Slc7a11 (solute carrier family 7 member 11) - Rat Genome Database

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Gene: Slc7a11 (solute carrier family 7 member 11) Rattus norvegicus
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Symbol: Slc7a11
Name: solute carrier family 7 member 11
RGD ID: 1309275
Description: Predicted to enable L-kynurenine transmembrane transporter activity and cystine:glutamate antiporter activity. Involved in several processes, including lens fiber cell differentiation; response to antibiotic; and response to nicotine. Predicted to be located in astrocyte projection; brush border membrane; and cell surface. Orthologous to human SLC7A11 (solute carrier family 7 member 11); INTERACTS WITH (+)-schisandrin B; (R)-lipoic acid; (S)-AMPA.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cystine/glutamate transporter; LOC310392; solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11; solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Slc7a11Tn(sb-T2/Bart3)2.266Mcwi
Genetic Models: F344-Slc7a11Tn(sb-T2/Bart3)2.266Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82136,532,912 - 136,668,560 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2136,532,246 - 136,695,695 (-)EnsemblGRCr8
mRatBN7.22134,382,002 - 134,517,622 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2133,963,107 - 134,517,536 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2141,015,140 - 141,089,464 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02139,127,676 - 139,201,998 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02133,756,818 - 133,831,146 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02139,453,774 - 139,528,479 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2139,453,774 - 139,528,162 (-)Ensemblrn6Rnor6.0
Rnor_5.02158,930,294 - 159,004,937 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42139,241,142 - 139,317,101 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2128,949,395 - 129,023,474 (-)NCBICelera
RGSC_v3.12139,198,359 - 139,266,947 (-)NCBI
Cytogenetic Map2q26NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-schisandrin B  (EXP)
(-)-alpha-phellandrene  (ISO)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
(E)-thiamethoxam  (ISO)
(R)-lipoic acid  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-AMPA  (EXP)
(S)-ropivacaine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine  (ISO)
1-nitropyrene  (ISO)
1-phenyl-1-cyclopentanecarboxylic acid 2-[2-(diethylamino)ethoxy]ethyl ester  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-(chloromethyl)pyridine  (ISO)
2-amino-4-methylphenol  (ISO)
2-butoxyethanol  (ISO)
2-deoxy-D-glucose  (ISO)
2-tert-butylhydroquinone  (ISO)
25-hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-(indol-3-yl)pyruvic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methyladenine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-methylene-bis-(2-chloroaniline)  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-aminosalicylic acid  (ISO)
4-Carboxyphenylglycine  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitro-1,2-phenylenediamine  (ISO)
4-phenylbutyric acid  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
7beta-aminocephalosporanic acid  (ISO)
8-Br-cAMP  (ISO)
[6]-Shogaol  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
acyclovir  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
alpidem  (ISO)
amikacin  (ISO)
amiodarone  (ISO)
ammonium hexachloroplatinate  (ISO)
amoxicillin  (EXP)
amphetamine  (EXP)
ampicillin  (ISO)
andrographolide  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
Arenobufagin  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
Augmentin  (EXP,ISO)
Azaspiracid  (ISO)
azathioprine  (ISO)
baicalein  (ISO)
belinostat  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzethonium chloride  (ISO)
benzidine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (EXP,ISO)
beryllium sulfate  (ISO)
beta-lapachone  (ISO)
bicalutamide  (ISO)
bilirubin IXalpha  (ISO)
biperiden  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
Bisphenol Z  (ISO)
brequinar  (ISO)
bromfenac  (ISO)
bromobenzene  (EXP)
busulfan  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
ceftriaxone  (EXP)
celastrol  (ISO)
celecoxib  (ISO)
cetylpyridinium  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chloroquine  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
