RGD Reference Report - Degree of hypercoagulability and hyperfibrinolysis is related to organ failure and prognosis after burn trauma. - Rat Genome Database

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Degree of hypercoagulability and hyperfibrinolysis is related to organ failure and prognosis after burn trauma.

Authors: Garcia-Avello, A  Lorente, JA  Cesar-Perez, J  Garcia-Frade, LJ  Alvarado, R  Arevalo, JM  Navarro, JL  Esteban, A 
Citation: Garcia-Avello A, etal., Thromb Res. 1998 Jan 15;89(2):59-64.
RGD ID: 11035250
Pubmed: PMID:9630308   (View Abstract at PubMed)

Severely burned patients often present a hypercoagulability situation. However, its magnitude, time course, and relationship with organ failure and outcome remains to be established. Forty-three patients were studied on the first and seventh day after burn for hypercoagulability and fibrinolysis parameters. A hypercoagulability and hyperfibrinolysis state was found the first day after burn demonstrated by high levels of activated factor VII (VIIa, p<0.01), thrombin-antithrombin III complex (TAT, p<0.01), tissue plasminogen activator (t-PA, p<0.001) and D dimer (DD, p<0.01) and low levels of antithrombin III (ATIII, p<0.01), protein C (PC, p<0.01), plasminogen (PG, p<0.001) and alpha2 antiplasmin (AP, p<0.001). A paradoxical coexisting hypofibrinolysis was found as suggested by a low global fibrinolytic activity in the euglobulin plasma fraction fibrin plate assay (FA, p<0.01) and high levels of tissue plasminogen activator inhibitor type 1 (PAI-1, p<0.01). On day 7, a less marked hypercoagulability situation was found, with low ATIII (p<0.01) and PC (p<0.01), persisting the hypofibrinolytic situation observed on the first day. Non-survivors (NS) showed higher levels of VIIa (p<0.01), TAT (p<0.05) and t-PA (p<0.05), and lower levels of ATIII (p<0.05), PC (p<0.05) and AP (p<0.001) than survivors (S) on the first day. Also, there was a positive correlation of Marshall organ failure score with ATIII, (r2=0.49, p<0.001), PC, (r2=0.14, p<0.045) and PG levels, (r2=0.41, p<0.0003). Severely burned patients show a state of transient disseminated intravascular coagulation, related to the development of organ failure and outcome.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Multiple Organ Failure disease_progressionIEP 11035250associated with Disseminated Intravascular CoagulationRGD 
Multiple Organ Failure disease_progressionISOSERPINC1 (Homo sapiens)11035250; 11035250associated with Disseminated Intravascular CoagulationRGD 

Objects Annotated

Genes (Rattus norvegicus)
Serpinc1  (serpin family C member 1)

Genes (Mus musculus)
Serpinc1  (serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1)

Genes (Homo sapiens)
SERPINC1  (serpin family C member 1)


Additional Information