Rb1 (RB transcriptional corepressor 1) - Rat Genome Database

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Gene: Rb1 (RB transcriptional corepressor 1) Rattus norvegicus
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Symbol: Rb1
Name: RB transcriptional corepressor 1
RGD ID: 3540
Description: Predicted to enable several functions, including disordered domain specific binding activity; enzyme binding activity; and importin-alpha family protein binding activity. Involved in negative regulation of apoptotic process; negative regulation of cell cycle; and spermatogenesis. Predicted to be located in PML body; cytoplasm; and spindle. Predicted to be part of Rb-E2F complex; chromatin lock complex; and cyclin/CDK positive transcription elongation factor complex. Predicted to be active in chromatin. Biomarker of acute kidney failure and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including high grade glioma (multiple); osteosarcoma; prostate cancer; retinoblastoma (multiple); and small cell carcinoma. Orthologous to human RB1 (RB transcriptional corepressor 1); PARTICIPATES IN ceramide signaling pathway; G1/S transition pathway; RNA polymerase III transcription pathway; INTERACTS WITH (Z)-3-butylidenephthalide; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: pp105; pRb; rb; retinoblastoma 1; Retinoblastoma 1 (including osteosarcoma); retinoblastoma protein; retinoblastoma-associated protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81554,780,858 - 54,911,989 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1554,780,858 - 54,911,857 (-)EnsemblGRCr8
mRatBN7.21548,371,295 - 48,502,473 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1548,371,296 - 48,502,302 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1552,511,872 - 52,643,399 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01553,623,446 - 53,754,974 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01550,468,702 - 50,599,902 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01555,081,582 - 55,209,060 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1555,083,140 - 55,209,342 (-)Ensemblrn6Rnor6.0
Rnor_5.01558,804,731 - 58,931,886 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41553,828,881 - 53,962,099 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1548,020,828 - 48,147,805 (-)NCBICelera
RGSC_v3.11553,844,684 - 53,977,640 (-)NCBI
Cytogenetic Map15q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Acute Erythroleukemia  (ISO)
acute kidney failure  (IEP)
acute lymphoblastic leukemia  (ISO)
Adrenal Gland Neoplasms  (ISO)
adrenocortical carcinoma  (ISO)
Animal Mammary Neoplasms  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
B-lymphoblastic leukemia/lymphoma with ETV6-RUNX1  (ISO)
basal cell carcinoma  (ISO)
bone osteosarcoma  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
cervix uteri carcinoma in situ  (ISO)
ductal carcinoma in situ  (ISO)
embryonal carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
familial retinoblastoma  (ISO)
fundus dystrophy  (ISO)
gastrointestinal stromal tumor  (ISO)
glioblastoma  (ISO)
glioblastoma proneural subtype  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular carcinoma  (IEP,ISO)
Hereditary Neoplastic Syndromes  (ISO)
hereditary nonpolyposis colorectal cancer type 4  (ISO)
in situ carcinoma  (ISO)
Insulin Resistance  (ISO)
intestinal pseudo-obstruction  (ISO)
lung adenocarcinoma  (ISO)
lung non-small cell carcinoma  (ISO)
lung oat cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
medulloblastoma  (ISO)
Neoplasm Metastasis  (ISO)
obesity  (ISO)
oligodendroglioma  (ISO)
optic atrophy  (ISO)
osteosarcoma  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
Phyllodes Tumor  (ISO)
Pituitary Neoplasms  (IEP)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
renal cell carcinoma  (ISO)
retinoblastoma  (ISO)
seminoma  (ISO)
Sezary's disease  (ISO)
small cell carcinoma  (ISO)
squamous cell carcinoma  (ISO)
Stevens-Johnson syndrome  (ISO)
trilateral retinoblastoma  (ISO)
urinary bladder cancer  (ISO)
Urinary Bladder Neoplasm  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
(Z)-3-butylidenephthalide  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1,3-thiazolidine-2,4-dione  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-butoxyethanol  (ISO)
2-cyclopenten-1-one  (ISO)
2-methylcholine  (ISO)
2-nitrofluorene  (EXP)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-aminobenzamide  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-nitropropanoic acid  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP,ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-nitroso-8-quinolinol  (ISO)
