Itpr1 (inositol 1,4,5-trisphosphate receptor, type 1) - Rat Genome Database

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Gene: Itpr1 (inositol 1,4,5-trisphosphate receptor, type 1) Rattus norvegicus
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Symbol: Itpr1
Name: inositol 1,4,5-trisphosphate receptor, type 1
RGD ID: 2933
Description: Enables several functions, including anion binding activity; inositol 1,4,5-trisphosphate-gated calcium channel activity; and transmembrane transporter binding activity. Involved in several processes, including calcium ion transmembrane transport; cellular response to cAMP; and regulation of apoptotic process. Located in several cellular components, including endoplasmic reticulum; neuronal cell body; and synaptic membrane. Part of protein-containing complex. Is active in several cellular components, including GABA-ergic synapse; postsynapse; and smooth endoplasmic reticulum membrane. Used to study asthma. Biomarker of Huntington's disease; cardiac arrest; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Gillespie syndrome; spinocerebellar ataxia type 15; and spinocerebellar ataxia type 29. Orthologous to human ITPR1 (inositol 1,4,5-trisphosphate receptor type 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: I145TR; inositol 1,4,5-triphosphate receptor 1; inositol 1,4,5-triphosphate receptor type 1; inositol 1,4,5-triphosphate receptor, type 1; inositol 1,4,5-trisphosphate receptor type 1; inositol 1,4,5-trisphosphate-gated calcium channel ITPR1; inositol 145-triphosphate receptor type 1; InsP3R; InsP3R1; IP-3-R; IP3 receptor; IP3R 1; IP3R1; P400; type 1 inositol 1,4,5-trisphosphate receptor; type 1 InsP3 receptor
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bp116
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84142,743,401 - 143,066,505 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4142,743,334 - 143,066,504 (+)EnsemblGRCr8
mRatBN7.24141,187,377 - 141,554,240 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4141,187,418 - 141,510,491 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4146,609,417 - 146,932,882 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04142,390,143 - 142,713,600 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04141,034,101 - 141,357,581 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04140,247,297 - 140,580,749 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4140,247,313 - 140,580,748 (+)Ensemblrn6Rnor6.0
Rnor_5.04204,714,729 - 205,047,901 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44143,705,360 - 144,030,051NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4129,839,611 - 130,162,657 (+)NCBICelera
RH 3.4 Map4 RGD
Cytogenetic Map4q41NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
(E)-thiamethoxam  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1D-myo-inositol 1,4,5-trisphosphate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
3-nitropropanoic acid  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetaldehyde  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium acetate  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
Anemoside B4  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calciol  (EXP)
calcitriol  (ISO)
calcium atom  (ISO)
calcium carbonate  (EXP)
calcium oxalate  (EXP)
calcium(0)  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
cypermethrin  (EXP,ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diuron  (EXP)
Doramectin  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP)
elaidic acid  (EXP)
emodin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
etoposide  (ISO)
eugenol  (EXP)
fenthion  (ISO)
fenvalerate  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fomepizole  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
genistein  (ISO)
glyoxylic acid  (EXP)
glyphosate  (ISO)
GW 4064  (ISO)
halothane  (ISO)
homocysteine  (ISO)
hydrogen peroxide  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (EXP)
lead diacetate  (ISO)
lead(0)  (EXP)
linsidomine  (ISO)
losartan  (EXP)
maneb  (ISO)
melatonin  (ISO)
metformin  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (ISO)
N-hexadecanoylsphingosine  (ISO)
nevirapine  (EXP)
nickel atom  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
oxycodone  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
potassium chloride  (EXP)
procaine  (ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (ISO)
pyrazinecarboxamide  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
sarin  (ISO)
SB 431542  (ISO)
scopolamine  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
succimer  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (ISO)
testosterone  (ISO)
thapsigargin  (EXP,ISO)
thiamethoxam  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
toluene  (EXP)
