Rassf1 (Ras association domain family member 1) - Rat Genome Database

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Gene: Rassf1 (Ras association domain family member 1) Rattus norvegicus
Analyze
Symbol: Rassf1
Name: Ras association domain family member 1
RGD ID: 1359383
Description: Predicted to enable identical protein binding activity and small GTPase binding activity. Predicted to be involved in several processes, including Ras protein signal transduction; positive regulation of protein ubiquitination; and protein stabilization. Predicted to act upstream of with a negative effect on regulation of cell cycle G1/S phase transition. Predicted to be located in cytoplasm and microtubule cytoskeleton. Predicted to be active in microtubule cytoskeleton and nucleus. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human RASSF1 (Ras association domain family member 1); PARTICIPATES IN p53 signaling pathway; non-small cell lung carcinoma pathway; urinary bladder cancer pathway; INTERACTS WITH (S)-colchicine; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC94319; Ras association (RalGDS/AF-6) domain family 1; Ras association (RalGDS/AF-6) domain family member 1; Ras association domain family 1; ras association domain-containing protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,103,665 - 117,114,805 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8117,103,362 - 117,114,805 (+)EnsemblGRCr8
mRatBN7.28108,225,023 - 108,236,164 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,225,023 - 108,236,164 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8113,852,061 - 113,863,191 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,051,217 - 112,062,347 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08109,893,998 - 109,905,128 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,307,149 - 116,318,289 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,307,141 - 116,318,289 (+)Ensemblrn6Rnor6.0
Rnor_5.08115,663,409 - 115,674,549 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48112,798,863 - 112,810,004 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8107,531,445 - 107,542,731 (+)NCBICelera
RGSC_v3.18112,822,246 - 112,829,459 (+)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-colchicine  (EXP)
1,2-dimethylhydrazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-methylcholine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
ABT-737  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzophenanthridine  (ISO)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
brequinar  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
citalopram  (EXP)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
furan  (EXP,ISO)
gentamycin  (EXP)
glycidol  (EXP)
GSK-J4  (ISO)
hydrogen chloride  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
isoprenaline  (EXP)
menadione  (ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel subsulfide  (EXP)
okadaic acid  (ISO)
orphenadrine  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP,ISO)
picoxystrobin  (ISO)
potassium chloride  (ISO)
procainamide  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
succimer  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (EXP)
vincristine  (EXP)
vinyl carbamate  (ISO)
vitamin E  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (IEA)
cytoskeleton  (IEA)
microtubule  (IEA)
microtubule cytoskeleton  (IBA,IEA,ISO)
nucleus  (IBA,IEA,ISO)
spindle pole  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The degradation of cell cycle regulators by SKP2/CKS1 ubiquitin ligase is genetically controlled in rodent liver cancer and contributes to determine the susceptibility to the disease. Calvisi DF, etal., Int J Cancer. 2009 Jun 16.
2. Quantitative promoter methylation analysis of multiple cancer-related genes in renal cell tumors. Costa VL, etal., BMC Cancer. 2007 Jul 23;7:133.
3. DNA methylation in benign breast epithelium in relation to age and breast cancer risk. Euhus DM, etal., Cancer Epidemiol Biomarkers Prev. 2008 May;17(5):1051-9.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. The role of RASSF1A methylation in cancer. Hesson LB, etal., Dis Markers. 2007;23(1-2):73-87.
6. Relationship between the expression of RASSF1A protein and promoter hypermethylation of RASSF1A gene in bladder tumor. Hu J, etal., J Huazhong Univ Sci Technolog Med Sci. 2008 Apr;28(2):182-4. Epub 2008 May 15.
7. Expression and promoter methylation of the RASSF1A gene in sporadic breast cancers in Chinese women. Li Y, etal., Oncol Rep. 2008 May;19(5):1149-53.
