Cyp11b2 (cytochrome P450, family 11, subfamily b, polypeptide 2) - Rat Genome Database

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Gene: Cyp11b2 (cytochrome P450, family 11, subfamily b, polypeptide 2) Mus musculus
Analyze
Symbol: Cyp11b2
Name: cytochrome P450, family 11, subfamily b, polypeptide 2
RGD ID: 10430
MGI Page MGI
Description: Enables steroid 11-beta-monooxygenase activity. Acts upstream of or within several processes, including aldosterone biosynthetic process; drinking behavior; and regulation of systemic arterial blood pressure by hormone. Predicted to be located in dendrite and mitochondrion. Predicted to be active in mitochondrial inner membrane. Is expressed in adrenal gland and gland. Human ortholog(s) of this gene implicated in several diseases, including congenital adrenal hyperplasia; corticosterone methyloxidase deficiency 1; diabetes mellitus (multiple); hypertension (multiple); and primary hyperaldosteronism (multiple). Orthologous to human CYP11B1 (cytochrome P450 family 11 subfamily B member 1) and CYP11B2 (cytochrome P450 family 11 subfamily B member 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ALDOS; aldosterone synthase; aldosterone-synthesizing enzyme; corticosterone 18-monooxygenase, CYP11B2; Cpn2; Cyp11; Cyp11b; Cyp11b-; Cyp11b-2; CYPXIB2; cytochrome P-450Aldo; cytochrome P-450C18; cytochrome P450 11B2, mitochondrial; cytochrome P450C11; MGC151285; steroid 11-beta-hydroxylase; steroid 11-beta-hydroxylase, CYP11B2; steroid 18-hydroxylase; steroid-11-beta-hydroxylase
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391574,722,467 - 74,728,080 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1574,722,859 - 74,728,167 (-)EnsemblGRCm39 Ensembl
GRCm381574,850,618 - 74,856,231 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1574,851,010 - 74,856,318 (-)EnsemblGRCm38mm10GRCm38
MGSCv371574,681,440 - 74,686,748 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361574,678,294 - 74,683,480 (-)NCBIMGSCv36mm8
Celera1576,357,529 - 76,362,843 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1534.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
11-deoxycorticosterone  (ISO)
11-deoxycortisol  (ISO)
18-hydroxycortisol  (ISO)
18-hydroxydeoxycorticosterone  (ISO)
18-oxocortisol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,3',4,4',5-Hexachlorobiphenyl  (ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenol  (ISO)
2,6-dibromophenol  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3,4,5,3',4',5'-Hexachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
acenaphthenes  (ISO)
Acetyl tributyl citrate  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (EXP,ISO)
alternariol  (ISO)
ammonium chloride  (ISO)
amoxicillin  (ISO)
androgen antagonist  (ISO)
Bay-K-8644  (ISO)
benazepril  (ISO)
benidipine  (ISO)
benzo[a]pyrene  (ISO)
benzofurans  (ISO)
bifenthrin  (ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (ISO)
caffeine  (ISO)
calmidazolium  (ISO)
candesartan  (ISO)
Candesartan cilexetil  (ISO)
carbamazepine  (ISO)
chlorohydrocarbon  (ISO)
clofibrate  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
Cuprizon  (ISO)
cyproconazole  (ISO)
D-glucose  (ISO)
DDE  (ISO)
deoxynivalenol  (ISO)
Di-n-hexyl phthalate  (ISO)
dibutyl phthalate  (ISO)
Dicyclohexyl phthalate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dipentyl phthalate  (ISO)
dutasteride  (ISO)
endosulfan  (ISO)
enniatin  (ISO)
epoxiconazole  (ISO)
erythromycin A  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gentamycin  (ISO)
glucose  (ISO)
glycyrrhizinic acid  (ISO)
hydrochlorothiazide  (ISO)
hydroxyitraconazole  (ISO)
imidapril  (ISO)
irbesartan  (ISO)
itraconazole  (ISO)
ketoconazole  (ISO)
KN-93  (ISO)
Methandrostenolone  (ISO)
methylmercury chloride  (ISO)
Mibefradil  (ISO)
Mitotane  (ISO)
mycotoxin  (ISO)
N-acetyl-L-cysteine  (ISO)
naringin  (ISO)
nitroglycerin  (ISO)
paracetamol  (ISO)
perflubron  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
posaconazole  (ISO)
potassium atom  (ISO)
potassium chloride  (ISO)
potassium dichromate  (EXP)
proanthocyanidin  (ISO)
rotenone  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium atom  (ISO)
sodium chloride  (ISO)
spironolactone  (ISO)
streptozocin  (ISO)
testosterone  (ISO)
torasemide  (ISO)
torcetrapib  (ISO)
triadimefon  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
triphenylstannane  (ISO)
Triptolide  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Fetal adrenal gland alterations in a rat model of adverse intrauterine environment. Bibeau K, etal., Am J Physiol Regul Integr Comp Physiol. 2010 Apr;298(4):R899-911. Epub 2009 Nov 18.
