SLC7A11 (solute carrier family 7 member 11) - Rat Genome Database

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Gene: SLC7A11 (solute carrier family 7 member 11) Canis lupus familiaris
Analyze
Symbol: SLC7A11
Name: solute carrier family 7 member 11
RGD ID: 12414326
Description: ENCODES a protein that exhibits cystine:glutamate antiporter activity (inferred); L-amino acid transmembrane transporter activity (inferred); L-kynurenine transmembrane transporter activity (inferred); INVOLVED IN adult behavior (ortholog); brain development (ortholog); cellular response to oxidative stress (ortholog); ASSOCIATED WITH contact dermatitis (ortholog); genetic disease (ortholog); Hermansky-Pudlak syndrome (ortholog); FOUND IN apical part of cell (inferred); astrocyte projection (inferred); brush border membrane (inferred)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cystine/glutamate exchanger; cystine/glutamate transporter; solute carrier family 7, (cationic amino acid transporter, y+ system) member 11; xCT
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1194,289,792 - 4,379,060 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl194,289,850 - 4,389,048 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha194,539,704 - 4,608,064 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0194,364,717 - 4,454,499 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl194,264,457 - 4,464,477 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1194,293,544 - 4,361,949 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0194,655,537 - 4,724,650 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0195,019,875 - 5,088,260 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult behavior  (IEA,ISO)
amino acid transmembrane transport  (IBA)
amino acid transport  (IEA)
brain development  (IEA,ISO)
cellular response to oxidative stress  (IEA,ISO)
dipeptide import across plasma membrane  (IEA,ISO)
glutathione metabolic process  (IEA,ISO)
glutathione transmembrane transport  (IEA,ISO)
intracellular glutamate homeostasis  (IEA,ISO)
L-alpha-amino acid transmembrane transport  (IEA)
L-cystine transport  (IEA)
L-glutamate import across plasma membrane  (IEA,ISO)
L-glutamate transmembrane transport  (IEA)
L-kynurenine transmembrane transport  (IEA)
lens fiber cell differentiation  (ISO)
limb development  (IEA,ISO)
lung alveolus development  (IEA,ISO)
modulation of chemical synaptic transmission  (IEA,ISO)
negative regulation of ferroptosis  (IEA)
neutral amino acid transport  (IEA)
organic substance transport  (IEA,ISO)
platelet aggregation  (IEA,ISO)
regulation of AMPA glutamate receptor clustering  (IEA,ISO)
regulation of cell population proliferation  (IEA,ISO)
regulation of cellular response to oxidative stress  (IEA,ISO)
regulation of cysteine metabolic process  (IEA,ISO)
regulation of glutamate metabolic process  (IEA,ISO)
regulation of glutathione biosynthetic process  (IEA,ISO)
regulation of melanin biosynthetic process  (IEA,ISO)
regulation of neutrophil apoptotic process  (IEA,ISO)
regulation of protein transport  (IEA,ISO)
regulation of synapse organization  (IEA,ISO)
response to nicotine  (ISO)
response to organic cyclic compound  (IEA,ISO)
response to oxidative stress  (ISO)
response to redox state  (IEA,ISO)
response to toxic substance  (IEA)
striatum development  (IEA,ISO)
transmembrane transport  (IEA)
ventricular system development  (IEA,ISO)
visual learning  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SLC7A11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1194,289,792 - 4,379,060 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl194,289,850 - 4,389,048 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha194,539,704 - 4,608,064 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0194,364,717 - 4,454,499 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl194,264,457 - 4,464,477 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1194,293,544 - 4,361,949 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0194,655,537 - 4,724,650 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0195,019,875 - 5,088,260 (+)NCBIUU_Cfam_GSD_1.0
SLC7A11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384138,164,097 - 138,312,671 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4138,164,097 - 138,242,349 (-)EnsemblGRCh38hg38GRCh38
GRCh374139,085,251 - 139,163,503 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364139,304,698 - 139,382,953 (-)NCBINCBI36Build 36hg18NCBI36
Build 344139,449,092 - 139,520,828NCBI
Celera4136,424,509 - 136,502,906 (-)NCBICelera
Cytogenetic Map4q28.3NCBI
HuRef4134,820,291 - 134,898,999 (-)NCBIHuRef
CHM1_14139,061,708 - 139,139,961 (-)NCBICHM1_1
T2T-CHM13v2.04141,487,564 - 141,636,430 (-)NCBIT2T-CHM13v2.0
Slc7a11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39350,319,385 - 50,403,947 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl349,846,975 - 50,398,063 (-)EnsemblGRCm39 Ensembl
GRCm38350,364,936 - 50,499,087 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl349,892,526 - 50,443,614 (-)EnsemblGRCm38mm10GRCm38
MGSCv37350,168,858 - 50,247,535 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36350,461,131 - 50,539,808 (-)NCBIMGSCv36mm8
Celera350,149,206 - 50,227,932 (-)NCBICelera
Cytogenetic Map3CNCBI
cM Map321.72NCBI
Slc7a11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82136,532,912 - 136,668,560 (-)NCBIGRCr8
mRatBN7.22134,382,002 - 134,517,622 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2133,963,107 - 134,517,536 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2141,015,140 - 141,089,464 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02139,127,676 - 139,201,998 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02133,756,818 - 133,831,146 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02139,453,774 - 139,528,479 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2139,453,774 - 139,528,162 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02158,930,294 - 159,004,937 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42139,241,142 - 139,317,101 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12139,198,359 - 139,266,947 (-)NCBI