topiramate  (EXP)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vanillic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)
xestospongin C  (ISO)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
calcium import into the mitochondrion  (IMP)
calcium ion transmembrane transport  (IEA)
calcium ion transport  (IEA,ISO)
calcium-mediated signaling  (IEA)
cell morphogenesis  (IEA,ISO)
cellular response to cAMP  (IDA)
cellular response to hypoxia  (IEP)
dendrite development  (IEP)
endoplasmic reticulum calcium ion homeostasis  (ISO)
epithelial fluid transport  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IEA,ISO,ISS)
liver regeneration  (IMP)
monoatomic ion transmembrane transport  (IEA)
monoatomic ion transport  (IEA)
negative regulation of apoptotic process  (IMP)
negative regulation of calcium-mediated signaling  (IEA,ISO)
phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway  (IEA,ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IDA,IEA,ISO)
positive regulation of apoptotic process  (IEA,IMP,ISO)
positive regulation of calcium ion transport  (IDA)
positive regulation of cytosolic calcium ion concentration  (IMP)
positive regulation of hepatocyte proliferation  (IMP)
positive regulation of neuron projection development  (IMP)
post-embryonic development  (ISO)
protein homotetramerization  (IDA,IEA,ISO,ISS)
regulation of calcium-mediated signaling  (ISO)
regulation of cytosolic calcium ion concentration  (IEA,ISO,ISS)
regulation of postsynaptic cytosolic calcium ion concentration  (IEA)
release of sequestered calcium ion into cytosol  (IBA,IEA,IMP,ISO)
release of sequestered calcium ion into cytosol by endoplasmic reticulum  (IEA,ISO,ISS)
response to hypoxia  (IEA,ISO)
single fertilization  (IEA,ISO,ISS)
transmembrane transport  (IEA)
voluntary musculoskeletal movement  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway   (ISO)
Alzheimer's disease pathway  (IEA)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway   (ISO)
calcium transport pathway   (ISO)
calcium/calcium-mediated signaling pathway  (IEA,ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
glutamate signaling pathway  (IEA)
gonadotropin-releasing hormone signaling pathway   (IEA)
Huntington's disease pathway  (IEA)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
long term depression  (IEA)
long term potentiation  (IEA)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
phosphatidylinositol 3-kinase signaling pathway  (IEA)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Involvement of the p97-Ufd1-Npl4 complex in the regulated endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors. Alzayady KJ, etal., J Biol Chem. 2005 Oct 14;280(41):34530-7. Epub 2005 Aug 15.
2. Fragmented inositol 1,4,5-trisphosphate receptors retain tetrameric architecture and form functional Ca2+ release channels. Alzayady KJ, etal., J Biol Chem. 2013 Apr 19;288(16):11122-34. doi: 10.1074/jbc.M113.453241. Epub 2013 Mar 11.
3. The homocysteine-inducible endoplasmic reticulum (ER) stress protein Herp counteracts mutant alpha-synuclein-induced ER stress via the homeostatic regulation of ER-resident calcium release channel proteins. Belal C, etal., Hum Mol Genet. 2012 Mar 1;21(5):963-77. doi: 10.1093/hmg/ddr502. Epub 2011 Nov 1.
4. Enhanced hypoxic preconditioning by isoflurane: signaling gene expression and requirement of intracellular Ca2+ and inositol triphosphate receptors. Bickler PE and Fahlman CS, Brain Res. 2010 Jun 22;1340:86-95. Epub 2010 Apr 29.
5. Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation. Cardenas C, etal., J Cell Sci. 2005 Jul 15;118(Pt 14):3131-40.
6. Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3. Chen X, etal., J Neurosci. 2008 Nov 26;28(48):12713-24.
7. Ins(1,4,5)P3 receptor type 1 associates with AKAP9 (AKAP450 variant) and protein kinase A type IIbeta in the Golgi apparatus in cerebellar granule cells. Collado-Hilly M and Coquil JF, Biol Cell. 2009 Jun 4;101(8):469-80. doi: 10.1042/BC20080184.
8. Inositol 1,4,5-trisphosphate receptors: distinct neuronal and nonneuronal forms derived by alternative splicing differ in phosphorylation. Danoff SK, etal., Proc Natl Acad Sci U S A 1991 Apr 1;88(7):2951-5.
9. Two Italian families with ITPR1 gene deletion presenting a broader phenotype of SCA15. Di Gregorio E, etal., Cerebellum. 2010 Mar;9(1):115-23.
10. Domoic acid enhances Bcl-2-calcineurin-inositol-1,4,5-trisphosphate receptor interactions and delayed neuronal death in rat brain slices. Erin N and Billingsley ML, Brain Res. 2004 Jul 16;1014(1-2):45-52.
11. Conformational motions and ligand-binding underlying gating and regulation in IP3R channel. Fan G, etal., Nat Commun. 2022 Nov 14;13(1):6942. doi: 10.1038/s41467-022-34574-1.
12. Gating machinery of InsP3R channels revealed by electron cryomicroscopy. Fan G, etal., Nature. 2015 Nov 19;527(7578):336-41. doi: 10.1038/nature15249. Epub 2015 Oct 12.
