RGD Reference Report - Mammalian cyclin-dependent kinases. - Rat Genome Database

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Mammalian cyclin-dependent kinases.

Authors: Malumbres, M  Barbacid, M 
Citation: Malumbres M and Barbacid M, Trends Biochem Sci. 2005 Nov;30(11):630-41. Epub 2005 Oct 19.
RGD ID: 8694150
Pubmed: PMID:16236519   (View Abstract at PubMed)
DOI: DOI:10.1016/j.tibs.2005.09.005   (Journal Full-text)

Cyclin-dependent kinases (Cdks) are the catalytic subunits of a family of mammalian heterodimeric serine/threonine kinases that have been implicated in the control of cell-cycle progression, transcription and neuronal function. Recent genetic evidence obtained with gene-targeted mice has shown that Cdk4 and Cdk6 are not needed for entry into the cell cycle after mitogenic stimuli and organogenesis; however, they are essential for the proliferation of some endocrine and hematopoietic cells. Cdk2 is also dispensable for the mitotic cell cycle. Indeed, mice without Cdk2 are normal except for their complete sterility: unexpectedly, Cdk2 is crucial for the first meiotic division of male and female germ cells. These findings have important implications both for our current understanding of the role of Cdks in regulating the mammalian cell cycle and for their potential use as therapeutic targets in cancer.

Objects Annotated

Genes (Rattus norvegicus)
Ccna1  (cyclin A1)
Ccna2  (cyclin A2)
Ccne1  (cyclin E1)
Ccne2  (cyclin E2)
Cdk2  (cyclin dependent kinase 2)
Cdk4  (cyclin-dependent kinase 4)
Cdk6  (cyclin-dependent kinase 6)
Rb1  (RB transcriptional corepressor 1)
Rbl1  (RB transcriptional corepressor like 1)
Rbl2  (RB transcriptional corepressor like 2)

Genes (Mus musculus)
Ccna1  (cyclin A1)
Ccna2  (cyclin A2)
Ccne1  (cyclin E1)
Ccne2  (cyclin E2)
Cdk2  (cyclin dependent kinase 2)
Cdk4  (cyclin dependent kinase 4)
Cdk6  (cyclin dependent kinase 6)
Rb1  (RB transcriptional corepressor 1)
Rbl1  (RB transcriptional corepressor like 1)
Rbl2  (RB transcriptional corepressor like 2)

Genes (Homo sapiens)
CCNA1  (cyclin A1)
CCNA2  (cyclin A2)
CCNE1  (cyclin E1)
CCNE2  (cyclin E2)
CDK2  (cyclin dependent kinase 2)
CDK4  (cyclin dependent kinase 4)
CDK6  (cyclin dependent kinase 6)
RB1  (RB transcriptional corepressor 1)
RBL1  (RB transcriptional corepressor like 1)
RBL2  (RB transcriptional corepressor like 2)


Additional Information