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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2050
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adora2b
Name: adenosine A2B receptor
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adora2bincreases expressionISOADORA2B (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of ADORA2B mRNAPMID:20064835 PMID:20106945 PMID:21632981 PMID:22316170 PMID:26238291 PMID:32234424
Adora2bincreases expressionISOAdora2b (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of ADORA2B mRNAPMID:23735875
Adora2bincreases methylationISOADORA2B (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of ADORA2B promoterPMID:27901495
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