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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10430
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp11b2
Name: cytochrome P450, family 11, subfamily b, polypeptide 2
Acc ID: CHEBI:81584
Term: 2,2',4,4'-Tetrabromodiphenyl ether
Definition: An organobromine compound that has formula C12H6Br4O.
Chemical ID: MESH:C511295
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp11b2increases expressionISOCyp11b3 (Rattus norvegicus)6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CYP11B3 mRNAPMID:27291303
Cyp11b2increases expressionISOCYP11B2 (Homo sapiens)6480464CTD2,2',4,4'-tetrabromodiphenyl ether metabolite results in increased expression of CYP11B2 mRNAPMID:18248924
Cyp11b2multiple interactionsISOCYP11B2 (Homo sapiens)6480464CTD[Tetrachlorodibenzodioxin co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with perfluorooctane sulfonic acid co-treated with hexabromocyclododecane co-treated with 2,2',4,4'-tetrabromodiphenyl ether co-treated with tributyltin co-treated with methylmercuric chloride] results in increased expression of CYP11B2 mRNAPMID:25765474
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