Gnao1 (guanine nucleotide binding protein, alpha O) - Rat Genome Database

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Gene: Gnao1 (guanine nucleotide binding protein, alpha O) Mus musculus
Analyze
Symbol: Gnao1
Name: guanine nucleotide binding protein, alpha O
RGD ID: 1550478
MGI Page MGI
Description: Enables GTP binding activity and GTPase activity. Involved in negative regulation of insulin secretion and postsynaptic modulation of chemical synaptic transmission. Acts upstream of with a negative effect on vesicle docking involved in exocytosis. Acts upstream of or within several processes, including G protein-coupled receptor signaling pathway; dopamine receptor signaling pathway; and locomotory behavior. Located in cell body and dendrite. Is active in several cellular components, including GABA-ergic synapse; parallel fiber to Purkinje cell synapse; and synaptic membrane. Is expressed in several structures, including alimentary system; brain; ganglia; genitourinary system; and sensory organ. Used to study developmental and epileptic encephalopathy 17 and neurodevelopmental disorder with involuntary movements. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 17 and neurodevelopmental disorder with involuntary movements. Orthologous to human GNAO1 (G protein subunit alpha o1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: a; alphaO; AW050213; expressed sequence AW050213; Ga; Galphao; Gnao; Go alpha; GTP-binding protein alpha-o subunit; guanine nucleotide-binding protein G(o) subunit alpha; heterotrimeric guanine nucleotide-binding protein 1g; Hg1g
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39894,537,213 - 94,696,016 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl894,536,594 - 94,696,016 (+)EnsemblGRCm39 Ensembl
GRCm38893,810,153 - 93,969,388 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl893,809,966 - 93,969,388 (+)EnsemblGRCm38mm10GRCm38
MGSCv37896,334,738 - 96,493,288 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36896,700,050 - 96,858,087 (+)NCBIMGSCv36mm8
Celera898,140,645 - 98,299,435 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map845.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
cannabidiol  (ISO)
cantharidin  (EXP)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (EXP)
Cuprizon  (ISO)
dexamethasone  (EXP)
diazinon  (ISO)
dichlorine  (ISO)
diethyl malate  (EXP)
dorsomorphin  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
Ethylenethiourea  (ISO)
fenvalerate  (ISO)
flavonoids  (ISO)
genistein  (EXP,ISO)
glyphosate  (ISO)
Guanabenz  (EXP)
guanosine 5'-[gamma-thio]triphosphate  (EXP)
haloperidol  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (EXP)
methapyrilene  (ISO)
methoxychlor  (ISO)
nickel atom  (ISO)
ozone  (EXP,ISO)
paraquat  (ISO)
pentanal  (ISO)
pentobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
reserpine  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (ISO)
tamoxifen  (EXP)
testosterone  (ISO)
thapsigargin  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (EXP)
valproic acid  (ISO)
venlafaxine hydrochloride  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal behavior  (IAGP)
abnormal body size  (IAGP)
abnormal bone structure  (IEA)
abnormal channel response  (IAGP)
abnormal cone electrophysiology  (IAGP)
abnormal eye electrophysiology  (IAGP)
abnormal gait  (IAGP)
abnormal glucose tolerance  (IAGP)
abnormal hormone level  (IAGP)
abnormal kindling response  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal myocardial fiber physiology  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal pancreas morphology  (IAGP)
abnormal pancreatic beta cell physiology  (IAGP)
abnormal reproductive system physiology  (IAGP)
abnormal response to new environment  (IAGP)
abnormal social investigation  (IAGP)
abnormal spike wave discharge  (IAGP)
abnormal survival  (IAGP)
abnormal vomeronasal sensory neuron physiology  (IAGP)
decreased anxiety-related response  (IEA)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral content  (IEA)
decreased circulating glucose level  (IAGP)
decreased circulating iron level  (IEA)
decreased circulating serum albumin level  (IEA)
decreased eosinophil cell number  (IEA)
decreased erythrocyte cell number  (IEA)
decreased exploration in new environment  (IAGP)
decreased fasting circulating glucose level  (IEA)
