Rb1 (RB transcriptional corepressor 1) - Rat Genome Database

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Pathways
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Gene: Rb1 (RB transcriptional corepressor 1) Heterocephalus glaber
Analyze
Symbol: Rb1
Name: RB transcriptional corepressor 1
RGD ID: 18915315
Description: ENCODES a protein that exhibits disordered domain specific binding (ortholog); DNA-binding transcription factor binding (ortholog); enzyme binding (ortholog); INVOLVED IN aortic valve morphogenesis (ortholog); apoptotic process (ortholog); cell division (ortholog); PARTICIPATES IN ceramide signaling pathway; G1/S transition pathway; RNA polymerase III transcription pathway; ASSOCIATED WITH Acute Erythroleukemia (ortholog); acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN chromatin lock complex (ortholog); cyclin/CDK positive transcription elongation factor complex (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: retinoblastoma-associated protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247486,358,180 - 6,533,249 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247486,358,588 - 6,533,217 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Erythroleukemia  (ISO)
acute kidney failure  (ISO)
acute lymphoblastic leukemia  (ISO)
Adrenal Gland Neoplasms  (ISO)
adrenocortical carcinoma  (ISO)
Animal Mammary Neoplasms  (ISO)
Autosomal Recessive Woolly Hair  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
B-lymphoblastic leukemia/lymphoma with ETV6-RUNX1  (ISO)
basal cell carcinoma  (ISO)
bone osteosarcoma  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
cervix uteri carcinoma in situ  (ISO)
chromosome 13q14 deletion syndrome  (ISO)
disease of cellular proliferation  (ISO)
ductal carcinoma in situ  (ISO)
embryonal carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
familial retinoblastoma  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
glioblastoma proneural subtype  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hereditary nonpolyposis colorectal cancer type 4  (ISO)
hypotrichosis 8  (ISO)
in situ carcinoma  (ISO)
Insulin Resistance  (ISO)
intellectual disability  (ISO)
intestinal pseudo-obstruction  (ISO)
lung adenocarcinoma  (ISO)
lung non-small cell carcinoma  (ISO)
lung oat cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
medulloblastoma  (ISO)
mitochondrial DNA depletion syndrome 5  (ISO)
Neoplasm Metastasis  (ISO)
obesity  (ISO)
oligodendroglioma  (ISO)
osteosarcoma  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
Phyllodes Tumor  (ISO)
Pituitary Neoplasms  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
renal cell carcinoma  (ISO)
retinoblastoma  (ISO)
seminoma  (ISO)
Sezary's disease  (ISO)
small cell carcinoma  (ISO)
squamous cell carcinoma  (ISO)
Stevens-Johnson syndrome  (ISO)
trilateral retinoblastoma  (ISO)
urinary bladder cancer  (ISO)
Urinary Bladder Neoplasm  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aortic valve morphogenesis  (ISO)
apoptotic process  (ISO)
cell differentiation  (IEA)
cell division  (ISO)
cell morphogenesis involved in neuron differentiation  (IEA,ISO)
cell population proliferation  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to xenobiotic stimulus  (ISO)
chondrocyte differentiation  (ISO)
chromatin organization  (IEA)
chromosome organization  (ISO)
digestive tract development  (ISO)
enucleate erythrocyte differentiation  (ISO)
epithelial cell proliferation  (ISO)
G1/S transition of mitotic cell cycle  (ISO)
glial cell apoptotic process  (ISO)
glial cell proliferation  (ISO)
hepatocyte apoptotic process  (ISO)
heterochromatin formation  (ISO)
maintenance of mitotic sister chromatid cohesion  (ISO)
myoblast differentiation  (ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of cell cycle  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cold-induced thermogenesis  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of G1/S transition of mitotic cell cycle  (IEA,ISO)
negative regulation of gene expression  (ISO)
negative regulation of glial cell proliferation  (ISO)
negative regulation of hepatocyte apoptotic process  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of mitotic cell cycle  (ISO)
negative regulation of myofibroblast differentiation  (ISO)
negative regulation of smoothened signaling pathway  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neuron apoptotic process  (ISO)
neuron differentiation  (ISO)
neuron maturation  (ISO)
neuron projection development  (IEA,ISO)
positive regulation of collagen fibril organization  (ISO)
positive regulation of extracellular matrix organization  (ISO)
positive regulation of macrophage differentiation  (ISO)
positive regulation of mitotic metaphase/anaphase transition  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
protein localization to chromosome, centromeric region  (ISO)
Ras protein signal transduction  (ISO)
regulation of cell cycle  (IEA,ISO)
regulation of cell growth  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of G1/S transition of mitotic cell cycle  (ISO)
regulation of macromolecule metabolic process  (IEA)
regulation of mitotic cell cycle  (ISO)
regulation of primary metabolic process  (IEA)
regulation of transcription by RNA polymerase II  (IEA)
sister chromatid biorientation  (ISO)
skeletal muscle cell differentiation  (ISO)
smoothened signaling pathway  (ISO)
spermatogenesis  (ISO)
striated muscle cell differentiation  (ISO)
tissue homeostasis  (ISO)
transcription by RNA polymerase II  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Rb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247486,358,180 - 6,533,249 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247486,358,588 - 6,533,217 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
RB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381348,303,751 - 48,481,890 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1348,303,744 - 48,599,436 (+)EnsemblGRCh38hg38GRCh38
GRCh371348,877,887 - 49,056,026 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361347,775,884 - 47,954,027 (+)NCBINCBI36Build 36hg18NCBI36
Build 341347,775,911 - 47,954,023NCBI
Celera1329,932,627 - 30,110,747 (+)NCBICelera
Cytogenetic Map13q14.2NCBI
HuRef1329,670,144 - 29,848,118 (+)NCBIHuRef
