Adora2b (adenosine A2B receptor) - Rat Genome Database

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Gene: Adora2b (adenosine A2B receptor) Rattus norvegicus
Analyze
Symbol: Adora2b
Name: adenosine A2B receptor
RGD ID: 2050
Description: Predicted to enable G protein-coupled adenosine receptor activity. Involved in several processes, including negative regulation of collagen biosynthetic process; positive regulation of biosynthetic process; and positive regulation of cAMP/PKA signal transduction. Located in cell surface. Orthologous to human ADORA2B (adenosine A2b receptor); PARTICIPATES IN adenosine signaling pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH (S)-AMPA; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adenosine receptor A2b
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Adora2bem2Mcwi ; Adora2bem1Mcwi
Genetic Models: SS-Adora2bem1Mcwi ; SS-Adora2bem2Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81047,439,712 - 47,456,092 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1047,439,701 - 47,456,091 (+)EnsemblGRCr8
mRatBN7.21046,940,394 - 46,956,772 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1046,940,384 - 46,956,772 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1051,644,175 - 51,660,562 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01051,134,721 - 51,151,112 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01046,638,130 - 46,654,520 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01048,569,563 - 48,586,366 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1048,569,555 - 48,586,365 (+)Ensemblrn6Rnor6.0
Rnor_5.01048,358,068 - 48,374,871 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41048,421,592 - 48,437,967 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1046,186,295 - 46,202,681 (+)NCBICelera
RGSC_v3.11048,435,217 - 48,451,589 (+)NCBI
Cytogenetic Map10q23NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-AMPA  (EXP)
(S)-amphetamine  (ISO)
1,7-dimethylxanthine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tert-butylphenol  (ISO)
5'-S-methyl-5'-thioadenosine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
actinomycin D  (ISO)
adenosine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alloxazine  (EXP)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
Azoxymethane  (ISO)
BAY 60-6583  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt atom  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diazinon  (ISO)
diclofenac  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
DPCPX  (ISO)
entinostat  (ISO)
ethanol  (ISO)
ferric oxide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
hexadecanoic acid  (ISO)
indometacin  (ISO)
isobutanol  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
MeIQx  (ISO)
melatonin  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
modafinil  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-ethyl-5'-carboxamidoadenosine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrogen dioxide  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propiconazole  (EXP)
raloxifene  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
triadimefon  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IBA,ISO)
G protein-coupled adenosine receptor signaling pathway  (IEA,ISO)
G protein-coupled receptor signaling pathway  (IEA)
negative regulation of cell population proliferation  (IMP)
negative regulation of collagen biosynthetic process  (IMP)
positive regulation of cAMP/PKA signal transduction  (IMP)
positive regulation of catecholamine secretion  (IMP)
positive regulation of cell population proliferation  (IMP)
positive regulation of chemokine production  (ISO)
positive regulation of chronic inflammatory response to non-antigenic stimulus  (ISO)
positive regulation of endothelial cell migration  (IMP)
positive regulation of endothelial cell proliferation  (IMP)
positive regulation of guanylate cyclase activity  (ISO)
positive regulation of interleukin-6 production  (IMP,ISO)
positive regulation of mast cell degranulation  (ISO)
positive regulation of norepinephrine secretion  (IMP)
positive regulation of steroid biosynthetic process  (IMP)
positive regulation of vascular endothelial growth factor production  (ISO)
presynaptic modulation of chemical synaptic transmission  (IEA,ISO)
regulation of amine transport  (IEA)
regulation of cell communication  (IEA)
regulation of glucose metabolic process  (IMP)
regulation of secretion by cell  (IEA)
regulation of signaling  (IEA)
relaxation of vascular associated smooth muscle  (ISO)
response to angiotensin  (IMP)
signal transduction  (IEA)
vasodilation  (IBA,IDA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Adenosine-stimulated adrenal steroidogenesis involves the adenosine A2A and A2B receptors and the Janus kinase 2-mitogen-activated protein kinase kinase-extracellular signal-regulated kinase signaling pathway. Chen YC, etal., Int J Biochem Cell Biol. 2008;40(12):2815-25. Epub 2008 Jun 5.
