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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2933 Species: Rattus norvegicus RGD Object: Gene Symbol: Itpr1 Name: inositol 1,4,5-trisphosphate receptor, type 1

Acc ID: CHEBI:28119 Term: 2,3,7,8-tetrachlorodibenzodioxine Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2. CasRN: 1746-01-6 Chemical ID: MESH:D013749

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:732978	6480464	CTD	Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ITPR1 mRNA]	PMID:11007951
increases expression	ISO	RGD:732978	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of ITPR1 mRNA	PMID:20106945 PMID:11007951
multiple interactions	ISO	RGD:10821	6480464	CTD	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ITPR1 mRNA	PMID:17942748
multiple interactions	ISO	RGD:732978	6480464	CTD	AHR protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to ITPR1 gene]] Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ITPR1 gene]	PMID:19574409
increases expression	ISO	RGD:732978	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of ITPR1 mRNA	PMID:20106945 PMID:11007951 PMID:19574409
increases expression	ISO	RGD:732978	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of ITPR1 mRNA	PMID:11007951 PMID:19574409 PMID:20106945
increases expression	ISO	RGD:732978	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of ITPR1 mRNA	PMID:19574409 PMID:11007951 PMID:20106945
increases expression	ISO	RGD:732978	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of ITPR1 mRNA	PMID:20106945 PMID:19574409 PMID:11007951
affects expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin affects the expression of ITPR1 mRNA	PMID:22298810
decreases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of ITPR1 mRNA	PMID:21215274
affects expression	ISO	RGD:10821	6480464	CTD	Tetrachlorodibenzodioxin affects the expression of ITPR1 mRNA	PMID:21570461
increases expression	ISO	RGD:732978	6480464	CTD	Tetrachlorodibenzodioxin results in increased expression of ITPR1 mRNA	PMID:11007951 PMID:19574409 PMID:20106945 PMID:21632981
decreases expression	EXP		6480464	CTD	Tetrachlorodibenzodioxin results in decreased expression of ITPR1 mRNA	PMID:20959002 PMID:21215274