Ppp3cb (protein phosphatase 3 catalytic subunit beta) - Rat Genome Database

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Gene: Ppp3cb (protein phosphatase 3 catalytic subunit beta) Rattus norvegicus
Analyze
Symbol: Ppp3cb
Name: protein phosphatase 3 catalytic subunit beta
RGD ID: 3383
Description: Enables calcium-dependent protein serine/threonine phosphatase activity and calmodulin binding activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and response to amphetamine. Located in plasma membrane. Part of protein-containing complex. Is active in synapse. Biomarker of schizophrenia. Human ortholog(s) of this gene implicated in aortic valve stenosis. Orthologous to human PPP3CB (protein phosphatase 3 catalytic subunit beta); PARTICIPATES IN calcineurin signaling pathway; dopamine signaling pathway; interleukin-12 signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: calcineurin subunit A beta; calmodulin-dependent calcineurin A subunit beta isoform; Calna2; CAM-PRP catalytic subunit; CaN Abeta; CNA beta; protein phosphatase 3, catalytic subunit, beta isoform; protein phosphatase 3, catalytic subunit, beta isozyme; protein phosphatase-2Bb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8153,809,182 - 3,854,204 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl153,809,262 - 3,854,203 (+)EnsemblGRCr8
mRatBN7.2153,759,950 - 3,804,976 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl153,760,030 - 3,804,981 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx153,770,195 - 3,814,366 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0155,156,614 - 5,200,790 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0153,769,006 - 3,813,183 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd153,762,414 - 3,806,574 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive154,351,095 - 4,395,129 (+)NCBILyon_Normotensive
Lyon_Hypertensive153,765,958 - 3,809,993 (+)NCBILyon_Hypertensive
F344_StmMcwi153,808,041 - 3,852,173 (+)NCBIF344_StmMcwi
Rnor_6.0154,209,702 - 4,236,895 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl154,209,703 - 4,236,895 (+)Ensemblrn6Rnor6.0
Rnor_5.0158,310,717 - 8,338,152 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4153,986,290 - 4,030,352 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera15790,760 - 817,953 (-)NCBICelera
RGSC_v3.1X153,471,064 - 153,474,197 (+)NCBI
Cytogenetic Map15p16NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-methylcholine  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
alpha,alpha-trehalose  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
doxorubicin  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
finasteride  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
nefazodone  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (EXP,ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
phenylephrine  (EXP,ISO)
potassium dichromate  (ISO)
rotenone  (ISO)
SCH 23390  (EXP)
sodium arsenite  (ISO)
T-2 toxin  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
theophylline  (ISO)
topotecan  (EXP)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
verapamil  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
calcineurin complex  (IBA,IEA,ISO,ISS)
cytoplasm  (IBA,IEA,ISO)
cytosol  (IEA,ISO,TAS)
glutamatergic synapse  (IEA,ISO)
plasma membrane  (IDA,IEA,ISO)
protein-containing complex  (IDA)
synapse  (IDA,IEP)
T-tubule  (IEA,ISO)
Z disc  (IEA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Altered Bad localization and interaction between Bad and Bcl-xL in the hippocampus after transient global ischemia. Abe T, etal., Brain Res. 2004 May 29;1009(1-2):159-68.
2. Calcineurin Abeta gene targeting predisposes the myocardium to acute ischemia-induced apoptosis and dysfunction. Bueno OF, etal., Circ Res. 2004 Jan 9;94(1):91-9. Epub 2003 Nov 13.
3. Calcineurin Agamma is a Functional Phosphatase That Modulates Synaptic Vesicle Endocytosis. Cottrell JR, etal., J Biol Chem. 2016 Jan 22;291(4):1948-56. doi: 10.1074/jbc.M115.705319. Epub 2015 Dec 1.
4. Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis. Donelan MJ, etal., J Biol Chem. 2002 Jul 5;277(27):24232-42. Epub 2002 Apr 26.
5. Maintenance of muscle mass is not dependent on the calcineurin-NFAT pathway. Dupont-Versteegden EE, etal., Am J Physiol Cell Physiol 2002 Jun;282(6):C1387-95.
6. Decreased hippocampal expression of the susceptibility gene PPP3CC and other calcineurin subunits in schizophrenia. Eastwood SL, etal., Biol Psychiatry. 2005 Apr 1;57(7):702-10. doi: 10.1016/j.biopsych.2004.12.029.