6-O-methylguanine  (ISO)
6-oxocampestanol  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
9-cis-retinoic acid  (ISO)
Abemaciclib  (ISO)
acetylsalicylic acid  (ISO)
aconitine  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
Actein  (ISO)
acteoside  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
albuterol  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-naphthoflavone  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
alvocidib  (ISO)
amlodipine  (ISO)
ammonium chloride  (EXP)
amodiaquine  (ISO)
andrographolide  (ISO)
aniline  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenous acid  (ISO)
Aspidin  (ISO)
atorvastatin calcium  (ISO)
auranofin  (ISO)
baicalein  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
benzophenanthridine  (ISO)
beta-naphthoflavone  (EXP)
betulinic acid  (ISO)
bexarotene  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
BMS-754807  (ISO)
bortezomib  (ISO)
brassinolide  (ISO)
bucladesine  (EXP,ISO)
buspirone  (EXP)
busulfan  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (EXP,ISO)
cadmium acetate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calciol  (ISO)
calcitriol  (ISO)
calix[6]arene  (ISO)
calmidazolium  (ISO)
calyculin A  (ISO)
camptothecin  (ISO)
canertinib  (ISO)
capecitabine  (ISO)
captan  (ISO)
carbamazepine  (ISO)
cefaloridine  (EXP)
celecoxib  (ISO)
CGP 52608  (ISO)
Chloramine  (ISO)
chlordecone  (ISO)
chlorohydrocarbon  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cudraflavone B  (ISO)
cumene  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
D-glucose  (ISO)
dactolisib  (ISO)
daunorubicin  (ISO)
DDT  (ISO)
deguelin  (ISO)
dehydroepiandrosterone  (EXP,ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
Diacetoxyscirpenol  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dicoumarol  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP,ISO)
dinaciclib  (ISO)
dioxygen  (ISO)
doxazosin  (EXP,ISO)
doxorubicin  (EXP,ISO)
ellagic acid  (EXP)
emodin  (ISO)
endosulfan  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ethyl trans-caffeate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
everolimus  (ISO)
farrerol  (ISO)
fenhexamid  (ISO)
ferulic acid  (EXP,ISO)
flavanone  (ISO)
flavonoids  (EXP)
fluorometholone  (ISO)
flutamide  (EXP)
fluvastatin  (ISO)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
fucoidan  (ISO)
fulvestrant  (EXP,ISO)
furan  (EXP)
gadolinium trichloride  (ISO)
galangin  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gamma-tocopherol  (ISO)
gefitinib  (ISO)
genistein  (ISO)
gentamycin  (EXP)
gingerol  (ISO)
glafenine  (EXP)
glucose  (ISO)
glutathione  (ISO)
GW 4064  (ISO)
heparin  (ISO)
heptachlor  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxyurea  (ISO)
Hypsiziprenol-A9  (ISO)
ibuprofen  (EXP)
ICI 118551  (ISO)
indirubin  (ISO)
indoles  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
irinotecan  (ISO)
isocyanates  (ISO)
isoeugenol  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
KN-93  (ISO)
L-cysteine  (ISO)
lapatinib  (ISO)
lead diacetate  (EXP)
lead nitrate  (ISO)
lead(0)  (EXP,ISO)
letrozole  (ISO)
levamisole  (ISO)
linsidomine  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
lonafarnib  (ISO)
lopinavir  (ISO)
lovastatin  (EXP,ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
Lysocellin  (ISO)
magnesium atom  (EXP)
maneb  (EXP)
masoprocol  (ISO)
Maxacalcitol  (ISO)
menadione  (ISO)
menaquinone  (ISO)
methapyrilene  (EXP,ISO)
methotrexate  (ISO)
methoxsalen  (ISO)
methoxyacetic acid  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP)
methylseleninic acid  (ISO)
miconazole  (ISO)
mifepristone  (ISO)
mitomycin C  (ISO)
monosodium L-glutamate  (EXP)
motexafin gadolinium  (ISO)
myo-inositol hexakisphosphate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nelfinavir  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
nitrogen dioxide  (ISO)
Nonylphenol  (ISO)
O-(chloroacetylcarbamoyl)fumagillol  (ISO)
O-methyleugenol  (EXP)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
oleandrigenin  (ISO)
oleic acid  (ISO)
olomoucine  (ISO)
orlistat  (ISO)
oxaliplatin  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
panaxydol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (EXP)
pentobarbital  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenethyl caffeate  (EXP)
phenobarbital  (EXP)
phenylephrine  (EXP)
PhIP  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosalone  (EXP)
picoxystrobin  (ISO)
pifithrin-alpha hydrobromide  (EXP)
pinosylvin  (ISO)
