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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2050
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adora2b
Name: adenosine A2B receptor
Acc ID: CHEBI:27732
Term: caffeine
Definition: A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.
Chemical ID: MESH:D002110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adora2bdecreases expressionEXP 6480464CTDCaffeine results in decreased expression of ADORA2B mRNAPMID:26367767
Adora2bmultiple interactionsISOADORA2B (Homo sapiens)6480464CTDADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein]; ADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of HSD11B2 mRNA]PMID:22701600
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