Serpinc1 (serpin family C member 1) - Rat Genome Database

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Gene: Serpinc1 (serpin family C member 1) Rattus norvegicus
Analyze
Symbol: Serpinc1
Name: serpin family C member 1
RGD ID: 1307404
Description: Enables heparin binding activity and serine-type endopeptidase inhibitor activity. Involved in acute inflammatory response to antigenic stimulus; lactation; and response to nutrient. Located in extracellular space. Used to study thrombosis. Biomarker of familial hyperlipidemia; nephrotic syndrome; and ovarian cancer. Human ortholog(s) of this gene implicated in antithrombin III deficiency; disseminated intravascular coagulation; intermediate coronary syndrome; thrombosis; and toxic shock syndrome. Orthologous to human SERPINC1 (serpin family C member 1); PARTICIPATES IN coagulation cascade pathway; enoxaparin pharmacodynamics pathway; fondaparinux pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: antithrombin III; antithrombin-III; LOC304917; serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; serpin peptidase inhibitor, clade C (antithrombin), member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Serpinc1em2Mcwi
Genetic Models: SS.BN-(D13Rat151-D13Rat197)-Serpinc1em2Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81375,790,558 - 75,804,826 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1375,790,546 - 75,817,643 (+)EnsemblGRCr8
mRatBN7.21373,257,208 - 73,271,476 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1373,257,179 - 73,284,293 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1375,850,045 - 75,864,212 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01377,134,244 - 77,148,512 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01374,393,803 - 74,408,067 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01378,806,107 - 78,820,375 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1378,805,347 - 78,833,192 (+)Ensemblrn6Rnor6.0
Rnor_5.01383,700,761 - 83,715,029 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41376,548,456 - 76,562,724 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1373,045,672 - 73,059,940 (+)NCBICelera
RGSC_v3.11376,562,643 - 76,576,911 (+)NCBI
Cytogenetic Map13q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-aminohexanoate  (ISO)
6-aminohexanoic acid  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
amidotrizoic acid  (ISO)
antimony(0)  (ISO)
antirheumatic drug  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
busulfan  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chlorotrianisene  (ISO)
chromium atom  (ISO)
chromium trinitrate  (ISO)
clobazam  (ISO)
clofibrate  (ISO)
clothianidin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dienogest  (ISO)
dimethylarsinic acid  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
fructose  (ISO)
furan  (EXP)
gestodene  (ISO)
glucose  (ISO)
heparin  (ISO)
herbicide  (ISO)
hydrogen peroxide  (ISO)
ioxaglic acid  (ISO)
ivermectin  (ISO)
levonorgestrel  (ISO)
Licochalcone B  (ISO)
medroxyprogesterone acetate  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methylarsonic acid  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nitrofen  (EXP)
norethisterone  (ISO)
norgestimate  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
oxybenzone  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (ISO)
phenobarbital  (EXP)
phenytoin  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
prednisone  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sulfasalazine  (ISO)
tamoxifen  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toremifene  (ISO)
trichloroethene  (EXP)
Triptolide  (EXP)
triptonide  (ISO)
valproic acid  (EXP,ISO)
warfarin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
extracellular region  (IEA)
extracellular space  (IBA,IDA,IEA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Comparison of intraperitoneal antithrombin III and heparin in experimental peritonitis. Akman S, etal., Pediatr Nephrol. 2008 Aug;23(8):1327-30. doi: 10.1007/s00467-008-0829-7. Epub 2008 May 6.
2. Coagulopathy of childhood nephrotic syndrome--a reappraisal of the role of natural anticoagulants and fibrinolysis. al-Mugeiren MM, etal., Haemostasis. 1996 Nov-Dec;26(6):304-10.
3. Enhancement of the coagulation system in spontaneously hypertensive and hyperlipidemic rats. Amagasa H, etal., J Atheroscler Thromb. 2005;12(4):191-8.
4. [Effect of antithrombin-III (AT-III) on intestinal epithelium changes related to obstructive icterus: experimental study in rats] Caglikulekci M, etal., Ann Chir. 2004 Jun;129(5):273-7.
5. Hepatic ischemia/reperfusion injury is diminished by atorvastatin in Wistar rats. Camara-Lemarroy CR, etal., Arch Med Res. 2014 Apr;45(3):210-6. doi: 10.1016/j.arcmed.2014.02.001. Epub 2014 Apr 13.