cisplatin  (ISO)
clavulanic acid  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
coumaphos  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
dapagliflozin  (EXP)
DDE  (ISO)
DDT  (ISO)
dehydroepiandrosterone  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (ISO)
diethyl malate  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
Dihydrocorynantheine  (EXP)
dimethyl fumarate  (ISO)
dimethyl sulfoxide  (ISO)
dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium  (ISO)
dimethylarsinic acid  (EXP)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
diphenhydramine  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
doramapimod  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
drometrizole  (ISO)
elemental selenium  (ISO)
elesclomol  (ISO)
empagliflozin  (EXP,ISO)
endosulfan  (EXP,ISO)
enniatin  (ISO)
entacapone  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
epichlorohydrin  (ISO)
erastin  (EXP,ISO)
eriodictyol  (ISO)
estriol  (ISO)
estrone  (ISO)
ethambutol  (EXP,ISO)
ethanol  (EXP,ISO)
Ethyl acrylate  (ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (ISO)
etoposide  (ISO)
eugenol  (ISO)
farnesol  (ISO)
ferrostatin-1  (EXP,ISO)
Fexofenadine hydrochloride  (ISO)
fludrocortisone  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
flutamide  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (EXP,ISO)
FR900359  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gedunin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
glycidol  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
hexadecanoic acid  (ISO)
hexamethylene diisocyanate  (ISO)
Hirsuteine  (EXP)
hydrocodone bitartrate  (EXP)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
hypochlorous acid  (ISO)
ibuprofen  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indoline  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
isobavachalcone  (ISO)
isoniazide  (EXP,ISO)
isoprenaline  (ISO)
ketoconazole  (ISO)
KN-93  (ISO)
L-ascorbic acid  (ISO)
L-cystine  (ISO)
L-glutamic acid  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
leflunomide  (ISO)
levofloxacin  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
lumiracoxib  (ISO)
LY294002  (ISO)
malonaldehyde  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
mebendazole  (ISO)
MeIQx  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
metformin  (EXP)
methamphetamine  (EXP)
methotrexate  (ISO)
methyl methacrylate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
microcystin-LR  (ISO)
mitomycin C  (ISO)
Moniliformin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
motexafin gadolinium  (ISO)
mycophenolic acid  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (EXP)
naphthalene-1,2-diol  (ISO)
nevirapine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
Nonylphenol  (ISO)
O-methyleugenol  (ISO)
o-xylene  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
olanzapine  (ISO)
oseltamivir  (ISO)
oxybenzone  (EXP)
ozone  (ISO)
p-anisidine  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
para-Cresidine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
patulin  (ISO)
penbutolol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenol  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
Picein  (ISO)
pifithrin-alpha hydrobromide  (EXP)
pinostrobin  (ISO)
pioglitazone  (ISO)
piroxicam  (ISO)
polymyxin B2  (ISO)
potassium bromate  (ISO)
potassium dichromate  (EXP,ISO)
prednisolone  (ISO)
pregabalin  (EXP)
procyanidin B1  (EXP)
procyclidine  (ISO)
progesterone  (ISO)
propan-2-ol  (ISO)
propofol  (EXP)
prothioconazole  (ISO)
protriptyline  (ISO)
pyrazinecarboxamide  (EXP)
quercetin  (ISO)
rac-1,2-dichloropropane  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
rifampicin  (EXP)
rotenone  (ISO)
Ruscogenin  (ISO)
Rutecarpine  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sevoflurane  (EXP)
Shikonin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sinapic acid  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP,ISO)
sodium hypochlorite  (ISO)
solasodine  (ISO)
sorafenib  (EXP,ISO)
streptozocin  (ISO)
succimer  (ISO)
sucrose  (EXP)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tauroursodeoxycholic acid  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
thapsigargin  (ISO)
thiamethoxam  (ISO)