decreased grip strength  (IAGP)
decreased locomotor activity  (IAGP)
decreased pancreatic beta cell mass  (IAGP)
decreased red blood cell distribution width  (IEA)
decreased respiratory quotient  (IEA)
decreased thermal nociceptive threshold  (IAGP)
hyperactivity  (IAGP)
hyperalgesia  (IAGP)
impaired coordination  (IAGP)
impaired exercise endurance  (IAGP)
impaired righting response  (IEA)
improved glucose tolerance  (IAGP)
increased blood urea nitrogen level  (IEA)
increased circulating amylase level  (IEA)
increased circulating creatinine level  (IEA)
increased circulating insulin level  (IAGP)
increased circulating triglyceride level  (IEA)
increased insulin secretion  (IAGP)
increased kindling response  (IAGP)
increased mean corpuscular hemoglobin  (IEA)
increased thigmotaxis  (IAGP)
infertility  (IAGP)
lethality, complete penetrance  (IAGP)
lethality, incomplete penetrance  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IEA)
preweaning lethality, incomplete penetrance  (IAGP)
short stride length  (IAGP)
sporadic seizures  (IAGP)
tremors  (IAGP)
unidirectional circling  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Neuropilin-2 mediates axonal fasciculation, zonal segregation, but not axonal convergence, of primary accessory olfactory neurons. Cloutier JF, etal., Neuron 2002 Mar 14;33(6):877-92.
2. Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain. Itoh H, etal., Proc Natl Acad Sci U S A 1986 Jun;83(11):3776-80.
3. Multiple neurological abnormalities in mice deficient in the G protein Go. Jiang M, etal., Proc Natl Acad Sci U S A 1998 Mar 17;95(6):3269-74.
4. GPR56, a novel secretin-like human G-protein-coupled receptor gene. Liu M, etal., Genomics 1999 Feb 1;55(3):296-305.
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. Functionally selective dopamine D(2), D(3) receptor partial agonists. Moller D, etal., J Med Chem. 2014 Jun 12;57(11):4861-75. doi: 10.1021/jm5004039. Epub 2014 May 23.
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1302014   PMID:1697681   PMID:2508088   PMID:2820999   PMID:7592771   PMID:7961675   PMID:8078103   PMID:8550614   PMID:8588930   PMID:8844497   PMID:8854875   PMID:8858601  
PMID:8889548   PMID:9050846   PMID:9300697   PMID:9339368   PMID:9479488   PMID:10087299   PMID:10196137   PMID:10226653   PMID:10349636   PMID:10480904   PMID:10570206   PMID:10669512  
PMID:10825203   PMID:10926822   PMID:10952889   PMID:11042159   PMID:11076861   PMID:11124982   PMID:11217851   PMID:11222144   PMID:11248120   PMID:11685543   PMID:11771389   PMID:12031548  
PMID:12077185   PMID:12454992   PMID:12477932   PMID:12533605   PMID:12670707   PMID:14660441   PMID:14681479   PMID:15226823   PMID:15313569   PMID:15363390   PMID:15489334   PMID:15585744  
PMID:15747579   PMID:15782199   PMID:15872115   PMID:16141072   PMID:16141073   PMID:16456099   PMID:16602821   PMID:16805845   PMID:17092954   PMID:17418106   PMID:17480014   PMID:17500595  
PMID:17634366   PMID:18064011   PMID:18156202   PMID:18184563   PMID:18187455   PMID:18287559   PMID:18378571   PMID:18434540   PMID:18460603   PMID:18586242   PMID:18606864   PMID:18614564  
PMID:18729205   PMID:18832081   PMID:19008227   PMID:19225179   PMID:19460419   PMID:19519663   PMID:19648111   PMID:19906969   PMID:20114047   PMID:20436479   PMID:20622165   PMID:21087508  
PMID:21220323   PMID:21267068   PMID:21317923   PMID:21752992   PMID:21768373   PMID:21835343   PMID:21850207   PMID:21873635   PMID:22383629   PMID:22581782   PMID:22640015   PMID:22794259  
PMID:23339194   PMID:23373526   PMID:23467353   PMID:23637329   PMID:23761911   PMID:23934215   PMID:24194600   PMID:24333658   PMID:24478091   PMID:24519419   PMID:24700286   PMID:24787734  
PMID:24886577   PMID:25012566   PMID:25044020   PMID:26620557   PMID:26755700   PMID:27195771   PMID:27507650   PMID:27528004   PMID:27625425   PMID:27626380   PMID:28134655   PMID:28378742  
PMID:28634551   PMID:28671696   PMID:28706196   PMID:28803787   PMID:28971229   PMID:29518331   PMID:29559301   PMID:29656874   PMID:29747224   PMID:30150362   PMID:30562941   PMID:31221179  
PMID:31493975   PMID:31653840   PMID:31907305   PMID:32325033   PMID:32513692   PMID:33107105   PMID:33358996   PMID:33535037   PMID:34135098   PMID:34248508   PMID:34292976   PMID:34321999  
