Ghr (growth hormone receptor) - Rat Genome Database

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Gene: Ghr (growth hormone receptor) Rattus norvegicus
Analyze
Symbol: Ghr
Name: growth hormone receptor
RGD ID: 2687
Description: Enables several functions, including SH2 domain binding activity; enzyme binding activity; and growth hormone receptor activity. Involved in several processes, including cell surface receptor signaling pathway via JAK-STAT; cellular response to peptide hormone stimulus; and positive regulation of receptor signaling pathway via JAK-STAT. Located in extracellular space and neuronal cell body. Biomarker of congenital hypothyroidism; muscular atrophy; osteopetrosis; and osteoporosis. Human ortholog(s) of this gene implicated in several diseases, including Laron syndrome; familial hypercholesterolemia; isolated growth hormone deficiency; osteoarthritis; and type 2 diabetes mellitus. Orthologous to human GHR (growth hormone receptor); PARTICIPATES IN growth hormone signaling pathway; cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GH receptor; GHR/BP; growth hormone receptor precursor splice variant D56; growth hormone receptor variant d5-6; growth hormone receptor/binding protein; MGC124963; MGC156665; somatotropin receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8254,269,066 - 54,532,595 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl254,270,206 - 54,532,331 (-)EnsemblGRCr8
mRatBN7.2252,541,452 - 52,804,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl252,542,594 - 52,804,735 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx259,642,577 - 59,799,676 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0257,701,311 - 57,858,396 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0252,732,297 - 52,881,985 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0253,149,225 - 53,413,954 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl253,150,370 - 53,413,638 (-)Ensemblrn6Rnor6.0
Rnor_5.0272,265,571 - 72,346,118 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0272,182,692 - 72,218,250 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4252,496,517 - 52,658,066 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera248,257,266 - 48,408,640 (-)NCBICelera
RGSC_v3.1252,424,749 - 52,586,299 (-)NCBI
RH 3.4 Map2332.2RGD
Cytogenetic Map2q16NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (EXP)
arsenite(3-)  (ISO)
atrazine  (EXP)
bacitracin  (EXP)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
capsaicin  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlormequat chloride  (EXP)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cyproconazole  (ISO)
cytarabine  (ISO)
DDT  (EXP)
deoxynivalenol  (EXP)
dexamethasone  (ISO)
dichlorine  (EXP)
diclofenac  (ISO)
diethylstilbestrol  (EXP)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP,ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fipronil  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ketoconazole  (EXP)
L-methionine  (ISO)
menadione  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mifepristone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (EXP)
N,N-diethyl-m-toluamide  (EXP,ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
naproxen  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenethyl caffeate  (EXP)
phenobarbital  (EXP)
phenylarsine oxide  (ISO)
phenylmercury acetate  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (EXP)
propiconazole  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sotorasib  (ISO)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
sulindac  (EXP)
sumatriptan  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thiabendazole  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trametinib  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Exon 3-deleted/full-length growth hormone receptor polymorphism genotype frequencies in Spanish short small-for-gestational-age (SGA) children and adolescents (n = 247) and in an adult control population (n = 289) show increased fl/fl in short SGA. Audi L, etal., J Clin Endocrinol Metab. 2006 Dec;91(12):5038-43. Epub 2006 Sep 26.
2. Protection against diabetes-induced nephropathy in growth hormone receptor/binding protein gene-disrupted mice. Bellush LL, etal., Endocrinology. 2000 Jan;141(1):163-8.
3. Insulin regulation of growth hormone receptor gene expression: involvement of both the PI-3 kinase and MEK/ERK signaling pathways. Bennett WL, etal., Endocrine. 2007 Oct;32(2):219-26. Epub 2007 Nov 27.
4. Growth hormone treatment prevents osteoporosis in uremic rats. Berger I, etal., Histol Histopathol. 2007 Nov;22(11):1231-9.