8. [Detection of circulating hypermethylated tumor-specific RASSF1A DNA in ovarian cancer patients] Ma L, etal., Zhonghua Bing Li Xue Za Zhi. 2005 Dec;34(12):785-7.
9. DNA methylation patterns in bladder cancer and washing cell sediments: a perspective for tumor recurrence detection. Negraes PD, etal., BMC Cancer. 2008 Aug 14;8(1):238.
10. Effect of aberrant promoter methylation of FHIT and RASSF1A genes on susceptibility to cervical cancer in a North Indian population. Neyaz MK, etal., Biomarkers. 2008 Apr 23:1-10.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. Promoter hypermethylation and reduced expression of RASSF1A are frequent molecular alterations of endometrial carcinoma. Pallares J, etal., Mod Pathol. 2008 Jun;21(6):691-9. Epub 2008 May 9.
13. Methylation of the RASSF1A gene in human cancers. Pfeifer GP, etal., Biol Chem. 2002 Jun;383(6):907-14.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Comprehensive gene review and curation RGD comprehensive gene curation
20. Promoter hypermethylation in circulating blood cells identifies prostate cancer progression. Roupret M, etal., Int J Cancer. 2008 Feb 15;122(4):952-6.
21. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:11857081   PMID:12024041   PMID:14743218   PMID:15109305   PMID:18566590   PMID:20008439   PMID:20920251   PMID:21134643   PMID:21565688   PMID:21938476   PMID:24945829   PMID:26401643  
PMID:31595551  


Genomics

Comparative Map Data
Rassf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,103,665 - 117,114,805 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8117,103,362 - 117,114,805 (+)EnsemblGRCr8
mRatBN7.28108,225,023 - 108,236,164 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,225,023 - 108,236,164 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8113,852,061 - 113,863,191 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,051,217 - 112,062,347 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08109,893,998 - 109,905,128 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,307,149 - 116,318,289 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,307,141 - 116,318,289 (+)Ensemblrn6Rnor6.0
Rnor_5.08115,663,409 - 115,674,549 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48112,798,863 - 112,810,004 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8107,531,445 - 107,542,731 (+)NCBICelera
RGSC_v3.18112,822,246 - 112,829,459 (+)NCBI
Cytogenetic Map8q32NCBI
RASSF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38350,329,788 - 50,340,836 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl350,329,782 - 50,340,980 (-)Ensemblhg38GRCh38
GRCh37350,367,219 - 50,378,267 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36350,342,221 - 50,353,371 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34350,342,220 - 50,353,371NCBI
Celera350,340,051 - 50,351,201 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef350,422,848 - 50,433,998 (-)NCBIHuRef
CHM1_1350,319,475 - 50,330,627 (-)NCBICHM1_1
T2T-CHM13v2.0350,359,511 - 50,370,560 (-)NCBIT2T-CHM13v2.0
Rassf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,428,752 - 107,439,460 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9107,428,754 - 107,439,466 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm389107,551,434 - 107,562,267 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,551,555 - 107,562,267 (+)Ensemblmm10GRCm38
MGSCv379107,456,987 - 107,464,591 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369107,412,757 - 107,420,361 (+)NCBIMGSCv36mm8
Celera9107,163,421 - 107,171,009 (+)NCBICelera
Cytogenetic Map9F1NCBI
cM Map958.12NCBI
Rassf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555322,132,822 - 2,142,106 (-)Ensembl
ChiLan1.0NW_0049555322,132,892 - 2,142,106 (-)NCBIChiLan1.0ChiLan1.0
RASSF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2250,310,363 - 50,321,411 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1350,315,138 - 50,326,157 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0350,255,897 - 50,267,042 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1351,491,548 - 51,502,386 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl351,491,548 - 51,502,392 (-)EnsemblpanPan2panpan1.1
