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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307404
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Serpinc1
Name: serpin family C member 1
Acc ID: CHEBI:28304
Term: heparin
Definition: A highly sulfated linear glycosaminoglycan comprising complex patterns of uronic acid-(1->4)-D-glucosamine repeating subunits. Used as an injectable anticoagulant, it has the highest negative charge density of any known biological molecule.
Chemical ID: MESH:D006493
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Serpinc1decreases expressionISOSERPINC1 (Homo sapiens)6480464CTDHeparin deficiency results in decreased expression of SERPINC1 protein; Heparin results in decreased expression of SERPINC1 proteinPMID:73932 PMID:7895349 PMID:8122184
Serpinc1multiple interactionsISOSERPINC1 (Homo sapiens)6480464CTDHeparin deficiency results in increased expression of [SERPINC1 protein binds to F2 protein]PMID:11869846
Serpinc1multiple interactionsISOSerpinc1 (Mus musculus)6480464CTDHeparin results in increased expression of [F2 protein binds to SERPINC1 protein]PMID:16961586
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