pioglitazone  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP)
piroxicam  (ISO)
prednisone  (ISO)
proanthocyanidin  (EXP)
procyanidin  (ISO)
progesterone  (ISO)
promethazine  (EXP)
pterostilbene  (EXP)
PX-866  (ISO)
quercetin  (EXP,ISO)
radicicol  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
ritonavir  (ISO)
Ro 41-5253  (ISO)
romidepsin  (ISO)
rottlerin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
SHP099  (ISO)
silibinin  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP,ISO)
sirtinol  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sorafenib  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (EXP)
sulindac  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
talazoparib  (ISO)
tamoxifen  (EXP,ISO)
tanespimycin  (ISO)
Tanshinone I  (ISO)
tauroursodeoxycholic acid  (EXP)
tazarotene  (ISO)
temozolomide  (ISO)
Temsirolimus  (ISO)
terephthalic acid  (EXP)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thiophenes  (ISO)
titanium dioxide  (ISO)
tocopherol  (ISO)
tolbutamide  (EXP)
toluene  (EXP)
toxaphene  (ISO)
trametinib  (ISO)
trans-isoeugenol  (ISO)
trans-pinosylvin  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP,ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vinyl carbamate  (ISO)
vorinostat  (ISO)
Withanone  (ISO)
wortmannin  (EXP,ISO)
Y-27632  (ISO)
zebularine  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aortic valve morphogenesis  (IEA,ISO)
apoptotic process  (IEA,ISO)
cell differentiation  (IBA)
cell division  (ISO)
cell morphogenesis involved in neuron differentiation  (IBA,ISO)
cellular response to insulin stimulus  (IEA,ISO)
cellular response to xenobiotic stimulus  (ISO)
chondrocyte differentiation  (IEA,ISO)
chromatin organization  (IEA)
chromosome organization  (IEA,ISO)
developmental process  (IEA)
digestive tract development  (ISO)
enucleate erythrocyte differentiation  (ISO)
G1/S transition of mitotic cell cycle  (ISO)
glial cell apoptotic process  (ISO)
hepatocyte apoptotic process  (ISO)
heterochromatin formation  (IEA,ISO)
maintenance of mitotic sister chromatid cohesion  (IEA,ISO)
myoblast differentiation  (IEA,ISO,ISS)
negative regulation of apoptotic signaling pathway  (IMP)
negative regulation of cell cycle  (IEA,IMP,ISO)
negative regulation of cell growth  (IEA,ISO,ISS)
negative regulation of cell population proliferation  (ISO)
negative regulation of cold-induced thermogenesis  (IEA,ISO,ISS)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of G1/S transition of mitotic cell cycle  (IBA,ISO)
negative regulation of gene expression  (ISO)
negative regulation of hepatocyte apoptotic process  (IMP)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of mitotic cell cycle  (ISO)
negative regulation of myofibroblast differentiation  (IEA,ISO)
negative regulation of protein kinase activity  (ISO,ISS)
negative regulation of signal transduction  (IEA)
negative regulation of smoothened signaling pathway  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neuron apoptotic process  (ISO)
neuron differentiation  (ISO)
neuron maturation  (ISO)
neuron projection development  (IBA,ISO)
positive regulation of collagen fibril organization  (IEA,ISO)
positive regulation of extracellular matrix organization  (IEA,ISO)
positive regulation of macrophage differentiation  (ISO)
positive regulation of mitotic metaphase/anaphase transition  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
protein localization to chromosome, centromeric region  (IEA,ISO)
Ras protein signal transduction  (IEA,ISO)
regulation of cell cycle  (IEA,ISO)
regulation of cell growth  (ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of G1/S transition of mitotic cell cycle  (ISO)
regulation of lipid kinase activity  (ISO,ISS)
regulation of mitotic cell cycle  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA)
sister chromatid biorientation  (IEA,ISO)
skeletal muscle cell differentiation  (ISO)
spermatogenesis  (IEP)
striated muscle cell differentiation  (ISO)
tissue homeostasis  (ISO)

Cellular Component
chromatin  (IBA)
chromatin lock complex  (IEA,ISO)
cyclin/CDK positive transcription elongation factor complex  (IEA,ISO,ISS)
cytoplasm  (IEA,ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO,ISS)
PML body  (IEA,ISO,ISS)
Rb-E2F complex  (IBA,IEA,ISO,ISS)
spindle  (IEA,ISO)
transcription regulator complex  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. MiR-26b, upregulated in Alzheimer's disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons. Absalon S, etal., J Neurosci. 2013 Sep 11;33(37):14645-59. doi: 10.1523/JNEUROSCI.1327-13.2013.