PMID:34875852   PMID:35080448   PMID:35090564   PMID:35839930   PMID:36293380   PMID:36383665   PMID:36808153   PMID:38331815   PMID:38355793  


Genomics

Comparative Map Data
Gnao1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39894,537,213 - 94,696,016 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl894,536,594 - 94,696,016 (+)EnsemblGRCm39 Ensembl
GRCm38893,810,153 - 93,969,388 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl893,809,966 - 93,969,388 (+)EnsemblGRCm38mm10GRCm38
MGSCv37896,334,738 - 96,493,288 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36896,700,050 - 96,858,087 (+)NCBIMGSCv36mm8
Celera898,140,645 - 98,299,435 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map845.94NCBI
GNAO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381656,191,489 - 56,357,444 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1656,191,390 - 56,357,444 (+)EnsemblGRCh38hg38GRCh38
GRCh371656,225,401 - 56,391,356 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361654,783,649 - 54,948,651 (+)NCBINCBI36Build 36hg18NCBI36
Build 341654,783,648 - 54,935,363NCBI
Celera1640,722,067 - 40,888,176 (+)NCBICelera
Cytogenetic Map16q13NCBI
HuRef1642,096,140 - 42,261,995 (+)NCBIHuRef
CHM1_11657,632,612 - 57,798,711 (+)NCBICHM1_1
T2T-CHM13v2.01661,986,534 - 62,152,480 (+)NCBIT2T-CHM13v2.0
Gnao1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81911,040,788 - 11,198,437 (-)NCBIGRCr8
mRatBN7.21911,034,874 - 11,192,531 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1911,035,956 - 11,192,493 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1911,003,977 - 11,161,720 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01911,769,148 - 11,926,880 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01911,056,156 - 11,213,897 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01911,513,201 - 11,669,578 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1911,513,201 - 11,669,578 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01911,487,578 - 11,643,367 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41911,472,083 - 11,623,600 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11911,476,908 - 11,628,426 (-)NCBI
Celera1910,919,521 - 11,074,052 (-)NCBICelera
Cytogenetic Map19p12NCBI
Gnao1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543314,004,813 - 14,172,707 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543314,004,813 - 14,170,631 (+)NCBIChiLan1.0ChiLan1.0
GNAO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21865,669,503 - 65,839,209 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11671,588,239 - 71,758,365 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01636,473,852 - 36,643,789 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11655,606,920 - 55,776,619 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1655,606,920 - 55,776,619 (+)Ensemblpanpan1.1panPan2
GNAO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,805,675 - 59,980,782 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,806,689 - 59,980,398 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha256,439,284 - 56,614,525 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0260,350,680 - 60,525,810 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl260,350,811 - 60,526,437 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1257,180,704 - 57,353,192 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0258,189,791 - 58,364,758 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0259,082,779 - 59,255,395 (-)NCBIUU_Cfam_GSD_1.0
Gnao1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934950,907,469 - 50,975,262 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364758,565,889 - 8,690,673 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364758,610,123 - 8,681,606 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNAO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl629,416,708 - 29,592,516 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1629,416,574 - 29,592,874 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2626,756,513 - 26,788,415 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GNAO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1542,105,295 - 42,272,573 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl542,105,334 - 42,273,059 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604734,092,746 - 34,260,108 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gnao1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624757178,616 - 346,443 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gnao1