13. Subunit oligomerization, and topology of the inositol 1,4, 5-trisphosphate receptor. Galvan DL, etal., J Biol Chem. 1999 Oct 8;274(41):29483-92. doi: 10.1074/jbc.274.41.29483.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Defective calcium homeostasis in the cerebellum in a mouse model of Niemann-Pick A disease. Ginzburg L and Futerman AH, J Neurochem. 2005 Dec;95(6):1619-28. Epub 2005 Nov 8.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Intracerebroventricular administration of quinolinic acid induces a selective decrease of inositol(1,4,5)-trisphosphate receptor in rat brain. Haug LS, etal., Neurochem Int. 1998 Aug;33(2):109-19.
18. Decreased inositol (1,4,5)-trisphosphate receptor levels in Alzheimer's disease cerebral cortex: selectivity of changes and possible correlation to pathological severity. Haug LS, etal., Neurodegeneration. 1996 Jun;5(2):169-76.
19. Mechanism of ER stress-induced brain damage by IP(3) receptor. Higo T, etal., Neuron. 2010 Dec 9;68(5):865-78.
20. Regulation of Ca(2+) signaling in rat bile duct epithelia by inositol 1,4,5-trisphosphate receptor isoforms. Hirata K, etal., Hepatology 2002 Aug;36(2):284-96.
21. Junctional membrane inositol 1,4,5-trisphosphate receptor complex coordinates sensitization of the silent EGF-induced Ca2+ signaling. Hur EM, etal., J Cell Biol. 2005 May 23;169(4):657-67.
22. Functional Role of Intracellular Calcium Receptor Inositol 1,4,5-Trisphosphate Type 1 in Rat Hippocampus after Neonatal Anoxia. Ikebara JM, etal., PLoS One. 2017 Jan 10;12(1):e0169861. doi: 10.1371/journal.pone.0169861. eCollection 2017.
23. Potentiation of NGF-induced neurite outgrowth in PC12 cells by papaverine: role played by PLC-¿, IP3 receptors. Itoh K, etal., Brain Res. 2011 Mar 4;1377:32-40. doi: 10.1016/j.brainres.2010.12.075. Epub 2011 Jan 4.
24. Activation of the Cl- channel ANO1 by localized calcium signals in nociceptive sensory neurons requires coupling with the IP3 receptor. Jin X, etal., Sci Signal. 2013 Aug 27;6(290):ra73. doi: 10.1126/scisignal.2004184.
25. Hypoxia modulates gene expression of IP3 receptors in rodent cerebellum. Jurkovicova D, etal., Pflugers Arch. 2007 Jun;454(3):415-25. Epub 2007 Feb 7.
26. Expression profiles of three isoforms of inositol 1,4,5-trisphosphate receptor in brown adipose tissue of the rat. Kajimoto K, etal., Biochem Pharmacol 2003 Mar 15;65(6):995-8.
27. Calpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1) has InsP(3)-independent gating and disrupts intracellular Ca(2+) homeostasis. Kopil CM, etal., J Biol Chem. 2011 Oct 14;286(41):35998-6010. Epub 2011 Aug 22.
28. Peripheral gene expression profile of mechanical hyperalgesia induced by repeated cold stress in SHRSP5/Dmcr rats. Kozaki Y, etal., J Physiol Sci. 2015 Sep;65(5):417-25. doi: 10.1007/s12576-015-0380-9. Epub 2015 May 14.
29. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
30. Proteasomal activation mediates down-regulation of inositol 1,4,5-trisphosphate receptor and calcium mobilization in rat pancreatic islets. Lee B, etal., Endocrinology 2001 May;142(5):1744-51.
31. Altered expression of type 1 inositol 1,4,5-trisphosphate receptor in the Ngsk Prnp deficient mice. Lee HP, etal., Neuroscience. 2010 May 19;167(3):799-808. Epub 2010 Feb 26.
32. Immobilization stress elevates IP(3) receptor mRNA in adult rat hearts in a glucocorticoid-dependent manner. Lencesova L, etal., FEBS Lett 2002 Nov 20;531(3):432-6.
33. The effect of substance P on asthmatic rat airway smooth muscle cell proliferation, migration, and cytoplasmic calcium concentration in vitro. Li M, etal., J Inflamm (Lond). 2011 Jul 21;8(1):18.
34. Polycystin 2 interacts with type I inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling. Li Y, etal., J Biol Chem. 2005 Dec 16;280(50):41298-306. Epub 2005 Oct 13.
35. Flexible architecture of IP3R1 by Cryo-EM. Ludtke SJ, etal., Structure. 2011 Aug 10;19(8):1192-9. doi: 10.1016/j.str.2011.05.003.
