Hspa1a (heat shock protein family A (Hsp70) member 1A) - Rat Genome Database

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Gene: Hspa1a (heat shock protein family A (Hsp70) member 1A) Rattus norvegicus
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Symbol: Hspa1a (Ensembl: Hspa1b)
Name: heat shock protein family A (Hsp70) member 1A (Ensembl:heat shock protein family A (Hsp70) member 1B)
RGD ID: 1593284
Description: Enables NF-kappaB binding activity and protease binding activity. Involved in several processes, including negative regulation of release of cytochrome c from mitochondria; negative regulation of vasoconstriction; and positive regulation of T cell mediated cytotoxicity. Located in apical plasma membrane; basolateral plasma membrane; and membrane raft. Part of protein-containing complex. Biomarker of graft-versus-host disease. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease of musculoskeletal system (multiple); cystic fibrosis; schizophrenia (multiple); and vascular dementia. Orthologous to human HSPA1A (heat shock protein family A (Hsp70) member 1A); PARTICIPATES IN antigen processing and presentation pathway; endocytosis pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (R)-lipoic acid; 1,3,5-trinitro-1,3,5-triazinane; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: heat shock 70 kDa protein 1; heat shock 70 kDa protein 1A; heat shock 70 kDa protein 1A/1B; heat shock 70 kDa protein 1B; Heat shock 70 kDa protein 2; heat shock 70kD protein 1A; heat shock 70kD protein 1B; heat shock protein 1A; heat shock protein 1B; heat shock protein 70; Heat shock protein 70-2; heat shock protein family A (Hsp70) member 1B; heat shock protein family A member 1A; HSP70; Hsp70-1; Hsp70-2; HSP70.1; HSP70.2; Hsp72; Hspa1; Hspa1b; Hspa2; LOC108348108
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Green Monkey
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SHR-Hspa1em1Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,875,411 - 3,877,866 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl203,855,780 - 3,877,979 (+)EnsemblGRCr8
mRatBN7.2203,870,765 - 3,873,221 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,856,006 - 3,873,227 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx204,554,562 - 4,558,670 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0203,916,620 - 3,920,728 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,454,457 - 4,458,467 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0202,699,707 - 2,701,856 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl202,699,712 - 2,701,815 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl204,877,324 - 4,879,779 (-)Ensemblrn6Rnor6.0
Rnor_5.0206,956,234 - 6,962,151 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4203,945,716 - 3,959,552 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera204,152,570 - 4,158,467 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(R)-lipoic acid  (EXP)
(S)-amphetamine  (ISO)
(Z)-PUGNAc  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dichloroindophenol  (ISO)
2,6-dimethoxyphenol  (ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,4-dihydrocoumarin  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-phenylbutyric acid  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
aminoglutethimide  (ISO)
ammonia  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
amphotericin B  (ISO)
aniline  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antimonite  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Aurin  (ISO)
azadiradione  (ISO)
azetidinecarboxylic acid  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
bromobenzene  (ISO)
C60 fullerene  (EXP)
cadmium acetate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carbonyl sulfide  (EXP)
carboplatin  (EXP)
carrageenan  (EXP)
cefaloridine  (EXP)
celastrol  (EXP,ISO)
cerium trichloride  (ISO)
chelerythrine  (EXP)
chloroform  (EXP)
chlorohydrocarbon  (EXP)
chloromethylisothiazolinone  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (EXP)
D-glucose  (ISO)
D-penicillamine  (ISO)
decabromodiphenyl ether  (EXP)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl disulfide  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
diethyl malate  (ISO)
diethylstilbestrol  (EXP,ISO)
dihydroxyacetone  (ISO)
Dimethyl adipate  (EXP)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dizocilpine maleate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
edaravone  (EXP)
elemental selenium  (ISO)
elesclomol  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
famotidine  (EXP)
fenbuconazole  (ISO)
fenthion  (ISO)
ferric ammonium citrate  (ISO)
ferric oxide  (ISO)
flavone  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
formetanate  (ISO)
furfural  (ISO)
