Predicted to enable G protein-coupled receptor activity. Involved in several processes, including negative regulation of collagen biosynthetic process; positive regulation of biosynthetic process; and positive regulation of cAMP-mediated signaling. Located in cell surface. Orthologous to human ADORA2B (adenosine A2b receptor); PARTICIPATES IN adenosine signaling pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH (S)-AMPA; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
[isoalloxazine binds to and results in decreased activity of ADORA2B protein] which results in decreased susceptibility to alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid and isoalloxazine inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid results in increased activity of ADORA2B protein]
[Estradiol co-treated with TGFB1 protein] results in decreased expression of ADORA2B mRNA and Estradiol promotes the reaction [ESR2 protein results in decreased expression of ADORA2B mRNA]
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ADORA2B mRNA
[isoalloxazine binds to and results in decreased activity of ADORA2B protein] which results in decreased susceptibility to alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid more ...
BAY 60-6583 promotes the reaction [Ethanol results in increased expression of ADORA2B mRNA] and BAY 60-6583 promotes the reaction [Ethanol results in increased expression of ADORA2B protein]
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ADORA2B mRNA
[[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of ADORA2B mRNA
ADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein] and ADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of HSD11B2 mRNA]
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ADORA2B mRNA
[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADORA2B mRNA
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ADORA2B mRNA
[[Gasoline co-treated with isobutyl alcohol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of ADORA2B mRNA
[Lipopolysaccharides co-treated with Melatonin] results in decreased expression of ADORA2B mRNA and Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of ADORA2B mRNA]
[Lipopolysaccharides co-treated with Melatonin] results in decreased expression of ADORA2B mRNA and Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of ADORA2B mRNA]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [ADORA2B protein inhibits the reaction [Ethanol results in increased phosphorylation of RELA protein]]
[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of ADORA2B mRNA and [Air Pollutants results in increased abundance of Ozone] which results in increased expression of ADORA2B mRNA
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ADORA2B mRNA
Adenosine-stimulated adrenal steroidogenesis involves the adenosine A2A and A2B receptors and the Janus kinase 2-mitogen-activated protein kinase kinase-extracellular signal-regulated kinase signaling pathway.
Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension.
Coupling to protein kinases A and C of adenosine A2B receptors involved in the facilitation of noradrenaline release in the prostatic portion of rat vas deferens.
Adenosine-regulated cell proliferation in pituitary folliculostellate and endocrine cells: differential roles for the A(1) and A(2B) adenosine receptors.