Gene:	Sos1 ( Rattus norvegicus ) Son of sevenless homolog 1 (Drosophila)
Description:	mouse homolog catalyzes the exchange of GDP for GTP on ras proteins; positively regulates the link between tyrosine kinase and ras proteins
Synonyms:	Sos1_predicted; Son of sevenless homolog 1 (Drosophila) (predicted); LOC313845;  (details...)
ArrayIDs:	rc_AI176851_at; 1385959_at; 1389710_at; rc_AA892860_at; rc_AA892860_g_at;  (details...)
Gene Type:	protein-coding
Strain:	NP.P-(D4Rat119-D4Rat55)/Iusm
Additional Data
Candidate gene for:	Alc22 - Alcohol consumption QTL 22
Homologs
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Sos1 Rat Celera Assembly 6 14209481 - 14286507     RGSC genome assembly v3.4 6 3309742 - 3391862     Cytogenetic 6 q11     genome assembly 3.1 6 3310822 - 3394313   View comparative maps:      NCBI MapViewer
Genome
View:
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Annotation
Molecular Function	Gene Ontology protein binding,  SH3 domain binding,  Rho guanyl-nucleotide exchange factor activity ...  (details...)
Biological Process	Gene Ontology regulation of small GTPase mediated signal transduction,  nerve growth factor receptor signaling pathway,  Ras protein signal transduction ...  (details...)
Cellular Component	Gene Ontology intracellular,  cell soma,  postsynaptic density ...  (details...)
Disease	Ontology Fibromatosis, Gingival (details...)
Pathway	Ontology epidermal growth factor/neuregulin signaling pathway,  Ras family mediated signaling pathway,  nerve growth factor signaling pathway ...  (details...)
External Links
Databases	DATABASE ID SOURCE SMART: RasGEF IPI SMART: RasGEFN IPI SMART: PH IPI SMART: RhoGEF IPI PROSITE: DH_2 IPI PROSITE: RASGEF_CAT IPI PROSITE: RASGEF_NTER IPI PROSITE: PH_DOMAIN IPI PROSITE: RASGEF IPI UNIPARC: UPI0000DBFA21 IPI UNIPARC: UPI000157E354 IPI UNIPARC: UPI0001B7ADE0 IPI KEGG Report: rno:313845 ENTREZGENE HomoloGene Group ID: 4117 ENTREZGENE Germonline: 1310949 Pfam: PH IPI Pfam: RasGEF IPI Pfam: Histone IPI Pfam: RhoGEF IPI Pfam: RasGEF_N IPI KEGG Pathway: 05223 ENTREZGENE KEGG Pathway: 04722 ENTREZGENE KEGG Pathway: 04650 ENTREZGENE KEGG Pathway: 04010 ENTREZGENE KEGG Pathway: 04630 ENTREZGENE KEGG Pathway: 04910 ENTREZGENE KEGG Pathway: 04912 ENTREZGENE KEGG Pathway: 05214 ENTREZGENE KEGG Pathway: 04660 ENTREZGENE KEGG Pathway: 05211 ENTREZGENE KEGG Pathway: 04810 ENTREZGENE KEGG Pathway: 05215 ENTREZGENE KEGG Pathway: 05200 ENTREZGENE KEGG Pathway: 04540 ENTREZGENE KEGG Pathway: 04510 ENTREZGENE KEGG Pathway: 04664 ENTREZGENE KEGG Pathway: 04012 ENTREZGENE KEGG Pathway: 05213 ENTREZGENE KEGG Pathway: 04320 ENTREZGENE KEGG Pathway: 05210 ENTREZGENE KEGG Pathway: 05220 ENTREZGENE KEGG Pathway: 04062 ENTREZGENE KEGG Pathway: 04662 ENTREZGENE KEGG Pathway: 05221 ENTREZGENE InterPro: Pleckstrin_homology. IPI InterPro: DH-domain. IPI InterPro: Histone_core_D. IPI InterPro: Histone-fold. IPI InterPro: Ras_G-nucl-exch_fac_CS. IPI InterPro: PH_type. IPI InterPro: Ras-like_Gua-exchang_fac_N. IPI InterPro: Ras_GEF. IPI InterPro: RasGRF_CDC25. IPI InterPro: Sos. IPI Ensembl Protein: ENSRNOP00000058691 IPI Ensembl Protein: ENSRNOP00000009359 IPI Ensembl Protein: ENSRNOP00000061334 IPI IPI: IPI00360064 IPI IPI: IPI00767217 IPI IPI: IPI00951639 IPI Gene3D-CATH: RhoGEF IPI Gene3D-CATH: Histone-fold IPI Gene3D-CATH: RasGRF_CDC25 IPI Gene3D-CATH: PH_type IPI Entrez Gene: Sos1 ENTREZGENE IMAGE_CLONE: IMAGE:7930046 IMAGE-MGC_LOAD MGC_CLONE: MGC:124890 IMAGE-MGC_LOAD UniProt: Q497A5_RAT IPI Ensembl Genes: ENSRNOG00000007106 IPI Superfamily-SCOP: Histone-fold IPI Superfamily-SCOP: DH-domain IPI Superfamily-SCOP: Ras_GEF IPI PANTHER: Ras_GEF IPI PANTHER: Sos IPI
Sequences	Nucleotide: NM_001100716 Get FASTA Search GEO Profiles Nucleotide: AAHX01041860 Get FASTA Search GEO Profiles Nucleotide: AAHX01041859 Get FASTA Search GEO Profiles Nucleotide: AAHX01041858 Get FASTA Search GEO Profiles Nucleotide: AAHX01041857 Get FASTA Search GEO Profiles Nucleotide: AAHX01041861 Get FASTA Search GEO Profiles Nucleotide: AAHX01041862 Get FASTA Search GEO Profiles Nucleotide: CH473947 Get FASTA Search GEO Profiles Nucleotide: XM_001062567 Get FASTA Search GEO Profiles Nucleotide: BC100642 Get FASTA Search GEO Profiles Nucleotide: XM_233820 Get FASTA Search GEO Profiles (View all 11 Nucleotide Accessions) Protein: XP_233820 Get FASTA Protein: XP_001062567 Get FASTA Protein: NP_001094186 Get FASTA Protein: EDM02758 Get FASTA Protein: AAI00643 Get FASTA Protein: Q497A5 Get FASTA (View all 6 Protein Accessions)
Clusters	UniGene: 91844
References
Curated References	10 references in RGD related to Sos1
Other References	7 other references at PubMed related to Sos1
Database Information
RGD ID	1310949
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 06-DEC-05: Sos1 Son of sevenless homolog 1 (Drosophila) Sos1_predicted Son of sevenless homolog 1 (Drosophila) (predicted) APPROVED Symbol and Name updated 1559027 12-JAN-05: Sos1_predicted Son of sevenless homolog 1 (Drosophila) (predicted) APPROVED Symbol and Name status set to approved 70820