RNA POLYMERASE III TRANSCRIPTION PATHWAY (PW:0000128)

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Description

The three eukaryotic RNA polymerases (RNAPs)- Pol I, II and III, transcribe different sets of genes and require distinct sets of factors to assemble a specific initiation complex which recruits them on gene promoters. The multi-subunit enzymes are composed of 14 (RNAPI), 12 (RNAPII) and 17 (RNAPIII) subunits of which some are shared and others are unique, yet converging on an overall similar structural topology. Complexes specific to each of the three systems share the universal transcription f

Pathway Diagram:

Elsevier Inc. pre-tRNA transcript tRNA maturation pathway Sub1 Rb1 TFIIIB Pou2f1 Rb1 ---- SNAPc Sub1 ---- TFIIIC TFIIIB ---- TFIIIC Sub1 ---- TFIIIB Zfp143 --+> SNAPc chromatin modification/remodeling pathway Pou2f1 --+> SNAPc Zfp143 Maf1 ---- RNA polymerase III Maf1 ---| RNA polymerase III Maf1 ---- TFIIIB Maf1 ---| TFIIIB SNAPc ---- TFIIIB RNA polymerase III ---- TFIIIB TFIIIA ---- TFIIIC Rb1 ---| TFIIIB Rb1 ---- TFIIIB Rb1 ---| SNAPc stress stress --+> Maf1 Maf1 mTOR signaling pathway ---| Maf1 SNAPc TFIIIC TFIIIA RNA polymerase III RNA polymerase III ---> pre-tRNA transcript mTOR signaling pathway
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RNA polymerase III transcription pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bdp1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB JBrowse link 2 30,248,458 30,340,211 RGD:9588284
RGD:9685218
G Brf1 BRF1, RNA polymerase III transcription initiation factor 90 subunit JBrowse link 6 137,762,230 137,808,573 RGD:9588284
RGD:9685218
G Brf2 BRF2, RNA polymerase III transcription initiation factor 50 subunit JBrowse link 16 69,089,955 69,094,678 RGD:9588284
RGD:9685218
G Crcp CGRP receptor component JBrowse link 12 30,125,237 30,160,857 RGD:9685217
G Gtf3a general transcription factor III A JBrowse link 12 9,856,841 9,864,791 RGD:9588284
G Gtf3c1 general transcription factor IIIC subunit 1 JBrowse link 1 197,032,473 197,098,676 RGD:9588284
G Gtf3c2 general transcription factor IIIC subunit 2 JBrowse link 6 26,560,601 26,584,533 RGD:9588284
G Gtf3c3 general transcription factor IIIC subunit 3 JBrowse link 9 60,999,159 61,033,612 RGD:9588284
G Gtf3c4 general transcription factor IIIC subunit 4 JBrowse link 3 7,404,857 7,422,779 RGD:9588284
G Gtf3c5 general transcription factor IIIC subunit 5 JBrowse link 3 7,144,354 7,164,678 RGD:9588284
G Gtf3c6 general transcription factor 3C subunit 6 JBrowse link 20 45,347,788 45,356,868 RGD:9588284
G Maf1 MAF1 homolog, negative regulator of RNA polymerase III JBrowse link 7 117,417,643 117,420,722 RGD:9588284
RGD:9685221
G Polr1c RNA polymerase I subunit C JBrowse link 9 17,120,759 17,124,871 RGD:9685217
RGD:9685218
G Polr2e RNA polymerase II subunit E JBrowse link 7 12,532,785 12,536,797 RGD:9685217
RGD:9685218
G Polr2f RNA polymerase II subunit F JBrowse link 7 120,380,543 120,392,214 RGD:9685217
RGD:9685218
G Polr2k RNA polymerase II subunit K JBrowse link 7 74,939,010 74,992,594 RGD:9685217
RGD:9685218
G Polr3a RNA polymerase III subunit A JBrowse link 16 717,821 756,002 RGD:9685217
RGD:9685218
G Polr3b RNA polymerase III subunit B JBrowse link 7 24,745,051 24,851,227 RGD:9685217
RGD:9685218
G Polr3c RNA polymerase III subunit C JBrowse link 2 198,836,282 198,852,368 RGD:9685217
RGD:9685218
