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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3540 Species: Rattus norvegicus RGD Object: Gene Symbol: Rb1 Name: retinoblastoma 1

Acc ID: CHEBI:17688 Term: (S)-nicotine Definition: An optically active form of nicotine having S-configuration. CasRN: 54-11-5 Chemical ID: MESH:D009538

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:731712	6480464	CTD	Aconitine analog inhibits the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]] Bungarotoxins inhibits the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]] ARRB1 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]] CHRNA7 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]] Nicotine inhibits the reaction [RB1 protein binds to CDC25A promoter] Nicotine inhibits the reaction [RB1 protein binds to CDC6 promoter] SRC protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]	PMID:16862215
multiple interactions	ISO	RGD:731712	6480464	CTD	4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in increased phosphorylation of RB1 protein]	PMID:18805435
multiple interactions	ISO	RGD:731712	6480464	CTD	L 663536 inhibits the reaction [Nicotine results in increased expression of RB1 protein modified form]	PMID:20061081
multiple interactions	ISO	RGD:731712	6480464	CTD	Nicotine inhibits the reaction [RB1 protein binds to BIRC5 promoter]	PMID:16601104
decreases expression	ISO	RGD:731712	6480464	CTD	Nicotine results in decreased expression of RB1 protein	PMID:16011614
increases expression	ISO	RGD:731712	6480464	CTD	Nicotine results in increased expression of RB1 protein modified form	PMID:20061081
increases phosphorylation	ISO	RGD:731712	6480464	CTD	Nicotine results in increased phosphorylation of RB1 protein	PMID:16862215 PMID:18805435 PMID:18448488
increases phosphorylation	ISO	RGD:11219	6480464	CTD	Nicotine results in increased phosphorylation of RB1 protein	PMID:15574422
increases phosphorylation	ISO	RGD:731712	6480464	CTD	Nicotine results in increased phosphorylation of RB1 protein	PMID:16862215 PMID:18448488 PMID:18805435
increases phosphorylation	ISO	RGD:731712	6480464	CTD	Nicotine results in increased phosphorylation of RB1 protein	PMID:18805435 PMID:18448488 PMID:16862215
increases phosphorylation	ISO	RGD:731712	6480464	CTD	Nicotine results in increased phosphorylation of RB1 protein	PMID:18805435 PMID:16862215 PMID:18448488