36. SCA15 due to large ITPR1 deletions in a cohort of 333 white families with dominant ataxia. Marelli C, etal., Arch Neurol. 2011 May;68(5):637-43.
37. Type 1 inositol 1,4,5-trisphosphate receptor knock-out mice: their phenotypes and their meaning in neuroscience and clinical practice. Matsumoto M and Nagata E, J Mol Med (Berl). 1999 May;77(5):406-11.
38. Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons. Maximov A, etal., Mol Cell Neurosci. 2003 Feb;22(2):271-83.
39. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
40. Structure and expression of the rat inositol 1,4,5-trisphosphate receptor. Mignery GA, etal., J Biol Chem 1990 Jul 25;265(21):12679-85.
41. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
42. Inositol 1,4,5 trisphosphate receptor and chromogranin B are concentrated in different regions of the hippocampus. Nicolay NH, etal., J Neurosci Res. 2007 Jul;85(9):2026-36.
43. Vitamin D and calcium co-therapy mitigates pre-established cadmium nephropathy by regulating renal calcium homeostatic molecules and improving anti-oxidative and anti-inflammatory activities in rat. Obaid AA, etal., J Trace Elem Med Biol. 2023 May 24;79:127221. doi: 10.1016/j.jtemb.2023.127221.
44. Calcium signalling from the type I inositol 1,4,5-trisphosphate receptor is required at early phase of liver regeneration. Oliveira AG, etal., Liver Int. 2015 Apr;35(4):1162-71. doi: 10.1111/liv.12587. Epub 2014 Jun 2.
45. Mapping a cardiomyopathy locus to chromosome 3p22-p25. Olson TM and Keating MT, J Clin Invest 1996 Jan 15;97(2):528-32.
46. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
47. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
48. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
49. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
50. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
51. Inositol 1,4,5-trisphosphate receptor expression in mammalian olfactory tissue. Smutzer G, etal., Brain Res Mol Brain Res 1997 Mar;44(2):347-54.
52. P400 protein is one of the major substrates for Ca2+/calmodulin-dependent protein kinase II in the postsynaptic density-enriched fraction isolated from rat cerebral cortex, hippocampus and cerebellum. Suzuki T, etal., Neurochem Int. 1992 Jan;20(1):61-7.
53. Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels. Szabadkai G, etal., J Cell Biol. 2006 Dec 18;175(6):901-11. doi: 10.1083/jcb.200608073.
54. Ca2+ stores in Purkinje neurons: endoplasmic reticulum subcompartments demonstrated by the heterogeneous distribution of the InsP3 receptor, Ca(2+)-ATPase, and calsequestrin. Takei K, etal., J Neurosci. 1992 Feb;12(2):489-505.
55. Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B. Tanaka S, etal., J Physiol Sci. 2011 May;61(3):221-9. doi: 10.1007/s12576-011-0140-4. Epub 2011 Mar 20.
56. Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model. Tang TS, etal., J Neurosci. 2009 Feb 4;29(5):1257-66.
57. Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1. Tang TS, etal., Neuron. 2003 Jul 17;39(2):227-39.
58. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
59. Regulation of inositol 1,4,5-trisphosphate receptors by cAMP independent of cAMP-dependent protein kinase. Tovey SC, etal., J Biol Chem. 2010 Apr 23;285(17):12979-89. doi: 10.1074/jbc.M109.096016. Epub 2010 Feb 26.
60. Functional characterization of mammalian inositol 1,4,5-trisphosphate receptor isoforms. Tu H, etal., Biophys J. 2005 Feb;88(2):1046-55. Epub 2004 Nov 8.
61. Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release by reversible phosphorylation and dephosphorylation. Vanderheyden V, etal., Biochim Biophys Acta. 2009 Jun;1793(6):959-70. doi: 10.1016/j.bbamcr.2008.12.003. Epub 2008 Dec 16.
62. Disrupted placental vitamin D metabolism and calcium signaling in gestational diabetes and pre-eclampsia patients. Varshney S, etal., Endocrine. 2023 Apr;80(1):191-200. doi: 10.1007/s12020-022-03272-9. Epub 2022 Dec 8.
63. Microtubule-dependent redistribution of the type-1 inositol 1,4,5-trisphosphate receptor in A7r5 smooth muscle cells. Vermassen E, etal., J Cell Sci. 2003 Apr 1;116(Pt 7):1269-77.
64. Differential regulation of the InsP₃ receptor type-1 and -2 single channel properties by InsP₃, Ca²⁺ and ATP. Wagner LE and Yule DI, J Physiol. 2012 Jul 15;590(14):3245-59. doi: 10.1113/jphysiol.2012.228320. Epub 2012 Apr 30.
65. Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes. Wang Y, etal., Nature. 2012 Apr 8;485(7396):128-32. doi: 10.1038/nature10988.
66. Inositol 1,4,5-trisphosphate receptor 1 mutation perturbs glucose homeostasis and enhances susceptibility to diet-induced diabetes. Ye R, etal., J Endocrinol. 2011 Aug;210(2):209-17. Epub 2011 May 12.
67. In situ hybridization of mRNA expression for IP3 receptor and IP3-3-kinase in rat brain after transient focal cerebral ischemia. Zhang SX, etal., Brain Res Mol Brain Res. 1995 Sep;32(2):252-60.
Additional References at PubMed
PMID:8663526   PMID:8889548   PMID:9716504   PMID:9858485   PMID:10191279   PMID:10828023   PMID:11117745   PMID:11285228   PMID:11587548   PMID:11972451   PMID:12167631   PMID:12477932  
PMID:12617961   PMID:12820984   PMID:14517800   PMID:14593108   PMID:14982933   PMID:15364918   PMID:15579147   PMID:15613488   PMID:15739177   PMID:15774532   PMID:15843050   PMID:16118475  
PMID:16198415   PMID:16223514   PMID:16237118   PMID:16377004   PMID:16691292   PMID:16723353   PMID:16793548   PMID:16840702   PMID:17284437   PMID:17327232   PMID:17416589   PMID:17496801  
PMID:17502376   PMID:17590087   PMID:17636122   PMID:18799650   PMID:18835357   PMID:18955483   PMID:19120137   PMID:19141613   PMID:19292454   PMID:19386591   PMID:19752026   PMID:19845505  
PMID:19934645   PMID:19946888   PMID:20378853   PMID:20713546   PMID:20813840   PMID:21071436   PMID:21098487   PMID:21389686   PMID:22207335   PMID:22286060   PMID:22762283   PMID:22871113  
PMID:23009366   PMID:23045459   PMID:23137780   PMID:23542070   PMID:23555994   PMID:23650371   PMID:24097979   PMID:25201980   PMID:25262337   PMID:25368151   PMID:28336440   PMID:28526746  
PMID:28923351   PMID:29476059   PMID:30053369   PMID:30090007   PMID:30470765   PMID:32357304   PMID:33812310   PMID:34035440   PMID:35657697   PMID:38308199   PMID:38685831  


Genomics

Comparative Map Data
Itpr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84142,743,401 - 143,066,505 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4142,743,334 - 143,066,504 (+)EnsemblGRCr8
mRatBN7.24141,187,377 - 141,554,240 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4141,187,418 - 141,510,491 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4146,609,417 - 146,932,882 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04142,390,143 - 142,713,600 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04141,034,101 - 141,357,581 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04140,247,297 - 140,580,749 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4140,247,313 - 140,580,748 (+)Ensemblrn6Rnor6.0
Rnor_5.04204,714,729 - 205,047,901 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44143,705,360 - 144,030,051NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4129,839,611 - 130,162,657 (+)NCBICelera
RH 3.4 Map4 RGD
Cytogenetic Map4q41NCBI
ITPR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3834,493,348 - 4,847,506 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl34,493,345 - 4,847,506 (+)Ensemblhg38GRCh38
GRCh3734,535,032 - 4,889,190 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3634,510,034 - 4,864,286 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3434,510,135 - 4,864,079NCBI
Celera34,473,120 - 4,827,522 (+)NCBICelera
Cytogenetic Map3p26.1NCBI
HuRef34,468,779 - 4,822,934 (+)NCBIHuRef
CHM1_134,485,103 - 4,839,760 (+)NCBICHM1_1
T2T-CHM13v2.034,487,354 - 4,841,309 (+)NCBIT2T-CHM13v2.0
Itpr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396108,190,044 - 108,528,077 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6108,190,057 - 108,528,070 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm386108,213,083 - 108,551,116 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6108,213,096 - 108,551,109 (+)Ensemblmm10GRCm38
MGSCv376108,163,090 - 108,501,108 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366108,178,895 - 108,516,886 (+)NCBIMGSCv36mm8
Celera6110,018,018 - 110,348,287 (+)NCBICelera
Cytogenetic Map6E1- E2NCBI
cM Map649.74NCBI
ITPR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v224,506,900 - 4,861,017 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan134,511,663 - 4,865,777 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v034,448,574 - 4,802,545 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.134,549,775 - 4,904,811 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl34,572,921 - 4,904,811 (+)EnsemblpanPan2panpan1.1