4142 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2655
Count of miRNA genes:771
Interacting mature miRNAs:990
Transcripts:ENSMUST00000034198, ENSMUST00000125695, ENSMUST00000125716, ENSMUST00000127900, ENSMUST00000130974, ENSMUST00000137202, ENSMUST00000138659, ENSMUST00000142466, ENSMUST00000144451, ENSMUST00000149530, ENSMUST00000155245
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873929123107929226Mouse
1301253Skmw2_mskeletal muscle weight 2 (mouse)Not determined886443553120443701Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined879245241113245331Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86151347995513605Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879808806113809031Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined872122809106123021Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined876411976110412125Mouse
1302049Heal1_mwound healing/regeneration 1 (mouse)Not determined886443553120443701Mouse
1301766Desp1_mdespair 1 (mouse)Not determined885486208119486373Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined871032003105032123Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined866084397100084549Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined876411976110412125Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined876402145110402251Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871829531105829637Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6418673698186736Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86466617698666325Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71740461124622354Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined871032003105032123Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)882345783116345783Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881819296115819296Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined866326836100326976Mouse
10045619Heal14_mwound healing/regeneration 14 (mouse)Not determined886443553120443701Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined876411976110412125Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)84016229795416226Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889726628130027694Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)874126628126826739Mouse

Markers in Region
AW050213  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38893,960,369 - 93,960,470UniSTSGRCm38
MGSCv37896,484,269 - 96,484,370UniSTSGRCm37
Celera898,290,417 - 98,290,518UniSTS
Cytogenetic Map8C5UniSTS
cM Map845.0UniSTS
Whitehead/MRC_RH81159.72UniSTS
Gnao1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C5UniSTS
cM Map845.0UniSTS
cM Map845.0UniSTS
RH143789  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38893,967,995 - 93,968,134UniSTSGRCm38
MGSCv37896,491,895 - 96,492,034UniSTSGRCm37
Celera898,298,043 - 98,298,182UniSTS
Cytogenetic Map8C5UniSTS
cM Map845.0UniSTS
UniSTS:235968  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38893,968,523 - 93,968,757UniSTSGRCm38
MGSCv37896,492,423 - 96,492,657UniSTSGRCm37
Celera898,298,571 - 98,298,805UniSTS
Cytogenetic Map8C5UniSTS
cM Map845.0UniSTS
RH139637  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38893,960,411 - 93,960,599UniSTSGRCm38
MGSCv37896,484,311 - 96,484,499UniSTSGRCm37
Celera898,290,459 - 98,290,647UniSTS
Cytogenetic Map8C5UniSTS
cM Map845.0UniSTS
PMC19731P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38893,949,410 - 93,950,409UniSTSGRCm38
MGSCv37896,473,310 - 96,474,309UniSTSGRCm37
Celera898,279,458 - 98,280,457UniSTS
Cytogenetic Map8C5UniSTS
cM Map845.0UniSTS
RH68394  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38893,969,148 - 93,969,309UniSTSGRCm38
MGSCv37896,493,048 - 96,493,209UniSTSGRCm37
Celera898,299,196 - 98,299,356UniSTS
Cytogenetic Map8C5UniSTS
cM Map845.0UniSTS
Gnao1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C5UniSTS
cM Map845.0UniSTS