2. Aldosterone excretion rate and blood pressure in essential hypertension are related to polymorphic differences in the aldosterone synthase gene CYP11B2. Davies E, etal., Hypertension. 1999 Feb;33(2):703-7.
3. Quantitative assessment of CYP11B1 and CYP11B2 expression in aldosterone-producing adenomas. Fallo F, etal., Eur J Endocrinol. 2002 Dec;147(6):795-802.
4. Metabolic acidosis has dual effects on sodium handling by rat kidney. Faroqui S, etal., Am J Physiol Renal Physiol. 2006 Aug;291(2):F322-31. Epub 2006 Feb 21.
5. Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage. Fiebeler A, etal., Circulation. 2005 Jun 14;111(23):3087-94. Epub 2005 Jun 6.
6. Mineralocorticoid receptor antagonist spironolactone prevents pig serum-induced hepatic fibrosis in rats. Fujisawa G, etal., Transl Res. 2006 Sep;148(3):149-56.
7. Cardiac specific increase in aldosterone production induces coronary dysfunction in aldosterone synthase-transgenic mice. Garnier A, etal., Circulation. 2004 Sep 28;110(13):1819-25. Epub 2004 Sep 13.
8. Aldosterone synthesis in the brain contributes to Dahl salt-sensitive rat hypertension. Gomez-Sanchez EP, etal., Exp Physiol. 2010 Jan;95(1):120-30. Epub 2009 Oct 16.
9. Central infusion of aldosterone synthase inhibitor prevents sympathetic hyperactivity and hypertension by central Na+ in Wistar rats. Huang BS, etal., Am J Physiol Regul Integr Comp Physiol. 2008 Jul;295(1):R166-72. Epub 2008 May 21.
10. Central infusion of aldosterone synthase inhibitor attenuates left ventricular dysfunction and remodelling in rats after myocardial infarction. Huang BS, etal., Cardiovasc Res. 2009 Feb 15;81(3):574-81. Epub 2008 Aug 8.
11. Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion. Keavney B, etal., J Clin Endocrinol Metab. 2005 Feb;90(2):1072-7. Epub 2004 Nov 2.
12. Polymorphism of the aldosterone synthase gene is not associated with progression of diabetic nephropathy, but associated with hypertension in type 2 diabetic patients. Ko GJ, etal., Nephrology (Carlton). 2008 Dec;13(6):492-9. Epub 2008 Sep 1.
13. Associations between human aldosterone synthase (CYP11B2) gene polymorphisms and left ventricular size, mass, and function. Kupari M, etal., Circulation. 1998 Feb 17;97(6):569-75.
14. Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice. Lee G, etal., Endocrinology. 2005 Jun;146(6):2650-6. Epub 2005 Feb 24.
15. Mutations in aldosterone synthase gene of Milan hypertensive rats: phenotypic consequences. Lloyd-MacGilp SA, etal., Am J Physiol Endocrinol Metab 2002 Mar;282(3):E608-17.
16. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
17. MGDs mouse GO annotations MGD data from the GO Consortium
18. MGD IEA MGD IEA
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. Lack of association among five genetic polymorphisms of the renin-angiotensin system and cardiac hypertrophy in patients with aortic stenosis. Ortlepp JR, etal., Am Heart J. 2001 Apr;141(4):671-6.
21. Mutations in the human CYP11B2 (aldosterone synthase) gene causing corticosterone methyloxidase II deficiency. Pascoe L, etal., Proc Natl Acad Sci U S A. 1992 Jun 1;89(11):4996-5000.
22. Variants of trophic factors and expression of cardiac hypertrophy in patients with hypertrophic cardiomyopathy. Patel R, etal., J Mol Cell Cardiol. 2000 Dec;32(12):2369-77.
23. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Payne AH and Hales DB, Endocr Rev. 2004 Dec;25(6):947-70.
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
26. Chronic renal insufficiency among Asian Indians with type 2 diabetes: I. Role of RAAS gene polymorphisms. Prasad P, etal., BMC Med Genet. 2006 May 3;7:42.
27. Genetic variation in aldosterone synthase predicts plasma glucose levels. Ranade K, etal., Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13219-24. Epub 2001 Oct 30.