CHM1_11348,845,597 - 49,023,603 (+)NCBICHM1_1
T2T-CHM13v2.01347,524,085 - 47,702,182 (+)NCBIT2T-CHM13v2.0
Rb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391473,430,298 - 73,563,446 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1473,421,113 - 73,563,262 (-)EnsemblGRCm39 Ensembl
GRCm381473,192,858 - 73,325,951 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1473,183,673 - 73,325,822 (-)EnsemblGRCm38mm10GRCm38
MGSCv371473,595,309 - 73,725,598 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361471,929,656 - 72,059,895 (-)NCBIMGSCv36mm8
Celera1470,715,843 - 70,870,859 (-)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1438.73NCBI
Rb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81554,780,858 - 54,911,989 (-)NCBIGRCr8
mRatBN7.21548,371,295 - 48,502,473 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1548,371,296 - 48,502,302 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1552,511,872 - 52,643,399 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01553,623,446 - 53,754,974 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01550,468,702 - 50,599,902 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01555,081,582 - 55,209,060 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1555,083,140 - 55,209,342 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01558,804,731 - 58,931,886 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41553,828,881 - 53,962,099 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11553,844,684 - 53,977,640 (-)NCBI
Celera1548,020,828 - 48,147,805 (-)NCBICelera
Cytogenetic Map15q11NCBI
Rb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554311,960,661 - 2,124,576 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554311,960,765 - 2,124,576 (+)NCBIChiLan1.0ChiLan1.0
RB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21449,752,343 - 49,924,312 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11348,403,509 - 48,575,444 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01329,453,872 - 29,624,665 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11348,155,608 - 48,326,396 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1348,155,795 - 48,324,575 (+)Ensemblpanpan1.1panPan2
RB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1223,061,621 - 3,204,625 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl223,063,239 - 3,257,726 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha223,090,617 - 3,235,458 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0223,143,918 - 3,320,581 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl223,050,839 - 3,321,505 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1222,960,514 - 3,106,149 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0223,023,421 - 3,169,707 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0223,028,586 - 3,174,226 (-)NCBIUU_Cfam_GSD_1.0
Rb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945158,103,473 - 158,265,512 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365651,597,593 - 1,746,846 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365651,596,227 - 1,746,706 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1119,186,761 - 19,317,690 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11119,186,754 - 19,317,642 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21119,648,360 - 19,770,943 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1326,220,783 - 26,393,671 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl326,220,803 - 26,394,546 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605717,512,606 - 17,688,151 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_004844186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01027571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01027572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01027573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01027574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01027575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01027576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01027577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01027578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01027579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01027580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01027581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01027582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01027583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01027584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GEBF01002508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSHGLT00000004941   ⟹   ENSHGLP00000004877
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247486,358,180 - 6,533,249 (-)Ensembl
RefSeq Acc Id: XM_004844186   ⟹   XP_004844243
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247486,358,588 - 6,533,217 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004844243 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000004877
GenBank Protein JAO01125 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004844243   ⟸   XM_004844186
- UniProtKB: A0A0P6JI57 (UniProtKB/TrEMBL),   G5BFH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000004877   ⟸   ENSHGLT00000004941


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000003581 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000004941 ENTREZGENE
Gene3D-CATH 1.10.472.140 UniProtKB/TrEMBL
  6.10.140.1380 UniProtKB/TrEMBL
  6.10.250.530 UniProtKB/TrEMBL
  Cyclin-like UniProtKB/TrEMBL
InterPro Cyclin-like UniProtKB/TrEMBL
  Cyclin-like_sf UniProtKB/TrEMBL
  RB_A UniProtKB/TrEMBL
  RB_B UniProtKB/TrEMBL
  RB_C UniProtKB/TrEMBL
  RB_fam UniProtKB/TrEMBL
  RB_N UniProtKB/TrEMBL
KEGG Report hgl:101703701 UniProtKB/TrEMBL
NCBI Gene Rb1 ENTREZGENE
PANTHER PTHR13742 UniProtKB/TrEMBL
  RETINOBLASTOMA-ASSOCIATED PROTEIN UniProtKB/TrEMBL
Pfam DUF3452 UniProtKB/TrEMBL
  RB_A UniProtKB/TrEMBL
  RB_B UniProtKB/TrEMBL
  Rb_C UniProtKB/TrEMBL
SMART CYCLIN UniProtKB/TrEMBL
  DUF3452 UniProtKB/TrEMBL
  RB_A UniProtKB/TrEMBL
  Rb_C UniProtKB/TrEMBL
Superfamily-SCOP Formin homology 2 domain (FH2 domain) UniProtKB/TrEMBL
  SSF47954 UniProtKB/TrEMBL
UniProt A0A0P6JI57 ENTREZGENE, UniProtKB/TrEMBL
  G5BFH6 ENTREZGENE, UniProtKB/TrEMBL