5. [Pro-inflammatory cytokines IL-1 beta and TNF-alpha reduce growth hormone receptor mRNA concentration in cultivated rat hepatocytes after stimulation with growth hormone] Bohm SA, etal., Langenbecks Arch Chir Suppl Kongressbd. 1998;115(Suppl I):185-8.
6. Growth hormone receptor expression in atrophying muscle fibers of rats. Casse AH, etal., Endocrinology. 2003 Aug;144(8):3692-7.
7. Protective effects of recombinant human growth hormone on cirrhotic rats. Chen S, etal., World J Gastroenterol. 2004 Oct 1;10(19):2894-7.
8. Growth hormone receptor immunoreactivity is increased in the subventricular zone of juvenile rat brain after focal ischemia: a potential role for growth hormone in injury-induced neurogenesis. Christophidis LJ, etal., Growth Horm IGF Res. 2009 Dec;19(6):497-506. Epub 2009 Jun 12.
9. Relationship between the functional exon 3 deleted growth hormone receptor polymorphism and symptomatic osteoarthritis in women. Claessen KM, etal., Ann Rheum Dis. 2014 Feb;73(2):433-6. doi: 10.1136/annrheumdis-2012-202713. Epub 2013 Jun 5.
10. Spatial distribution of growth hormone receptor, insulin-like growth factor-I receptor and apoptotic chondrocytes during growth plate development. Cruickshank J, etal., J Endocrinol. 2005 Mar;184(3):543-53.
11. Interaction of the growth hormone receptor with cytokine-induced Src homology domain 2 protein in rat adipocytes. Du L, etal., Endocrinology 2003 Mar;144(3):868-76.
12. The expression of growth hormone receptor gene transcript in the prefrontal cortex is affected in male mice with diabetes-induced learning impairments. Enhamre E, etal., Neurosci Lett. 2012 Aug 8;523(1):82-6. doi: 10.1016/j.neulet.2012.06.050. Epub 2012 Jun 27.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Activation of the Jak/Stat signal transduction pathway in GH-treated rat osteoblast-like cells in culture. Gerland K, etal., Mol Cell Endocrinol. 2000 Oct 25;168(1-2):1-9.
15. Localization and regulation of the growth hormone receptor and growth hormone-binding protein in the rat growth plate. Gevers EF, etal., J Bone Miner Res 2002 Aug;17(8):1408-19.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Characterization of the human growth hormone receptor gene and demonstration of a partial gene deletion in two patients with Laron-type dwarfism. Godowski PJ, etal., Proc Natl Acad Sci U S A. 1989 Oct;86(20):8083-7.
18. Recruitment of a repressosome complex at the growth hormone receptor promoter and its potential role in diabetic nephropathy. Gowri PM, etal., Mol Cell Biol. 2003 Feb;23(3):815-25.
19. Additive effect of GHRd3 and COLIA1 polymorphisms on the GH-substitution dose in GH-deficient adults. Hartleb S, etal., Pharmacogenomics. 2011 Dec;12(12):1653-61. doi: 10.2217/pgs.11.113. Epub 2011 Oct 25.
20. Alterations in growth hormone receptor abundance regulate growth hormone signaling in murine obstructive cholestasis. Held MA, etal., Am J Physiol Gastrointest Liver Physiol. 2005 May;288(5):G986-93. Epub 2004 Dec 16.
21. Growth hormone receptor interaction with Jak proteins differs between tissues. Hellgren G, etal., J Interferon Cytokine Res. 2001 Feb;21(2):75-83.
22. Autoregulation of growth hormone receptor and growth hormone binding protein transcripts in brain and peripheral tissues of the rat. Hull KL and Harvey S, Growth Horm IGF Res. 1998 Apr;8(2):167-73.
23. Growth hormone exerts antiapoptotic and proliferative effects through two different pathways involving nuclear factor-kappaB and phosphatidylinositol 3-kinase. Jeay S, etal., Endocrinology 2001 Jan;142(1):147-56.