ITPR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12012,746,171 - 13,065,256 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2012,747,315 - 13,064,198 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2012,719,920 - 13,038,750 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02012,789,247 - 13,108,309 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2012,789,627 - 13,108,328 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12012,494,231 - 12,813,462 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02012,835,196 - 13,153,754 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02012,821,769 - 13,140,816 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Itpr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494210,941,137 - 11,243,016 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365773,896,390 - 4,198,411 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365773,896,455 - 4,198,396 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITPR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1361,068,126 - 61,398,912 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11361,068,131 - 61,398,918 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21367,499,295 - 67,702,956 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITPR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12240,574,569 - 40,925,857 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2240,574,374 - 40,926,842 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041125,743,247 - 126,095,217 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itpr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477314,856,804 - 15,193,168 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477314,856,803 - 15,193,173 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Itpr1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1638,248,197 - 38,571,331 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Itpr1
2177 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:2097
Count of miRNA genes:288
Interacting mature miRNAs:363
Transcripts:ENSRNOT00000040255, ENSRNOT00000041130, ENSRNOT00000043646, ENSRNOT00000064025
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4107346299152346299Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4117737142152833657Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4111383604156383604Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4108206096153206096Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4111383604156383604Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4134199006168870974Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4113634167149763391Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4103834277148834277Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4121020385148834277Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat

Markers in Region
D4Rat195  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24141,356,262 - 141,356,570 (+)MAPPERmRatBN7.2
mRatBN7.24141,356,262 - 141,356,469 (+)MAPPERmRatBN7.2
Rnor_6.04140,425,986 - 140,426,293NCBIRnor6.0
Rnor_6.04140,425,986 - 140,426,192NCBIRnor6.0
Rnor_5.04204,893,198 - 204,893,404UniSTSRnor5.0
Rnor_5.04204,893,198 - 204,893,505UniSTSRnor5.0
RGSC_v3.44143,875,116 - 143,875,322UniSTSRGSC3.4
RGSC_v3.44143,875,115 - 143,875,322RGDRGSC3.4
RGSC_v3.44143,875,116 - 143,875,423UniSTSRGSC3.4
Celera4130,008,518 - 130,008,724UniSTS
Celera4130,008,518 - 130,008,825UniSTS
RGSC_v3.14144,119,957 - 144,120,163RGD
RH 3.4 Map4890.8RGD
RH 3.4 Map4890.8UniSTS
RH 2.0 Map4897.9RGD
SHRSP x BN Map465.6899RGD
Cytogenetic Map4q41UniSTS
D4Rat196  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24141,235,569 - 141,235,720 (+)MAPPERmRatBN7.2
Rnor_6.04140,295,371 - 140,295,521NCBIRnor6.0
Rnor_5.04204,762,862 - 204,763,012UniSTSRnor5.0
RGSC_v3.44143,753,495 - 143,753,646RGDRGSC3.4
RGSC_v3.44143,753,496 - 143,753,646UniSTSRGSC3.4
Celera4129,887,354 - 129,887,504UniSTS
RGSC_v3.14143,998,336 - 143,998,487RGD
SHRSP x BN Map465.65RGD
SHRSP x BN Map465.65UniSTS
Cytogenetic Map4q41UniSTS
D4Got259  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24141,480,540 - 141,480,804 (+)MAPPERmRatBN7.2
Rnor_6.04140,550,598 - 140,550,861NCBIRnor6.0
Rnor_5.04205,017,750 - 205,018,013UniSTSRnor5.0
RGSC_v3.44144,000,102 - 144,000,365UniSTSRGSC3.4
Celera4130,132,792 - 130,133,055UniSTS
Cytogenetic Map4q41UniSTS
RH133754  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84142,878,751 - 142,878,932 (+)Marker Load Pipeline
mRatBN7.24141,322,729 - 141,322,910 (+)MAPPERmRatBN7.2
Rnor_6.04140,382,763 - 140,382,943NCBIRnor6.0
