RGD Reference Report - A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse). - Rat Genome Database

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A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse).

Authors: Zhou, Y  Xu, BC  Maheshwari, HG  He, L  Reed, M  Lozykowski, M  Okada, S  Cataldo, L  Coschigamo, K  Wagner, TE  Baumann, G  Kopchick, JJ 
Citation: Zhou Y, etal., Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13215-20.
RGD ID: 11565834
Pubmed: PMID:9371826   (View Abstract at PubMed)
PMCID: PMC24289   (View Article at PubMed Central)

Laron syndrome [growth hormone (GH) insensitivity syndrome] is a hereditary dwarfism resulting from defects in the GH receptor (GHR) gene. GHR deficiency has not been reported in mammals other than humans. Many aspects of GHR dysfunction remain unknown because of ethical and practical limitations in studying humans. To create a mammalian model for this disease, we generated mice bearing a disrupted GHR/binding protein (GHR/BP) gene through a homologous gene targeting approach. Homozygous GHR/BP knockout mice showed severe postnatal growth retardation, proportionate dwarfism, absence of the GHR and GH binding protein, greatly decreased serum insulin-like growth factor I and elevated serum GH concentrations. These characteristics represent the phenotype typical of individuals with Laron syndrome. Animals heterozygous for the GHR/BP defect show only minimal growth impairment but have an intermediate biochemical phenotype, with decreased GHR and GH binding protein expression and slightly diminished insulin-like growth factor I levels. These findings indicate that the GHR/BP-deficient mouse (Laron mouse) is a suitable model for human Laron syndrome that will prove useful for the elucidation of many aspects of GHR/BP function that cannot be obtained in humans.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Laron syndrome  ISOGhr (Mus musculus)11565834; 11565834 RGD 
Laron syndrome  IMP 11565834 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ghr  (growth hormone receptor)

Genes (Mus musculus)
Ghr  (growth hormone receptor)

Genes (Homo sapiens)
GHR  (growth hormone receptor)


Additional Information