gadolinium trichloride  (EXP)
gamma-hexachlorocyclohexane  (ISO)
gedunin  (ISO)
gefitinib  (ISO)
geldanamycin  (EXP,ISO)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
glucose  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphene oxide  (ISO)
GSK-J4  (ISO)
GYKI 52466  (ISO)
hydrogen chloride  (EXP)
hydrogen peroxide  (ISO)
hypochlorous acid  (ISO)
ibuprofen  (ISO)
imidazopyrazole  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
iron atom  (EXP)
iron dichloride  (ISO)
iron(0)  (EXP)
ivermectin  (EXP)
kainic acid  (ISO)
kojic acid  (EXP)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
LY294002  (ISO)
melatonin  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
methamphetamine  (EXP)
methomyl  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
microcystin-LR  (ISO)
morphine  (EXP)
motexafin gadolinium  (ISO)
Muconic dialdehyde  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naloxone  (EXP)
naphthalene  (ISO)
NCX-4040  (ISO)
nickel atom  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nitrobenzenes  (EXP)
nobiletin  (ISO)
Nonylphenol  (EXP)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
organoselenium compound  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
Pachymic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
phenylarsine oxide  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
pirimicarb  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
polaprezinc  (EXP)
poly(I:C)  (EXP)
potassium dichromate  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
Protolichesterinic acid  (ISO)
pyrene  (ISO)
quartz  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
radicicol  (ISO)
raloxifene  (EXP,ISO)
ranitidine  (EXP)
reactive oxygen species  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
SCH772984  (EXP)
selenium atom  (ISO)
selenomethionine  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
sodium hypochlorite  (ISO)
sotorasib  (ISO)
styrene  (ISO)
sulfasalazine  (ISO)
syringic acid  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
taurodeoxycholic acid  (ISO)
temozolomide  (ISO)
teprenone  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
tetraphene  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trametinib  (ISO)
triazines  (ISO)
tributylstannane  (EXP)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
tungsten  (EXP)
Tungsten carbide  (ISO)
urethane  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vemurafenib  (ISO)
Vicanicin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
wortmannin  (ISO)
zearalenone  (ISO)
zinc acetate  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc molecular entity  (EXP,ISO)
zinc oxide  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ATP metabolic process  (ISO)
cellular heat acclimation  (ISO)
cellular response to heat  (ISO)
cellular response to unfolded protein  (ISO)
chaperone-mediated protein complex assembly  (ISO)
defense response  (IEA)
DNA repair  (ISO)
endoplasmic reticulum unfolded protein response  (ISO)
lysosomal transport  (ISO,ISS)
mRNA catabolic process  (ISO,ISS)
negative regulation of apoptotic process  (IMP,ISO)
negative regulation of cell growth  (ISO,ISS)
negative regulation of cell population proliferation  (ISO,ISS)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
negative regulation of inclusion body assembly  (ISO)
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (ISO)
negative regulation of protein ubiquitination  (ISO)
negative regulation of release of cytochrome c from mitochondria  (IEA)
negative regulation of transcription by RNA polymerase II  (ISO,ISS)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
negative regulation of vasoconstriction  (IEA)
neuron differentiation  (IEP)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of erythrocyte differentiation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of microtubule nucleation  (ISO,ISS)
positive regulation of neuron differentiation  (IMP)
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IBA,ISO)
positive regulation of RNA splicing  (ISO)
positive regulation of T cell mediated cytotoxicity  (IEA)
positive regulation of tumor necrosis factor-mediated signaling pathway  (ISO)
protein folding  (ISO)
protein refolding  (IBA,ISO,ISS)
protein stabilization  (ISO)
regulation of mitotic spindle assembly  (ISO,ISS)
regulation of protein ubiquitination  (ISO)
response to ethanol  (IEP)
response to heat  (ISO)
response to ischemia  (IEP)
response to mechanical stimulus  (IEP)
response to unfolded protein  (IMP,ISO,ISS)
telomere maintenance  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. HSPA1A is upregulated in periodontal ligament at early stage of tooth movement in rats. Arai C, etal., Histochem Cell Biol. 2010 Oct;134(4):337-43. Epub 2010 Sep 1.