2. A cyclin D2-Rb pathway regulates cardiac myocyte size and RNA polymerase III after biomechanical stress in adult myocardium. Angelis E, etal., Circ Res. 2008 May 23;102(10):1222-9. doi: 10.1161/CIRCRESAHA.107.163550. Epub 2008 Apr 17.
3. Deregulation of the RB pathway in human testicular germ cell tumours. Bartkova J, etal., J Pathol. 2003 Jun;200(2):149-56.
4. Chromosomal imbalances, loss of heterozygosity, and immunohistochemical expression of TP53, RB1, and PTEN in intraductal cancer, intraepithelial neoplasia, and invasive adenocarcinoma of the prostate. Bettendorf O, etal., Genes Chromosomes Cancer. 2008 Jul;47(7):565-72.
5. Loss of heterozygosity at 13q14 correlates with RB1 gene underexpression in human breast cancer. Bieche I and Lidereau R, Mol Carcinog. 2000 Nov;29(3):151-8.
6. Mutations in Rb1 pathway-related genes are associated with poor prognosis in anaplastic astrocytomas. Bäcklund LM, etal., Br J Cancer. 2005 Jul 11;93(1):124-30. doi: 10.1038/sj.bjc.6602661.
7. Loss of heterozygosity and mutations are the major mechanisms of RB1 gene inactivation in Chinese with sporadic retinoblastoma. Choy KW, etal., Hum Mutat. 2002 Nov;20(5):408.
8. Estrogen-induced rat pituitary tumor is associated with loss of retinoblastoma susceptibility gene product. Chun TY, etal., Mol Cell Endocrinol. 1998 Nov 25;146(1-2):87-92.
9. Cyclooxygenase-1 is overexpressed in multiple genetically engineered mouse models of epithelial ovarian cancer. Daikoku T, etal., Cancer Res. 2006 Mar 1;66(5):2527-31.
10. The retinoblastoma gene product inhibits TGF-beta1 induced apoptosis in primary rat hepatocytes and human HuH-7 hepatoma cells. Fan G, etal., Oncogene. 1996 May 2;12(9):1909-19.
11. A context-specific role for retinoblastoma protein-dependent negative growth control in suppressing mammary tumorigenesis. Francis SM, etal., PLoS One. 2011 Feb 22;6(2):e16434. doi: 10.1371/journal.pone.0016434.
12. Retinoblastoma protein prevents enteric nervous system defects and intestinal pseudo-obstruction. Fu M, etal., J Clin Invest. 2013 Dec 2;123(12):5152-64. doi: 10.1172/JCI67653. Epub 2013 Nov 1.
13. Differences in E2F subunit expression in quiescent and proliferating vascular smooth muscle cells. Fujita N, etal., Am J Physiol Heart Circ Physiol 2002 Jul;283(1):H204-12.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Subcellular compartmentalization of E2F family members is required for maintenance of the postmitotic state in terminally differentiated muscle. Gill RM and Hamel PA, J Cell Biol. 2000 Mar 20;148(6):1187-201.
16. RNA polymerase III repression by the retinoblastoma tumor suppressor protein. Gjidoda A and Henry RW, Biochim Biophys Acta. 2013 Mar-Apr;1829(3-4):385-92. doi: 10.1016/j.bbagrm.2012.09.011. Epub 2012 Oct 12.
17. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
18. Clinical stratification of glioblastoma based on alterations in retinoblastoma tumor suppressor protein (RB1) and association with the proneural subtype. Goldhoff P, etal., J Neuropathol Exp Neurol. 2012 Jan;71(1):83-9. doi: 10.1097/NEN.0b013e31823fe8f1.
