Gene:	Ppp3cb ( Rattus norvegicus ) protein phosphatase 3, catalytic subunit, beta isoform
Description:	calmodulin-dependent protein phosphatase; dephosphorylates nuclear factors of activated T cells; may play a role during skeletal muscle atrophy
Synonyms:	calcineurin subunit A beta; Calna2;
ArrayIDs:	6701776; 6055115; 1375882_at; 1379314_at; 6325931; 6358125; 5860349; 5783272; rc_AI170309_at; 6738500; 5707653; 5930557; 6343947; 5940832; 5682563; M31809_at; 6130047; 6617499; 5842215; 5816884; 6577145; 1387261_at; 5625410; 6352976;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: PPP3CB     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Ppp3cb     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Ppp3cb genome assembly 3.1 X 153471064 - 153474197     Rat Celera Assembly 15 790760 - 817951     RGSC genome assembly v3.4 15 4003161 - 4030352     Cytogenetic 15 p16 Mus musculus Ppp3cb Mouse genome assembly build 36.1 14 21319262 - 21365766     Cytogenetic 14 14 B Homo sapiens PPP3CB human genome assembly 10 74866617 - 74925760     Human genome assembly build 36.2 10 74866618 - 74925758     Cytogenetic 10 q21-q22   View comparative maps:      NCBI MapViewer
Genome
View:
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Annotation
Molecular Function	Gene Ontology zinc ion binding,  calmodulin binding,  iron ion binding ...  (details...)
Biological Process	Note Reference calcium binding regulatory subunit which is activated by intracellular calcium anions 628398 mediates hypertropic response of muscle cells 628398 Gene Ontology response to amphetamine,  response to cytokine stimulus,  regulation of gene expression ...  (details...)
Cellular Component	Gene Ontology protein complex,  calcineurin complex,  soluble fraction ...  (details...)
Disease	Ontology Hypertrophy, Right Ventricular,  Hypertrophy, Left Ventricular,  Aortic Valve Stenosis ...  (details...)
Phenotype	Ontology cardiac hypertrophy (details...)
Pathway	Ontology calcineurin signaling pathway (details...)
Protein	Note Reference 19 kDa in size 628398
Regulation	Note Reference activated by intracellular calcuim and dephosphorylates nuclear factors of activated T cells (NFATs) 628398
Drugs	Note Reference cyclosporin acts as a inhibitor partially blocking the muscle size 628398
External Links
Databases	DATABASE ID SOURCE SMART: PP2Ac IPI PROSITE: SER_THR_PHOSPHATASE IPI UNIPARC: UPI0000130FD8 IPI KEGG Report: rno:24675 ENTREZGENE HomoloGene Group ID: 56429 ENTREZGENE Germonline: 3383 Pfam: Metallophos IPI KEGG Pathway: 04662 ENTREZGENE KEGG Pathway: 04360 ENTREZGENE KEGG Pathway: 04020 ENTREZGENE KEGG Pathway: 04720 ENTREZGENE KEGG Pathway: 04010 ENTREZGENE KEGG Pathway: 04650 ENTREZGENE KEGG Pathway: 04660 ENTREZGENE KEGG Pathway: 04370 ENTREZGENE KEGG Pathway: 04310 ENTREZGENE KEGG Pathway: 04210 ENTREZGENE KEGG Pathway: 05014 ENTREZGENE KEGG Pathway: 05010 ENTREZGENE InterPro: M-pesterase. IPI InterPro: Ser/Thr-sp_prot-phosphatase. IPI IPI: IPI00201407 IPI Ensembl Protein: ENSRNOP00000010476 IPI Entrez Gene: Ppp3cb ENTREZGENE UniProt: PP2BB_RAT IPI Ensembl Genes: ENSRNOG00000007757 IPI RatMap: 34320 ENTREZGENE PANTHER: T_phtase_apaH IPI PRINTS: STPHPHTASE. IPI
Sequences	Nucleotide: CH474061 Get FASTA Search GEO Profiles Nucleotide: D90036 Get FASTA Search GEO Profiles Nucleotide: NM_017042 Get FASTA Search GEO Profiles Nucleotide: M31809 Get FASTA Search GEO Profiles (View all 4 Nucleotide Accessions) Protein: AAA40848 Get FASTA Protein: P20651 Get FASTA Protein: NP_058738 Get FASTA Protein: EDL86229 Get FASTA Protein: BAA14084 Get FASTA Protein: EDL86231 Get FASTA Protein: EDL86232 Get FASTA Protein: EDL86230 Get FASTA (View all 8 Protein Accessions)
Clusters	UniGene: 11063
References
Curated References	16 references in RGD related to Ppp3cb
Other References	17 other references at PubMed related to Ppp3cb
Database Information
RGD ID	3383
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 24-OCT-01: Ppp3cb protein phosphatase 3, catalytic subunit, beta isoform APPROVED Name updated to reflect Human and Mouse nomenclature 68913