24. Clinical and biochemical consequences of an intragenic growth hormone receptor (GHR) deletion in a large Chinese pedigree. Klammt J, etal., Clin Endocrinol (Oxf). 2015 Mar;82(3):453-61. doi: 10.1111/cen.12606. Epub 2014 Oct 20.
25. The involvement of growth hormone-binding protein in altered GH-IGF axis in IDDM. Kobayashi K, etal., Endocr J. 1999 Mar;46 Suppl:S67-9.
26. Regulation of the acid-labile subunit in sustained endotoxemia. Kong SE, etal., Am J Physiol Endocrinol Metab 2002 Oct;283(4):E692-701.
27. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
28. Differential expression of renal growth hormone receptor and its binding protein in experimental diabetes mellitus. Landau D, etal., Growth Horm IGF Res. 1998 Feb;8(1):39-45.
29. Changes in the growth hormone-IGF-I axis in non-obese diabetic mice. Landau D, etal., Int J Exp Diabetes Res. 2000;1(1):9-18.
30. Effect of two human growth hormone receptor antagonists on glomerulosclerosis in streptozotocin-induced diabetic rats. Li W, etal., Acta Pharmacol Sin. 2004 Apr;25(4):490-5.
31. Regulation of rat growth hormone receptor gene expression. Mathews LS, etal., J Biol Chem 1989 Jun 15;264(17):9905-10.
32. Tissue-specific regulation of the growth hormone receptor gene in streptozocin-induced diabetes in the rat. Menon RK, etal., J Endocrinol. 1994 Sep;142(3):453-62.
33. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
34. Distinct neuronal growth hormone receptor ligand specificity in the rat brain. Moderscheim TA, etal., Brain Res. 2007 Mar 16;1137(1):29-34. Epub 2006 Dec 20.
35. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
36. Parenteral versus enteral nutrition: effect on serum cytokines and the hepatic expression of mRNA of suppressor of cytokine signaling proteins, insulin-like growth factor-1 and the growth hormone receptor in rodent sepsis. O'Leary MJ, etal., Crit Care. 2007;11(4):R79.
37. In rats with sepsis, the acute fall in IGF-I is associated with an increase in circulating growth hormone-binding protein levels. O'Leary MJ, etal., Intensive Care Med. 2000 Oct;26(10):1547-52.
38. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
39. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
40. Growth hormone-binding protein is directly and IGFBP-3 is inversely associated with risk of female breast cancer. Pazaitou-Panayiotou K, etal., Eur J Endocrinol. 2007 Feb;156(2):187-94.
41. Etiopathogenesis of hepatic osteodystrophy in Wistar rats with cholestatic liver disease. Pereira FA, etal., Calcif Tissue Int. 2009 Jul;85(1):75-83. doi: 10.1007/s00223-009-9249-3. Epub 2009 May 8.
42. Growth hormone activity in mitochondria depends on GH receptor Box 1 and involves caveolar pathway targeting. Perret-Vivancos C, etal., Exp Cell Res. 2006 Feb 1;312(3):215-32.
43. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
44. GOA pipeline RGD automated data pipeline
45. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
46. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
47. Growth hormone receptor mutations in children with idiopathic short stature. Sanchez JE, etal., J Clin Endocrinol Metab. 1998 Nov;83(11):4079-83.
48. Growth hormone receptor antagonism prevents early renal changes in nonobese diabetic mice. Segev Y, etal., J Am Soc Nephrol. 1999 Nov;10(11):2374-81.
49. Nine novel growth hormone receptor gene mutations in patients with Laron syndrome. Sobrier ML, etal., J Clin Endocrinol Metab. 1997 Feb;82(2):435-7.
50. Mutation of the SHP-2 binding site in growth hormone (GH) receptor prolongs GH-promoted tyrosyl phosphorylation of GH receptor, JAK2, and STAT5B. Stofega MR, etal., Mol Endocrinol. 2000 Sep;14(9):1338-50.