2. New targets of urocortin-mediated cardioprotection. Barry SP, etal., J Mol Endocrinol. 2010 Aug;45(2):69-85. doi: 10.1677/JME-09-0148. Epub 2010 May 25.
3. Heat-shock protein gene polymorphisms and the risk of nephropathy in patients with Type 2 diabetes. Buraczynska M, etal., Clin Sci (Lond). 2009 Jan;116(1):81-6. doi: 10.1042/CS20070411.
4. Heat shock protein 70 gene polymorphisms in sudden sensorineural hearing loss. Chien CY, etal., Audiol Neurootol. 2012;17(6):381-5. doi: 10.1159/000341815. Epub 2012 Aug 22.
5. Ancestral haplotype 8.1 and lung disease severity in European cystic fibrosis patients. Corvol H, etal., J Cyst Fibros. 2012 Jan;11(1):63-7. Epub 2011 Oct 10.
6. Hsp70 gene transfer by adeno-associated virus inhibits MPTP-induced nigrostriatal degeneration in the mouse model of Parkinson disease. Dong Z, etal., Mol Ther. 2005 Jan;11(1):80-8.
7. Extracellular heat shock protein 70 (HSPA1A) and classical vascular risk factors in a general population. Dulin E, etal., Cell Stress Chaperones. 2010 Nov;15(6):929-37. Epub 2010 May 20.
8. Genetic variations of HSPA1A, the heat shock protein levels, and risk of atherosclerosis. Dulin E, etal., Cell Stress Chaperones. 2012 Jul;17(4):507-16. doi: 10.1007/s12192-012-0328-4. Epub 2012 Feb 11.
9. Heat shock protein 70 and tumor necrosis factor alpha in Taiwanese patients with dementia. Fung HC, etal., Dement Geriatr Cogn Disord. 2005;20(1):1-7. Epub 2005 Apr 12.
10. Polymorphisms in the Hsp70 gene locus are genetically associated with systemic lupus erythematosus. Furnrohr BG, etal., Ann Rheum Dis. 2010 Nov;69(11):1983-9. Epub 2010 May 24.
11. Heat-shock protein 70-2 (HSP70-2) expression in bladder urothelial carcinoma is associated with tumour progression and promotes migration and invasion. Garg M, etal., Eur J Cancer. 2010 Jan;46(1):207-15. doi: 10.1016/j.ejca.2009.10.020. Epub .
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Gene transfer with HSP 70 in rat chondrocytes confers cytoprotection in vitro and during experimental osteoarthritis. Grossin L, etal., FASEB J. 2006 Jan;20(1):65-75.
14. Functional SNPs in HSPA1A gene predict risk of coronary heart disease. He M, etal., PLoS One. 2009;4(3):e4851. doi: 10.1371/journal.pone.0004851. Epub 2009 Mar 31.
15. Genomic profile of Toll-like receptor pathways in traumatically brain-injured mice: effect of exogenous progesterone. Hua F, etal., J Neuroinflammation. 2011 May 8;8:42.
16. Elevated extracellular HSP70 (HSPA1A) level as an independent prognostic marker of mortality in patients with heart failure. Jenei ZM, etal., Cell Stress Chaperones. 2013 Apr 7.
17. Persistently elevated extracellular HSP70 (HSPA1A) level as an independent prognostic marker in post-cardiac-arrest patients. Jenei ZM, etal., Cell Stress Chaperones. 2013 Jul;18(4):447-54. doi: 10.1007/s12192-012-0399-2. Epub 2013 Jan 16.
18. Polymorphic analysis of the heat-shock protein 70 gene (HSPA1A) in Meniere's disease. Kawaguchi S, etal., Acta Otolaryngol. 2008 Nov;128(11):1173-7. doi: 10.1080/00016480801901675.
19. SAMe treatment prevents the ethanol-induced epigenetic alterations of genes in the Toll-like receptor pathway. Khachatoorian R, etal., Exp Mol Pathol. 2013 Feb;94(1):243-6. doi: 10.1016/j.yexmp.2012.09.024. Epub 2012 Oct 6.
