Gene:	Pak1 ( Rattus norvegicus ) p21 protein (Cdc42/Rac)-activated kinase 1
Description:	serine/threonine protein kinase; binds and forms complex specifically with activated (GTP-bound) p21, leading to inhibiting p21 GTPase activity
Synonyms:	p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p21 (CDKN1A)-activated kinase 1;
ArrayIDs:	6681329; 1387377_a_at; 6260182; GE21941; U49953_s_at; rc_AI175989_at; 1389093_at; 5737745; 6148164; 6314038; 6154627; rc_AI172085_at; 6057005; GE20413; 6245055; AA851136_g_at; 5658177; 6618640; 5639380; 6108713; 6712296; 5649965; A_44_P325005; 5642567; 5959129; 6621099; 5976163; 6515772; 5963907;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: PAK1     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Pak1     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Pak1 genome assembly 3.1 1 155136027 - 155253120     Rat Celera Assembly 1 150203043 - 150317598     RGSC genome assembly v3.4 1 155057622 - 155174714     Cytogenetic 1 q32 Mus musculus Pak1 Mouse genome assembly build 36.1 7 104991449 - 105060891     Cytogenetic 7 7 E2 Homo sapiens PAK1 human genome assembly 11 76710708 - 76862581     Human genome assembly build 36.2 11 76710708 - 76862581     Cytogenetic 11 q13-q14   View comparative maps:      NCBI MapViewer
Genome
View:
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Annotation
Molecular Function	Note Reference phosphorylates protein serine/threonine residues 61685, 70317 Gene Ontology protein kinase activity,  protein kinase binding,  nucleotide binding ...  (details...)
Biological Process	Gene Ontology receptor clustering,  protein amino acid autophosphorylation,  MAPKKK cascade ...  (details...)
Cellular Component	Gene Ontology nucleus,  intercalated disc,  nuclear membrane ...  (details...)
Disease	Ontology Brain Ischemia,  Ovarian Neoplasms,  Carcinoma, Renal Cell ...  (details...)
Pathway	Ontology mitogen activated protein kinase signaling pathway (details...)
Product	Note Reference mitogen activated protein kinase kinase kinase family member 61685, 70317
Protein	Note Reference 67 kDa 61685, 70317
Regulation	Note Reference activated by receptor tyrosine kinases and trimeric G protein-linked receptors 70317
External Links
Databases	DATABASE ID SOURCE SMART: PBD IPI SMART: S_TKc IPI PROSITE: CRIB IPI PROSITE: PROTEIN_KINASE_ATP IPI PROSITE: PROTEIN_KINASE_DOM IPI PROSITE: PROTEIN_KINASE_ST IPI UNIPARC: UPI000013121D IPI KEGG Report: rno:29431 ENTREZGENE HomoloGene Group ID: 1936 ENTREZGENE Germonline: 3250 Pfam: PBD IPI Pfam: Pkinase IPI KEGG Pathway: 04062 ENTREZGENE KEGG Pathway: 04012 ENTREZGENE KEGG Pathway: 04666 ENTREZGENE KEGG Pathway: 04510 ENTREZGENE KEGG Pathway: 04010 ENTREZGENE KEGG Pathway: 04810 ENTREZGENE KEGG Pathway: 05211 ENTREZGENE KEGG Pathway: 04360 ENTREZGENE KEGG Pathway: 04650 ENTREZGENE KEGG Pathway: 04660 ENTREZGENE InterPro: Kinase-like_dom. IPI InterPro: Ser/Thr_prot_kinase_AS. IPI InterPro: Ser/Thr_kinase_Pak-rel. IPI InterPro: Se/Thr_prot_kinase-like_dom. IPI InterPro: Protein_kinase_ATP_BS. IPI InterPro: Prot_kinase_cat_dom. IPI InterPro: PAK_box_Rho_bd. IPI InterPro: Ser/Thr_prot_kinase_dom. IPI IPI: IPI00198685 IPI Ensembl Protein: ENSRNOP00000045832 IPI Entrez Gene: Pak1 ENTREZGENE TIGR: TC219838 UniProt: PAK1_RAT IPI Ensembl Genes: ENSRNOG00000029784 IPI Superfamily-SCOP: Kinase_like IPI PANTHER: Pak_like IPI
Sequences	Nucleotide: CH473956 Get FASTA Search GEO Profiles Nucleotide: U23443 Get FASTA Search GEO Profiles Nucleotide: NM_017198 Get FASTA Search GEO Profiles Nucleotide: U49953 Get FASTA Search GEO Profiles (View all 4 Nucleotide Accessions) Protein: EDM18461 Get FASTA Protein: EDM18462 Get FASTA Protein: EDM18463 Get FASTA Protein: NP_058894 Get FASTA Protein: EDM18458 Get FASTA Protein: AAB61533 Get FASTA Protein: P35465 Get FASTA Protein: EDM18460 Get FASTA Protein: EDM18459 Get FASTA Protein: AAB95646 Get FASTA (View all 10 Protein Accessions)
Clusters	UniGene: 9149
References
Curated References	31 references in RGD related to Pak1
Other References	40 other references at PubMed related to Pak1
Database Information
RGD ID	3250
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 27-MAY-09: Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 Pak1 p21 (CDKN1A)-activated kinase 1 APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 10-JUN-02: Pak1 p21 (CDKN1A)-activated kinase 1 APPROVED Symbol and Name status set to approved 70586