2. An antagonistic interaction between A2B adenosine and D2 dopamine receptors modulates the function of rat carotid body chemoreceptor cells. Conde SV, etal., J Neurochem. 2008 Dec;107(5):1369-81. Epub 2008 Sep 24.
3. A(2B) adenosine receptors stimulate growth of porcine and rat arterial endothelial cells. Dubey RK, etal., Hypertension 2002 Feb;39(2 Pt 2):530-5.
4. Adenosine inhibits collagen and protein synthesis in cardiac fibroblasts: role of A2B receptors. Dubey RK, etal., Hypertension. 1998 Apr;31(4):943-8.
5. A(2b) receptors mediate the antimitogenic effects of adenosine in cardiac fibroblasts. Dubey RK, etal., Hypertension. 2001 Feb;37(2 Part 2):716-21.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. 1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists. Hayallah AM, etal., J Med Chem 2002 Mar 28;45(7):1500-10.
9. Oral methylthioadenosine administration attenuates fibrosis and chronic liver disease progression in Mdr2-/- mice. Latasa MU, etal., PLoS One. 2010 Dec 29;5(12):e15690. doi: 10.1371/journal.pone.0015690.
10. Adenosine A 2B receptors modulate cAMP levels and induce CREB but not ERK1/2 and p38 phosphorylation in rat skeletal muscle cells. Lynge J, etal., Biochem Biophys Res Commun. 2003 Jul 18;307(1):180-7.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension. Nayak S, etal., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Adenosine A2B-receptor-mediated cyclic AMP accumulation in primary rat astrocytes. Peakman MC and Hill SJ, Br J Pharmacol. 1994 Jan;111(1):191-8.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. Coupling to protein kinases A and C of adenosine A2B receptors involved in the facilitation of noradrenaline release in the prostatic portion of rat vas deferens. Queiroz G, etal., Neuropharmacology. 2004 Aug;47(2):216-24.
18. Adenosine-regulated cell proliferation in pituitary folliculostellate and endocrine cells: differential roles for the A(1) and A(2B) adenosine receptors. Rees DA, etal., Endocrinology 2002 Jun;143(6):2427-36.
19. GOA pipeline RGD automated data pipeline
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Role of adenosine A(2B) receptors in vasodilation of rat pial artery and cerebral blood flow autoregulation. Shin HK, etal., Am J Physiol Heart Circ Physiol. 2000 Feb;278(2):H339-44.
22. Molecular cloning and expression of the cDNA for a novel A2-adenosine receptor subtype. Stehle JH, etal., Mol Endocrinol 1992 Mar;6(3):384-93.
23. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
24. Role of renal medullary adenosine in the control of blood flow and sodium excretion. Zou AP, etal., Am J Physiol 1999 Mar;276(3 Pt 2):R790-8.
