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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1593284
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspa1a
Name: heat shock protein family A (Hsp70) member 1A
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa1aaffects expressionISOHSPA1A (Homo sapiens)6480464CTDArsenic Trioxide affects the expression of HSPA1A mRNAPMID:12749819
Hspa1aaffects response to substanceISOHSPA1A (Homo sapiens)6480464CTDHSPA1A protein affects the susceptibility to Arsenic TrioxidePMID:19371599
Hspa1aincreases expressionISOHSPA1A (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of HSPA1A mRNA; Arsenic Trioxide results in increased expression of HSPA1A proteinPMID:14610070 PMID:18081892 PMID:19364129 PMID:19417148 PMID:20458559 PMID:20724260 PMID:22496356
Hspa1amultiple interactionsISOHSPA1A (Homo sapiens)6480464CTD2-(morpholin-4-yl)benzo(h)chromen-4-one inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA1A protein]; HSF1 protein affects the reaction [Arsenic Trioxide results in increased expression of HSPA1A protein]; HSPA1A protein promotes the reaction [Arsenic Trioxide results in increased phosphorylation of HSF1 protein]; KNK 437 inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA1A protein]; PI103 inhibits the reaction [Arsenic Trioxide results in increased expression of HSPA1A mRNA]PMID:20724260 PMID:22496356
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