RGD Reference Report - Antithrombin ameliorates endotoxin-induced organ dysfunction more efficiently when combined with danaparoid sodium than with unfractionated heparin. - Rat Genome Database

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Antithrombin ameliorates endotoxin-induced organ dysfunction more efficiently when combined with danaparoid sodium than with unfractionated heparin.

Authors: Iba, T  Kidokoro, A  Fukunaga, M  Nagakari, K  Suda, M  Yoshikawa, S  Ida, Y 
Citation: Iba T, etal., Intensive Care Med. 2005 Aug;31(8):1101-8. Epub 2005 Jul 2.
RGD ID: 1599332
Pubmed: PMID:15995859   (View Abstract at PubMed)
DOI: DOI:10.1007/s00134-005-2707-0   (Journal Full-text)

OBJECTIVE: This study investigated the potential benefits of combination therapy using antithrombin (AT) with danaparoid sodium (DA) compared with the use of AT with unfractionated heparin (UFH) in the treatment of sepsis. METHODS: Rats infused with lipopolysaccharide were treated with either DA alone, AT alone, AT plus DA, AT plus UFH, or human serum albumin as controls. AT (125 U/kg) was injected into the AT group immediately after lipopolysaccharide infusion. The AT/DA and AT/UFH groups received the same dose of AT in conjunction with either DA (400 U/kg) or UFH (400 U/kg). The status of the mesenteric microcirculation was examined by intra-vital microscopy and the laboratory indices of coagulation, inflammation, and organ dysfunction were measured. RESULTS: The coagulation markers were improved following the administration of DA or UFH. The decreases in the WBC counts were significantly suppressed in the AT/DA group. The elevation of IL-6 decreased in the AT, DA, and AT/DA groups (all p<0.01) but not in the AT/UFH group. The prostaglandin I2 levels were significantly elevated only in the AT/DA group (p<0.05). The WBC adhesion was significantly suppressed in the DA, AT/UFH, and AT/DA groups (p<0.05), and the RBC velocity was best maintained in the AT/DA group with no associated increase in capillary hemorrhage. The elevation of ALT and BUN significantly improved only in the AT/DA group. ONCLUSION: Organ dysfunction can thus be alleviated by even moderate doses of AT replacement when co-administered with DA.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Endotoxemia  ISOSerpinc1 (Rattus norvegicus)1599332; 1599332 RGD 
Endotoxemia  IEP 1599332 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Serpinc1  (serpin family C member 1)

Genes (Mus musculus)
Serpinc1  (serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1)

Genes (Homo sapiens)
SERPINC1  (serpin family C member 1)


Additional Information