Additional References at PubMed
PMID:1333049   PMID:8157966   PMID:11454903   PMID:12477932   PMID:12807441   PMID:12817016   PMID:15284071   PMID:16040158   PMID:16103269   PMID:16601261   PMID:16841096   PMID:16980350  
PMID:17363336   PMID:17391106   PMID:17519974   PMID:17920149   PMID:17979185   PMID:17995930   PMID:18060864   PMID:18340377   PMID:18559975   PMID:19536477   PMID:19695259   PMID:20462966  
PMID:20797398   PMID:20805305   PMID:21246204   PMID:21622827   PMID:23069939   PMID:23315335   PMID:23396225   PMID:23584760   PMID:23638125   PMID:23885058   PMID:24327108   PMID:25704806  
PMID:25728851   PMID:27466291   PMID:27757725   PMID:28266889   PMID:29587249   PMID:29626279   PMID:31206753   PMID:32251679   PMID:33771554   PMID:34288817   PMID:35653908   PMID:36330948  
PMID:37402944   PMID:38874549  


Genomics

Comparative Map Data
Adora2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81047,439,712 - 47,456,092 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1047,439,701 - 47,456,091 (+)EnsemblGRCr8
mRatBN7.21046,940,394 - 46,956,772 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1046,940,384 - 46,956,772 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1051,644,175 - 51,660,562 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01051,134,721 - 51,151,112 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01046,638,130 - 46,654,520 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01048,569,563 - 48,586,366 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1048,569,555 - 48,586,365 (+)Ensemblrn6Rnor6.0
Rnor_5.01048,358,068 - 48,374,871 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41048,421,592 - 48,437,967 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1046,186,295 - 46,202,681 (+)NCBICelera
RGSC_v3.11048,435,217 - 48,451,589 (+)NCBI
Cytogenetic Map10q23NCBI
ADORA2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381715,850,362 - 15,975,746 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1715,945,130 - 15,975,746 (+)Ensemblhg38GRCh38
GRCh371715,848,444 - 15,879,060 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361715,788,956 - 15,819,935 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341715,788,955 - 15,819,935NCBI
Celera1715,751,524 - 15,782,216 (+)NCBICelera
Cytogenetic Map17p12NCBI
HuRef1715,715,812 - 15,746,515 (+)NCBIHuRef
CHM1_11715,856,999 - 15,887,687 (+)NCBICHM1_1
T2T-CHM13v2.01715,756,782 - 15,877,924 (+)NCBIT2T-CHM13v2.0
Adora2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391162,139,810 - 62,157,278 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1162,139,810 - 62,157,279 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381162,248,984 - 62,266,452 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1162,248,984 - 62,266,453 (+)Ensemblmm10GRCm38
MGSCv371162,062,486 - 62,079,954 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361162,065,179 - 62,082,647 (+)NCBIMGSCv36mm8
Celera1168,108,085 - 68,109,506 (+)NCBICelera
Cytogenetic Map11B2NCBI
cM Map1137.96NCBI
Adora2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554671,342,271 - 1,363,138 (+)Ensembl
ChiLan1.0NW_0049554671,342,271 - 1,363,149 (+)NCBIChiLan1.0ChiLan1.0
ADORA2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21956,660,548 - 56,691,891 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11761,470,994 - 61,502,786 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01734,849,466 - 34,880,088 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ADORA2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1539,884,375 - 39,908,214 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha540,030,728 - 40,054,092 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0539,987,745 - 40,018,058 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl539,948,932 - 40,018,382 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1539,966,436 - 39,990,226 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0539,911,700 - 39,935,489 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0540,102,972 - 40,126,790 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Adora2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560259,204,009 - 59,233,091 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936821580,675 - 608,245 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936821583,463 - 608,189 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADORA2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1259,431,513 - 59,449,672 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11259,431,834 - 59,449,701 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ADORA2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11615,682,669 - 15,712,079 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1615,683,077 - 15,711,858 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660595,247,130 - 5,277,974 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adora2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248774,422,022 - 4,447,460 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248774,421,307 - 4,447,574 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Adora2b
