Ensemblrn6Rnor6.0
Rnor_5.01103,194,473 - 103,275,508 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4196,622,574 - 96,703,723 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera190,849,685 - 90,928,224 (-)NCBICelera
RGSC_v3.1196,700,590 - 96,781,880 (-)NCBI
Cytogenetic Map1q22NCBI
ABCC8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381117,392,498 - 17,476,845 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1117,392,498 - 17,476,894 (-)Ensemblhg38GRCh38
GRCh371117,414,045 - 17,498,392 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361117,371,008 - 17,455,025 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341117,371,008 - 17,455,025NCBI
Celera1117,544,259 - 17,628,301 (-)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1117,098,250 - 17,182,251 (-)NCBIHuRef
CHM1_11117,414,230 - 17,498,274 (-)NCBICHM1_1
T2T-CHM13v2.01117,490,094 - 17,574,439 (-)NCBIT2T-CHM13v2.0
Abcc8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,753,952 - 45,829,441 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,753,947 - 45,829,457 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38746,104,523 - 46,180,039 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl746,104,523 - 46,180,033 (-)Ensemblmm10GRCm38
MGSCv37753,359,893 - 53,435,403 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36745,972,565 - 46,048,075 (-)NCBIMGSCv36mm8
Celera741,577,813 - 41,653,419 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.66NCBI
Abcc8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541432,216,196 - 32,289,053 (-)Ensembl
ChiLan1.0NW_00495541432,216,243 - 32,289,028 (-)NCBIChiLan1.0ChiLan1.0
ABCC8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2919,726,501 - 19,810,466 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11119,686,950 - 19,770,932 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01117,447,564 - 17,531,513 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11117,133,063 - 17,216,870 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,133,063 - 17,216,870 (-)EnsemblpanPan2panpan1.1
ABCC8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12139,963,001 - 40,037,040 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2139,962,947 - 40,036,981 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2139,461,452 - 39,537,172 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02141,066,585 - 41,142,504 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2141,066,585 - 41,142,564 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12140,079,280 - 40,154,977 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02140,286,724 - 40,362,392 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02140,625,433 - 40,701,220 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Abcc8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494745,574,794 - 45,648,893 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365281,608,757 - 1,682,975 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365281,608,782 - 1,682,873 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCC8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl241,666,909 - 41,754,620 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1241,666,974 - 41,754,624 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2244,725,495 - 44,812,691 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABCC8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1147,494,861 - 47,578,818 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl147,494,959 - 47,578,882 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038144,915,676 - 145,009,083 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abcc8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247669,018,721 - 9,092,287 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247669,018,616 - 9,092,365 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Abcc8
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12153,324,398 - 153,405,223 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Abcc8
967 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:102
Count of miRNA genes:46
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000028696, ENSRNOT00000038798
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat

Markers in Region
D1Rat379  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81105,764,254 - 105,764,425 (+)Marker Load Pipeline
mRatBN7.2196,627,828 - 96,627,999 (+)MAPPERmRatBN7.2
Rnor_6.01102,139,876 - 102,140,046NCBIRnor6.0
Rnor_5.01103,224,290 - 103,224,460UniSTSRnor5.0
RGSC_v3.4196,652,504 - 96,652,675RGDRGSC3.4
RGSC_v3.4196,652,505 - 96,652,675UniSTSRGSC3.4
Celera190,878,874 - 90,879,044UniSTS
RGSC_v3.1196,730,582 - 96,730,967RGD
FHH x ACI Map148.9499UniSTS
FHH x ACI Map148.9499RGD
Cytogenetic Map1q22UniSTS
BF388506  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,640,887 - 96,641,058 (+)MAPPERmRatBN7.2
Rnor_6.01102,152,934 - 102,153,104NCBIRnor6.0
Rnor_5.01103,237,348 - 103,237,518UniSTSRnor5.0
RGSC_v3.4196,665,563 - 96,665,733UniSTSRGSC3.4
Celera190,892,041 - 90,892,211UniSTS
RH 3.4 Map1909.8UniSTS
Cytogenetic Map1q22UniSTS
BE110066  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,639,181 - 96,639,344 (+)MAPPERmRatBN7.2
Rnor_6.01102,151,230 - 102,151,392NCBIRnor6.0
Rnor_5.01103,235,644 - 103,235,806UniSTSRnor5.0
RGSC_v3.4196,663,859 - 96,664,021UniSTSRGSC3.4
Celera190,890,228 - 90,890,390UniSTS
RH 3.4 Map1908.8UniSTS
Cytogenetic Map1q22UniSTS
Abcc8  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81105,737,712 - 105,738,655 (+)Marker Load Pipeline
mRatBN7.2196,601,288 - 96,602,231 (+)MAPPERmRatBN7.2
Rnor_6.01102,113,334 - 102,114,276NCBIRnor6.0
Rnor_5.01103,197,099 - 103,198,041UniSTSRnor5.0
RGSC_v3.4196,625,200 - 96,626,142UniSTSRGSC3.4
Celera190,852,311 - 90,853,253UniSTS
Cytogenetic Map1q22UniSTS


Genetic Models
This gene Abcc8 is modified in the following models/strains:
SD-Abcc8em1Cgen    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 11 66 143 90 86 59 23 59 6 282 121 9 121 79 92 27 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000028696   ⟹   ENSRNOP00000028696
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1105,734,992 - 105,815,982 (-)Ensembl
mRatBN7.2 Ensembl196,598,647 - 96,679,510 (-)Ensembl
Rnor_6.0 Ensembl1102,110,708 - 102,191,287 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000038798   ⟹   ENSRNOP00000035010
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1105,734,992 - 105,815,982 (-)Ensembl
mRatBN7.2 Ensembl196,598,647 - 96,679,510 (-)Ensembl
Rnor_6.0 Ensembl1102,110,708 - 102,191,287 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099423   ⟹   ENSRNOP00000078710
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1105,734,992 - 105,815,982 (-)Ensembl
mRatBN7.2 Ensembl196,598,647 - 96,679,510 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000133769   ⟹   ENSRNOP00000112645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1105,734,992 - 105,815,982 (-)Ensembl
RefSeq Acc Id: NM_001412033   ⟹   NP_001398962
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,734,992 - 105,815,982 (-)NCBI
mRatBN7.2196,598,568 - 96,679,563 (-)NCBI
RefSeq Acc Id: NM_001412034   ⟹   NP_001398963
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,734,992 - 105,815,982 (-)NCBI
mRatBN7.2196,598,568 - 96,679,563 (-)NCBI
RefSeq Acc Id: NM_013039   ⟹   NP_037171
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,734,992 - 105,815,982 (-)NCBI
mRatBN7.2196,598,568 - 96,679,563 (-)NCBI
Rnor_6.01102,110,708 - 102,191,287 (-)NCBI
Rnor_5.01103,194,473 - 103,275,508 (-)NCBI
RGSC_v3.4196,622,574 - 96,703,723 (-)RGD
Celera190,849,685 - 90,928,224 (-)RGD
Sequence:
RefSeq Acc Id: XM_008759320   ⟹   XP_008757542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,734,992 - 105,816,264 (-)NCBI
mRatBN7.2196,598,663 - 96,679,495 (-)NCBI
Rnor_6.01102,110,708 - 102,191,287 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101882   ⟹   XP_038957810
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,747,923 - 105,816,272 (-)NCBI
mRatBN7.2196,611,499 - 96,679,495 (-)NCBI
RefSeq Acc Id: XM_063281903   ⟹   XP_063137973
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,743,667 - 105,816,270 (-)NCBI
RefSeq Acc Id: XM_063281905   ⟹   XP_063137975
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,734,992 - 105,776,507 (-)NCBI
RefSeq Acc Id: NP_037171   ⟸   NM_013039
- Peptide Label: isoform 1
