Adora2b<sup>em2Mcwi</sup> (adenosine A2B receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin) - Rat Genome Database

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Gene: Adora2bem2Mcwi (adenosine A2B receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin) Rattus norvegicus
Analyze
Symbol: Adora2bem2Mcwi
Name: adenosine A2B receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
RGD ID: 5687698
Description: This allele was made by ZFN mutagenesis. The resulting mutation is a 162-bp deletion in exon 1 (del 96-257)
ASSOCIATED WITH decreased inflammatory response; increased body weight; increased circulating interleukin-6 level
Type: allele  of Adora2b  
Previously known as: Adora2b^[em2Mcwi]; Adora2bem2Mcwi
Is Marker For: Strains:   SS-Adora2bem2Mcwi  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Cytogenetic Map10 RGD


References

References - curated
# Reference Title Reference Citation
1. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
2. Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension. Nayak S, etal., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18.
3. PhysGen Knockouts PhysGen Knockout strains

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Adora2bem2Mcwi-var1 chr10 48358163 48358324 GCTGGCCCGGCCATGCAGCTAGAGACGCAGGACGCGCTGTACGTGGCGCTGGAGCTGGTTATCGCCGCGCTGGCAGTGGCGGGCAACGTGCTGGTGTGCGCTGCGGTGGGAGCCTCGAGTGCTTTACAGACCCCCACCAACTACTTTCTGGTGTCCCTGGCG - deletion Rnor_5.0

Related Rat Strains
The following Strains have been annotated to Adora2bem2Mcwi
SS-Adora2bem2Mcwi    


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles


Additional Information