20. Association analysis of heat shock protein 70 gene polymorphisms in schizophrenia. Kim JJ, etal., Eur Arch Psychiatry Clin Neurosci. 2008 Jun;258(4):239-44.
21. Heat shock protein 70 gene polymorphisms are associated with paranoid schizophrenia in the Polish population. Kowalczyk M, etal., Cell Stress Chaperones. 2013 Jul 28.
22. Proteomic characterisation of neuronal sphingolipid-cholesterol microdomains: role in plasminogen activation. Ledesma MD, etal., Brain Res. 2003 Oct 10;987(1):107-16.
23. Molecular changes induced in rat liver by hemorrhage and effects of melanocortin treatment. Lonati C, etal., Anesthesiology. 2012 Mar;116(3):692-700. doi: 10.1097/ALN.0b013e318246ea68.
24. HLA class III genes involvement in Kawasaki disease: a case-control study in Caucasian population. Maggioli E, etal., Int J Immunogenet. 2014 Feb;41(1):44-53. doi: 10.1111/iji.12077. Epub 2013 Jul 22.
25. Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70. Maheswaran S, etal., Genes Dev. 1998 Apr 15;12(8):1108-20.
26. Gene expression changes in the skin of rats induced by prolonged 35 GHz millimeter-wave exposure. Millenbaugh NJ, etal., Radiat Res. 2008 Mar;169(3):288-300. doi: 10.1667/RR1121.1.
27. Mutant HSP70 reverses autoimmune depigmentation in vitiligo. Mosenson JA, etal., Sci Transl Med. 2013 Feb 27;5(174):174ra28. doi: 10.1126/scitranslmed.3005127.
28. Heat shock protein 72, a chaperone abundant in renal papilla, counteracts urea-mediated inhibition of enzymes. Neuhofer W, etal., Pflugers Arch 2002 Oct;445(1):67-73. Epub 2002 Sep 19.
29. Correlation of Hsp70-1 and Hsp70-2 gene expression with the degree of graft-versus-host reaction in a rat skin explant model. Novota P, etal., Transplantation. 2008 Jun 27;85(12):1809-16. doi: 10.1097/TP.0b013e31817753f7.
30. Heat-shock protein-70 genes and response to antidepressants in major depression. Pae CU, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jun 30;31(5):1006-11. Epub 2007 Feb 27.
31. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
32. Neurofilament heavy chain and heat shock protein 70 as markers of seizure-related brain injury. Rejdak K, etal., Epilepsia. 2012 May;53(5):922-7. doi: 10.1111/j.1528-1167.2012.03459.x. Epub 2012 Apr 17.
33. GOA pipeline RGD automated data pipeline
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Comprehensive gene review and curation RGD comprehensive gene curation
36. Phosphatidylcholine-specific phospholipase C/heat shock protein 70 (Hsp70)/transcription factor B-cell translocation gene 2 signaling in rat bone marrow stromal cell differentiation to cholinergic neuron-like cells. Shao J, etal., Int J Biochem Cell Biol. 2012 Dec;44(12):2253-60. doi: 10.1016/j.biocel.2012.09.013. Epub 2012 Sep 20.
37. Identification of a NF-kappaB cardioprotective gene program: NF-kappaB regulation of Hsp70.1 contributes to cardioprotection after permanent coronary occlusion. Wilhide ME, etal., J Mol Cell Cardiol. 2011 Jul;51(1):82-9. doi: 10.1016/j.yjmcc.2011.03.011. Epub 2011 Mar 23.
38. CHIP represses myocardin-induced smooth muscle cell differentiation via ubiquitin-mediated proteasomal degradation. Xie P, etal., Mol Cell Biol. 2009 May;29(9):2398-408. doi: 10.1128/MCB.01737-08. Epub 2009 Feb 23.
39. Association of hsp70 polymorphisms with risk of noise-induced hearing loss in Chinese automobile workers. Yang M, etal., Cell Stress Chaperones. 2006 Autumn;11(3):233-9.
