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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309275
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc7a11
Name: solute carrier family 7 member 11
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc7a11increases expressionEXP 6480464CTDParaquat results in increased expression of SLC7A11 mRNAPMID:32680482
Slc7a11decreases expressionISOSLC7A11 (Homo sapiens)6480464CTDParaquat results in decreased expression of SLC7A11 proteinPMID:37507096
Slc7a11increases expressionISOSLC7A11 (Homo sapiens)6480464CTDParaquat results in increased expression of SLC7A11 mRNAPMID:34097952
Slc7a11increases expressionISOSlc7a11 (Mus musculus)6480464CTDParaquat results in increased expression of SLC7A11 mRNAPMID:23085521
Slc7a11increases response to substanceISOSlc7a11 (Mus musculus)6480464CTDSLC7A11 gene mutant form results in increased susceptibility to ParaquatPMID:23085521
Slc7a11multiple interactionsISOSLC7A11 (Homo sapiens)6480464CTD[alpha-Tocopherol co-treated with Paraquat] results in increased expression of SLC7A11 mRNA; [alpha-Tocopherol co-treated with Paraquat] results in increased expression of SLC7A11 protein; NFE2L2 protein inhibits the reaction [Paraquat results in decreased expression of SLC7A11 protein]PMID:24530478 PMID:37507096
Slc7a11multiple interactionsISOSlc7a11 (Mus musculus)6480464CTD[SLC7A11 gene mutant form results in increased susceptibility to Paraquat] which results in decreased abundance of GlutathionePMID:23085521
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