thiazoles  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
tienilic acid  (ISO)
titanium dioxide  (EXP,ISO)
tolcapone  (ISO)
toluene  (ISO)
trazodone  (ISO)
triacsin C  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
Trihexyphenidyl  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
Valtratum  (ISO)
vanillin  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
wedelolactone  (ISO)
zafirlukast  (ISO)
zearalenone  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult behavior  (ISO)
amino acid import across plasma membrane  (ISO)
amino acid transmembrane transport  (IBA,IEA)
amino acid transport  (IEA)
brain development  (ISO)
cellular response to oxidative stress  (ISO)
cellular response to stress  (ISO)
dipeptide import across plasma membrane  (ISO)
glutathione metabolic process  (ISO)
glutathione transmembrane transport  (ISO)
intracellular glutamate homeostasis  (ISO)
L-cystine transport  (ISO)
L-glutamate import across plasma membrane  (ISO)
L-glutamate transmembrane transport  (ISO)
L-kynurenine transmembrane transport  (ISO)
lens fiber cell differentiation  (IEP)
limb development  (ISO)
lung alveolus development  (ISO)
lysosomal lumen pH elevation  (ISO)
modulation of chemical synaptic transmission  (ISO)
negative regulation of ferroptosis  (ISO)
neutral amino acid transport  (IEA)
platelet aggregation  (ISO)
proton transmembrane transport  (ISO)
regulation of AMPA glutamate receptor clustering  (ISO)
regulation of cell population proliferation  (ISO)
regulation of cellular response to oxidative stress  (ISO)
regulation of cysteine metabolic process  (ISO)
regulation of glutamate metabolic process  (ISO)
regulation of glutathione biosynthetic process  (ISO)
regulation of melanin biosynthetic process  (ISO)
regulation of neutrophil apoptotic process  (ISO)
regulation of protein transport  (ISO)
regulation of synapse organization  (ISO)
response to antibiotic  (IEP)
response to nicotine  (IEP)
response to oxidative stress  (IEP)
response to redox state  (ISO)
response to toxic substance  (ISO)
striatum development  (ISO)
transmembrane transport  (IEA)
ventricular system development  (ISO)
visual learning  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. E-cigarette aerosols containing nicotine modulate nicotinic acetylcholine receptors and astroglial glutamate transporters in mesocorticolimbic brain regions of chronically exposed mice. Alasmari F, etal., Chem Biol Interact. 2021 Jan 5;333:109308. doi: 10.1016/j.cbi.2020.109308. Epub 2020 Nov 23.
2. Peri-adolescent drinking of ethanol and/or nicotine modulates astroglial glutamate transporters and metabotropic glutamate receptor-1 in female alcohol-preferring rats. Alasmari F, etal., Pharmacol Biochem Behav. 2018 Jul;170:44-55. doi: 10.1016/j.pbb.2018.05.006. Epub 2018 May 10.
3. Effects of a Novel Beta Lactam Compound, MC-100093, on the Expression of Glutamate Transporters/Receptors and Ethanol Drinking Behavior of Alcohol-Preferring Rats. Alhaddad H, etal., J Pharmacol Exp Ther. 2022 Dec;383(3):208-216. doi: 10.1124/jpet.122.001147. Epub 2022 Sep 24.
4. Effects of ceftriaxone on hydrocodone seeking behavior and glial glutamate transporters in P rats. Alshehri FS, etal., Behav Brain Res. 2018 Jul 16;347:368-376. doi: 10.1016/j.bbr.2018.03.043. Epub 2018 Mar 28.
5. Expression of the cystine-glutamate exchanger (xc-) in retinal ganglion cells and regulation by nitric oxide and oxidative stress. Dun Y, etal., Cell Tissue Res. 2006 May;324(2):189-202. Epub 2006 Jan 28.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Amoxicillin and amoxicillin/clavulanate reduce ethanol intake and increase GLT-1 expression as well as AKT phosphorylation in mesocorticolimbic regions. Goodwani S, etal., Brain Res. 2015 Oct 5;1622:397-408. doi: 10.1016/j.brainres.2015.07.008. Epub 2015 Jul 10.
9. Effects of orally administered Augmentin on glutamate transporter 1, cystine-glutamate exchanger expression and ethanol intake in alcohol-preferring rats. Hakami AY, etal., Behav Brain Res. 2017 Mar 1;320:316-322. doi: 10.1016/j.bbr.2016.12.016. Epub 2016 Dec 16.
10. Effects of Amoxicillin and Augmentin on Cystine-Glutamate Exchanger and Glutamate Transporter 1 Isoforms as well as Ethanol Intake in Alcohol-Preferring Rats. Hakami AY, etal., Front Neurosci. 2016 Apr 25;10:171. doi: 10.3389/fnins.2016.00171. eCollection 2016.