28. Mouse MP Annotation Import Pipeline RGD automated import pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. -344C/T Variant in the promoter of the aldosterone synthase gene (CYP11B2) is associated with metabolic syndrome in men. Russo P, etal., Am J Hypertens. 2007 Feb;20(2):218-22.
32. Aldosterone synthase gene polymorphism, stroke volume and age-related changes in aortic pulse wave velocity in subjects with hypertension. Safar ME, etal., J Hypertens. 2005 Jun;23(6):1159-66.
33. Evidence for compromised aldosterone synthase enzyme activity in preeclampsia. Shojaati K, etal., Kidney Int. 2004 Dec;66(6):2322-8.
34. Spironolactone exhibits direct renoprotective effects and inhibits renal renin-angiotensin-aldosterone system in diabetic rats. Taira M, etal., Eur J Pharmacol. 2008 Jul 28;589(1-3):264-71. Epub 2008 Jun 10.
35. [Effects of various diuretics on cardiac function in rats with heart failure]. Tanaka H, etal., Yakugaku Zasshi. 2009 Jul;129(7):871-9.
36. Torasemide, a long-acting loop diuretic, reduces the progression of myocarditis to dilated cardiomyopathy. Veeraveedu PT, etal., Eur J Pharmacol. 2008 Feb 26;581(1-2):121-31. Epub 2007 Nov 28.
Additional References at PubMed
PMID:1686470   PMID:2233742   PMID:2546938   PMID:2783417   PMID:7476975   PMID:7588219   PMID:7590346   PMID:7628695   PMID:7669222   PMID:8645611   PMID:10029587   PMID:10405217  
PMID:10861000   PMID:11932209   PMID:12231255   PMID:12399432   PMID:12477932   PMID:14651853   PMID:14681479   PMID:15289436   PMID:16118390   PMID:17075030   PMID:17984374   PMID:18039983  
PMID:18599507   PMID:18614015   PMID:19955443   PMID:20118198   PMID:20624970   PMID:21256921   PMID:21467193   PMID:21519965   PMID:21677750   PMID:21873635   PMID:22622494   PMID:22933298  
PMID:23303406   PMID:23314847   PMID:23471215   PMID:23761669   PMID:24035414   PMID:24135228   PMID:24285498   PMID:25668066   PMID:25774556   PMID:25933105   PMID:26047574   PMID:26108225  
PMID:26180185   PMID:26324851   PMID:26362633   PMID:26471128   PMID:27798095   PMID:29212953   PMID:29879378   PMID:30046010   PMID:30321360   PMID:30541888   PMID:30580687   PMID:30692207  
PMID:31398249   PMID:32245948   PMID:32245949   PMID:32320669   PMID:32540969   PMID:32561853   PMID:34905510   PMID:35288482   PMID:35830806   PMID:36778748   PMID:37102205   PMID:37129912  
PMID:37310791   PMID:38301271   PMID:38341019  


Genomics

Comparative Map Data
Cyp11b2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391574,722,467 - 74,728,080 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1574,722,859 - 74,728,167 (-)EnsemblGRCm39 Ensembl
GRCm381574,850,618 - 74,856,231 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1574,851,010 - 74,856,318 (-)EnsemblGRCm38mm10GRCm38
MGSCv371574,681,440 - 74,686,748 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361574,678,294 - 74,683,480 (-)NCBIMGSCv36mm8
Celera1576,357,529 - 76,362,843 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1534.29NCBI
CYP11B2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388142,910,559 - 142,917,843 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8142,910,559 - 142,917,843 (-)EnsemblGRCh38hg38GRCh38
GRCh378143,991,975 - 143,999,259 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368143,988,977 - 143,996,261 (-)NCBINCBI36Build 36hg18NCBI36
Build 348143,988,976 - 143,996,261NCBI
Celera8140,301,421 - 140,308,694 (-)NCBICelera
Cytogenetic Map8q24.3NCBI
HuRef8139,244,244 - 139,251,515 (-)NCBIHuRef
CHM1_18144,032,236 - 144,039,525 (-)NCBICHM1_1
T2T-CHM13v2.08144,053,900 - 144,061,172 (-)NCBIT2T-CHM13v2.0
Cyp11b3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87108,689,319 - 108,694,808 (-)NCBIGRCr8
mRatBN7.27106,808,559 - 106,814,048 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7106,808,559 - 106,814,048 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7108,534,544 - 108,540,024 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07110,758,218 - 110,763,690 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07110,704,151 - 110,709,631 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07116,155,928 - 116,161,781 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7116,156,219 - 116,255,167 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07116,059,008 - 116,064,497 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47113,013,335 - 113,018,824 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17113,047,564 - 113,053,054 (-)NCBI
Celera7103,180,975 - 103,186,464 (-)NCBICelera