19. Expression of the cell cycle proteins p21, p27, and pRb in clear cell renal cell carcinoma and their prognostic significance. Haitel A, etal., Urology. 2001 Sep;58(3):477-81.
20. Phase II trial of adjuvant gemcitabine plus cisplatin-based chemotherapy in patients with locally advanced bladder cancer. Jin JO, etal., Clin Genitourin Cancer. 2006 Sep;5(2):150-4.
21. Independent prognostic significance of cell cycle regulator proteins p16(INK4a) and pRb in advanced-stage ovarian carcinoma including optimally debulked patients: a translational research subprotocol of a randomised study of the Arbeitsgemeinschaft Gynaekologische Onkologie Ovarian Cancer Study Group. Kommoss S, etal., Br J Cancer. 2007 Jan 29;96(2):306-13.
22. Low p53 and retinoblastoma protein expression in cervical intraepithelial neoplasia grade 3 lesions is associated with coexistent adenocarcinoma in situ. Kruse AJ, etal., Hum Pathol. 2008 Apr;39(4):573-8. Epub 2008 Jan 30.
23. Progressive deregulation of the cell cycle with higher tumor grade in the stroma of breast phyllodes tumors. Kuijper A, etal., Am J Clin Pathol. 2005 May;123(5):690-8.
24. Mammalian cyclin-dependent kinases. Malumbres M and Barbacid M, Trends Biochem Sci. 2005 Nov;30(11):630-41. Epub 2005 Oct 19.
25. Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Marino S, etal., Genes Dev 2000 Apr 15;14(8):994-1004.
26. Haploinsufficiency of the retinoblastoma protein gene reduces diet-induced obesity, insulin resistance, and hepatosteatosis in mice. Mercader J, etal., Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E184-93. doi: 10.1152/ajpendo.00163.2009. Epub 2009 May 5.
27. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
28. Decreased RB1 mRNA, protein, and activity reflect obesity-induced altered adipogenic capacity in human adipose tissue. Moreno-Navarrete JM, etal., Diabetes. 2013 Jun;62(6):1923-31. doi: 10.2337/db12-0977. Epub 2013 Jan 11.
29. Promoter hypermethylation of the RB1 gene in glioblastomas. Nakamura M, etal., Lab Invest. 2001 Jan;81(1):77-82.
30. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
31. [Correlation of E2F-1 and Rb expression with papillomatosis and ductal carcinoma in situ of the breast] Niu Y, etal., Zhonghua Zhong Liu Za Zhi. 2004 May;26(5):290-3.
32. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
33. Interaction of rat Cdc37-related protein with retinoblastoma gene product. Ozaki T and Sakiyama S, DNA Cell Biol. 1996 Nov;15(11):975-9.
34. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
35. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
36. A calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression. Qiu Z and Ghosh A, Neuron. 2008 Dec 10;60(5):775-87. doi: 10.1016/j.neuron.2008.09.040.
37. GOA pipeline RGD automated data pipeline
38. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
39. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
40. Licochalcone B Ameliorates Liver Cancer via Targeting of Apoptotic Genes, DNA Repair Systems, and Cell Cycle Control. Sadek K, etal., Iran J Pharm Res. 2020 Fall;19(4):372-386. doi: 10.22037/ijpr.2020.1101292.
41. Expression of the cell-cycle regulatory proteins (pRb, cyclin D1, p16INK4A and cdk4) in human endometrial cancer: correlation with clinicopathological features. Semczuk A, etal., Arch Gynecol Obstet. 2004 Jan;269(2):104-10. Epub 2002 Nov 22.
42. Common variants in RB1 gene and risk of invasive ovarian cancer. Song H, etal., Cancer Res. 2006 Oct 15;66(20):10220-6.
43. Expression of ras Rb1 and p53 proteins in human breast cancer. Spandidos DA, etal., Anticancer Res. 1992 Jan-Feb;12(1):81-9.
44. Androgen regulation of stage-dependent cyclin D2 expression in Sertoli cells suggests a role in modulating androgen action on spermatogenesis. Tan KA, etal., Biol Reprod. 2005 May;72(5):1151-60. Epub 2005 Jan 19.
45. Genotype-phenotype correlations in hereditary familial retinoblastoma. Taylor M, etal., Hum Mutat. 2007 Mar;28(3):284-93.
46. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
47. A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability. Woitach JT, etal., Nat Genet 1998 Aug;19(4):371-4.
48. Acute renal failure during sepsis: potential role of cell cycle regulation. Yang QH, etal., J Infect. 2009 Jun;58(6):459-64. doi: 10.1016/j.jinf.2009.04.003. Epub 2009 Apr 17.
Additional References at PubMed
PMID:7665085   PMID:7797074   PMID:7958874   PMID:8245034   PMID:8288605   PMID:8336704   PMID:8441612   PMID:8612582   PMID:8889548   PMID:9054499   PMID:9178770   PMID:9448006  
PMID:9858607   PMID:10082561   PMID:10783144   PMID:10888886   PMID:10944455   PMID:11246230   PMID:11301474   PMID:11331592   PMID:11549719   PMID:12037672   PMID:12065415   PMID:12200151  
PMID:12221087   PMID:12695505   PMID:12757710   PMID:12853964   PMID:14693709   PMID:15069084   PMID:15084472   PMID:15169903   PMID:15459751   PMID:15509711   PMID:15541338   PMID:15542848  
PMID:15616565   PMID:15640164   PMID:15701640   PMID:15735701   PMID:15735762   PMID:15831459   PMID:15843406   PMID:15870077   PMID:15898111   PMID:16126730   PMID:16286473   PMID:16360038  
PMID:16407335   PMID:16513252   PMID:16616919   PMID:16896691   PMID:17257418   PMID:17540172   PMID:17989570   PMID:18348166   PMID:18351461   PMID:18364697   PMID:18583990   PMID:18656278  
PMID:18692063   PMID:18700867   PMID:19123049   PMID:19223331   PMID:19505811   PMID:20023236   PMID:20213763   PMID:20224733   PMID:20485545   PMID:20551165   PMID:20924203   PMID:21504794  
PMID:22147266   PMID:22885065   PMID:23371354   PMID:23487765   PMID:24068000   PMID:24726645   PMID:25100735   PMID:27056896   PMID:29304157  


Genomics

Comparative Map Data
Rb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81554,780,858 - 54,911,989 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1554,780,858 - 54,911,857 (-)EnsemblGRCr8
mRatBN7.21548,371,295 - 48,502,473 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1548,371,296 - 48,502,302 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1552,511,872 - 52,643,399 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01553,623,446 - 53,754,974 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01550,468,702 - 50,599,902 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01555,081,582 - 55,209,060 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1555,083,140 - 55,209,342 (-)Ensemblrn6Rnor6.0
Rnor_5.01558,804,731 - 58,931,886 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41553,828,881 - 53,962,099 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1548,020,828 - 48,147,805 (-)NCBICelera
RGSC_v3.11553,844,684 - 53,977,640 (-)NCBI
Cytogenetic Map15q11NCBI
RB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381348,303,751 - 48,481,890 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1348,303,735 - 48,599,436 (+)Ensemblhg38GRCh38
GRCh371348,877,887 - 49,056,026 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361347,775,884 - 47,954,027 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341347,775,911 - 47,954,023NCBI
Celera1329,932,627 - 30,110,747 (+)NCBICelera
Cytogenetic Map13q14.2NCBI
HuRef1329,670,144 - 29,848,118 (+)NCBIHuRef
CHM1_11348,845,597 - 49,023,603 (+)NCBICHM1_1
T2T-CHM13v2.01347,524,085 - 47,702,182 (+)NCBIT2T-CHM13v2.0
Rb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391473,430,298 - 73,563,446 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1473,421,113 - 73,563,262 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381473,192,858 - 73,325,951 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1473,183,673 - 73,325,822 (-)Ensemblmm10GRCm38
MGSCv371473,595,309 - 73,725,598 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361471,929,656 - 72,059,895 (-)NCBIMGSCv36mm8
Celera1470,715,843 - 70,870,859 (-)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1438.73NCBI
Rb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554311,960,661 - 2,124,576 (+)Ensembl
ChiLan1.0NW_0049554311,960,765 - 2,124,576 (+)NCBIChiLan1.0ChiLan1.0