Gnao1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C5UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001113384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001414907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001414908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_188943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC102398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC138118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK030718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK035907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK047197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK051968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP760325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA317761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA323860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ871846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L34216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M36777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M36778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M59929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OU667064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U12017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000034198   ⟹   ENSMUSP00000034198
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl894,537,466 - 94,696,016 (+)Ensembl
GRCm38.p6 Ensembl893,810,838 - 93,969,388 (+)Ensembl
RefSeq Acc Id: ENSMUST00000125695
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl894,537,264 - 94,538,398 (+)Ensembl
GRCm38.p6 Ensembl893,810,636 - 93,811,770 (+)Ensembl
RefSeq Acc Id: ENSMUST00000125716   ⟹   ENSMUSP00000114144
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl894,537,468 - 94,695,584 (+)Ensembl
GRCm38.p6 Ensembl893,810,840 - 93,968,956 (+)Ensembl
RefSeq Acc Id: ENSMUST00000127900   ⟹   ENSMUSP00000116826
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl894,622,859 - 94,694,791 (+)Ensembl
GRCm38.p6 Ensembl893,896,231 - 93,968,163 (+)Ensembl
RefSeq Acc Id: ENSMUST00000130974
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl894,676,133 - 94,677,303 (+)Ensembl
GRCm38.p6 Ensembl893,949,505 - 93,950,675 (+)Ensembl
RefSeq Acc Id: ENSMUST00000137202   ⟹   ENSMUSP00000119220
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl894,536,594 - 94,677,031 (+)Ensembl
GRCm38.p6 Ensembl893,809,966 - 93,950,403 (+)Ensembl
RefSeq Acc Id: ENSMUST00000138659   ⟹   ENSMUSP00000148550
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl894,537,941 - 94,687,318 (+)Ensembl
GRCm38.p6 Ensembl893,811,313 - 93,960,690 (+)Ensembl
RefSeq Acc Id: ENSMUST00000142466   ⟹   ENSMUSP00000118463
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl894,677,033 - 94,694,688 (+)Ensembl
GRCm38.p6 Ensembl893,950,405 - 93,968,060 (+)Ensembl
RefSeq Acc Id: ENSMUST00000144451
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl894,679,575 - 94,683,208 (+)Ensembl
GRCm38.p6 Ensembl893,952,947 - 93,956,580 (+)Ensembl
RefSeq Acc Id: ENSMUST00000149530   ⟹   ENSMUSP00000115007
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl894,677,033 - 94,694,709 (+)Ensembl
GRCm38.p6 Ensembl893,950,405 - 93,968,081 (+)Ensembl
RefSeq Acc Id: ENSMUST00000155245
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl894,689,472 - 94,693,649 (+)Ensembl
GRCm38.p6 Ensembl893,962,844 - 93,967,021 (+)Ensembl
RefSeq Acc Id: ENSMUST00000212008
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl894,692,424 - 94,695,838 (+)Ensembl
GRCm38.p6 Ensembl893,965,796 - 93,969,210 (+)Ensembl
RefSeq Acc Id: NM_001113384   ⟹   NP_001106855
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39894,537,213 - 94,687,319 (+)NCBI
GRCm38893,810,838 - 93,960,694 (+)NCBI
MGSCv37896,334,738 - 96,493,288 (+)RGD
Celera898,140,645 - 98,299,435 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001414907   ⟹   NP_001401836
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39894,537,213 - 94,696,016 (+)NCBI
RefSeq Acc Id: NM_001414908   ⟹   NP_001401837
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39894,537,213 - 94,696,016 (+)NCBI
RefSeq Acc Id: NM_010308   ⟹   NP_034438
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39894,537,213 - 94,696,016 (+)NCBI
GRCm38893,810,838 - 93,969,388 (+)NCBI
MGSCv37896,334,738 - 96,493,288 (+)RGD
Celera898,140,645 - 98,299,435 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_188943
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39894,537,213 - 94,687,319 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_034438   ⟸   NM_010308