RASSF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,014,639 - 39,023,393 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,014,666 - 39,022,585 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2038,935,865 - 38,944,610 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02039,370,859 - 39,379,601 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2039,370,874 - 39,379,600 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12038,738,691 - 38,747,434 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02039,142,254 - 39,150,992 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02039,422,263 - 39,431,009 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rassf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560265,096,680 - 65,105,871 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365291,857,145 - 1,867,260 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365291,857,177 - 1,866,198 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RASSF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1332,816,156 - 32,825,226 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11332,816,156 - 32,825,486 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,994,689 - 36,003,831 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RASSF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12211,716,969 - 11,728,646 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2211,716,918 - 11,725,027 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041155,258,161 - 155,269,986 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rassf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247304,181,462 - 4,190,431 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247304,181,207 - 4,190,603 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Rassf1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1898,867,653 - 98,878,939 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rassf1
229 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:533
Count of miRNA genes:249
Interacting mature miRNAs:306
Transcripts:ENSRNOT00000037363, ENSRNOT00000037375
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
631217Activ1Activity QTL 115.9voluntary movement trait (VT:0003491)number of photobeam interruptions in an experimental apparatus (CMO:0001517)8111249511117802327Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat

Markers in Region
RH136990  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28108,224,544 - 108,224,724 (+)MAPPERmRatBN7.2
Rnor_6.08116,306,671 - 116,306,850NCBIRnor6.0
Rnor_5.08115,662,931 - 115,663,110UniSTSRnor5.0
RGSC_v3.48112,798,385 - 112,798,564UniSTSRGSC3.4
Celera8107,530,967 - 107,531,146UniSTS
Cytogenetic Map8q32UniSTS
RH141417  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28108,229,210 - 108,229,412 (+)MAPPERmRatBN7.2
Rnor_6.08116,311,336 - 116,311,537NCBIRnor6.0
Rnor_5.08115,667,596 - 115,667,797UniSTSRnor5.0
RGSC_v3.48112,803,051 - 112,803,252UniSTSRGSC3.4
Celera8107,535,778 - 107,535,979UniSTS
RH 3.4 Map81118.9UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000037363   ⟹   ENSRNOP00000034233
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8117,107,333 - 117,114,805 (+)Ensembl
mRatBN7.2 Ensembl8108,228,844 - 108,236,164 (+)Ensembl
Rnor_6.0 Ensembl8116,311,078 - 116,318,289 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000037375   ⟹   ENSRNOP00000030024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8117,103,362 - 117,114,805 (+)Ensembl
mRatBN7.2 Ensembl8108,225,023 - 108,235,545 (+)Ensembl
Rnor_6.0 Ensembl8116,307,141 - 116,318,289 (+)Ensembl
RefSeq Acc Id: NM_001007754   ⟹   NP_001007755
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,107,594 - 117,114,805 (+)NCBI
mRatBN7.28108,228,953 - 108,236,164 (+)NCBI
Rnor_6.08116,311,078 - 116,318,289 (+)NCBI
Rnor_5.08115,663,409 - 115,674,549 (+)NCBI
RGSC_v3.48112,798,863 - 112,810,004 (+)RGD