Rnor_5.04204,850,254 - 204,850,434UniSTSRnor5.0
RGSC_v3.44143,841,369 - 143,841,549UniSTSRGSC3.4
Celera4129,974,518 - 129,974,698UniSTS
RH 3.4 Map4885.6UniSTS
Cytogenetic Map4q41UniSTS
RH94529  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24141,510,212 - 141,510,376 (+)MAPPERmRatBN7.2
Rnor_6.04140,580,470 - 140,580,633NCBIRnor6.0
Rnor_5.04205,047,622 - 205,047,785UniSTSRnor5.0
RGSC_v3.44144,029,773 - 144,029,936UniSTSRGSC3.4
Celera4130,162,378 - 130,162,541UniSTS
RH 3.4 Map4890.9UniSTS
Cytogenetic Map4q41UniSTS
RH140203  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84143,065,958 - 143,066,152 (+)Marker Load Pipeline
mRatBN7.24141,509,945 - 141,510,139 (+)MAPPERmRatBN7.2
Rnor_6.04140,580,203 - 140,580,396NCBIRnor6.0
Rnor_5.04205,047,355 - 205,047,548UniSTSRnor5.0
RGSC_v3.44144,029,506 - 144,029,699UniSTSRGSC3.4
Celera4130,162,111 - 130,162,304UniSTS
RH 3.4 Map4886.7UniSTS
Cytogenetic Map4q41UniSTS
AU048843  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24141,306,952 - 141,307,250 (+)MAPPERmRatBN7.2
Rnor_6.04140,366,986 - 140,367,283NCBIRnor6.0
Rnor_5.04204,834,477 - 204,834,774UniSTSRnor5.0
RGSC_v3.44143,825,377 - 143,825,674UniSTSRGSC3.4
Celera4129,958,745 - 129,959,042UniSTS
Cytogenetic Map4q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001007235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC091346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF402715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ233032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J05510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M64698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M64699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U38653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U38665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U38812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000040255   ⟹   ENSRNOP00000043615
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4140,247,313 - 140,579,675 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000041130   ⟹   ENSRNOP00000049540
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4142,765,910 - 143,066,504 (+)Ensembl
mRatBN7.2 Ensembl4141,209,285 - 141,510,491 (+)Ensembl
Rnor_6.0 Ensembl4140,247,335 - 140,580,748 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000043646   ⟹   ENSRNOP00000048661
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4142,743,334 - 143,066,503 (+)Ensembl
mRatBN7.2 Ensembl4141,187,418 - 141,510,491 (+)Ensembl
Rnor_6.0 Ensembl4140,247,335 - 140,580,748 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000064025   ⟹   ENSRNOP00000063885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4142,743,334 - 143,066,503 (+)Ensembl
mRatBN7.2 Ensembl4141,187,418 - 141,510,491 (+)Ensembl
Rnor_6.0 Ensembl4140,247,335 - 140,580,748 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082723   ⟹   ENSRNOP00000075403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4142,873,555 - 143,066,503 (+)Ensembl
mRatBN7.2 Ensembl4141,317,533 - 141,510,491 (+)Ensembl
Rnor_6.0 Ensembl4140,377,565 - 140,579,477 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000143626   ⟹   ENSRNOP00000105276
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4142,743,334 - 143,066,503 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000151720   ⟹   ENSRNOP00000111175
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4142,743,334 - 143,066,503 (+)Ensembl
RefSeq Acc Id: NM_001007235   ⟹   NP_001007236
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84142,743,440 - 143,066,505 (+)NCBI
mRatBN7.24141,187,418 - 141,510,492 (+)NCBI
Rnor_6.04140,247,335 - 140,580,749 (+)NCBI
Rnor_5.04204,714,729 - 205,047,901 (+)NCBI
RGSC_v3.44143,705,360 - 144,030,051 (+)RGD
Celera4129,839,611 - 130,162,657 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270596   ⟹   NP_001257525
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84142,743,440 - 143,066,505 (+)NCBI
mRatBN7.24141,187,418 - 141,510,492 (+)NCBI
Rnor_6.04140,247,335 - 140,580,749 (+)NCBI
Rnor_5.04204,714,729 - 205,047,901 (+)NCBI
Celera4129,839,611 - 130,162,657 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270597   ⟹   NP_001257526
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84142,743,440 - 143,066,505 (+)NCBI
mRatBN7.24141,187,418 - 141,510,492 (+)NCBI
Rnor_6.04140,247,335 - 140,580,749 (+)NCBI
Rnor_5.04204,714,729 - 205,047,901 (+)NCBI
Celera4129,839,611 - 130,162,657 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063285577   ⟹   XP_063141647