51. GHR exon 3 polymorphism: association with type 2 diabetes mellitus and metabolic disorder. Strawbridge RJ, etal., Growth Horm IGF Res. 2007 Oct;17(5):392-8. Epub 2007 May 29.
52. Reduced growth hormone receptor immunoreactivity in osteoclasts adjacent to the erupting molar in the incisor-absent (osteopetrotic) rat. Symons AL Eur J Oral Sci. 2003 Dec;111(6):503-9.
53. Changes in growth hormone (GH), GH receptor, and GH signal transduction in hippocampus of congenital hypothyroid rats. Tang H, etal., J Neurosci Res. 2011 Feb;89(2):248-55. doi: 10.1002/jnr.22540. Epub 2010 Dec 8.
54. Alteration of gene expression profiles in skeletal muscle of rats exposed to microgravity during a spaceflight. Taylor WE, etal., J Gravit Physiol. 2002 Dec;9(2):61-70.
55. Morphine decreases the levels of the gene transcripts of growth hormone receptor and growth hormone binding protein in the male rat hippocampus and spinal cord. Thornwall-Le Greves M, etal., Neurosci Lett. 2001 May 18;304(1-2):69-72.
56. Expression of growth hormone receptor by peripheral blood lymphocytes in children: evaluation in clinical conditions of impaired growth. Valerio G, etal., Clin Endocrinol (Oxf). 1997 Sep;47(3):329-35.
57. Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome. van der Pluijm I, etal., PLoS Biol. 2007 Jan;5(1):e2.
58. Domains of the growth hormone receptor required for association and activation of JAK2 tyrosine kinase. VanderKuur JA, etal., J Biol Chem. 1994 Aug 26;269(34):21709-17.
59. Expression of growth hormone receptor and its mRNA in hepatic cirrhosis. Wang HT, etal., World J Gastroenterol. 2003 Apr;9(4):765-70.
60. Zhonghua wai ke za zhi [Chinese journal of surgery] Wang P, etal., Zhonghua Wai Ke Za Zhi. 2002 Dec;40(12):940-4.
61. The exon-3 deleted growth hormone receptor polymorphism predisposes to long-term complications of acromegaly. Wassenaar MJ, etal., J Clin Endocrinol Metab. 2009 Dec;94(12):4671-8. doi: 10.1210/jc.2009-1172. Epub 2009 Oct 28.
62. Age-related cataract progression in five mouse models for anti-oxidant protection or hormonal influence. Wolf N, etal., Exp Eye Res. 2005 Sep;81(3):276-85.
63. Immunohistochemical localisation of growth hormone (GH), GH receptor (GHR), insulin-like growth factor I (IGF-I) and type I IGF-I receptor, and gene expression of GH and GHR in rat pre-antral follicles. Zhao J, etal., Zygote 2002 Feb;10(1):85-94.
64. A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse). Zhou Y, etal., Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13215-20.
Additional References at PubMed
PMID:1446642   PMID:1549776   PMID:2792761   PMID:2825030   PMID:6303755   PMID:7545168   PMID:7565946   PMID:7615519   PMID:7835307   PMID:8137822   PMID:8702683   PMID:8921876  
PMID:8943276   PMID:9144201   PMID:9231797   PMID:9360546   PMID:9571026   PMID:10556780   PMID:10585430   PMID:11834450   PMID:12477932   PMID:12488452   PMID:12552091   PMID:15609625  
PMID:15664698   PMID:15763517   PMID:16116438   PMID:16154995   PMID:16867182   PMID:17088403   PMID:17090972   PMID:17658679   PMID:18648510   PMID:20814072   PMID:21177131   PMID:21195069  
PMID:22715380   PMID:24006456   PMID:24963636  


Genomics

Comparative Map Data
Ghr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8254,269,066 - 54,532,595 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl254,270,206 - 54,532,331 (-)EnsemblGRCr8
mRatBN7.2252,541,452 - 52,804,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl252,542,594 - 52,804,735 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx259,642,577 - 59,799,676 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0257,701,311 - 57,858,396 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0252,732,297 - 52,881,985 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0253,149,225 - 53,413,954 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl253,150,370 - 53,413,638 (-)Ensemblrn6Rnor6.0
Rnor_5.0272,265,571 - 72,346,118 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0272,182,692 - 72,218,250 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4252,496,517 - 52,658,066 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera248,257,266 - 48,408,640 (-)NCBICelera
RGSC_v3.1252,424,749 - 52,586,299 (-)NCBI
RH 3.4 Map2332.2RGD
Cytogenetic Map2q16NCBI
GHR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38542,423,439 - 42,721,878 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl542,423,439 - 42,721,878 (+)Ensemblhg38GRCh38
GRCh37542,423,541 - 42,721,980 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36542,459,783 - 42,757,683 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34542,459,782 - 42,757,682NCBI
Celera542,314,115 - 42,611,474 (+)NCBICelera
Cytogenetic Map5p13.1-p12NCBI
HuRef542,375,464 - 42,673,429 (+)NCBIHuRef
CHM1_1542,425,901 - 42,723,964 (+)NCBICHM1_1
T2T-CHM13v2.0542,678,916 - 42,974,806 (+)NCBIT2T-CHM13v2.0
Ghr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39153,347,237 - 3,612,834 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl153,347,242 - 3,612,974 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38153,317,755 - 3,583,352 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl153,317,760 - 3,583,492 (-)Ensemblmm10GRCm38
MGSCv37153,267,760 - 3,533,230 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36153,267,774 - 3,533,231 (-)NCBIMGSCv36mm8
Celera153,182,321 - 3,448,882 (-)NCBICelera
Cytogenetic Map15A1NCBI
cM Map151.84NCBI
Ghr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542626,689,581 - 26,871,684 (+)Ensembl
ChiLan1.0NW_00495542626,553,509 - 26,873,619 (+)NCBIChiLan1.0ChiLan1.0
GHR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2467,606,168 - 67,904,442 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1565,759,794 - 66,082,475 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0567,654,326 - 67,953,140 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1572,700,150 - 72,997,356 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl572,700,150 - 72,871,278 (-)EnsemblpanPan2panpan1.1
GHR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1467,021,821 - 67,245,499 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl467,022,252 - 67,290,473 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha466,705,544 - 66,845,096 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0467,531,090 - 67,802,322 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl467,532,966 - 67,802,335 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1467,276,975 - 67,416,597 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0467,407,363 - 67,546,744 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0467,943,814 - 68,083,513 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ghr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213230,991,608 - 231,135,845 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936518235,990 - 380,272 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936518235,996 - 380,225 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GHR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1627,126,734 - 27,421,449 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11627,126,300 - 27,422,618 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21628,691,739 - 28,855,136 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GHR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1441,171,038 - 41,464,474 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl441,285,712 - 41,464,666 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607131,608,844 - 31,907,481 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ghr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475912,285,594 - 12,570,906 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475912,282,295 - 12,570,106 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ghr
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13176,485,597 - 176,716,127 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ghr
1804 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:362
Count of miRNA genes:214
Interacting mature miRNAs:257
Transcripts:ENSRNOT00000021081, ENSRNOT00000046951
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21332504158325041Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23675034481750344Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21605188361051883Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
731166Mamtr2Mammary tumor resistance QTL 20.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358154623581Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22888999173889991Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21436870759368707Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24490435585286097Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266683465677Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)25126685996266859Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23686864381868643Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)24490435589904355Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)23326999678269996Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266673652666Rat

Markers in Region
D2Chm149  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2252,692,967 - 52,693,212 (+)MAPPERmRatBN7.2
Rnor_6.0253,302,376 - 53,302,618NCBIRnor6.0
Rnor_5.0272,334,610 - 72,334,852UniSTSRnor5.0
RGSC_v3.4252,646,559 - 52,646,801UniSTSRGSC3.4
Celera248,397,132 - 48,397,374UniSTS
Cytogenetic Map2q16UniSTS
RH142196  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8254,270,186 - 54,270,348 (+)Marker Load Pipeline
mRatBN7.2252,542,574 - 52,542,736 (+)MAPPERmRatBN7.2
Rnor_6.0253,150,351 - 53,150,512NCBIRnor6.0
Rnor_5.0272,182,673 - 72,182,834UniSTSRnor5.0
RGSC_v3.4252,496,498 - 52,496,659UniSTSRGSC3.4
Celera248,257,247 - 48,257,408UniSTS
RH 3.4 Map2332.2UniSTS
Cytogenetic Map2q16UniSTS
RH141289  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2252,542,348 - 52,542,548 (+)MAPPERmRatBN7.2
Rnor_6.0253,150,125 - 53,150,324NCBIRnor6.0
Rnor_5.0272,182,447 - 72,182,646UniSTSRnor5.0
RGSC_v3.4252,496,272 - 52,496,471UniSTSRGSC3.4
Celera248,257,021 - 48,257,220UniSTS
RH 3.4 Map2330.5UniSTS
Cytogenetic Map2q16UniSTS
Ghr  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2252,551,768 - 52,552,167 (+)MAPPERmRatBN7.2
Rnor_6.0253,159,545 - 53,159,941NCBIRnor6.0
Rnor_5.0272,191,867 - 72,192,263UniSTSRnor5.0
RGSC_v3.4252,505,691 - 52,506,087UniSTSRGSC3.4
Celera248,266,438 - 48,266,834UniSTS
Cytogenetic Map2q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 66 59 6 330 166 11 139 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001437872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001437875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH006760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC103659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC127501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC161852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JF330099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JF412704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW395402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S49003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S76627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X60198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z83757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000021081   ⟹   ENSRNOP00000021081