6. Effect of diallyl trisulfide-rich garlic oil on blood coagulation and plasma activity of anticoagulation factors in rats. Chan KC, etal., Food Chem Toxicol. 2006 Oct 20;.
7. Anticoagulatory and antiinflammatory effects of astaxanthin in diabetic rats. Chan KC, etal., J Food Sci. 2012 Feb;77(2):H76-80. doi: 10.1111/j.1750-3841.2011.02558.x. Epub 2012 Feb 6.
8. Haemostatic imbalance following carrageenan-induced rat paw oedema. Cicala C, etal., Eur J Pharmacol. 2007 Dec 22;577(1-3):156-61. Epub 2007 Aug 14.
9. Abnormalities of coagulation in experimental nephrotic syndrome. Cruz C, etal., Nephron. 1994;68(4):489-96.
10. Role of antithrombin and factor XIII in leukocyte-independent plasma extravasation during endotoxemia: an intravital-microscopic study in the rat. Czabanka M, etal., J Surg Res. 2006 Dec;136(2):219-26. Epub 2006 Feb 2.
11. Molecular basis and thrombotic manifestations of antithrombin deficiency in 15 unrelated Chinese patients. Ding Q, etal., Thromb Res. 2013 Sep;132(3):367-73. doi: 10.1016/j.thromres.2013.07.013. Epub 2013 Aug 8.
12. Antithrombin III pretreatment reduces neutrophil recruitment into the lung and skeletal muscle tissues in the rat model of bilateral lower limb ischemia and reperfusion: a pilot study. Duru S, etal., Acta Anaesthesiol Scand. 2005 Sep;49(8):1142-8.
13. Effects of warfarin and L-carnitine on hemostatic function and oxidative stress in streptozotocin-induced diabetic rats. ElGendy AA and Abbas AM, J Physiol Biochem. 2014 Jun;70(2):535-46. doi: 10.1007/s13105-014-0333-4. Epub 2014 Mar 27.
14. Efficacy of antithrombin III supplementation in animal models of fulminant Escherichia coli endotoxemia or bacteremia. Emerson TE Jr, etal., Am J Med. 1989 Sep 11;87(3B):27S-33S.
15. Effects of antithrombin III on myeloperoxidase activity, superoxide dismutase activity, and malondialdehyde levels and histopathological findings after spinal cord injury in the rat. Erman T, etal., Neurosurgery. 2005 Apr;56(4):828-35.
16. Possible cause of primary graft non-function after orthotopic liver transplantation: a hypothesis with rat models. Fujiwara K, etal., J Gastroenterol Hepatol. 1995;10 Suppl 1:S88-91.
17. Degree of hypercoagulability and hyperfibrinolysis is related to organ failure and prognosis after burn trauma. Garcia-Avello A, etal., Thromb Res. 1998 Jan 15;89(2):59-64.
18. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
19. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
20. Development of hyperfibrinogenemia in spontaneously hypertensive and hyperlipidemic rats: a potentially useful animal model as a complication of hypertension and hyperlipidemia. Gomibuchi H, etal., Exp Anim. 2007 Jan;56(1):1-10.
21. Ketamine reduces intestinal injury and inflammatory cell infiltration after ischemia/reperfusion in rats. Guzman-De La Garza FJ, etal., Surg Today. 2010 Nov;40(11):1055-62. doi: 10.1007/s00595-009-4177-4. Epub 2010 Nov 3.
22. High-dose antithrombin III prevents heat stroke by attenuating systemic inflammation in rats. Hagiwara S, etal., Inflamm Res. 2010 Jul;59(7):511-8. doi: 10.1007/s00011-009-0155-y. Epub 2010 Jan 3.
23. High dose antithrombin III inhibits HMGB1 and improves endotoxin-induced acute lung injury in rats. Hagiwara S, etal., Intensive Care Med. 2008 Feb;34(2):361-7. Epub 2007 Oct 17.
24. Antithrombin III prevents cerulein-induced acute pancreatitis in rats. Hagiwara S, etal., Pancreas. 2009 Oct;38(7):746-51. doi: 10.1097/MPA.0b013e3181aba9fa.
25. Antithrombin reduces ischemia/reperfusion-induced liver injury in rats by activation of cyclooxygenase-1. Harada N, etal., Thromb Haemost. 2004 Sep;92(3):550-8.
26. Antithrombin reduces endotoxin-induced hypotension by enhancing pulmonary sensory neuron activation in rats. Harada N, etal., Thromb Haemost. 2006 Jun;95(6):1011-8.
