RGD Reference Report - [Pro-inflammatory cytokines IL-1 beta and TNF-alpha reduce growth hormone receptor mRNA concentration in cultivated rat hepatocytes after stimulation with growth hormone] - Rat Genome Database

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[Pro-inflammatory cytokines IL-1 beta and TNF-alpha reduce growth hormone receptor mRNA concentration in cultivated rat hepatocytes after stimulation with growth hormone]

Authors: Bohm, SA  Wolf, M  Kreymann, G  Holscher, AH 
Citation: Bohm SA, etal., Langenbecks Arch Chir Suppl Kongressbd. 1998;115(Suppl I):185-8.
RGD ID: 2307375
Pubmed: PMID:14518239   (View Abstract at PubMed)

Critical illness is associated with catabolism caused by the alteration of several hormonal systems. Low levels of insulin-like growth factor I (IGF-I) in critical illness are observed despite increased or normal levels of growth hormone (GH). The mechanisms for this apparent GH resistance have not been elucidated. Since proinflammatory cytokines mediate many of the acute responses in critical illness, we evaluated the effects of IL-1 beta and TNF-alpha on growth hormone receptor-(GHR-)mRNA in cultured rat hepatocytes. Diminished GHR-mRNA concentrations in response to cytokine stimulation indicate that low IGF-I levels in the beginning of severe illness, may at least be partially a cause of GHR synthesis suppression by proinflammatory cytokines.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to interleukin-1  IEP 2307375 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ghr  (growth hormone receptor)


Additional Information