Cytogenetic Map7q34NCBI
CYP11B2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27160,346,798 - 160,354,193 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18135,873,004 - 135,880,399 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08139,622,632 - 139,630,014 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18142,666,534 - 142,672,575 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8142,666,534 - 142,672,575 (-)Ensemblpanpan1.1panPan2
CYP11B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11336,866,476 - 36,880,625 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1336,823,864 - 36,833,784 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01337,342,302 - 37,352,691 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11337,015,530 - 37,025,564 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01337,134,290 - 37,144,097 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01337,610,637 - 37,619,980 (+)NCBIUU_Cfam_GSD_1.0
CYP11B2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.141,365,725 - 1,373,138 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC101700701
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473513,701,382 - 13,708,750 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cyp11b2
177 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:162
Count of miRNA genes:156
Interacting mature miRNAs:160
Transcripts:ENSMUST00000167634
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141952W3q7_mweight 3 weeks QTL 7 (mouse)Not determined348969478601286Mouse
4142252Tailaq4_mtail length adjusted QTL 4 (mouse)Not determined348969478601286Mouse
4142448Tailq6_mtail length QTL 6 (mouse)Not determined348969478601286Mouse
1357559Scfq2_msubcutaneous fat pad weight QTL 2 (mouse)Not determined15348969478601286Mouse
1357659Epfpq4_mepididymal fat percentage QTL 4 (mouse)Not determined15348969478601286Mouse
27226786Feml11_mfemur length 11, 5 week (mouse)15612948175871849Mouse
27095932Ulnl11_mulna length 11, 16 week (mouse)15612948176384200Mouse
27226717Tibw4_mtibia width 4, proximal, 10 week (mouse)15612948178684200Mouse
27226734Tibmd5_mtibia midshaft diameter 5, 10 week (mouse)15612948186684201Mouse
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156129481100797881Mouse
27226721Tibw8_mtibia width 8, proximal, 16 week (mouse)15692948175871849Mouse
27226773Tibl16_mtibia length 16, 10 week (mouse)15692948175871849Mouse
27226777Tibl8_mtibia length 8, 5 week (mouse)15692948184584201Mouse
1301433Rapop5_mradiation-induced apoptosis 5 (mouse)Not determined15927302279474762Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402203102896555Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800146102008435Mouse
26884392Humsd8_mhumerus midshaft diameter 8, 16 week (mouse)152930014676084200Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578416103425899Mouse
27226729Tibmd2_mtibia midshaft diameter 2, 5 week (mouse)153800024486684201Mouse
26884402Cvht9_mcranial vault height 9, 16 week (mouse)154216339695497881Mouse
1357703Vtbt17_mvertebral trabecular bone trait 17 (mouse)Not determined154455331378553437Mouse
1301568Tria2_mT-cell receptor induced activation 2 (mouse)Not determined154485914178859281Mouse
1357756Alaa4_malopecia areata 4 (mouse)Not determined154638964680389845Mouse
10755515Amzn3_manatomical modifier of Zfp423 3 (mouse)154638964680389845Mouse
1301006Hfib1_mhepatic fibrogenesis 1 (mouse)Not determined154730633481306479Mouse
1301860Gct3_mgranulosa cell tumorigenesis 3 (mouse)Not determined154740959681409691Mouse
26884397Humsd5_mhumerus midshaft diameter 5, 10 week (mouse)154836339698397881Mouse
26884399Humsd1_mhumerus midshaft diameter 1, 5 week (mouse)1548363396101708435Mouse
1301429Pcir3_mperiosteal circumference 3 (mouse)Not determined154846536282465496Mouse
1301779Dpml_mdopamine loss (mouse)Not determined155100469476794493Mouse
4142198Hbtq_mhabituation QTL (mouse)Not determined155116070885160833Mouse
10045637Heal27_mwound healing/regeneration 29 (mouse)Not determined155141836185418511Mouse
10412067Pain2_mpain 2 (mouse)Not determined155164533985645626Mouse
1302080Szs13_mseizure susceptibility 13 (mouse)Not determined155168583285694449Mouse
1301708Cocrb14_mcocaine related behavior 14 (mouse)Not determined155180651585806651Mouse
38501067Tip3_mtuberculosis immunophenotype 3, IFN-g level (mouse)155356339689584203Mouse
13504731Cath5_mcarotid atherosclerosis 5 (mouse)155478912988789129Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556186708103425899Mouse
27095936Ulnl4_mulna length 4, 5 week (mouse)155676339687684201Mouse