27. Antithrombotic activity of kininogen is mediated by inhibitory effects of domain 3 during arterial injury in vivo. Hassan S, etal., Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2959-65. Epub 2007 Feb 9.
28. Discovery of serum biomarkers implicated in the onset and progression of serous ovarian cancer in a rat model using iTRAQ technique. Huang Y, etal., Eur J Obstet Gynecol Reprod Biol. 2012 Nov;165(1):96-103. doi: 10.1016/j.ejogrb.2012.06.031. Epub 2012 Jul 18.
29. Antithrombin ameliorates endotoxin-induced organ dysfunction more efficiently when combined with danaparoid sodium than with unfractionated heparin. Iba T, etal., Intensive Care Med. 2005 Aug;31(8):1101-8. Epub 2005 Jul 2.
30. Haemostatic abnormalities persist despite glycaemic improvement by insulin therapy in lean type 2 diabetic patients. Knobl P, etal., Thromb Haemost. 1994 Jun;71(6):692-7.
31. In vivo anticoagulant effect of ethyl pyruvate in endotoxemic rats. Kung CW, etal., Thromb Res. 2011 Jun;127(6):582-8. Epub 2011 Mar 10.
32. Antithrombin reduces reperfusion-induced hepatic metastasis of colon cancer cells. Kurata M, etal., World J Gastroenterol. 2006 Jan 7;12(1):60-5.
33. Antithrombin-III plasma activity during and after prolonged use of heparin in unstable angina. Lidon RM, etal., Thromb Res. 1993 Oct 1;72(1):23-32.
34. [Effect of UC-MSCs on inflammation and thrombosis of the rats with collagen type II induced arthritis]. Lin CM, etal., Zhonghua Xue Ye Xue Za Zhi. 2012 Mar;33(3):215-9.
35. Impact of antithrombin III on hepatic and intestinal microcirculation in experimental liver cirrhosis and bowel inflammation: an in vivo analysis. Maksan SM, etal., World J Gastroenterol. 2005 Aug 28;11(32):4997-5001.
36. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
37. Antithrombin III injection via the portal vein suppresses liver damage. Miyazaki M, etal., World J Gastroenterol. 2012 Apr 28;18(16):1884-91. doi: 10.3748/wjg.v18.i16.1884.
38. Blood coagulation. Norris LA, Best Pract Res Clin Obstet Gynaecol. 2003 Jun;17(3):369-83.
39. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
40. Antithrombin Phe229Leu: a new homozygous variant leading to spontaneous antithrombin polymerization in vivo associated with severe childhood thrombosis. Picard V, etal., Blood. 2003 Aug 1;102(3):919-25. Epub 2003 Feb 20.
41. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
42. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
43. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
44. GOA pipeline RGD automated data pipeline
45. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
46. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
47. Evidence linking familial thrombosis with a defective antithrombin III gene in two British kindreds. Sacks SH, etal., J Med Genet. 1988 Jan;25(1):20-4.
48. Acute and severe coagulopathy in adult mice following silencing of hepatic antithrombin and protein C production. Safdar H, etal., Blood. 2013 May 23;121(21):4413-6. doi: 10.1182/blood-2012-11-465674. Epub 2013 Apr 2.
49. Changes in coagulation and fibrinolysis of post-SARS osteonecrosis in a Chinese population. Sun W, etal., Int Orthop. 2006 Jun;30(3):143-6. doi: 10.1007/s00264-005-0067-6. Epub 2006 Mar 18.
50. [Hematological changes and related gene mutation of post-severe acute respiratory syndrome patients with osteonecrosis]. Sun W, etal., Zhonghua Yi Xue Za Zhi. 2006 Feb 21;86(7):442-5.
51. Purification and characterization of rat plasma antithrombin III. Takahara H and Sinohara H, Biochim Biophys Acta. 1980 Mar 14;612(1):185-94.
52. Beneficial effects of magnolol in a rodent model of endotoxin shock. Tsai YC, etal., Eur J Pharmacol. 2010 Sep 1;641(1):67-73. Epub 2010 May 25.
53. Changes in blood parameters and the expression of coagulation-related genes in lactating Sprague-Dawley rats. Urasoko Y, etal., J Am Assoc Lab Anim Sci. 2012 Mar;51(2):144-9.