7. Differential expression of calcineurin A subunit mRNA isoforms during rat hippocampal and cerebellar development. Eastwood SL, etal., Eur J Neurosci. 2005 Dec;22(12):3017-24.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Comparative Analysis of Gene Expression Profiles Involved in Calcium Signaling Pathways Using the NLVH Animal Model of Schizophrenia. Genis-Mendoza A, etal., J Mol Neurosci. 2018 Jan;64(1):111-116. doi: 10.1007/s12031-017-1013-y. Epub 2017 Dec 6.
10. Calcineurin and matrix protein expression in cardiac hypertrophy : Evidence for calcineurin B to control excessive hypertrophic signaling. Grammer JB, etal., Basic Res Cardiol. 2006 Jul;101(4):292-300. Epub 2006 May 10.
11. Direct association of the unique C-terminal tail of transmembrane AMPA receptor regulatory protein gamma-8 with calcineurin. Itakura M, etal., FEBS J. 2014 Mar;281(5):1366-78. doi: 10.1111/febs.12708. Epub 2014 Jan 27.
12. Evidence for a second isoform of the catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin A). Kuno T, etal., Biochem Biophys Res Commun 1989 Dec 29;165(3):1352-8.
13. Distinct cellular expression of calcineurin A alpha and A beta in rat brain. Kuno T, etal., J Neurochem. 1992 May;58(5):1643-51.
14. The mAKAPbeta scaffold regulates cardiac myocyte hypertrophy via recruitment of activated calcineurin. Li J, etal., J Mol Cell Cardiol. 2010 Feb;48(2):387-94. Epub 2009 Oct 31.
15. Decreased calcineurin and increased phosphothreonine-DARPP-32 in the striatum of rats behaviorally sensitized to methamphetamine. Lin XH, etal., Synapse 2002 Jun 1;44(3):181-7.
16. L-type calcium channel blocker suppresses calcineurin signal pathway and development of right ventricular hypertrophy. Liu CZ, etal., J Formos Med Assoc. 2005 Nov;104(11):798-803.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Molkentin JD, etal., Cell. 1998 Apr 17;93(2):215-28.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Upregulation of myocardial estrogen receptors in human aortic stenosis. Nordmeyer J, etal., Circulation. 2004 Nov 16;110(20):3270-5. Epub 2004 Nov 8.
21. Regulation of calcineurin through transcriptional induction of the calcineurin A beta promoter in vitro and in vivo. Oka T, etal., Mol Cell Biol. 2005 Aug;25(15):6649-59.
22. The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling. Pare GC, etal., J Cell Sci. 2005 Dec 1;118(Pt 23):5637-46.
23. Substrate selectivity and sensitivity to inhibition by FK506 and cyclosporin A of calcineurin heterodimers composed of the alpha or beta catalytic subunit. Perrino BA, etal., Eur J Biochem 2002 Jul;269(14):3540-8.
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
26. GOA pipeline RGD automated data pipeline
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Calcium-calcineurin signaling in the regulation of cardiac hypertrophy. Wilkins BJ and Molkentin JD, Biochem Biophys Res Commun. 2004 Oct 1;322(4):1178-91.
29. MicroRNA-30 family members regulate calcium/calcineurin signaling in podocytes. Wu J, etal., J Clin Invest. 2015 Nov 2;125(11):4091-106. doi: 10.1172/JCI81061. Epub 2015 Oct 5.
30. DARPP-32, Jack of All Trades... Master of Which? Yger M and Girault JA, Front Behav Neurosci. 2011 Sep 8;5:56. doi: 10.3389/fnbeh.2011.00056. eCollection 2011.