193 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:74
Count of miRNA genes:59
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000003966
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103589326352293000Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH138913  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21046,952,750 - 46,952,896 (+)MAPPERmRatBN7.2
Rnor_6.01048,582,345 - 48,582,490NCBIRnor6.0
Rnor_5.01048,370,850 - 48,370,995UniSTSRnor5.0
RGSC_v3.41048,433,946 - 48,434,091UniSTSRGSC3.4
Celera1046,198,660 - 46,198,805UniSTS
RH 3.4 Map10545.9UniSTS
Cytogenetic Map10q23UniSTS
RH131534  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21046,956,150 - 46,956,331 (+)MAPPERmRatBN7.2
Rnor_6.01048,585,745 - 48,585,925NCBIRnor6.0
Rnor_5.01048,374,250 - 48,374,430UniSTSRnor5.0
RGSC_v3.41048,437,346 - 48,437,526UniSTSRGSC3.4
Celera1046,202,060 - 46,202,240UniSTS
RH 3.4 Map10545.9UniSTS
Cytogenetic Map10q23UniSTS


Genetic Models
This gene Adora2b is modified in the following models/strains:
SS-Adora2bem1Mcwi     SS-Adora2bem2Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 88 59 6 344 188 11 139 73 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000003966   ⟹   ENSRNOP00000003966
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1047,439,701 - 47,456,091 (+)Ensembl
mRatBN7.2 Ensembl1046,940,384 - 46,956,772 (+)Ensembl
Rnor_6.0 Ensembl1048,569,555 - 48,586,365 (+)Ensembl
RefSeq Acc Id: NM_017161   ⟹   NP_058857
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81047,439,712 - 47,456,092 (+)NCBI
mRatBN7.21046,940,394 - 46,956,772 (+)NCBI
Rnor_6.01048,569,563 - 48,586,366 (+)NCBI
Rnor_5.01048,358,068 - 48,374,871 (+)NCBI
RGSC_v3.41048,421,592 - 48,437,967 (+)RGD
Celera1046,186,295 - 46,202,681 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058857 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA20981 (Get FASTA)   NCBI Sequence Viewer  
  AAC33130 (Get FASTA)   NCBI Sequence Viewer  
  AAI61854 (Get FASTA)   NCBI Sequence Viewer  
  EDM04698 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003966
GenBank Protein P29276 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058857   ⟸   NM_017161
- UniProtKB: P29276 (UniProtKB/Swiss-Prot),   B1WBR3 (UniProtKB/TrEMBL),   A6HF93 (UniProtKB/TrEMBL),   F7EVK1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003966   ⟸   ENSRNOT00000003966
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P29276-F1-model_v2 AlphaFold P29276 1-332 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697269
Promoter ID:EPDNEW_R7794
Type:initiation region
Name:Adora2b_1
Description:adenosine A2B receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01048,569,552 - 48,569,612EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2050 AgrOrtholog
BioCyc Gene G2FUF-24779 BioCyc
Ensembl Genes ENSRNOG00000002922 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000003966 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:9024632 IMAGE-MGC_LOAD
InterPro Adeno_A2B_rcpt UniProtKB/Swiss-Prot
  Adenosn_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:29316 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187380 IMAGE-MGC_LOAD
NCBI Gene 29316 ENTREZGENE
PANTHER ADENOSINE RECEPTOR A2B UniProtKB/Swiss-Prot
  OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB ADORA2B RGD
PhenoGen Adora2b PhenoGen
PRINTS ADENOSINA2BR UniProtKB/Swiss-Prot
  ADENOSINER UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002922 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
TIGR TC233101
UniProt A6HF93 ENTREZGENE, UniProtKB/TrEMBL
  AA2BR_RAT UniProtKB/Swiss-Prot
  B1WBR3 ENTREZGENE
  F7EVK1 ENTREZGENE, UniProtKB/TrEMBL
  P29276 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Adora2b  adenosine A2B receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_drugs inhibited by 1,8-disubstituted xanthine derivatives 631809
gene_expression expressed in pituitary 631808
gene_expression 3,7-dimethyl-1-prparglylxanthine (DMPX) decreases outer and inner medullary blood flows, urine flow and sodium excretion 628573
gene_function mediates adenosine induced endothelial cell growth 631750
gene_function diuretic and natriuretic adenosine receptor 628573
gene_process may regulate angiogenesis and blood vessel remodeling after injury 631750
gene_process may promote adenosine mediated dilation of medullary vessesl and increase in medullary blood flow 628573
gene_process upon activation dilates pre- and postglomerular vessels and inhibits reabsorption of tubular sodium 628573
gene_product member of the G-protein coupled receptor family 631750