54. Antithrombin III/SerpinC1 insufficiency exacerbates renal ischemia/reperfusion injury. Wang F, etal., Kidney Int. 2015 Oct;88(4):796-803. doi: 10.1038/ki.2015.176. Epub 2015 Jun 24.
55. Immunocytochemical localization of endogenous anti-thrombin III in the vasculature of rat tissues reveals locations of anticoagulantly active heparan sulfate proteoglycans. Xu Y and Slayter HS, J Histochem Cytochem. 1994 Oct;42(10):1365-76.
56. Association and linkage analyses of restriction fragment length polymorphisms for the human renin and antithrombin III genes in essential hypertension. Zee RY, etal., J Hypertens. 1991 Sep;9(9):825-30.
Additional References at PubMed
PMID:1695900   PMID:12477932   PMID:15853774   PMID:16502470   PMID:18923394   PMID:19295486   PMID:22516433   PMID:23376485   PMID:23533145   PMID:28767184  


Genomics

Comparative Map Data
Serpinc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81375,790,558 - 75,804,826 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1375,790,546 - 75,817,643 (+)EnsemblGRCr8
mRatBN7.21373,257,208 - 73,271,476 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1373,257,179 - 73,284,293 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1375,850,045 - 75,864,212 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01377,134,244 - 77,148,512 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01374,393,803 - 74,408,067 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01378,806,107 - 78,820,375 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1378,805,347 - 78,833,192 (+)Ensemblrn6Rnor6.0
Rnor_5.01383,700,761 - 83,715,029 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41376,548,456 - 76,562,724 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1373,045,672 - 73,059,940 (+)NCBICelera
RGSC_v3.11376,562,643 - 76,576,911 (+)NCBI
Cytogenetic Map13q22NCBI
SERPINC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381173,903,800 - 173,917,327 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1173,903,519 - 173,917,543 (-)Ensemblhg38GRCh38
GRCh371173,872,938 - 173,886,465 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361172,139,565 - 172,153,096 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341170,604,599 - 170,618,130NCBI
Celera1146,982,409 - 146,995,977 (-)NCBICelera
Cytogenetic Map1q25.1NCBI
HuRef1145,098,064 - 145,111,634 (-)NCBIHuRef
CHM1_11175,295,382 - 175,308,956 (-)NCBICHM1_1
T2T-CHM13v2.01173,261,916 - 173,275,453 (-)NCBIT2T-CHM13v2.0
Serpinc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391160,806,153 - 160,830,113 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1160,806,155 - 160,833,433 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381160,978,583 - 161,002,543 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1160,978,585 - 161,005,863 (+)Ensemblmm10GRCm38
MGSCv371162,908,737 - 162,933,146 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361162,824,166 - 162,839,687 (+)NCBIMGSCv36mm8
Celera1163,418,142 - 163,442,757 (+)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map169.75NCBI
Serpinc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540614,024,313 - 14,035,948 (-)Ensembl
ChiLan1.0NW_00495540614,024,183 - 14,036,206 (-)NCBIChiLan1.0ChiLan1.0
SERPINC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2175,810,862 - 75,823,085 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1175,484,873 - 75,495,989 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01149,421,737 - 149,435,301 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11153,126,031 - 153,139,369 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1153,126,031 - 153,139,369 (-)EnsemblpanPan2panpan1.1
SERPINC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1725,322,668 - 25,333,022 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl725,316,129 - 25,332,987 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha724,855,807 - 24,866,147 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0725,073,311 - 25,083,857 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl725,066,205 - 25,083,857 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1724,993,149 - 25,003,688 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0725,074,836 - 25,085,380 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0725,220,039 - 25,230,581 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Serpinc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934496,134,261 - 96,146,884 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648113,981,019 - 13,993,634 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648113,981,014 - 13,993,750 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERPINC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9116,181,670 - 116,193,201 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.19116,181,988 - 116,193,100 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29127,817,120 - 127,828,237 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SERPINC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12555,271,823 - 55,289,855 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605556,831,874 - 56,851,329 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Serpinc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247717,955,739 - 7,966,637 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247717,955,778 - 7,966,637 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Serpinc1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11040,270,506 - 40,285,507 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Serpinc1