RB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21449,752,343 - 49,924,312 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11348,403,509 - 48,575,444 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01329,453,872 - 29,624,665 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11348,155,608 - 48,326,396 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1348,155,795 - 48,324,575 (+)EnsemblpanPan2panpan1.1
RB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1223,061,621 - 3,204,625 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl223,063,239 - 3,257,726 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha223,090,617 - 3,235,458 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0223,143,918 - 3,320,581 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl223,050,839 - 3,321,505 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1222,960,514 - 3,106,149 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0223,023,421 - 3,169,707 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0223,028,586 - 3,174,226 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945158,103,473 - 158,265,512 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365651,597,593 - 1,746,846 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365651,596,227 - 1,746,706 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1119,186,761 - 19,317,690 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11119,186,754 - 19,317,642 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21119,648,360 - 19,770,943 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1326,220,783 - 26,393,671 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl326,220,803 - 26,394,546 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605717,512,606 - 17,688,151 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247486,358,180 - 6,533,249 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247486,358,588 - 6,533,217 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Rb1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11251,063,499 - 51,215,976 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rb1
600 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:677
Count of miRNA genes:300
Interacting mature miRNAs:381
Transcripts:ENSRNOT00000021752
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1544806773104695021Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)154367724488677244Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)154046315285463152Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)154367724488677244Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154446544756583797Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)154367724488677244Rat

Markers in Region
RH94875  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21548,372,696 - 48,372,923 (+)MAPPERmRatBN7.2
Rnor_6.01555,082,984 - 55,083,210NCBIRnor6.0
Rnor_5.01558,806,133 - 58,806,359UniSTSRnor5.0
RGSC_v3.41553,830,283 - 53,830,509UniSTSRGSC3.4
Celera1548,022,230 - 48,022,456UniSTS
Cytogenetic Map15q12UniSTS
PMC104404P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81554,911,758 - 54,912,090 (+)Marker Load Pipeline
RGSC_v3.41553,962,001 - 53,962,504UniSTSRGSC3.4
Cytogenetic Map15q12UniSTS
M26391  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21548,372,900 - 48,372,983 (+)MAPPERmRatBN7.2
Rnor_6.01555,083,188 - 55,083,270NCBIRnor6.0
Rnor_5.01558,806,337 - 58,806,419UniSTSRnor5.0
RGSC_v3.41553,830,487 - 53,830,569UniSTSRGSC3.4
Celera1548,022,434 - 48,022,516UniSTS
Cytogenetic Map15q12UniSTS
BE098816  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21548,428,262 - 48,428,442 (+)MAPPERmRatBN7.2
Rnor_6.01555,138,656 - 55,138,835NCBIRnor6.0
Rnor_5.01558,861,789 - 58,861,968UniSTSRnor5.0
RGSC_v3.41553,887,416 - 53,887,595UniSTSRGSC3.4
Celera1548,077,756 - 48,077,935UniSTS
Cytogenetic Map15q12UniSTS
RH94505  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21548,372,062 - 48,372,257 (+)MAPPERmRatBN7.2
mRatBN7.21548,372,108 - 48,372,257 (+)MAPPERmRatBN7.2
Rnor_6.01555,082,396 - 55,082,544NCBIRnor6.0
Rnor_6.01555,082,350 - 55,082,544NCBIRnor6.0
Rnor_5.01558,805,545 - 58,805,693UniSTSRnor5.0
Rnor_5.01558,805,499 - 58,805,693UniSTSRnor5.0
RGSC_v3.41553,829,649 - 53,829,843UniSTSRGSC3.4
RGSC_v3.41553,829,695 - 53,829,843UniSTSRGSC3.4
