Plcg1 Rat Gene (phospholipase C, gamma 1)

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Keyword

Gene:
Plcg1 ( Rattus norvegicus )
phospholipase C, gamma 1
Description: mediates intracellular agonist-induced Ca2+ entry (ACE); serves as a guanine nucleotide exchange factor for the nuclear GTPase PIKE
Synonyms: PPLCA;
ArrayIDs: J03806_at; 6203538; 6743915; 5685275; 5783076; 6681100; 6207596; 6722446; 6227258; 6592308; 5637355; 6081936; 6407824; 1368183_at; 6370091; 6586439; 6280862; 5662024; 6065173; 6350049; 6239188; 6407163; 6469382; 5650934; 6587102; 6329155; 6096442; 5835151; 5745564; 5887062; 6395900; 5976410; 6569214; 6345296; 5848098; 5884478; 5825457; rc_AA943027_at; 6550989;  (details...)
Gene Type: protein-coding

Additional Data

primer pair: 635222

Homologs
Homo sapiens: PLCG1     See the Human gene in context in:     UCSC     NCBI MapViewer

Mus musculus: Plcg1     See the Mouse gene in context in:     UCSC     NCBI MapViewer

Comparative Map Data
Species Symbol Map Name Chr. Position
Rattus norvegicus Plcg1 genome assembly 3.1 3 151428984 - 151460034
Rat Celera Assembly 3 148059477 - 148090220
RH 3.4 3 1368.6
RGSC genome assembly v3.4 3 151522949 - 151553998
Cytogenetic 3 q42
Mus musculus Plcg1 Mouse genome assembly build 36.1 2 160557046 - 160601496
Cytogenetic 2 2 H2
Homo sapiens PLCG1 human genome assembly 20 39199574 - 39237771
Human genome assembly build 36.2 20 39199575 - 39237771
Cytogenetic 20 q12-q13.1

View comparative maps:      NCBI MapViewer

Genome
View:

Browsers:

Annotation
Molecular Function

Gene Ontology

signal transducer activity,  protein binding,  glutamate receptor binding ... (details...)
Biological Process

Note Reference

plays role in vesicle transport via its interaction with Vdp (vesicle docking protein) 734467

Gene Ontology

response to gravity,  vesicle-mediated transport,  response to hydrogen peroxide ... (details...)
Cellular Component

Gene Ontology

neuron projection,  cytoplasm,  plasma membrane ... (details...)
Disease

Ontology

Diabetes Mellitus, Experimental,  Breast Neoplasms,  Polycystic Kidney Diseases (details...)
Phenotype

Ontology

abnormal erythropoiesis,  embryonic growth arrest,  abnormal vasculogenesis (details...)
Pathway

Ontology

scatter factor/hepatocyte growth factor signaling pathway,  vascular endothelial growth factor signaling pathway,  inositol phosphate metabolic pathway ... (details...)
Regulation

Note Reference

activated by tyrosine kinase receptors and nonreceptor tyrosine kinases 729542

Physical interaction

Note Reference

binds to SOS1, a p21 Ras-specific guanine nucleotide exchange factor, through its SH3 domain 729542

protein interacts with Vdp, vesicle docking protein, through its SH2 and SH3 domains 734467

External Links
Databases
DATABASE ID SOURCE
SMART: SH3 IPI
SMART: SH2 IPI
SMART: PLCYc IPI
SMART: PLCXc IPI
SMART: PH IPI
SMART: C2 IPI
PROSITE: SH3 IPI
PROSITE: SH2 IPI
PROSITE: PIPLC_Y_DOMAIN IPI
PROSITE: PIPLC_X_DOMAIN IPI
PROSITE: PH_DOMAIN IPI
PROSITE: EF_HAND_2 IPI
PROSITE: EF_HAND_1 IPI
PROSITE: C2 IPI
UNIPARC: UPI0000131AA6 IPI
KEGG Report: rno:25738 ENTREZGENE
HomoloGene Group ID: 1997 ENTREZGENE
Germonline: 3347
Pfam: SH3_1 IPI
Pfam: SH2 IPI
Pfam: PI-PLC-Y IPI
Pfam: PI-PLC-X IPI
Pfam: PH IPI
Pfam: C2 IPI
KEGG Pathway: 04370 ENTREZGENE
KEGG Pathway: 04660 ENTREZGENE
KEGG Pathway: 04070 ENTREZGENE
KEGG Pathway: 05200 ENTREZGENE
KEGG Pathway: 05223 ENTREZGENE
KEGG Pathway: 04722 ENTREZGENE
KEGG Pathway: 04650 ENTREZGENE
KEGG Pathway: 01100 ENTREZGENE
KEGG Pathway: 04670 ENTREZGENE
KEGG Pathway: 00562 ENTREZGENE
KEGG Pathway: 05214 ENTREZGENE
KEGG Pathway: 04666 ENTREZGENE
KEGG Pathway: 04664 ENTREZGENE
KEGG Pathway: 04012 ENTREZGENE
KEGG Pathway: 04020 ENTREZGENE
InterPro: SH3_region. IPI
InterPro: SH3_domain. IPI
InterPro: SH2. IPI
InterPro: Pleckstrin_homology. IPI
InterPro: PLC-like_Pdiesterase_TIM-brl. IPI
InterPro: PLC-gamma. IPI
InterPro: Phospholipase_C_Pinositol-sp_Y. IPI
InterPro: Phospholipase_C_Pinositol-sp_X. IPI
InterPro: Phospholipase_C_Pinositol-sp_C. IPI
InterPro: PH_type. IPI
InterPro: EF_HAND_2. IPI
InterPro: EF_Hand_1_Ca_BS. IPI
InterPro: C2_membr_targeting. IPI
InterPro: C2_Ca/lipid-bd_reg_CaLB. IPI
InterPro: C2_Ca-dep. IPI
Ensembl Protein: ENSRNOP00000022276 IPI
IPI: IPI00192532 IPI
Gene3D-CATH: PLC-like_Pdiesterase_TIM-brl IPI
Gene3D-CATH: PH_type IPI
Entrez Gene: Plcg1 ENTREZGENE
PIRSF: PLC-gamma IPI
Ensembl Genes: ENSRNOG00000016340 IPI
TIGR: TC216671
UniProt: PLCG1_RAT IPI
RatMap: 44475 ENTREZGENE
Superfamily-SCOP: SH3 IPI
Superfamily-SCOP: PLC-like_Pdiesterase_TIM-brl IPI
Superfamily-SCOP: C2_CaLB IPI
PRINTS: SH3DOMAIN. IPI
PRINTS: SH2DOMAIN. IPI
PRINTS: PHPHLIPASEC. IPI
Sequences
Nucleotide: J03806 Get FASTA Search GEO Profiles
Nucleotide: NM_013187 Get FASTA Search GEO Profiles
Nucleotide: CH474005 Get FASTA Search GEO Profiles
(View all 3 Nucleotide Accessions)
Protein: EDL96615 Get FASTA
Protein: NP_037319 Get FASTA
Protein: P10686 Get FASTA
Protein: EDL96614 Get FASTA
Protein: AAA41921 Get FASTA
(View all 5 Protein Accessions)
Clusters
UniGene: 11243

References
Curated References
32 references in RGD related to Plcg1

Other References
49 other references at PubMed related to Plcg1

Database Information
RGD ID 3347
History

Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference

10-JUN-02: Plcg1 Phospholipase C, gamma 1 APPROVED Symbol and Name status set to approved 70586