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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2933
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Itpr1
Name: inositol 1,4,5-trisphosphate receptor, type 1
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Itpr1decreases expressionISOItpr1 (Mus musculus)6480464CTDArsenic Trioxide results in decreased expression of ITPR1 mRNAPMID:24831965
Itpr1increases expressionISOItpr1 (Mus musculus)6480464CTDArsenic Trioxide results in increased expression of ITPR1 protein modified formPMID:27638049
Itpr1increases expressionISOITPR1 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of ITPR1 mRNAPMID:27829220
Itpr1increases phosphorylationISOItpr1 (Mus musculus)6480464CTDArsenic Trioxide results in increased phosphorylation of ITPR1 proteinPMID:27461142
Itpr1multiple interactionsISOItpr1 (Mus musculus)6480464CTD2-aminoethyl diphenylborinate inhibits the reaction [Arsenic Trioxide results in increased expression of ITPR1 protein modified form]; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of ITPR1 protein modified form]; ATF4 protein promotes the reaction [Arsenic Trioxide results in increased expression of ITPR1 protein modified form]PMID:27638049
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