40. Transient elevation of synaptosomal mitoenergetic proteins and Hsp70 early in a rat model of chronic cerebrovascular hypoperfusion. Zhang HN, etal., Neurol Sci. 2013 Apr;34(4):471-7. doi: 10.1007/s10072-012-1063-4. Epub 2012 Apr 18.
41. Variants of HSPA1A in combination with plasma Hsp70 and anti-Hsp70 antibody levels associated with higher risk of acute coronary syndrome. Zhang X, etal., Cardiology. 2011;119(1):57-64. doi: 10.1159/000329917. Epub 2011 Aug 17.
Additional References at PubMed
PMID:7927536   PMID:8086479   PMID:8141767   PMID:8271311   PMID:8862176   PMID:9499401   PMID:10205060   PMID:10679071   PMID:10811660   PMID:10859165   PMID:11785981   PMID:11820796  
PMID:12150907   PMID:12543451   PMID:14701760   PMID:15060004   PMID:15381648   PMID:15543931   PMID:15603737   PMID:15632090   PMID:15885686   PMID:16135962   PMID:16397188   PMID:16609151  
PMID:16809764   PMID:16906134   PMID:17167422   PMID:17182002   PMID:17289661   PMID:18755693   PMID:18850735   PMID:19190083   PMID:19199708   PMID:19472539   PMID:19723345   PMID:20458337  
PMID:20625543   PMID:21231916   PMID:21423176   PMID:21909508   PMID:21975426   PMID:22495301   PMID:22516433   PMID:22658674   PMID:22681889   PMID:23349634   PMID:23533145   PMID:23921388  
PMID:24061851   PMID:24395641   PMID:24613385   PMID:24625528   PMID:24790089   PMID:25281747   PMID:25446099   PMID:25468996   PMID:26126513   PMID:27137183   PMID:27496612   PMID:27708256  
PMID:27789271  


Genomics

Comparative Map Data
Hspa1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,875,411 - 3,877,866 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl203,855,780 - 3,877,979 (+)EnsemblGRCr8
mRatBN7.2203,870,765 - 3,873,221 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,856,006 - 3,873,227 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx204,554,562 - 4,558,670 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0203,916,620 - 3,920,728 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,454,457 - 4,458,467 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0202,699,707 - 2,701,856 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl202,699,712 - 2,701,815 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl204,877,324 - 4,879,779 (-)Ensemblrn6Rnor6.0
Rnor_5.0206,956,234 - 6,962,151 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4203,945,716 - 3,959,552 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera204,152,570 - 4,158,467 (-)NCBICelera
Cytogenetic Map20p12NCBI
HSPA1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,815,543 - 31,817,942 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl631,815,543 - 31,817,994 (+)Ensemblhg38GRCh38
GRCh37631,783,320 - 31,785,719 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,891,316 - 31,893,698 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34631,891,315 - 31,893,698NCBI
Celera633,381,540 - 33,383,968 (+)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef631,569,698 - 31,572,209 (+)NCBIHuRef
CHM1_1631,785,425 - 31,787,853 (+)NCBICHM1_1
T2T-CHM13v2.0631,668,600 - 31,670,999 (+)NCBIT2T-CHM13v2.0
Hspa1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,188,335 - 35,191,132 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1735,188,166 - 35,191,132 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381734,969,359 - 34,972,156 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,969,190 - 34,972,156 (-)Ensemblmm10GRCm38
MGSCv371735,106,304 - 35,109,101 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361734,577,246 - 34,580,180 (-)NCBIMGSCv36mm8
Celera1738,065,583 - 38,068,380 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.51NCBI
HSPA1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2546,292,775 - 46,294,988 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1642,254,270 - 42,256,491 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0631,476,710 - 31,491,411 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1632,363,499 - 32,366,005 (+)NCBIPanPan1.1PanPan1.1panPan2
LOC101956126
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494635,825,952 - 35,828,975 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367271,733,018 - 1,734,943 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367271,732,323 - 1,735,128 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPA1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11740,203,647 - 40,206,028 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1740,203,936 - 40,205,858 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236679469,302 - 10,259 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Hspa1a
47 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015332005306452Rat
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2016693431Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362632310078622Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)2016693431Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036263239244918Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat

Markers in Region
PMC117401P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map20p12UniSTS
RH128946  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2203,872,885 - 3,873,070 (-)MAPPERmRatBN7.2
Rnor_6.0204,877,475 - 4,877,659NCBIRnor6.0
Rnor_5.0206,957,875 - 6,958,059UniSTSRnor5.0
RGSC_v3.4203,957,727 - 3,957,911UniSTSRGSC3.4
Celera204,154,211 - 4,154,395UniSTS
RH 3.4 Map2051.62UniSTS
Cytogenetic Map20p12UniSTS
RH131596  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2203,858,636 - 3,858,854 (-)MAPPERmRatBN7.2
Rnor_6.0204,955,962 - 4,956,179NCBIRnor6.0
Rnor_5.0207,029,332 - 7,029,549UniSTSRnor5.0
Celera204,167,999 - 4,168,216UniSTS
RH 3.4 Map2052.42UniSTS
Cytogenetic Map20p12UniSTS
RH94530  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2203,872,918 - 3,873,105 (-)MAPPERmRatBN7.2
Rnor_6.0204,877,440 - 4,877,626NCBIRnor6.0
Rnor_5.0206,957,840 - 6,958,026UniSTSRnor5.0
RGSC_v3.4203,957,760 - 3,957,946UniSTSRGSC3.4
Celera204,154,176 - 4,154,362UniSTS
RH 3.4 Map2052.22UniSTS
Cytogenetic Map20p12UniSTS
PMC314357P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2203,871,310 - 3,871,800 (-)MAPPERmRatBN7.2
mRatBN7.2203,856,718 - 3,857,207 (-)MAPPERmRatBN7.2
Rnor_6.0204,878,745 - 4,879,233NCBIRnor6.0
Rnor_6.0202,700,781 - 2,701,269NCBIRnor6.0
Rnor_5.0204,803,650 - 4,804,138UniSTSRnor5.0
Rnor_5.0206,959,145 - 6,959,633UniSTSRnor5.0
RGSC_v3.4203,956,153 - 3,956,641UniSTSRGSC3.4
Celera204,155,481 - 4,155,969UniSTS
Celera204,169,646 - 4,170,134UniSTS
Cytogenetic Map20p12UniSTS
D20Wox12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2203,868,846 - 3,869,052 (-)MAPPERmRatBN7.2
Rnor_6.0204,881,491 - 4,881,694NCBIRnor6.0
Rnor_5.0206,961,891 - 6,962,094UniSTSRnor5.0
Cytogenetic Map20p12UniSTS


Related Rat Strains
The following Strains have been annotated to Hspa1a
SHR-Hspa1em1Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 12 61 132 54 57 38 79 38 288 161 11 123 71 73 19 17 17

Sequence


RefSeq Acc Id: NM_001329896   ⟹   NP_001316825
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,875,411 - 3,877,866 (+)NCBI
mRatBN7.2203,870,765 - 3,873,221 (+)NCBI
RefSeq Acc Id: NP_001316825   ⟸   NM_001329896
- UniProtKB: Q63256 (UniProtKB/Swiss-Prot),   Q07439 (UniProtKB/Swiss-Prot),   P42853 (UniProtKB/Swiss-Prot),   P0DMW1 (UniProtKB/Swiss-Prot),   P0DMW0 (UniProtKB/Swiss-Prot),   A0A8L2RAM6 (UniProtKB/TrEMBL),   A6KTP2 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0DMW0-F1-model_v2 AlphaFold P0DMW0 1-641 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701281
Promoter ID:EPDNEW_R11804
Type:single initiation site
Name:Hspa1a_1
Description:heat shock protein family A member 1A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0202,701,861 - 2,701,921EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593284 AgrOrtholog
Ensembl Genes ENSRNOG00000045654 Ensembl
  ENSRNOG00000050647 Ensembl
Gene3D-CATH 1.20.1270.10 UniProtKB/Swiss-Prot
  3.30.30.30 UniProtKB/Swiss-Prot
  3.30.420.40 UniProtKB/Swiss-Prot
  Actin, Chain A, domain 4 UniProtKB/Swiss-Prot
  Substrate Binding Domain Of DNAk, Chain A, domain 1 UniProtKB/Swiss-Prot
InterPro ATPase_NBD UniProtKB/Swiss-Prot
  Heat_shock_70_CS UniProtKB/Swiss-Prot
  HSP70_C_sf UniProtKB/Swiss-Prot
  HSP70_peptide-bd_sf UniProtKB/Swiss-Prot
  Hsp_70_fam UniProtKB/Swiss-Prot
KEGG Report rno:108348108 UniProtKB/Swiss-Prot
  rno:24472 UniProtKB/Swiss-Prot
NCBI Gene Hspa1b ENTREZGENE
PANTHER PTHR19375 UniProtKB/Swiss-Prot
Pfam HSP70 UniProtKB/Swiss-Prot
PhenoGen Hspa1a PhenoGen
PRINTS HEATSHOCK70 UniProtKB/Swiss-Prot
PROSITE HSP70_1 UniProtKB/Swiss-Prot
  HSP70_2 UniProtKB/Swiss-Prot
  HSP70_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000045654 RatGTEx
  ENSRNOG00000050647 RatGTEx
Superfamily-SCOP SSF100920 UniProtKB/Swiss-Prot
  SSF100934 UniProtKB/Swiss-Prot
  SSF53067 UniProtKB/Swiss-Prot
UniProt A0A8L2RAM6 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L6F2_RAT UniProtKB/TrEMBL
  A6KTP2 ENTREZGENE, UniProtKB/TrEMBL
  HS71A_RAT UniProtKB/Swiss-Prot
  HS71B_RAT UniProtKB/Swiss-Prot
  P0DMW0 ENTREZGENE
  P0DMW1 ENTREZGENE
  P42853 ENTREZGENE
  Q07439 ENTREZGENE
  Q63256 ENTREZGENE
UniProt Secondary P42853 UniProtKB/Swiss-Prot
  Q07439 UniProtKB/Swiss-Prot
  Q63256 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-10-24 Hspa1a  heat shock protein family A (Hsp70) member 1A  Hspa  heat shock protein family A (Hsp70) member  Name and Symbol changed 629549 APPROVED
2023-10-24 Hspa  heat shock protein family A (Hsp70) member  Hspa1b  heat shock protein family A (Hsp70) member 1B  Name and Symbol changed 629549 APPROVED
2022-10-14 Hspa1b  heat shock protein family A (Hsp70) member 1B  Hspa1a  heat shock protein family A member 1A  Symbol and Name updated 625702 APPROVED
2022-10-14 Hspa1a  heat shock protein family A (Hsp70) member 1A  LOC108348108  heat shock 70 kDa protein 1A  Data merged from RGD:11425585 737654 PROVISIONAL
2016-10-12 Hspa1a  heat shock protein family A (Hsp70) member 1A  Hspa1a  heat shock protein family A member 1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-09-09 Hspa1a  heat shock protein family A member 1A  Hspa1a  heat shock protein 1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-08-02 LOC108348108  heat shock 70 kDa protein 1A      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-12 Hspa1a  heat shock 70kD protein 1A  Hspa1  heat shock 70kD protein 1  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2008-03-12 Hspa1a  heat shock protein 1A  Hspa1a  heat shock 70kD protein 1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13   heat shock 70kD protein 1B  Hspa1b  heat shock 70kD protein 1B (mapped)  Name updated 737654 APPROVED
2007-04-11 Hspa1b  heat shock 70kD protein 1B (mapped)  Hspa1b_mapped  heat shock 70kD protein 1B (mapped)  Data merged from RGD:2841 737654 APPROVED
2006-11-20 Hspa1b  heat shock 70kD protein 1B (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Hspa1b_mapped  heat shock 70kD protein 1B (mapped)      Symbol and Name updated 1556543 APPROVED
2002-11-06 Hspa1b  heat shock 70kD protein 1B    Heat shock protein 70-2  Name updated 625702 APPROVED
2002-06-10 Hspa1b  Heat shock protein 70-2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process involved in counteracting urea-mediated effects on protein function in the renal papilla 1300068