11. Effect of amoxicillin/clavulanic acid in attenuating pregabalin-induced condition place preference. Hammad AM, etal., Behav Brain Res. 2023 Feb 15;439:114244. doi: 10.1016/j.bbr.2022.114244. Epub 2022 Dec 2.
12. The role of cystine-glutamate exchange in nicotine dependence in rats and humans. Knackstedt LA, etal., Biol Psychiatry. 2009 May 15;65(10):841-5. Epub 2008 Dec 21.
13. Expression and developmental regulation of the cystine/glutamate exchanger (xc-) in the rat. La Bella V, etal., Neurochem Res. 2007 Jun;32(6):1081-90. Epub 2007 Mar 31.
14. Molecular characterization of the cystine/glutamate exchanger and the excitatory amino acid transporters in the rat lens. Lim J, etal., Invest Ophthalmol Vis Sci. 2005 Aug;46(8):2869-77.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Changes in the glutamate biomarker expression in rats vulnerable or resistant to the rewarding effects of cocaine and their reversal by ceftriaxone. Niedzielska-Andres E, etal., Behav Brain Res. 2019 Sep 16;370:111945. doi: 10.1016/j.bbr.2019.111945. Epub 2019 May 14.
17. Effects of ceftriaxone on chronic ethanol consumption: a potential role for xCT and GLT1 modulation of glutamate levels in male P rats. Rao PS and Sari Y, J Mol Neurosci. 2014 Sep;54(1):71-7. doi: 10.1007/s12031-014-0251-5. Epub 2014 Feb 18.
18. Effects of ceftriaxone on GLT1 isoforms, xCT and associated signaling pathways in P rats exposed to ethanol. Rao PS, etal., Psychopharmacology (Berl). 2015 Jul;232(13):2333-42. doi: 10.1007/s00213-015-3868-3. Epub 2015 Jan 27.
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Comprehensive gene review and curation RGD comprehensive gene curation
22. Prognostic significance of amino-acid transporter expression (LAT1, ASCT2, and xCT) in surgically resected tongue cancer. Toyoda M, etal., Br J Cancer. 2014 May 13;110(10):2506-13. doi: 10.1038/bjc.2014.178. Epub 2014 Apr 24.
Additional References at PubMed
PMID:8699821   PMID:16037214   PMID:16144837   PMID:16399997   PMID:17035536   PMID:17200146   PMID:17575980   PMID:17963724   PMID:19017641   PMID:21191088   PMID:21490221   PMID:21639880  
PMID:22095285   PMID:23085521   PMID:23192314   PMID:24548853   PMID:24687412   PMID:24866234   PMID:25063885   PMID:25429150   PMID:26851652   PMID:27570548   PMID:29024663   PMID:29038291  
PMID:29045497   PMID:29350434   PMID:29488137   PMID:34259984   PMID:35786456   PMID:36456793   PMID:36929608   PMID:37146710   PMID:37391124   PMID:37603538   PMID:37691947   PMID:37822721  
PMID:38816686   PMID:39354361  


Genomics

Comparative Map Data
Slc7a11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82136,532,912 - 136,668,560 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2136,532,246 - 136,695,695 (-)EnsemblGRCr8
mRatBN7.22134,382,002 - 134,517,622 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2133,963,107 - 134,517,536 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2141,015,140 - 141,089,464 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02139,127,676 - 139,201,998 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02133,756,818 - 133,831,146 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02139,453,774 - 139,528,479 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2139,453,774 - 139,528,162 (-)Ensemblrn6Rnor6.0
Rnor_5.02158,930,294 - 159,004,937 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42139,241,142 - 139,317,101 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2128,949,395 - 129,023,474 (-)NCBICelera
RGSC_v3.12139,198,359 - 139,266,947 (-)NCBI
Cytogenetic Map2q26NCBI
SLC7A11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384138,164,097 - 138,242,349 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4138,164,097 - 138,242,349 (-)Ensemblhg38GRCh38
GRCh374139,085,251 - 139,163,503 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364139,304,698 - 139,382,953 (-)NCBIBuild 36Build 36hg18NCBI36
Build 344139,449,092 - 139,520,828NCBI
Celera4136,424,509 - 136,502,906 (-)NCBICelera
Cytogenetic Map4q28.3NCBI
HuRef4134,820,291 - 134,898,999 (-)NCBIHuRef
CHM1_14139,061,708 - 139,139,961 (-)NCBICHM1_1
T2T-CHM13v2.04141,487,564 - 141,572,425 (-)NCBIT2T-CHM13v2.0
Slc7a11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39350,319,385 - 50,403,947 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl349,846,975 - 50,398,063 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38350,364,936 - 50,499,087 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl349,892,526 - 50,443,614 (-)Ensemblmm10GRCm38
