GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Slc7a11 | increases abundance | ISO | Slc7a11 (Mus musculus) | 6480464 | CTD | SLC7A11 results in increased abundance of Glutathione | PMID:19015640 | Slc7a11 | multiple interactions | ISO | SLC7A11 (Homo sapiens) | 6480464 | CTD | [[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[BGN mRNA alternative form binds to OTUB1 protein] which binds to and results in decreased ubiquitination of and results in increased stability of SLC7A11 protein] which results in increased chemical synthesis of Glutathione; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione | PMID:22216172 PMID:35234341 | Slc7a11 | multiple interactions | ISO | Slc7a11 (Mus musculus) | 6480464 | CTD | [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased abundance of Glutathione] which results in increased abundance of Reactive Oxygen Species; [SLC7A11 gene mutant form results in increased susceptibility to Paraquat] which results in decreased abundance of Glutathione; [SLC7A11 results in increased abundance of Glutathione] which results in decreased abundance of Reactive Oxygen Species; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased abundance of Glutathione | PMID:19015640 PMID:23085521 | | ||||||||||||||||||||||
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