Additional References at PubMed
PMID:2174876   PMID:2556704   PMID:8524402   PMID:9388246   PMID:11005320   PMID:11904392   PMID:12091710   PMID:15514034   PMID:16648267   PMID:17303652   PMID:18097009   PMID:18295934  
PMID:19150448   PMID:19154138   PMID:19233846   PMID:19287093   PMID:20810903   PMID:21423799   PMID:21531385   PMID:22305959   PMID:22688515   PMID:23382378   PMID:23549689   PMID:26794871  
PMID:28131823   PMID:30053369   PMID:32357304   PMID:37926341  


Genomics

Comparative Map Data
Ppp3cb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8153,809,182 - 3,854,204 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl153,809,262 - 3,854,203 (+)EnsemblGRCr8
mRatBN7.2153,759,950 - 3,804,976 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl153,760,030 - 3,804,981 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx153,770,195 - 3,814,366 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0155,156,614 - 5,200,790 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0153,769,006 - 3,813,183 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd153,762,414 - 3,806,574 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive154,351,095 - 4,395,129 (+)NCBILyon_Normotensive
Lyon_Hypertensive153,765,958 - 3,809,993 (+)NCBILyon_Hypertensive
F344_StmMcwi153,808,041 - 3,852,173 (+)NCBIF344_StmMcwi
Rnor_6.0154,209,702 - 4,236,895 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl154,209,703 - 4,236,895 (+)Ensemblrn6Rnor6.0
Rnor_5.0158,310,717 - 8,338,152 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4153,986,290 - 4,030,352 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera15790,760 - 817,953 (-)NCBICelera
RGSC_v3.1X153,471,064 - 153,474,197 (+)NCBI
Cytogenetic Map15p16NCBI
PPP3CB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381073,436,433 - 73,496,024 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1073,436,418 - 73,496,026 (-)Ensemblhg38GRCh38
GRCh371075,196,191 - 75,255,782 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361074,866,618 - 74,925,758 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341074,866,617 - 74,925,760NCBI
Celera1068,482,159 - 68,541,381 (-)NCBICelera
Cytogenetic Map10q22.2NCBI
HuRef1069,190,274 - 69,249,395 (-)NCBIHuRef
CHM1_11075,478,325 - 75,537,525 (-)NCBICHM1_1
T2T-CHM13v2.01074,307,846 - 74,367,439 (-)NCBIT2T-CHM13v2.0
Ppp3cb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391420,549,432 - 20,596,641 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1420,549,432 - 20,596,641 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381420,499,364 - 20,546,573 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1420,499,364 - 20,546,573 (-)Ensemblmm10GRCm38
MGSCv371421,318,536 - 21,365,795 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361419,288,592 - 19,335,096 (-)NCBIMGSCv36mm8
Celera1416,880,736 - 16,928,039 (-)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1411.53NCBI
Ppp3cb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543718,323,857 - 18,377,815 (+)Ensembl
ChiLan1.0NW_00495543718,323,852 - 18,377,815 (+)NCBIChiLan1.0ChiLan1.0
PPP3CB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2885,612,605 - 85,671,784 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11085,617,928 - 85,677,107 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01069,984,241 - 70,043,352 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11072,443,051 - 72,501,752 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1072,443,051 - 72,501,752 (-)EnsemblpanPan2panpan1.1
PPP3CB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1423,976,023 - 24,028,139 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl423,977,317 - 24,028,153 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha424,113,678 - 24,165,855 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0424,256,065 - 24,308,378 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl424,256,216 - 24,308,467 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1424,153,587 - 24,206,028 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0424,353,994 - 24,406,243 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0424,708,924 - 24,761,154 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ppp3cb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721357,084,002 - 57,122,013 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365215,575,996 - 5,615,370 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365215,576,705 - 5,614,738 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP3CB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1476,248,841 - 76,305,328 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11476,239,497 - 76,305,345 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21482,376,144 - 82,430,833 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPP3CB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1957,782,256 - 57,841,307 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl957,782,304 - 57,844,573 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604818,363,439 - 18,423,643 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp3cb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247547,045,532 - 7,097,652 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247547,045,532 - 7,097,658 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ppp3cb