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl254,278,360 - 54,532,331 (-)Ensembl
mRatBN7.2 Ensembl252,551,639 - 52,804,735 (-)Ensembl
Rnor_6.0 Ensembl253,159,873 - 53,413,638 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000046951   ⟹   ENSRNOP00000044119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl254,270,206 - 54,432,075 (-)Ensembl
mRatBN7.2 Ensembl252,542,594 - 52,704,478 (-)Ensembl
Rnor_6.0 Ensembl253,150,370 - 53,313,884 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081558   ⟹   ENSRNOP00000072873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl253,159,525 - 53,185,926 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088876   ⟹   ENSRNOP00000071833
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl254,271,047 - 54,532,331 (-)Ensembl
mRatBN7.2 Ensembl252,543,435 - 52,804,735 (-)Ensembl
Rnor_6.0 Ensembl253,151,211 - 53,300,404 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096351   ⟹   ENSRNOP00000096274
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl254,270,206 - 54,432,075 (-)Ensembl
mRatBN7.2 Ensembl252,542,594 - 52,704,478 (-)Ensembl
RefSeq Acc Id: NM_017094   ⟹   NP_058790
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8254,270,206 - 54,432,075 (-)NCBI
mRatBN7.2252,542,594 - 52,704,478 (-)NCBI
Rnor_6.0253,150,370 - 53,313,884 (-)NCBI
Rnor_5.0272,182,692 - 72,218,250 (-)NCBI
Rnor_5.0272,265,571 - 72,346,118 (-)NCBI
RGSC_v3.4252,496,517 - 52,658,066 (-)RGD
Celera248,257,266 - 48,408,640 (-)RGD
Sequence:
RefSeq Acc Id: XM_008760754   ⟹   XP_008758976
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8254,269,066 - 54,532,595 (-)NCBI
mRatBN7.2252,541,454 - 52,804,960 (-)NCBI
Rnor_6.0253,149,225 - 53,413,954 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101769   ⟹   XP_038957697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8254,269,066 - 54,522,128 (-)NCBI
mRatBN7.2252,541,452 - 52,794,526 (-)NCBI
RefSeq Acc Id: XM_039101770   ⟹   XP_038957698
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8254,269,066 - 54,532,027 (-)NCBI
mRatBN7.2252,541,452 - 52,803,747 (-)NCBI
RefSeq Acc Id: XM_039101771   ⟹   XP_038957699
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8254,279,248 - 54,532,572 (-)NCBI
mRatBN7.2252,551,636 - 52,804,960 (-)NCBI
RefSeq Acc Id: XM_063281321   ⟹   XP_063137391
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8254,269,066 - 54,532,027 (-)NCBI
RefSeq Acc Id: XM_063281322   ⟹   XP_063137392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8254,279,248 - 54,532,006 (-)NCBI
RefSeq Acc Id: XM_063281323   ⟹   XP_063137393
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8254,279,248 - 54,432,269 (-)NCBI
RefSeq Acc Id: XM_063281324   ⟹   XP_063137394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8254,279,248 - 54,522,128 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001424801 (Get FASTA)   NCBI Sequence Viewer  
  NP_001424803 (Get FASTA)   NCBI Sequence Viewer  
  NP_001424804 (Get FASTA)   NCBI Sequence Viewer  
  NP_058790 (Get FASTA)   NCBI Sequence Viewer  
  XP_008758976 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957697 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957698 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957699 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137391 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137392 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137393 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137394 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41219 (Get FASTA)   NCBI Sequence Viewer  
  AAC52916 (Get FASTA)   NCBI Sequence Viewer  
  AAC52917 (Get FASTA)   NCBI Sequence Viewer  
  AAH86591 (Get FASTA)   NCBI Sequence Viewer  
  AAI03660 (Get FASTA)   NCBI Sequence Viewer  
  AAI27502 (Get FASTA)   NCBI Sequence Viewer  
  AAP13886 (Get FASTA)   NCBI Sequence Viewer  
  AAP31905 (Get FASTA)   NCBI Sequence Viewer  
  AEA34991 (Get FASTA)   NCBI Sequence Viewer  
  AEZ52406 (Get FASTA)   NCBI Sequence Viewer  
  CAA42756 (Get FASTA)   NCBI Sequence Viewer  
  EDL75743 (Get FASTA)   NCBI Sequence Viewer  
  EDL75744 (Get FASTA)   NCBI Sequence Viewer  
  EDL75745 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021081
  ENSRNOP00000021081.6
  ENSRNOP00000044119
  ENSRNOP00000044119.3
GenBank Protein P16310 (Get FASTA)   NCBI Sequence Viewer  