Celera2128,949,395 - 129,023,474 (-)NCBICelera
Cytogenetic Map2q26NCBI
Slc7a11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554285,237,865 - 5,309,085 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554285,238,460 - 5,309,085 (+)NCBIChiLan1.0ChiLan1.0
SLC7A11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23136,031,904 - 136,178,341 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14136,428,877 - 136,575,218 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04130,529,677 - 130,601,396 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14141,841,526 - 141,919,678 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4141,849,343 - 141,959,849 (-)Ensemblpanpan1.1panPan2
Slc7a11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530151,740,115 - 51,806,268 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365359,177,143 - 9,242,566 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365359,177,305 - 9,242,743 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC7A11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl888,608,174 - 88,687,250 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1888,608,083 - 88,690,589 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SLC7A11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1785,149,810 - 85,225,061 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl785,154,068 - 85,225,144 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603764,647,689 - 64,726,569 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc7a11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477718,546,799 - 18,619,947 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477718,540,006 - 18,619,881 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SLC7A11
990 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 1
Low 2 11 1 6 1 6 10 6
Below cutoff 3 5 11 5 5 6 8 3 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000006034   ⟹   ENSCAFP00000005591
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl194,289,850 - 4,371,635 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000076935   ⟹   ENSCAFP00000046886
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl194,289,850 - 4,358,298 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000077969   ⟹   ENSCAFP00000065735
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl194,289,850 - 4,389,048 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845040486   ⟹   ENSCAFP00845031699
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl194,264,457 - 4,448,999 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845040612   ⟹   ENSCAFP00845031789
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl194,300,816 - 4,464,477 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845040719   ⟹   ENSCAFP00845031873
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl194,300,816 - 4,448,999 (+)Ensembl
RefSeq Acc Id: NM_001301862   ⟹   NP_001288791
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1194,289,850 - 4,358,298 (+)NCBI
Dog10K_Boxer_Tasha194,539,704 - 4,608,064 (+)NCBI
ROS_Cfam_1.0194,365,580 - 4,433,964 (+)NCBI
UMICH_Zoey_3.1194,293,544 - 4,361,949 (+)NCBI
UNSW_CanFamBas_1.0194,655,537 - 4,724,650 (+)NCBI
UU_Cfam_GSD_1.0195,019,875 - 5,088,260 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038425575   ⟹   XP_038281503
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0194,364,717 - 4,454,499 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001288791   ⟸   NM_001301862
- UniProtKB: A0A089ZZW0 (UniProtKB/TrEMBL),   A2TC22 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000005591   ⟸   ENSCAFT00000006034
RefSeq Acc Id: ENSCAFP00000065735   ⟸   ENSCAFT00000077969
RefSeq Acc Id: ENSCAFP00000046886   ⟸   ENSCAFT00000076935
RefSeq Acc Id: XP_038281503   ⟸   XM_038425575
- Peptide Label: isoform X1
- UniProtKB: A0A8C0N5H6 (UniProtKB/TrEMBL),   A0A8I3PLX9 (UniProtKB/TrEMBL),   A0A8C0R4X0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845031789   ⟸   ENSCAFT00845040612
RefSeq Acc Id: ENSCAFP00845031873   ⟸   ENSCAFT00845040719
RefSeq Acc Id: ENSCAFP00845031699   ⟸   ENSCAFT00845040486


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003749 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030011972 UniProtKB/TrEMBL
  ENSCAFG00040010201 UniProtKB/TrEMBL
  ENSCAFG00845022942 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000006034.4 UniProtKB/TrEMBL
  ENSCAFT00000076935.2 UniProtKB/TrEMBL
  ENSCAFT00000077969.2 UniProtKB/TrEMBL
  ENSCAFT00030022182.1 UniProtKB/TrEMBL
  ENSCAFT00030022303.1 UniProtKB/TrEMBL
  ENSCAFT00030022360.1 UniProtKB/TrEMBL
  ENSCAFT00040018919.1 UniProtKB/TrEMBL
  ENSCAFT00040019027.1 UniProtKB/TrEMBL
  ENSCAFT00845040486.1 UniProtKB/TrEMBL
  ENSCAFT00845040612 ENTREZGENE
  ENSCAFT00845040612.1 UniProtKB/TrEMBL
  ENSCAFT00845040719 ENTREZGENE
  ENSCAFT00845040719.1 UniProtKB/TrEMBL
Gene3D-CATH Amino acid/polyamine transporter I UniProtKB/TrEMBL
InterPro AA/rel_permease1 UniProtKB/TrEMBL
  L_AA_transporter UniProtKB/TrEMBL
KEGG Report cfa:483821 UniProtKB/TrEMBL
NCBI Gene SLC7A11 ENTREZGENE
PANTHER AMINO ACID TRANSPORTER UniProtKB/TrEMBL
  CYSTINE/GLUTAMATE TRANSPORTER UniProtKB/TrEMBL
Pfam AA_permease_2 UniProtKB/TrEMBL
PIRSF AA_transporter UniProtKB/TrEMBL
UniProt A0A089ZZW0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0N5H6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0N5L3_CANLF UniProtKB/TrEMBL
  A0A8C0NDN2_CANLF UniProtKB/TrEMBL
  A0A8C0R4X0 ENTREZGENE
  A0A8C0S6C0_CANLF UniProtKB/TrEMBL
  A0A8C0S6L8_CANLF UniProtKB/TrEMBL
  A0A8I3PH36_CANLF UniProtKB/TrEMBL
  A0A8I3PKJ6_CANLF UniProtKB/TrEMBL
  A0A8I3PLX9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0N6L2_CANLF UniProtKB/TrEMBL
  A0A8P0PEB2_CANLF UniProtKB/TrEMBL
  A2TC22 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:46472 ENTREZGENE