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11290,305,466 - 90,350,356 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ppp3cb
201 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:276
Count of miRNA genes:184
Interacting mature miRNAs:221
Transcripts:ENSRNOT00000010476
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15132342855Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
1300142Bp191Blood pressure QTL 1913.14arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)15115177511Rat

Markers in Region
AU022835  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8153,846,158 - 3,846,306 (+)Marker Load Pipeline
Celera15797,890 - 798,036UniSTS
Cytogenetic Map15p16UniSTS
RH131331  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2153,804,603 - 3,804,817 (+)MAPPERmRatBN7.2
Rnor_6.0154,237,291 - 4,237,504NCBIRnor6.0
Rnor_5.0158,338,548 - 8,338,761UniSTSRnor5.0
RGSC_v3.4154,030,748 - 4,030,961UniSTSRGSC3.4
Celera15790,151 - 790,364UniSTS
RH 3.4 Map1564.5UniSTS
Cytogenetic Map15p16UniSTS
RH143458  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X145,949,718 - 145,949,835 (+)MAPPERmRatBN7.2
Rnor_6.0X151,819,554 - 151,819,670NCBIRnor6.0
Rnor_5.0X151,809,605 - 151,809,721UniSTSRnor5.0
RGSC_v3.4X153,397,829 - 153,397,945UniSTSRGSC3.4
CeleraX141,796,043 - 141,796,159UniSTS
Cytogenetic Map15p16UniSTS
Cytogenetic Map15p11UniSTS
RH140251  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2153,775,103 - 3,775,284 (+)MAPPERmRatBN7.2
Rnor_6.0154,207,794 - 4,207,974NCBIRnor6.0
Rnor_5.0158,308,807 - 8,308,987UniSTSRnor5.0
RGSC_v3.4154,001,251 - 4,001,431UniSTSRGSC3.4
Celera15819,681 - 819,861UniSTS
RH 3.4 Map1563.9UniSTS
Cytogenetic Map15p16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC091344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D90036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M31809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M58441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000082236   ⟹   ENSRNOP00000074339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl153,825,386 - 3,853,436 (+)Ensembl
mRatBN7.2 Ensembl153,776,155 - 3,804,208 (+)Ensembl
Rnor_6.0 Ensembl154,209,703 - 4,236,895 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100861   ⟹   ENSRNOP00000090043
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl153,826,245 - 3,852,788 (+)Ensembl
mRatBN7.2 Ensembl153,760,030 - 3,803,560 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101580   ⟹   ENSRNOP00000090582
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl153,809,262 - 3,853,789 (+)Ensembl
mRatBN7.2 Ensembl153,760,030 - 3,804,208 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107965   ⟹   ENSRNOP00000096220
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl153,826,245 - 3,854,203 (+)Ensembl
mRatBN7.2 Ensembl153,760,030 - 3,804,981 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117871   ⟹   ENSRNOP00000086753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl153,825,587 - 3,854,203 (+)Ensembl
mRatBN7.2 Ensembl153,776,356 - 3,804,208 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000126811   ⟹   ENSRNOP00000109024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl153,826,243 - 3,854,203 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000139795   ⟹   ENSRNOP00000098670
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl153,826,042 - 3,854,203 (+)Ensembl
RefSeq Acc Id: NM_017042   ⟹   NP_058738
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8153,809,262 - 3,853,436 (+)NCBI
mRatBN7.2153,760,030 - 3,804,208 (+)NCBI
Dahl_SR_JrHsd153,762,414 - 3,806,574 (+)NCBI
Lyon_Normotensive154,351,095 - 4,395,129 (+)NCBI
Lyon_Hypertensive153,765,958 - 3,809,993 (+)NCBI
F344_StmMcwi153,808,041 - 3,852,173 (+)NCBI
Rnor_6.0154,209,702 - 4,236,895 (+)NCBI
Rnor_5.0158,310,717 - 8,338,152 (+)NCBI
RGSC_v3.4153,986,290 - 4,030,352 (+)RGD
Celera15790,760 - 817,953 (-)RGD
Sequence:
RefSeq Acc Id: XM_039092985   ⟹   XP_038948913
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8153,809,182 - 3,854,204 (+)NCBI
mRatBN7.2153,759,950 - 3,804,976 (+)NCBI
RefSeq Acc Id: XM_039092986   ⟹   XP_038948914
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8153,809,182 - 3,854,204 (+)NCBI
mRatBN7.2153,759,950 - 3,804,976 (+)NCBI
RefSeq Acc Id: XM_039092987   ⟹   XP_038948915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8153,809,182 - 3,854,204 (+)NCBI
mRatBN7.2153,759,950 - 3,804,976 (+)NCBI