1300800Ses3_msalmonella enteritidis susceptibility 3 (mouse)Not determined155711700591117153Mouse
1357407Pfat4_mpredicted fat percentage 4 (mouse)8.6Body fat amountpredicted fat percentage155711700591117153Mouse
12880420V25Dq8_mvitamin D inactive form serum level QTL 8 (mouse)156158420095584200Mouse
1301601Faq9_mfluctuating asymmetry QTL 9 (mouse)Not determined156316390397163995Mouse
1558786Msq1_mMAV-1 susceptibility QTL 1 (mouse)Not determined156338964681086436Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564306334103425899Mouse
4141135Cia35_mcollagen induced arthritis 35 (mouse)Not determined156481182698811946Mouse
1301119Drb7_mdopamine receptor binding 7 (mouse)Not determined156533657899341028Mouse
1301171Brm2_mbrachyury modifier 2 (mouse)Not determined156552537699525499Mouse
4141921Pstc3_mperiosteal circumference 3 (mouse)Not determined1567270698101270847Mouse
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570345653104073951Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570349271104073951Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570349271104073951Mouse
25671381Hrsq3_mhost response to SARS QTL 3, eosinophilia (mouse)157214453975844833Mouse
1300844Emo2_memotionality 2 (mouse)Not determined157237245976794493Mouse
1302002Cocia2_mcocaine induced activation 2 (mouse)Not determined157237245979899178Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572382669104073951Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573430144104073951Mouse
15092079Igly6_mIgG glycosylation 6, GP6 (mouse)157410054082674156Mouse
13442492Mecth2_mmechanosensation threshold 2 (mouse)157466284979387201Mouse

Markers in Region
Cyp11b2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15D3UniSTS
cM Map1544.9UniSTS
Cyp11b1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15D3UniSTS
cM Map1544.9UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000167634   ⟹   ENSMUSP00000131503
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1574,722,859 - 74,728,167 (-)Ensembl
GRCm38.p6 Ensembl1574,851,010 - 74,856,318 (-)Ensembl
RefSeq Acc Id: ENSMUST00000238900   ⟹   ENSMUSP00000158954
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1574,722,859 - 74,728,167 (-)Ensembl
GRCm38.p6 Ensembl1574,851,010 - 74,856,318 (-)Ensembl
RefSeq Acc Id: NM_009991   ⟹   NP_034121
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391574,722,467 - 74,728,080 (-)NCBI
GRCm381574,850,618 - 74,856,231 (-)NCBI
MGSCv371574,681,440 - 74,686,748 (-)RGD
Celera1576,357,529 - 76,362,843 (-)RGD
cM Map15 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_034121 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB21517 (Get FASTA)   NCBI Sequence Viewer  
  AAI16909 (Get FASTA)   NCBI Sequence Viewer  
  AAI19322 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000131503.2
  ENSMUSP00000158954
  ENSMUSP00000158954.2
GenBank Protein P15539 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_034121   ⟸   NM_009991
- UniProtKB: Q14AB5 (UniProtKB/Swiss-Prot),   P15539 (UniProtKB/Swiss-Prot),   Q64661 (UniProtKB/Swiss-Prot),   G3UWE4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000158954   ⟸   ENSMUST00000238900
RefSeq Acc Id: ENSMUSP00000131503   ⟸   ENSMUST00000167634

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15539-F1-model_v2 AlphaFold P15539 1-500 view protein structure

Promoters
RGD ID:8683980
Promoter ID:EPDNEW_M20021
Type:initiation region
Name:Cyp11b2_1
Description:Mus musculus cytochrome P450, family 11, subfamily b, polypeptide2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381574,856,229 - 74,856,289EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88584 AgrOrtholog
Ensembl Genes ENSMUSG00000022589 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000167634.2 UniProtKB/TrEMBL
  ENSMUST00000238900 ENTREZGENE
  ENSMUST00000238900.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_mitochondrial UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13072 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:88584 ENTREZGENE
NCBI Gene 13072 ENTREZGENE
PANTHER CYTOCHROME P450 11B2, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24279 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CYP11B2 RGD
PhenoGen Cyp11b2 PhenoGen
PRINTS MITP450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt C11B2_MOUSE UniProtKB/Swiss-Prot
  G3UWE4 ENTREZGENE, UniProtKB/TrEMBL
  P15539 ENTREZGENE
  Q14AB5 ENTREZGENE
  Q64661 ENTREZGENE
UniProt Secondary Q14AB5 UniProtKB/Swiss-Prot
  Q64661 UniProtKB/Swiss-Prot