G Polr3d RNA polymerase III subunit D JBrowse link 15 52,129,471 52,134,140 RGD:9685217
RGD:9685218
G Polr3e RNA polymerase III subunit E JBrowse link 1 190,852,954 190,881,539 RGD:9685217
RGD:9685218
G Polr3f RNA polymerase III subunit F JBrowse link 3 138,684,685 138,701,055 RGD:9685217
RGD:9685218
G Polr3g RNA polymerase III subunit G JBrowse link 2 9,537,642 9,578,551 RGD:9685217
RGD:9685218
G Polr3gl RNA polymerase III subunit G like JBrowse link 2 198,698,044 198,719,609 RGD:9685218
G Polr3h RNA polymerase III subunit H JBrowse link 7 123,146,248 123,156,558 RGD:9685217
RGD:9685218
G Polr3k RNA polymerase III subunit K JBrowse link 3 177,374,812 177,379,009 RGD:9685217
RGD:9685218
G Pou2f1 POU class 2 homeobox 1 JBrowse link 13 84,075,316 84,217,368 RGD:9685218
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:9685222
G Snapc1 small nuclear RNA activating complex, polypeptide 1 JBrowse link 6 96,871,675 96,893,422 RGD:9588284
G Snapc2 small nuclear RNA activating complex, polypeptide 2 JBrowse link 12 2,537,291 2,540,774 RGD:9588284
G Snapc3 small nuclear RNA activating complex, polypeptide 3 JBrowse link 5 101,526,591 101,554,015 RGD:9588284
G Snapc4 small nuclear RNA activating complex, polypeptide 4 JBrowse link 3 3,808,596 3,827,425 RGD:9588284
G Snapc5 small nuclear RNA activating complex, polypeptide 5 JBrowse link 8 69,127,708 69,131,539 RGD:9588284
G Sub1 SUB1 homolog, transcriptional regulator JBrowse link 2 62,019,902 62,034,704 RGD:9685220
RGD:9685221
G Tbp TATA box binding protein JBrowse link 1 57,491,381 57,509,335 RGD:9588284
RGD:9685218
G Zfp143 zinc finger protein 143 JBrowse link 1 174,702,310 174,738,133 RGD:9685218
tRNA maturation pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clp1 cleavage and polyadenylation factor I subunit 1 JBrowse link 3 72,125,269 72,137,122 RGD:9685342
G Elac1 elaC ribonuclease Z 1 JBrowse link 18 69,706,522 69,723,869 RGD:9685334
G Elac2 elaC ribonuclease Z 2 JBrowse link 10 51,478,378 51,501,167 RGD:9685334
G Pop1 POP1 homolog, ribonuclease P/MRP subunit JBrowse link 7 73,270,403 73,298,209 RGD:9685326
G Pop4 POP4 homolog, ribonuclease P/MRP subunit JBrowse link 1 94,661,127 94,669,461 RGD:9685326
G Pop7 POP7 homolog, ribonuclease P/MRP subunit JBrowse link 12 22,259,713 22,260,754 RGD:9685326
G Rpp14 ribonuclease P/MRP 14 subunit JBrowse link 15 18,625,963 18,636,157 RGD:9685326
G Rpp21 ribonuclease P/MRP 21 subunit JBrowse link 20 2,515,541 2,517,471 RGD:9685326
G Rpp25 ribonuclease P/MRP 25 subunit JBrowse link 8 62,283,336 62,284,716 RGD:9685326
G Rpp30 ribonuclease P/MRP subunit p30 JBrowse link 1 254,697,247 254,720,093 RGD:9685326
G Rpp38 ribonuclease P/MRP 38 subunit JBrowse link 17 78,915,450 78,919,144 RGD:9685326
G Rpp40 ribonuclease P/MRP 40 subunit JBrowse link 17 29,638,647 29,647,709 RGD:9685326
G Rtcb RNA 2',3'-cyclic phosphate and 5'-OH ligase JBrowse link 7 23,913,830 23,933,191 RGD:9685342
G Ssb Sjogren syndrome antigen B JBrowse link 3 56,092,425 56,102,008 RGD:9685334
G Tsen15 tRNA splicing endonuclease subunit 15 JBrowse link 13 69,765,093 69,781,019 RGD:9685342
G Tsen2 tRNA splicing endonuclease subunit 2 JBrowse link 4 147,455,506 147,490,869 RGD:9685342
G Tsen34 tRNA splicing endonuclease subunit 34 JBrowse link 1 64,023,924 64,031,756 RGD:9685342
G Tsen54 tRNA splicing endonuclease subunit 54 JBrowse link 10 104,358,401 104,366,926 RGD:9685342

