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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2050
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adora2b
Name: adenosine A2B receptor
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adora2bdecreases expressionISOADORA2B (Homo sapiens)6480464CTDLipopolysaccharides results in decreased expression of ADORA2B mRNAPMID:20067761
Adora2bincreases expressionISOAdora2b (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of ADORA2B mRNAPMID:21461237 PMID:25890327
Adora2bmultiple interactionsISOADORA2B (Homo sapiens)6480464CTD[S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of ADORA2B mRNA; [S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in decreased expression of ADORA2B mRNAPMID:35811015
Adora2bmultiple interactionsISOAdora2b (Mus musculus)6480464CTD[Lipopolysaccharides co-treated with Melatonin] results in decreased expression of ADORA2B mRNA; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of ADORA2B mRNA]PMID:21461237
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