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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3786
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc8
Name: ATP binding cassette subfamily C member 8
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc8affects bindingEXP 6480464CTDEstradiol binds to ABCC8 protein mutant formPMID:19095654
Abcc8decreases response to substanceEXP 6480464CTDABCC8 protein mutant form results in decreased susceptibility to EstradiolPMID:19095654
Abcc8increases response to substanceEXP 6480464CTDABCC8 protein mutant form results in increased susceptibility to Estradiol; ABCC8 protein results in increased susceptibility to EstradiolPMID:19095654
Abcc8multiple interactionsEXP 6480464CTD[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of ABCC8 mRNA; ABCC8 protein promotes the reaction [Estradiol results in increased activity of CASP3 protein]; ABCC8 protein promotes the reaction [Estradiol results in increased activity of CASP8 protein]; ABCC8 protein promotes the reaction [Estradiol results in increased activity of CASP9 protein]; Adenosine Triphosphate deficiency inhibits the reaction [Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein]]; Estradiol binds to and affects the activity of ABCC8 protein; Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein mutant form]; Estradiol inhibits the reaction [Glyburide binds to ABCC8 protein]PMID:19095654 PMID:32741896
Abcc8affects response to substanceISOAbcc8 (Mus musculus)6480464CTDABCC8 protein affects the susceptibility to EstradiolPMID:19095654
Abcc8multiple interactionsISOAbcc8 (Mus musculus)6480464CTDEstradiol binds to and affects the activity of ABCC8 proteinPMID:19095654
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