Pathway Gene Annotations

Disease Annotations Associated with Genes in the RNA polymerase III transcription pathway
Disease TermsGene Symbols
Absent Radii and ThrombocytopeniaPolr3c , Polr3gl
Acute Kidney InjuryRb1
Adrenal Gland NeoplasmsRb1
Adrenocortical CarcinomaRb1
Alzheimer DiseaseTbp
Anemia, Diamond-BlackfanPolr3a
Brain IschemiaRb1
Breast NeoplasmsRb1
CarcinomaRb1
Carcinoma in SituRb1
Carcinoma, Basal CellRb1
Carcinoma, EmbryonalRb1
Carcinoma, HepatocellularRb1
Carcinoma, Intraductal, NoninfiltratingRb1
Carcinoma, Non-Small-Cell LungRb1
Carcinoma, Renal CellRb1
Carcinoma, Small CellRb1
Cardiofaciocutaneous SyndromeSnapc5
CardiomegalyBrf1 , Rb1
Cerebellofaciodental SyndromeBrf1
Cervical Intraepithelial NeoplasiaRb1
Ciliary Dyskinesia, Primary, 28Polr2k
Diabetes Mellitus, Type 1Tbp
Disease ProgressionPolr3k
Endometrial NeoplasmsRb1
Esophageal Squamous Cell CarcinomaRb1
FibromaBrf1
Hirschsprung Disease 1Polr2f
HIV InfectionsGtf3a
Huntington DiseaseTbp
HyperalgesiaCrcp
HypotrichosisRb1
Hypotrichosis, Localized, Autosomal Recessive, 3Rb1
Infantile Cerebellar-Retinal DegenerationPolr3h
Insulin ResistanceRb1
Intellectual DisabilityPolr3b
Intestinal Pseudo-ObstructionRb1
Kartagener SyndromePolr2k
Leukodystrophy, Hypomyelinating, 8, with or without Oligodontia and/or Hypogonadotropic HypogonadismPolr3b
Leukodystrophy, Hypomyelinating, with Hypodontia and Hypogonadotropic HypogonadismPolr3a , Polr3b
Liver Neoplasms, ExperimentalRb1
Long QT SyndromeSnapc4 , Snapc5
Mammary Neoplasms, AnimalRb1
Mammary Neoplasms, ExperimentalRb1
Mandibulofacial DysostosisPolr1c
Mandibulofacial Dysostosis, Treacher Collins Type, Autosomal RecessivePolr1c
MedulloblastomaRb1
Neoplasm MetastasisRb1
Neoplasms, ExperimentalRb1
Noonan SyndromeSnapc5
ObesityRb1
Optic Atrophy 8Polr3h
OPTIC ATROPHY 9Polr3h
OsteosarcomaRb1
Ovarian NeoplasmsRb1
Pancreatic NeoplasmsRb1
Parkinson Disease, Late-OnsetTbp
Peripheral Demyelinating Neuropathy, Central Dysmyelination, Waardenburg Syndrome, and Hirschsprung DiseasePolr2f
Phyllodes TumorRb1
Pituitary NeoplasmsRb1
Precursor Cell Lymphoblastic Leukemia-LymphomaRb1
Prostatic NeoplasmsBrf2 , Rb1
RASopathiesSnapc5
RetinoblastomaRb1
SchizophreniaPolr3e , Tbp
Sciatic NeuropathyCrcp
SeminomaRb1
Sezary SyndromeRb1
Sleep Apnea SyndromesTbp
Small Cell Lung CarcinomaRb1
Spinal Cord InjuriesTbp
Spinocerebellar Ataxia 17Tbp
Spinocerebellar AtaxiasTbp
Stevens-Johnson SyndromeRb1
Stomach NeoplasmsPolr3k
Urinary Bladder NeoplasmsRb1
Waardenburg SyndromePolr2f
Waardenburg Syndrome Type 2Polr2f
Waardenburg Syndrome, Type 4cPolr2f
Woolly Hair, Autosomal RecessiveRb1
Pathway Annotations Associated with Genes in the RNA polymerase III transcription pathway

References Associated with the RNA polymerase III transcription pathway:

Ontology Path Diagram:

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