- Peptide Label: isoform A
- UniProtKB: P18873 (UniProtKB/Swiss-Prot),   P18872 (UniProtKB/Swiss-Prot),   Q543S2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001106855   ⟸   NM_001113384
- Peptide Label: isoform B
- UniProtKB: P18872 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000114144   ⟸   ENSMUST00000125716
RefSeq Acc Id: ENSMUSP00000148550   ⟸   ENSMUST00000138659
RefSeq Acc Id: ENSMUSP00000116826   ⟸   ENSMUST00000127900
RefSeq Acc Id: ENSMUSP00000034198   ⟸   ENSMUST00000034198
RefSeq Acc Id: ENSMUSP00000115007   ⟸   ENSMUST00000149530
RefSeq Acc Id: ENSMUSP00000119220   ⟸   ENSMUST00000137202
RefSeq Acc Id: ENSMUSP00000118463   ⟸   ENSMUST00000142466
RefSeq Acc Id: NP_001401837   ⟸   NM_001414908
- Peptide Label: isoform C
RefSeq Acc Id: NP_001401836   ⟸   NM_001414907
- Peptide Label: isoform A
- UniProtKB: P18872 (UniProtKB/Swiss-Prot),   P18873 (UniProtKB/Swiss-Prot),   Q543S2 (UniProtKB/TrEMBL)
Protein Domains
G-alpha

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18872-F1-model_v2 AlphaFold P18872 1-354 view protein structure

Promoters
RGD ID:8667877
Promoter ID:EPDNEW_M11969
Type:initiation region
Name:Gnao1_1
Description:Mus musculus guanine nucleotide binding protein, alpha O , transcriptvariant A, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38893,810,838 - 93,810,898EPDNEW
RGD ID:6843251
Promoter ID:MM_KWN:55303
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000085920
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36896,333,726 - 96,334,226 (+)MPROMDB
RGD ID:6843252
Promoter ID:MM_KWN:55306
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000085921
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36896,419,776 - 96,420,276 (+)MPROMDB
RGD ID:6843258
Promoter ID:MM_KWN:55308
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000085919,   OTTMUST00000085925
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36896,473,876 - 96,474,376 (+)MPROMDB
RGD ID:6843253
Promoter ID:MM_KWN:55309
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Lung
Transcripts:OTTMUST00000085923
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36896,476,036 - 96,476,627 (+)MPROMDB
RGD ID:6843254
Promoter ID:MM_KWN:55310
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000085924
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36896,486,676 - 96,487,176 (+)MPROMDB
RGD ID:6848291
Promoter ID:MM_ACW:48465
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   Brain,   MEF_B6
Transcripts:GNAO1.GSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36896,492,366 - 96,492,866 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95775 AgrOrtholog
Ensembl Genes ENSMUSG00000031748 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034198 ENTREZGENE
  ENSMUST00000034198.15 UniProtKB/Swiss-Prot
  ENSMUST00000125716 ENTREZGENE
  ENSMUST00000125716.8 UniProtKB/Swiss-Prot
  ENSMUST00000127900.2 UniProtKB/TrEMBL
  ENSMUST00000137202.8 UniProtKB/TrEMBL
  ENSMUST00000138659 ENTREZGENE
  ENSMUST00000138659.9 UniProtKB/Swiss-Prot
  ENSMUST00000142466.2 UniProtKB/TrEMBL
  ENSMUST00000149530.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Gprotein_alpha_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gprotein_alpha_su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GproteinA_insert UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14681 UniProtKB/Swiss-Prot
MGD MGI:95775 ENTREZGENE
NCBI Gene 14681 ENTREZGENE
PANTHER GUANINE NUCLEOTIDE-BINDING PROTEIN G(O) SUBUNIT ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10218 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam G-alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gnao1 PhenoGen
PRINTS GPROTEINA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPROTEINAI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART G_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3Z2M7_MOUSE UniProtKB/TrEMBL
  F6W1B2_MOUSE UniProtKB/TrEMBL
  F6WC15_MOUSE UniProtKB/TrEMBL
  F7BLT7_MOUSE UniProtKB/TrEMBL
  GNAO_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  P18873 ENTREZGENE
  Q543S2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P18873 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Gnao1  guanine nucleotide binding protein, alpha O  AW050213  expressed sequence AW050213  Data merged from RGD:1609550 737654 PROVISIONAL