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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307404 Species: Rattus norvegicus RGD Object: Gene Symbol: Serpinc1 Name: serpin peptidase inhibitor, clade C (antithrombin), member 1

Acc ID: CHEBI:8382 Term: prednisone Definition: A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid. CasRN: 53-03-2 Chemical ID: MESH:D011241

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:1316583	6480464	CTD	Prednisone results in increased expression of SERPINC1 protein	PMID:11304663