GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Abcc8 | affects binding | EXP | | 6480464 | CTD | Estradiol binds to ABCC8 protein mutant form | PMID:19095654 | Abcc8 | decreases response to substance | EXP | | 6480464 | CTD | ABCC8 protein mutant form results in decreased susceptibility to Estradiol | PMID:19095654 | Abcc8 | increases response to substance | EXP | | 6480464 | CTD | ABCC8 protein mutant form results in increased susceptibility to Estradiol; ABCC8 protein results in increased susceptibility to Estradiol | PMID:19095654 | Abcc8 | multiple interactions | EXP | | 6480464 | CTD | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of ABCC8 mRNA; ABCC8 protein promotes the reaction [Estradiol results in increased activity of CASP3 protein]; ABCC8 protein promotes the reaction [Estradiol results in increased activity of CASP8 protein]; ABCC8 protein promotes the reaction [Estradiol results in increased activity of CASP9 protein]; Adenosine Triphosphate deficiency inhibits the reaction [Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein]]; Estradiol binds to and affects the activity of ABCC8 protein; Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein mutant form]; Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein] | PMID:19095654 PMID:32741896 | Abcc8 | affects response to substance | ISO | Abcc8 (Mus musculus) | 6480464 | CTD | ABCC8 protein affects the susceptibility to Estradiol | PMID:19095654 | Abcc8 | multiple interactions | ISO | Abcc8 (Mus musculus) | 6480464 | CTD | Estradiol binds to and affects the activity of ABCC8 protein | PMID:19095654 | |
Go Back to source page | Continue to Ontology report |