- UniProtKB: P70532 (UniProtKB/Swiss-Prot),   O54989 (UniProtKB/Swiss-Prot),   Q9EQT0 (UniProtKB/Swiss-Prot),   Q09429 (UniProtKB/Swiss-Prot),   Q70X89 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757542   ⟸   XM_008759320
- Peptide Label: isoform X1
- UniProtKB: Q70X89 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000035010   ⟸   ENSRNOT00000038798
Ensembl Acc Id: ENSRNOP00000028696   ⟸   ENSRNOT00000028696
RefSeq Acc Id: XP_038957810   ⟸   XM_039101882
- Peptide Label: isoform X4
- UniProtKB: A6JBB4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000078710   ⟸   ENSRNOT00000099423
RefSeq Acc Id: NP_001398962   ⟸   NM_001412033
- Peptide Label: isoform 2
- UniProtKB: Q70X90 (UniProtKB/TrEMBL),   Q70X89 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001398963   ⟸   NM_001412034
- Peptide Label: isoform 3
- UniProtKB: Q70X89 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137975   ⟸   XM_063281905
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063137973   ⟸   XM_063281903
- Peptide Label: isoform X2
- UniProtKB: A6JBB4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000112645   ⟸   ENSRNOT00000133769
Protein Domains
ABC transmembrane type-1   ABC transporter

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q09429-F1-model_v2 AlphaFold Q09429 1-1582 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3786 AgrOrtholog
BioCyc Gene G2FUF-59632 BioCyc
Ensembl Genes ENSRNOG00000021130 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028696 ENTREZGENE
  ENSRNOT00000028696.8 UniProtKB/Swiss-Prot
  ENSRNOT00000038798 ENTREZGENE
  ENSRNOT00000038798.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1560.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
InterPro AAA+_ATPase UniProtKB/Swiss-Prot
  ABC1_TM_dom UniProtKB/Swiss-Prot
  ABC1_TM_sf UniProtKB/Swiss-Prot
  ABC_transporter-like UniProtKB/Swiss-Prot
  ABC_transporter_C UniProtKB/Swiss-Prot
  ABC_transporter_CS UniProtKB/Swiss-Prot
  ABCC8 UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  Sulphorea_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:25559 UniProtKB/Swiss-Prot
NCBI Gene 25559 ENTREZGENE
PANTHER ATP-BINDING CASSETTE SUB-FAMILY C UniProtKB/Swiss-Prot
  ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 UniProtKB/Swiss-Prot
Pfam ABC_membrane UniProtKB/Swiss-Prot
  ABC_tran UniProtKB/Swiss-Prot
PharmGKB ABCC8 RGD
PhenoGen Abcc8 PhenoGen
PRINTS SULFNYLUR1 UniProtKB/Swiss-Prot
  SULFNYLUREAR UniProtKB/Swiss-Prot
PROSITE ABC_TM1F UniProtKB/Swiss-Prot
  ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021130 RatGTEx
SMART AAA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
  SSF90123 UniProtKB/Swiss-Prot
UniProt A0A8I5ZLC8_RAT UniProtKB/TrEMBL
  A0ABK0M9L2_RAT UniProtKB/TrEMBL
  A6JBB2_RAT UniProtKB/TrEMBL
  A6JBB4 ENTREZGENE, UniProtKB/TrEMBL
  ABCC8_RAT UniProtKB/Swiss-Prot
  O54989 ENTREZGENE
  P70532 ENTREZGENE
  Q09429 ENTREZGENE
  Q70X89 ENTREZGENE, UniProtKB/TrEMBL
  Q70X90 ENTREZGENE, UniProtKB/TrEMBL
  Q9EQT0 ENTREZGENE
UniProt Secondary O54989 UniProtKB/Swiss-Prot
  P70532 UniProtKB/Swiss-Prot
  Q9EQT0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Abcc8  ATP binding cassette subfamily C member 8  Abcc8  ATP-binding cassette, subfamily C (CFTR/MRP), member 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-11-16 Abcc8  ATP-binding cassette, subfamily C (CFTR/MRP), member 8  Abcc8  ATP-binding cassette, sub-family C (CFTR/MRP), member 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Abcc8  ATP-binding cassette, sub-family C (CFTR/MRP), member 8    ATP-binding cassette, subfamily C (CFTR/MRP), member 8  Name updated 1299863 APPROVED
2002-06-10 Abcc8  ATP-binding cassette, subfamily C (CFTR/MRP), member 8      Symbol and Name status set to approved 70586 APPROVED
2002-01-14 Abcc8  ATP-binding cassette, subfamily C (CFTR/MRP), member 8      Symbol and Name updated to reflect Human and Mouse nomenclature 69665 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutation of the human homolog is detected in patients with familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI) 728122
gene_function putative subunit of the beta-cell ATP-sensitive potassium channel (KATP) 724707
gene_process regulator of ATP-sensitive K+ channels and insulin release 724707