58 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:84
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000003748, ENSRNOT00000046512
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
Serpinc1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21373,263,427 - 73,264,975 (+)MAPPERmRatBN7.2
Rnor_6.01378,812,327 - 78,813,874NCBIRnor6.0
Rnor_5.01383,706,981 - 83,708,528UniSTSRnor5.0
RGSC_v3.41376,554,676 - 76,556,223UniSTSRGSC3.4
Celera1373,051,892 - 73,053,439UniSTS
Cytogenetic Map13q22UniSTS


Genetic Models
This gene Serpinc1 is modified in the following models/strains:
SS.BN-(D13Rat151-D13Rat197)-Serpinc1em2Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 12 30 98 91 90 59 60 59 6 278 117 5 80 79 64 31 11 11

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001012027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC113837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY321346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000003748   ⟹   ENSRNOP00000003748
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1375,795,200 - 75,817,643 (+)Ensembl
mRatBN7.2 Ensembl1373,258,468 - 73,271,478 (+)Ensembl
Rnor_6.0 Ensembl1378,805,347 - 78,820,381 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000046512
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1375,795,610 - 75,817,643 (+)Ensembl
mRatBN7.2 Ensembl1373,262,260 - 73,284,293 (+)Ensembl
Rnor_6.0 Ensembl1378,811,159 - 78,833,192 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076043   ⟹   ENSRNOP00000067902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1373,257,179 - 73,265,339 (+)Ensembl
Rnor_6.0 Ensembl1378,812,394 - 78,814,347 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115784   ⟹   ENSRNOP00000077314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1375,790,546 - 75,805,361 (+)Ensembl
mRatBN7.2 Ensembl1373,257,184 - 73,271,478 (+)Ensembl
RefSeq Acc Id: NM_001012027   ⟹   NP_001012027
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81375,790,558 - 75,804,826 (+)NCBI
mRatBN7.21373,257,208 - 73,271,476 (+)NCBI
Rnor_6.01378,806,107 - 78,820,375 (+)NCBI
Rnor_5.01383,700,761 - 83,715,029 (+)NCBI
RGSC_v3.41376,548,456 - 76,562,724 (+)RGD
Celera1373,045,672 - 73,059,940 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001012027 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88467 (Get FASTA)   NCBI Sequence Viewer  
  AAP86278 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003748.6
  ENSRNOP00000077314
  ENSRNOP00000077314.1
  ENSRNOP00000088946.1
RefSeq Acc Id: NP_001012027   ⟸   NM_001012027
- Peptide Label: precursor
- UniProtKB: Q5M7T5 (UniProtKB/TrEMBL),   F7EY53 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067902   ⟸   ENSRNOT00000076043
Ensembl Acc Id: ENSRNOP00000003748   ⟸   ENSRNOT00000003748
Ensembl Acc Id: ENSRNOP00000077314   ⟸   ENSRNOT00000115784
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5M7T5-F1-model_v2 AlphaFold Q5M7T5 1-465 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698928
Promoter ID:EPDNEW_R9453
Type:initiation region
Name:Serpinc1_1
Description:serpin family C member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01378,806,124 - 78,806,184EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307404 AgrOrtholog
BioCyc Gene G2FUF-17753 BioCyc
Ensembl Genes ENSRNOG00000002783 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003748.9 UniProtKB/TrEMBL
  ENSRNOT00000046512.6 UniProtKB/TrEMBL
  ENSRNOT00000115784 ENTREZGENE
  ENSRNOT00000115784.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7127992 IMAGE-MGC_LOAD
InterPro Antithrombin_domain UniProtKB/TrEMBL
  Protease_inhib_I4_serpin UniProtKB/TrEMBL
  Protease_inhib_I4_serpin_CS UniProtKB/TrEMBL
  Sepin_dom UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
KEGG Report rno:304917 UniProtKB/TrEMBL
MGC_CLONE MGC:95125 IMAGE-MGC_LOAD
NCBI Gene 304917 ENTREZGENE
PANTHER Prot_inh_serpin UniProtKB/TrEMBL
  PTHR11461:SF53 UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PhenoGen Serpinc1 PhenoGen
PROSITE SERPIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002783 RatGTEx
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP Prot_inh_serpin UniProtKB/TrEMBL
UniProt F7EY53 ENTREZGENE, UniProtKB/TrEMBL
  Q5M7T5 ENTREZGENE, UniProtKB/TrEMBL
  Q7TPI9_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Serpinc1  serpin family C member 1  Serpinc1  serpin peptidase inhibitor, clade C (antithrombin), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Serpinc1  serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1    serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1  Name updated 1299863 APPROVED
2005-12-06 Serpinc1  serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1  Serpinc1_predicted  serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Serpinc1_predicted  serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED