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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1593284
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspa1a
Name: heat shock protein family A (Hsp70) member 1A
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa1aincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of HSPA1A mRNAPMID:33387578
Hspa1aaffects expressionISOHspa1a (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of HSPA1A mRNAPMID:21570461
Hspa1aincreases expressionISOHSPA1A (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of HSPA1A mRNAPMID:20106945
Hspa1aincreases expressionISOHspa1a (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of HSPA1A mRNAPMID:17035482
Hspa1amultiple interactionsISOHSPA1A (Homo sapiens)6480464CTD[Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] results in decreased expression of HSPA1A mRNAPMID:29704546
Hspa1amultiple interactionsISOHspa1a (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HSPA1A mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HSPA1A promoter]PMID:17942748 PMID:19654925
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