Gene:	Apc ( Rattus norvegicus ) adenomatous polyposis coli
Description:	binds microtubules; may play a role in the regulation of cell polarity
Synonyms:	RATAPC;
ArrayIDs:	L19304_s_at; 6682094; 6391576; 1387837_at; 5819509; 5775671; 6573703; L19306_s_at; D38629_at; 6592529; 5872775; 6222712; A_44_P448864; 6116943; rc_AA955065_at; 5647475; 5876971; 5923876; 6692865; GE19786; 6153169; 5897411; 5799994; 1376629_at; 5685990; 6128681; 6597048; rc_AA946327_at; 5709080; 5645349; 6053460; 6237364; 6304401; 6371777; 6367429; A_44_P276106; 6482216;  (details...)
Gene Type:	protein-coding
Strain:	F344-Apcm1/Kyo
Additional Data
Candidate gene for:	Colcr3 - Colorectal carcinoma resistance QTL 3
Curated Variants:	ApcPirc
Homologs
Homo sapiens: APC     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Apc     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Apc genome assembly 3.1 18 26758792 - 26817029     Rat Celera Assembly 18 25606119 - 25663749     RGSC genome assembly v3.4 18 26732147 - 26790383     Cytogenetic 18 p12 Mus musculus Apc Mouse genome assembly build 36.1 18 34380638 - 34479735     Cytogenetic 18 18 B1 Homo sapiens APC human genome assembly 5 112101482 - 112209834     Human genome assembly build 36.2 5 112101483 - 112209835     Cytogenetic 5 q21-q22   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Note Reference interacts with microtubles 632398 Gene Ontology protein kinase regulator activity,  protein binding,  protein kinase binding ...  (details...)
Biological Process	Note Reference may play a role in the regulation of cell polarity 632398 Gene Ontology thymus development,  cell cycle arrest,  positive regulation of apoptosis ...  (details...)
Cellular Component	Gene Ontology nucleus,  cytoplasmic microtubule,  tight junction ...  (details...)
Disease	Note Reference mutations are associated with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induced colon tumors 634649 human homolog is involved in colon tumorigenesis 634649 Ontology Colorectal Neoplasms,  Adenomatous Polyposis Coli (details...)
Pathway	Ontology altered canonical Wnt signaling pathway,  colorectal cancer pathway,  canonical Wnt signaling pathway (details...)
External Links
Databases	DATABASE ID SOURCE SMART: ARM IPI PROSITE: ARM_REPEAT IPI UNIPARC: UPI0000125C36 IPI UNIPARC: UPI0001B79E17 IPI KEGG Report: rno:24205 ENTREZGENE HomoloGene Group ID: 30950 ENTREZGENE Germonline: 2123 Pfam: APC_crr IPI Pfam: APC_basic IPI Pfam: APC_15aa IPI Pfam: SAMP IPI Pfam: EB1_binding IPI Pfam: Arm IPI KEGG Pathway: 04810 ENTREZGENE KEGG Pathway: 05217 ENTREZGENE KEGG Pathway: 05210 ENTREZGENE KEGG Pathway: 05213 ENTREZGENE KEGG Pathway: 04310 ENTREZGENE InterPro: APC_basic. IPI InterPro: APC_15aa. IPI InterPro: ARM-type_fold. IPI InterPro: SAMP. IPI InterPro: EB1_bd. IPI InterPro: Armadillo. IPI InterPro: APC_crr. IPI InterPro: ARM-like. IPI IPI: IPI00188859 IPI IPI: IPI00778481 IPI Ensembl Protein: ENSRNOP00000057599 IPI Ensembl Protein: ENSRNOP00000027691 IPI Gene3D-CATH: ARM-like IPI Entrez Gene: Apc ENTREZGENE TIGR: TC228425 UniProt: APC_RAT IPI Ensembl Genes: ENSRNOG00000020423 IPI RatMap: 77 ENTREZGENE Superfamily-SCOP: ARM-type_fold IPI
Sequences	Nucleotide: AB071693 Get FASTA Search GEO Profiles Nucleotide: D38629 Get FASTA Search GEO Profiles Nucleotide: CH473974 Get FASTA Search GEO Profiles Nucleotide: NM_012499 Get FASTA Search GEO Profiles (View all 4 Nucleotide Accessions) Protein: NP_036631 Get FASTA Protein: EDL76212 Get FASTA Protein: EDL76213 Get FASTA Protein: EDL76214 Get FASTA Protein: EDL76215 Get FASTA Protein: EDL76216 Get FASTA Protein: EDL76217 Get FASTA Protein: EDL76218 Get FASTA Protein: BAB68311 Get FASTA Protein: BAA07609 Get FASTA Protein: P70478 Get FASTA (View all 11 Protein Accessions)
Clusters	UniGene: 88057
References
Curated References	13 references in RGD related to Apc
Other References	14 other references at PubMed related to Apc
Database Information
RGD ID	2123
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 10-JUN-02: Apc Adenomatosis polyposis coli APPROVED Symbol and Name status set to approved 70586