Celera1548,021,642 - 48,021,790UniSTS
Celera1548,021,596 - 48,021,790UniSTS
Cytogenetic Map15q12UniSTS
RH138574  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21548,416,875 - 48,417,014 (+)MAPPERmRatBN7.2
Rnor_6.01555,127,281 - 55,127,419NCBIRnor6.0
Rnor_5.01558,850,398 - 58,850,536UniSTSRnor5.0
RGSC_v3.41553,875,791 - 53,875,929UniSTSRGSC3.4
Celera1548,066,406 - 48,066,544UniSTS
Cytogenetic Map15p11UniSTS
Cytogenetic Map15q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000021752   ⟹   ENSRNOP00000021752
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1554,780,858 - 54,911,857 (-)Ensembl
mRatBN7.2 Ensembl1548,371,296 - 48,502,302 (-)Ensembl
Rnor_6.0 Ensembl1555,083,140 - 55,209,342 (-)Ensembl
RefSeq Acc Id: NM_017045   ⟹   NP_058741
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81554,780,858 - 54,911,857 (-)NCBI
mRatBN7.21548,371,295 - 48,502,302 (-)NCBI
Rnor_6.01555,081,582 - 55,209,060 (-)NCBI
Rnor_5.01558,804,731 - 58,931,886 (-)NCBI
RGSC_v3.41553,828,881 - 53,962,099 (-)RGD
Celera1548,020,828 - 48,147,805 (-)RGD
Sequence:
RefSeq Acc Id: XM_039092994   ⟹   XP_038948922
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81554,830,805 - 54,911,989 (-)NCBI
mRatBN7.21548,431,120 - 48,502,473 (-)NCBI
RefSeq Acc Id: XM_063273967   ⟹   XP_063130037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81554,780,858 - 54,809,543 (-)NCBI
Protein Sequences
Protein RefSeqs NP_058741 (Get FASTA)   NCBI Sequence Viewer  
  XP_038948922 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130037 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42090 (Get FASTA)   NCBI Sequence Viewer  
  BAA04958 (Get FASTA)   NCBI Sequence Viewer  
  EDM02266 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021752
  ENSRNOP00000021752.6
GenBank Protein P33568 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058741   ⟸   NM_017045
- UniProtKB: P33568 (UniProtKB/Swiss-Prot),   Q63527 (UniProtKB/Swiss-Prot),   R9PXV5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021752   ⟸   ENSRNOT00000021752
RefSeq Acc Id: XP_038948922   ⟸   XM_039092994
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063130037   ⟸   XM_063273967
- Peptide Label: isoform X2
Protein Domains
Cyclin-like   Retinoblastoma-associated protein A-box   Retinoblastoma-associated protein C-terminal   Retinoblastoma-associated protein N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P33568-F1-model_v2 AlphaFold P33568 1-920 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3540 AgrOrtholog
BioCyc Gene G2FUF-13166 BioCyc
Ensembl Genes ENSRNOG00000016029 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021752 ENTREZGENE
  ENSRNOT00000021752.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.472.140 UniProtKB/Swiss-Prot
  6.10.140.1380 UniProtKB/Swiss-Prot
  6.10.250.530 UniProtKB/Swiss-Prot
  Cyclin-like UniProtKB/Swiss-Prot
InterPro Cyclin-like UniProtKB/Swiss-Prot
  Cyclin-like_sf UniProtKB/Swiss-Prot
  RB_A UniProtKB/Swiss-Prot
  RB_B UniProtKB/Swiss-Prot
  RB_C UniProtKB/Swiss-Prot
  RB_fam UniProtKB/Swiss-Prot
  RB_N UniProtKB/Swiss-Prot
KEGG Report rno:24708 UniProtKB/Swiss-Prot
NCBI Gene 24708 ENTREZGENE
PANTHER PTHR13742 UniProtKB/Swiss-Prot
  RETINOBLASTOMA-ASSOCIATED PROTEIN UniProtKB/Swiss-Prot
Pfam DUF3452 UniProtKB/Swiss-Prot
  RB_A UniProtKB/Swiss-Prot
  RB_B UniProtKB/Swiss-Prot
  Rb_C UniProtKB/Swiss-Prot
PharmGKB RB1 RGD
PhenoGen Rb1 PhenoGen
RatGTEx ENSRNOG00000016029 RatGTEx
SMART CYCLIN UniProtKB/Swiss-Prot
  DUF3452 UniProtKB/Swiss-Prot
  RB_A UniProtKB/Swiss-Prot
  Rb_C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47954 UniProtKB/Swiss-Prot
TIGR TC230434
UniProt A6HTQ3_RAT UniProtKB/TrEMBL
  P33568 ENTREZGENE
  Q63527 ENTREZGENE
  R9PXV5 ENTREZGENE, UniProtKB/TrEMBL
  RB_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q63527 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-03 Rb1  RB transcriptional corepressor 1  Rb1  retinoblastoma 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Rb1  Retinoblastoma 1 (including osteosarcoma)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease human homolog is inactivated in many tumors 734501