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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2933
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Itpr1
Name: inositol 1,4,5-trisphosphate receptor, type 1
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Itpr1increases expressionEXP 6480464CTDperfluorooctane sulfonic acid results in increased expression of ITPR1 mRNAPMID:20136073
Itpr1multiple interactionsISOItpr1 (Mus musculus)6480464CTD[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of ITPR1 mRNA; perfluorooctane sulfonic acid inhibits the reaction [ITPR1 protein binds to HSPA9 protein binds to VDAC1 protein]; perfluorooctane sulfonic acid promotes the reaction [ITPR1 protein binds to AKT1 protein]PMID:28288859 PMID:36331819
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