Celera8107,535,374 - 107,542,731 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001037555   ⟹   NP_001032644
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,103,665 - 117,114,186 (+)NCBI
mRatBN7.28108,225,023 - 108,235,545 (+)NCBI
Rnor_6.08116,307,149 - 116,317,670 (+)NCBI
Rnor_5.08115,663,409 - 115,674,549 (+)NCBI
RGSC_v3.48112,798,863 - 112,810,004 (+)RGD
Celera8107,531,445 - 107,542,112 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039081797   ⟹   XP_038937725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,107,464 - 117,114,805 (+)NCBI
mRatBN7.28108,229,065 - 108,236,164 (+)NCBI
RefSeq Acc Id: NP_001032644   ⟸   NM_001037555
- Peptide Label: isoform 1
- UniProtKB: Q5FAQ9 (UniProtKB/TrEMBL),   F1M9A9 (UniProtKB/TrEMBL),   A0A9K3Y7P1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001007755   ⟸   NM_001007754
- Peptide Label: isoform 2
- UniProtKB: Q68FW0 (UniProtKB/TrEMBL),   A6I2X9 (UniProtKB/TrEMBL),   F7F8L4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000030024   ⟸   ENSRNOT00000037375
Ensembl Acc Id: ENSRNOP00000034233   ⟸   ENSRNOT00000037363
RefSeq Acc Id: XP_038937725   ⟸   XM_039081797
- Peptide Label: isoform X1
Protein Domains
Phorbol-ester/DAG-type   Ras-associating   SARAH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5FAQ9-F1-model_v2 AlphaFold Q5FAQ9 1-340 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696270
Promoter ID:EPDNEW_R6794
Type:initiation region
Name:Rassf1_2
Description:Ras association domain family member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6795  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08116,307,124 - 116,307,184EPDNEW
RGD ID:13696272
Promoter ID:EPDNEW_R6795
Type:initiation region
Name:Rassf1_1
Description:Ras association domain family member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6794  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08116,310,981 - 116,311,041EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359383 AgrOrtholog
BioCyc Gene G2FUF-29198 BioCyc
Ensembl Genes ENSRNOG00000021548 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000037363 ENTREZGENE
  ENSRNOT00000037363.6 UniProtKB/TrEMBL
  ENSRNOT00000037375 ENTREZGENE
  ENSRNOT00000037375.8 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.110 UniProtKB/TrEMBL
  3.30.60.20 UniProtKB/TrEMBL
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7132629 IMAGE-MGC_LOAD
InterPro C-RASSF UniProtKB/TrEMBL
  C1-like_sf UniProtKB/TrEMBL
  Prot_Kinase_C-like_PE/DAG-bd UniProtKB/TrEMBL
  Ras-assoc UniProtKB/TrEMBL
  RASSF1 UniProtKB/TrEMBL
  SARAH UniProtKB/TrEMBL
  Ubiquitin-rel_dom UniProtKB/TrEMBL
KEGG Report rno:363140 UniProtKB/TrEMBL
MGC_CLONE MGC:94319 IMAGE-MGC_LOAD
NCBI Gene 363140 ENTREZGENE
PANTHER PTHR22738 UniProtKB/TrEMBL
  PTHR22738:SF12 UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/TrEMBL
  Nore1-SARAH UniProtKB/TrEMBL
  PF00788 UniProtKB/TrEMBL
PhenoGen Rassf1 PhenoGen
PROSITE PS50200 UniProtKB/TrEMBL
  SARAH UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021548 RatGTEx
SMART SM00109 UniProtKB/TrEMBL
  SM00314 UniProtKB/TrEMBL
Superfamily-SCOP SSF54236 UniProtKB/TrEMBL
  SSF57889 UniProtKB/TrEMBL
UniProt A0A9K3Y7P1 ENTREZGENE, UniProtKB/TrEMBL
  A6I2X9 ENTREZGENE, UniProtKB/TrEMBL
  F1M9A9 ENTREZGENE
  F7F8L4 ENTREZGENE, UniProtKB/TrEMBL
  Q33DQ9_RAT UniProtKB/TrEMBL
  Q5FAQ9 ENTREZGENE, UniProtKB/TrEMBL
  Q68FW0 ENTREZGENE
UniProt Secondary F1M9A9 UniProtKB/TrEMBL
  Q68FW0 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Rassf1  Ras association domain family member 1  Rassf1  Ras association (RalGDS/AF-6) domain family member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-25 Rassf1  Ras association (RalGDS/AF-6) domain family member 1  Rassf1  Ras association (RalGDS/AF-6) domain family 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Rassf1  Ras association (RalGDS/AF-6) domain family 1      Name updated 1299863 APPROVED
2005-07-29 Rassf1  Ras association domain family 1      Symbol and Name status set to provisional 70820 PROVISIONAL