RefSeq Acc Id: XM_039092988   ⟹   XP_038948916
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8153,809,182 - 3,854,204 (+)NCBI
mRatBN7.2153,759,950 - 3,804,976 (+)NCBI
RefSeq Acc Id: XM_039092989   ⟹   XP_038948917
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8153,809,182 - 3,854,204 (+)NCBI
mRatBN7.2153,759,950 - 3,804,976 (+)NCBI
RefSeq Acc Id: XM_039092990   ⟹   XP_038948918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8153,809,182 - 3,854,204 (+)NCBI
mRatBN7.2153,759,950 - 3,804,976 (+)NCBI
RefSeq Acc Id: XM_039092991   ⟹   XP_038948919
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8153,809,182 - 3,854,204 (+)NCBI
mRatBN7.2153,759,950 - 3,804,976 (+)NCBI
RefSeq Acc Id: NP_058738   ⟸   NM_017042
- UniProtKB: Q6LDJ7 (UniProtKB/Swiss-Prot),   P20651 (UniProtKB/Swiss-Prot),   A0A8I6A2X6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074339   ⟸   ENSRNOT00000082236
RefSeq Acc Id: XP_038948913   ⟸   XM_039092985
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AAD3 (UniProtKB/TrEMBL),   A0A8I6A2X6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948917   ⟸   XM_039092989
- Peptide Label: isoform X5
- UniProtKB: A0A8I6A2X6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948914   ⟸   XM_039092986
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A2X6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948918   ⟸   XM_039092990
- Peptide Label: isoform X6
- UniProtKB: A0A8I6GLZ4 (UniProtKB/TrEMBL),   A0A8I6A2X6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948916   ⟸   XM_039092988
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A2X6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948919   ⟸   XM_039092991
- Peptide Label: isoform X7
- UniProtKB: A0A8I6A2X6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948915   ⟸   XM_039092987
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A2X6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000090582   ⟸   ENSRNOT00000101580
Ensembl Acc Id: ENSRNOP00000090043   ⟸   ENSRNOT00000100861
Ensembl Acc Id: ENSRNOP00000096220   ⟸   ENSRNOT00000107965
Ensembl Acc Id: ENSRNOP00000086753   ⟸   ENSRNOT00000117871
Ensembl Acc Id: ENSRNOP00000098670   ⟸   ENSRNOT00000139795
Ensembl Acc Id: ENSRNOP00000109024   ⟸   ENSRNOT00000126811
Protein Domains
Serine/threonine specific protein phosphatases

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20651-F1-model_v2 AlphaFold P20651 1-525 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3383 AgrOrtholog
BioCyc Gene G2FUF-14541 BioCyc
Ensembl Genes ENSRNOG00000054782 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000082236 ENTREZGENE
  ENSRNOT00000100861 ENTREZGENE
  ENSRNOT00000101580 ENTREZGENE
  ENSRNOT00000107965 ENTREZGENE
  ENSRNOT00000126811 ENTREZGENE
Gene3D-CATH 3.60.21.10 UniProtKB/Swiss-Prot
InterPro Calcineurin-like_PHP_ApaH UniProtKB/Swiss-Prot
  Metallo-depent_PP-like UniProtKB/Swiss-Prot
  MPP_PP2B UniProtKB/Swiss-Prot
  PP2B UniProtKB/Swiss-Prot
  Ser/Thr-sp_prot-phosphatase UniProtKB/Swiss-Prot
KEGG Report rno:24675 UniProtKB/Swiss-Prot
NCBI Gene 24675 ENTREZGENE
PANTHER PTHR45673 UniProtKB/Swiss-Prot
Pfam Metallophos UniProtKB/Swiss-Prot
PhenoGen Ppp3cb PhenoGen
PRINTS STPHPHTASE UniProtKB/Swiss-Prot
PROSITE SER_THR_PHOSPHATASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000054782 RatGTEx
SMART PP2Ac UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56300 UniProtKB/Swiss-Prot
UniProt A0A0G2K7T5_RAT UniProtKB/TrEMBL
  A0A8I6A2X6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A8I8_RAT UniProtKB/TrEMBL
  A0A8I6AAD3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GLZ4 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L7Y3_RAT UniProtKB/TrEMBL
  A0ABK0M1W5_RAT UniProtKB/TrEMBL
  A6KKN5_RAT UniProtKB/TrEMBL
  A6KKN6_RAT UniProtKB/TrEMBL
  A6KKN7_RAT UniProtKB/TrEMBL
  A6KKN8_RAT UniProtKB/TrEMBL
  P20651 ENTREZGENE, UniProtKB/Swiss-Prot
  Q6LDJ7 ENTREZGENE
UniProt Secondary Q6LDJ7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Ppp3cb  protein phosphatase 3 catalytic subunit beta  Ppp3cb  protein phosphatase 3, catalytic subunit, beta isozyme  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-26 Ppp3cb  protein phosphatase 3, catalytic subunit, beta isozyme  Ppp3cb  protein phosphatase 3, catalytic subunit, beta isoform  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-10-24 Ppp3cb  protein phosphatase 3, catalytic subunit, beta isoform      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_drugs cyclosporin acts as a inhibitor partially blocking the muscle size 628398
gene_process calcium binding regulatory subunit which is activated by intracellular calcium anions 628398
gene_process mediates hypertropic response of muscle cells 628398
gene_protein 19 kDa in size 628398
gene_regulation activated by intracellular calcuim and dephosphorylates nuclear factors of activated T cells (NFATs) 628398