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84142,743,401 - 143,066,505 (+)NCBI
RefSeq Acc Id: NP_001007236   ⟸   NM_001007235
- Peptide Label: isoform 1
- UniProtKB: Q62869 (UniProtKB/Swiss-Prot),   P29994 (UniProtKB/Swiss-Prot),   C7E1V2 (UniProtKB/TrEMBL),   F1LQS8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257526   ⟸   NM_001270597
- Peptide Label: isoform 3
- UniProtKB: A0A0A0MY31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257525   ⟸   NM_001270596
- Peptide Label: isoform 2
- UniProtKB: Q62869 (UniProtKB/Swiss-Prot),   P29994 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075403   ⟸   ENSRNOT00000082723
Ensembl Acc Id: ENSRNOP00000049540   ⟸   ENSRNOT00000041130
Ensembl Acc Id: ENSRNOP00000048661   ⟸   ENSRNOT00000043646
Ensembl Acc Id: ENSRNOP00000043615   ⟸   ENSRNOT00000040255
Ensembl Acc Id: ENSRNOP00000063885   ⟸   ENSRNOT00000064025
RefSeq Acc Id: XP_063141647   ⟸   XM_063285577
- Peptide Label: isoform X1
- UniProtKB: A0A8J8XAG4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000111175   ⟸   ENSRNOT00000151720
Ensembl Acc Id: ENSRNOP00000105276   ⟸   ENSRNOT00000143626
Protein Domains
Ion transport   MIR   RIH   RyR/IP3R Homology associated

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693288
Promoter ID:EPDNEW_R3807
Type:single initiation site
Name:Itpr1_1
Description:inositol 1,4,5-trisphosphate receptor, type 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04140,247,229 - 140,247,289EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2933 AgrOrtholog
BioCyc Gene G2FUF-43454 BioCyc
Ensembl Genes ENSRNOG00000007104 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000043646 ENTREZGENE
  ENSRNOT00000064025 ENTREZGENE
  ENSRNOT00000151720 ENTREZGENE
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  2.80.10.50 UniProtKB/Swiss-Prot
  IP3 receptor type 1 binding core, RIH domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7316579 IMAGE-MGC_LOAD
InterPro ARM-type_fold UniProtKB/Swiss-Prot
  Ins145_P3_rcpt UniProtKB/Swiss-Prot
  InsP3_rcpt UniProtKB/Swiss-Prot
  Ion_trans_dom UniProtKB/Swiss-Prot
  MIR_dom_sf UniProtKB/Swiss-Prot
  MIR_motif UniProtKB/Swiss-Prot
  RIH_assoc-dom UniProtKB/Swiss-Prot
  RIH_dom UniProtKB/Swiss-Prot
  Ryanodine_IP3_receptor UniProtKB/Swiss-Prot
  RyR/IP3R_RIH_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:25262 UniProtKB/Swiss-Prot
MGC_CLONE MGC:109369 IMAGE-MGC_LOAD
NCBI Gene 25262 ENTREZGENE
PANTHER INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR, TYPE 1A UniProtKB/Swiss-Prot
  MIR DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
Pfam Ins145_P3_rec UniProtKB/Swiss-Prot
  Ion_trans UniProtKB/Swiss-Prot
  MIR UniProtKB/Swiss-Prot
  RIH_assoc UniProtKB/Swiss-Prot
  RYDR_ITPR UniProtKB/Swiss-Prot
PharmGKB ITPR1 RGD
PhenoGen Itpr1 PhenoGen
PRINTS INSP3RECEPTR UniProtKB/Swiss-Prot
PROSITE MIR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007104 RatGTEx
SMART MIR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF100909 UniProtKB/Swiss-Prot
  SSF48371 UniProtKB/Swiss-Prot
  SSF82109 UniProtKB/Swiss-Prot
TIGR TC228573
UniProt A0A0A0MY31 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2KAH9_RAT UniProtKB/TrEMBL
  A0A8J8XAG4 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LT22_RAT UniProtKB/TrEMBL
  A0ABK0LX94_RAT UniProtKB/TrEMBL
  A6IBL0_RAT UniProtKB/TrEMBL
  C7E1V2 ENTREZGENE, UniProtKB/TrEMBL
  F1LQS8 ENTREZGENE
  F1LQX8_RAT UniProtKB/TrEMBL
  ITPR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5BJS8_RAT UniProtKB/TrEMBL
  Q62869 ENTREZGENE
UniProt Secondary Q62869 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Itpr1  inositol 1,4,5-trisphosphate receptor, type 1  Itpr1  inositol 1,4,5-triphosphate receptor, type 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-17 Itpr1  inositol 1,4,5-triphosphate receptor, type 1  Itpr1  inositol 1,4,5-triphosphate receptor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Itpr1  inositol 1,4,5-triphosphate receptor 1    inositol 1,4,5-triphosphate receptor type 1  Name updated 629478 APPROVED
2002-06-10 Itpr1  inositol 1,4,5-triphosphate receptor type 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process mobilizes calcium ion permeability in insulin secreting cells 68695
gene_process plays a role in insulin secretion 68695
gene_regulation down regulated in response to muscarinic receptor activation by carbachol 68695
gene_transcript has two alternative splicing forms which are differentially expressed in a neuronal and non-neuronal manner 729259