MGSCv37350,168,858 - 50,247,535 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36350,461,131 - 50,539,808 (-)NCBIMGSCv36mm8
Celera350,149,206 - 50,227,932 (-)NCBICelera
Cytogenetic Map3CNCBI
cM Map321.72NCBI
Slc7a11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554285,237,865 - 5,309,085 (+)Ensembl
ChiLan1.0NW_0049554285,238,460 - 5,309,085 (+)NCBIChiLan1.0ChiLan1.0
SLC7A11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23136,031,904 - 136,178,341 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14136,428,877 - 136,575,218 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04130,529,677 - 130,601,396 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14141,841,526 - 141,919,678 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4141,849,343 - 141,959,849 (-)EnsemblpanPan2panpan1.1
SLC7A11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1194,289,792 - 4,379,060 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl194,289,850 - 4,389,048 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha194,539,704 - 4,608,064 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0194,364,717 - 4,454,499 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl194,264,457 - 4,464,477 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1194,293,544 - 4,361,949 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0194,655,537 - 4,724,650 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0195,019,875 - 5,088,260 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc7a11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530151,740,115 - 51,806,268 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365359,177,143 - 9,242,566 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365359,177,305 - 9,242,743 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC7A11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl888,608,174 - 88,687,250 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1888,608,083 - 88,690,589 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SLC7A11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1785,149,810 - 85,225,061 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl785,154,068 - 85,225,144 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603764,647,689 - 64,726,569 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc7a11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477718,546,799 - 18,619,947 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477718,540,006 - 18,619,881 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc7a11
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13103,935,497 - 104,003,516 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc7a11
651 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:998
Count of miRNA genes:319
Interacting mature miRNAs:468
Transcripts:ENSRNOT00000014317
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)2105628029150628029Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2124103798154505346Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317886Alcrsp23Alcohol response QTL 232.40.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)295142371140142371Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2120039407159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2100807373145807373Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2106869825151869825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2120039407151869825Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)293602631145807373Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2104957381149957381Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2120339555165339555Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2114032149150226270Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)2114440891159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2116804572161804572Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat

Markers in Region
RH135019  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22134,443,162 - 134,443,349 (+)MAPPERmRatBN7.2
Rnor_6.02139,453,895 - 139,454,081NCBIRnor6.0
Rnor_5.02158,930,415 - 158,930,601UniSTSRnor5.0
RGSC_v3.42139,241,263 - 139,241,449UniSTSRGSC3.4
Celera2128,949,516 - 128,949,702UniSTS
RH 3.4 Map2822.8UniSTS