  QST77438 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058790   ⟸   NM_017094
- Peptide Label: precursor
- UniProtKB: Q64236 (UniProtKB/Swiss-Prot),   Q80XW9 (UniProtKB/Swiss-Prot),   P16310 (UniProtKB/Swiss-Prot),   A6KGC0 (UniProtKB/TrEMBL),   I1SRC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008758976   ⟸   XM_008760754
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000021081   ⟸   ENSRNOT00000021081
Ensembl Acc Id: ENSRNOP00000072873   ⟸   ENSRNOT00000081558
Ensembl Acc Id: ENSRNOP00000044119   ⟸   ENSRNOT00000046951
Ensembl Acc Id: ENSRNOP00000071833   ⟸   ENSRNOT00000088876
RefSeq Acc Id: XP_038957698   ⟸   XM_039101770
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038957697   ⟸   XM_039101769
- Peptide Label: isoform X1
- UniProtKB: Q64236 (UniProtKB/Swiss-Prot),   P16310 (UniProtKB/Swiss-Prot),   Q80XW9 (UniProtKB/Swiss-Prot),   A6KGC0 (UniProtKB/TrEMBL),   I1SRC4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957699   ⟸   XM_039101771
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000096274   ⟸   ENSRNOT00000096351
RefSeq Acc Id: XP_063137391   ⟸   XM_063281321
- Peptide Label: isoform X1
- UniProtKB: Q80XW9 (UniProtKB/Swiss-Prot),   Q64236 (UniProtKB/Swiss-Prot),   P16310 (UniProtKB/Swiss-Prot),   A6KGC0 (UniProtKB/TrEMBL),   I1SRC4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137392   ⟸   XM_063281322
- Peptide Label: isoform X2
- UniProtKB: Q5RJL5 (UniProtKB/TrEMBL),   A0A0H2UHM8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137394   ⟸   XM_063281324
- Peptide Label: isoform X2
- UniProtKB: Q5RJL5 (UniProtKB/TrEMBL),   A0A0H2UHM8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137393   ⟸   XM_063281323
- Peptide Label: isoform X2
- UniProtKB: Q5RJL5 (UniProtKB/TrEMBL),   A0A0H2UHM8 (UniProtKB/TrEMBL)
Protein Domains
Fibronectin type-III   Growth hormone-binding protein   Growth hormone/erythropoietin receptor ligand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P16310-F1-model_v2 AlphaFold P16310 1-638 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691161
Promoter ID:EPDNEW_R1686
Type:single initiation site
Name:Ghr_2
Description:growth hormone receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1687  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0253,313,805 - 53,313,865EPDNEW
RGD ID:13691168
Promoter ID:EPDNEW_R1687
Type:initiation region
Name:Ghr_1
Description:growth hormone receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1686  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0253,413,708 - 53,413,768EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2687 AgrOrtholog
BioCyc Gene G2FUF-54204 BioCyc
Ensembl Genes ENSRNOG00000015654 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021081 ENTREZGENE
  ENSRNOT00000021081.7 UniProtKB/Swiss-Prot
  ENSRNOT00000046951 ENTREZGENE
  ENSRNOT00000046951.6 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
InterPro FN3_dom UniProtKB/Swiss-Prot
  FN3_sf UniProtKB/Swiss-Prot
  GHBP UniProtKB/Swiss-Prot
  Growth/epo_recpt_lig-bind UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Long_hematopoietin_rcpt_CS UniProtKB/Swiss-Prot
KEGG Report rno:25235 UniProtKB/Swiss-Prot
NCBI Gene 25235 ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/Swiss-Prot
  INTERLEUKIN 5 RECEPTOR SUBUNIT ALPHA UniProtKB/Swiss-Prot
Pfam EpoR_lig-bind UniProtKB/Swiss-Prot
  GHBP UniProtKB/Swiss-Prot
PharmGKB GHR RGD
PhenoGen Ghr PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot
  HEMATOPO_REC_L_F1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015654 RatGTEx
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot
UniProt A0A0G2K1G7_RAT UniProtKB/TrEMBL
  A0A0H2UHM8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8A1UAK4_RAT UniProtKB/TrEMBL
  A0A8A1UAN7_RAT UniProtKB/TrEMBL
  A0A8A1UD65_RAT UniProtKB/TrEMBL
  A0A8A1UF68_RAT UniProtKB/TrEMBL
  A6KGC0 ENTREZGENE, UniProtKB/TrEMBL
  A6KGC1_RAT UniProtKB/TrEMBL
  A6KGC2_RAT UniProtKB/TrEMBL
  GHR_RAT UniProtKB/Swiss-Prot
  H6AC53_RAT UniProtKB/TrEMBL
  I1SRC4 ENTREZGENE, UniProtKB/TrEMBL
  P16310 ENTREZGENE
  Q5RJL5 ENTREZGENE, UniProtKB/TrEMBL
  Q64236 ENTREZGENE
  Q80WG8_RAT UniProtKB/TrEMBL
  Q80XW9 ENTREZGENE
UniProt Secondary Q64236 UniProtKB/Swiss-Prot
  Q80XW9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ghr  growth hormone receptor      Symbol and Name status set to approved 70586 APPROVED