Cytogenetic Map2q26UniSTS


Genetic Models
This gene Slc7a11 is modified in the following models/strains:
F344-Slc7a11Tn(sb-T2/Bart3)2.266Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 54 162 84 83 52 90 52 6 312 174 9 143 62 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000014317   ⟹   ENSRNOP00000014317
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2133,963,107 - 134,517,536 (-)Ensembl
Rnor_6.0 Ensembl2139,453,774 - 139,528,162 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114420   ⟹   ENSRNOP00000091221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2136,593,952 - 136,676,380 (-)Ensembl
mRatBN7.2 Ensembl2134,447,464 - 134,517,536 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000120596   ⟹   ENSRNOP00000098235
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2136,532,246 - 136,668,264 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000171441   ⟹   ENSRNOP00000110408
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2136,593,952 - 136,695,695 (-)Ensembl
RefSeq Acc Id: NM_001107673   ⟹   NP_001101143
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82136,593,952 - 136,668,264 (-)NCBI
mRatBN7.22134,443,042 - 134,517,358 (-)NCBI
Rnor_6.02139,453,774 - 139,528,162 (-)NCBI
Rnor_5.02158,930,294 - 159,004,937 (-)NCBI
RGSC_v3.42139,241,142 - 139,317,101 (-)RGD
Celera2128,949,395 - 129,023,474 (-)RGD
Sequence:
RefSeq Acc Id: XM_039102258   ⟹   XP_038958186
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82136,532,915 - 136,668,560 (-)NCBI
mRatBN7.22134,382,005 - 134,517,228 (-)NCBI
RefSeq Acc Id: XM_039102259   ⟹   XP_038958187
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82136,601,293 - 136,668,560 (-)NCBI
mRatBN7.22134,451,766 - 134,517,228 (-)NCBI
RefSeq Acc Id: XM_039102260   ⟹   XP_038958188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82136,532,912 - 136,668,533 (-)NCBI
mRatBN7.22134,382,002 - 134,517,622 (-)NCBI
RefSeq Acc Id: XM_063281786   ⟹   XP_063137856
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82136,593,952 - 136,668,533 (-)NCBI
RefSeq Acc Id: NP_001101143   ⟸   NM_001107673
- UniProtKB: D4ADU2 (UniProtKB/TrEMBL),   A0A8I6AB70 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014317   ⟸   ENSRNOT00000014317
RefSeq Acc Id: XP_038958188   ⟸   XM_039102260
- Peptide Label: isoform X3
- UniProtKB: D4ADU2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958186   ⟸   XM_039102258
- Peptide Label: isoform X1
- UniProtKB: D4ADU2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958187   ⟸   XM_039102259
- Peptide Label: isoform X2
- UniProtKB: D4ADU2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000091221   ⟸   ENSRNOT00000114420
RefSeq Acc Id: XP_063137856   ⟸   XM_063281786
- Peptide Label: isoform X4
- UniProtKB: D4ADU2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000098235   ⟸   ENSRNOT00000120596
Ensembl Acc Id: ENSRNOP00000110408   ⟸   ENSRNOT00000171441

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ADU2-F1-model_v2 AlphaFold D4ADU2 1-502 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309275 AgrOrtholog
BioCyc Gene G2FUF-53144 BioCyc
Ensembl Genes ENSRNOG00000010210 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000114420 ENTREZGENE
  ENSRNOT00000114420.3 UniProtKB/TrEMBL
  ENSRNOT00000120596 ENTREZGENE
  ENSRNOT00000120596.2 UniProtKB/TrEMBL
  ENSRNOT00000171441.1 UniProtKB/TrEMBL
Gene3D-CATH Amino acid/polyamine transporter I UniProtKB/TrEMBL
InterPro AA/rel_permease1 UniProtKB/TrEMBL
  AminoAcid_Transporter UniProtKB/TrEMBL
  L_AA_transporter UniProtKB/TrEMBL
KEGG Report rno:310392 UniProtKB/TrEMBL
NCBI Gene 310392 ENTREZGENE
PANTHER AMINO ACID TRANSPORTER UniProtKB/TrEMBL
  CYSTINE/GLUTAMATE TRANSPORTER UniProtKB/TrEMBL
Pfam AA_permease_2 UniProtKB/TrEMBL
PharmGKB SLC7A11 RGD
PhenoGen Slc7a11 PhenoGen
PIRSF AA_transporter UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010210 RatGTEx
UniProt A0A8I6AB70 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LCF6_RAT UniProtKB/TrEMBL
  A0ABK0LY33_RAT UniProtKB/TrEMBL
  D4ADU2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Slc7a11  solute carrier family 7 (cationic amino acid transporter, y+ system), member 11   Slc7a11_predicted  solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Slc7a11_predicted  solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 (predicted)      Symbol and Name status set to approved 70820 APPROVED