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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 11-deoxycorticosterone | affects metabolic processing | EXP | | 6480464 | CYP11B2 protein affects the metabolism of Desoxycorticosterone | CTD | PMID:15985365 | 11-deoxycortisol | affects metabolic processing | EXP | | 6480464 | CYP11B2 protein affects the metabolism of Cortodoxone | CTD | PMID:15743198 | 11-deoxycortisol | increases metabolic processing | EXP | | 6480464 | CYP11B2 protein results in increased metabolism of Cortodoxone | CTD | PMID:19900470 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:10430 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CYP11B2 mRNA | CTD | PMID:16962184 | 2,6-dibromophenol | decreases expression | EXP | | 6480464 | 2,6-dibromophenol results in decreased expression of CYP11B2 mRNA | CTD | PMID:17447562 | 3,3',4,4',5-pentachlorobiphenyl | increases expression | EXP | | 6480464 | 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP11B2 mRNA | CTD | PMID:14962509 more ... | 3,3',4,4',5-pentachlorobiphenyl | increases expression | EXP | | 6480464 | 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP11B2 mRNA | CTD | PMID:16216300 more ... | 3,3',4,4',5-pentachlorobiphenyl | increases activity | EXP | | 6480464 | 3,4,5,3',4'-pentachlorobiphenyl results in increased activity of CYP11B2 protein | CTD | PMID:14962509 PMID:15703266 | 3,3',4,4',5-pentachlorobiphenyl | multiple interactions | EXP | | 6480464 | 3',4'-dimethoxyflavone promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP11B2 mRNA] | CTD | PMID:16396990 | 3,3',4,4',5-pentachlorobiphenyl | increases expression | EXP | | 6480464 | 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP11B2 mRNA | CTD | PMID:16216300 more ... | 3,3',4,4',5-pentachlorobiphenyl | increases expression | EXP | | 6480464 | 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP11B2 mRNA | CTD | PMID:14962509 more ... | 3,3',4,4',5-pentachlorobiphenyl | increases expression | EXP | | 6480464 | 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP11B2 mRNA | CTD | PMID:15703266 more ... | 3,3',4,4',5-pentachlorobiphenyl | increases expression | EXP | | 6480464 | 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP11B2 mRNA | CTD | PMID:16396990 more ... | 3,3',4,4',5-pentachlorobiphenyl | increases activity | EXP | | 6480464 | 3,4,5,3',4'-pentachlorobiphenyl results in increased activity of CYP11B2 protein | CTD | PMID:15703266 PMID:14962509 | 3,3',4,4'-tetrachlorobiphenyl | increases expression | EXP | | 6480464 | 3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP11B2 mRNA | CTD | PMID:16396990 | 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol | decreases expression | EXP | | 6480464 | 1H,1H,2H,2H-perfluorodecanol results in decreased expression of CYP11B2 protein; more ... | CTD | PMID:20615422 | 8-bromo-3',5'-cyclic AMP | increases expression | EXP | | 6480464 | 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of CYP11B2 mRNA | CTD | PMID:22079614 | aldosterone | affects chemical synthesis | EXP | | 6480464 | CYP11B2 protein affects the chemical synthesis of Aldosterone | CTD | PMID:12525251 | aldosterone | increases chemical synthesis | EXP | | 6480464 | CYP11B2 protein results in increased chemical synthesis of Aldosterone | CTD | PMID:16054388 PMID:19900470 | aldosterone | affects chemical synthesis | ISO | RGD:2454 | 6480464 | CYP11B2 protein affects the chemical synthesis of Aldosterone | CTD | PMID:16043663 | aldosterone | affects chemical synthesis | ISO | RGD:10430 | 6480464 | CYP11B2 protein affects the chemical synthesis of Aldosterone | CTD | PMID:15731365 | aldosterone | increases chemical synthesis | EXP | | 6480464 | CYP11B2 protein results in increased chemical synthesis of Aldosterone | CTD | PMID:16054388 | aldosterone | increases chemical synthesis | EXP | | 6480464 | CYP11B2 protein polymorphism results in increased chemical synthesis of Aldosterone | CTD | PMID:12783697 | ammonium chloride | affects expression | ISO | RGD:2454 | 6480464 | Ammonium Chloride affects the expression of CYP11B2 mRNA | CTD | PMID:16483693 | amoxicillin | increases expression | EXP | | 6480464 | Amoxicillin results in increased expression of CYP11B2 | CTD | PMID:17822730 | benazepril | affects response to substance | EXP | | 6480464 | CYP11B2 gene polymorphism affects the susceptibility to benazepril | CTD | PMID:16765146 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of CYP11B2 mRNA | CTD | PMID:15808406 | candesartan | affects response to substance | EXP | | 6480464 | CYP11B2 protein polymorphism affects the susceptibility to candesartan | CTD | PMID:12065207 | candesartan | decreases expression | ISO | RGD:2454 | 6480464 | candesartan results in decreased expression of CYP11B2 mRNA | CTD | PMID:18796534 | carbamazepine | increases expression | EXP | | 6480464 | Carbamazepine results in increased expression of CYP11B2 mRNA | CTD | PMID:19566492 | cis-ketoconazole | decreases activity | EXP | | 6480464 | Ketoconazole results in decreased activity of CYP11B2 protein | CTD | PMID:15743198 | corticosterone | affects metabolic processing | EXP | | 6480464 | CYP11B2 protein affects the metabolism of Corticosterone | CTD | PMID:16054388 | D-glucose | decreases expression | ISO | RGD:2454 | 6480464 | Glucose results in decreased expression of CYP11B2 mRNA | CTD | PMID:15017115 | diisononyl phthalate | decreases expression | ISO | RGD:2454 | 6480464 | diisononyl phthalate results in decreased expression of CYP11B2 mRNA | CTD | PMID:22112501 | dimethyl sulfoxide | multiple interactions | ISO | RGD:2454 | 6480464 | Dimethyl Sulfoxide inhibits the reaction [adrenocorticotropin zinc results in decreased expression of CYP11B2 mRNA]; more ... | CTD | PMID:10822027 | dipentyl phthalate | decreases expression | ISO | RGD:2454 | 6480464 | di-n-pentyl phthalate results in decreased expression of CYP11B2 mRNA | CTD | PMID:22112501 | erythromycin A | increases expression | EXP | | 6480464 | Erythromycin results in increased expression of CYP11B2 | CTD | PMID:17822730 | gamma-hexachlorocyclohexane | multiple interactions | EXP | | 6480464 | Lindane inhibits the reaction [Forskolin results in increased expression of CYP11B2 mRNA] | CTD | PMID:17080404 | glucose | decreases expression | ISO | RGD:2454 | 6480464 | Glucose results in decreased expression of CYP11B2 mRNA | CTD | PMID:15017115 | glycyrrhizinic acid | decreases expression | ISO | RGD:2454 | 6480464 | Glycyrrhizic Acid results in decreased expression of CYP11B2 mRNA | CTD | PMID:11798659 PMID:10474021 | glycyrrhizinic acid | decreases expression | ISO | RGD:2454 | 6480464 | Glycyrrhizic Acid results in decreased expression of CYP11B2 mRNA | CTD | PMID:10474021 PMID:11798659 | irbesartan | increases response to substance | EXP | | 6480464 | CYP11B2 gene SNP results in increased susceptibility to irbesartan | CTD | PMID:12022239 | nitroglycerin | decreases expression | ISO | RGD:2454 | 6480464 | Nitroglycerin results in decreased expression of CYP11B2 mRNA | CTD | PMID:12102619 | perfluorooctanoic acid | multiple interactions | ISO | RGD:10430 | 6480464 | [perfluorooctanoic acid co-treated with PPARA] results in increased expression of CYP11B2 mRNA | CTD | PMID:20118188 | phenylephrine | increases expression | ISO | RGD:2454 | 6480464 | Phenylephrine results in increased expression of CYP11B2 mRNA | CTD | PMID:19966502 | phorbol 13-acetate 12-myristate | decreases expression | EXP | | 6480464 | Tetradecanoylphorbol Acetate results in decreased expression of CYP11B2 mRNA | CTD | PMID:15666830 | potassium atom | multiple interactions | EXP | | 6480464 | calmidazolium inhibits the reaction [Potassium results in increased expression of CYP11B2 mRNA]; more ... | CTD | PMID:12193581 | potassium atom | increases expression | EXP | | 6480464 | Potassium results in increased expression of CYP11B2 mRNA | CTD | PMID:9139807 PMID:12193581 | potassium atom | increases expression | ISO | RGD:2454 | 6480464 | Potassium results in increased expression of CYP11B2 mRNA | CTD | PMID:14642076 | potassium atom | increases expression | EXP | | 6480464 | Potassium results in increased expression of CYP11B2 mRNA | CTD | PMID:12193581 PMID:9139807 | potassium chloride | multiple interactions | EXP | | 6480464 | benidipine inhibits the reaction [Potassium Chloride results in increased expression of CYP11B2 mRNA] | CTD | PMID:18331727 | potassium chloride | increases expression | EXP | | 6480464 | Potassium Chloride results in increased expression of CYP11B2 mRNA | CTD | PMID:18331727 | sodium atom | affects response to substance | EXP | | 6480464 | CYP11B2 protein polymorphism affects the susceptibility to Sodium | CTD | PMID:12624609 | sodium chloride | increases activity | ISO | RGD:2454 | 6480464 | Sodium Chloride results in increased activity of CYP11B2 protein | CTD | PMID:15134804 | sodium chloride | increases expression | ISO | RGD:2454 | 6480464 | Sodium Chloride results in increased expression of CYP11B2 mRNA | CTD | PMID:15134804 | spironolactone | increases expression | ISO | RGD:2454 | 6480464 | Spironolactone results in increased expression of CYP11B2 mRNA | CTD | PMID:15218317 | streptozocin | increases expression | ISO | RGD:2454 | 6480464 | Streptozocin results in increased expression of CYP11B2 protein; more ... | CTD | PMID:16043663 | testosterone | increases chemical synthesis | EXP | | 6480464 | CYP11B2 protein polymorphism results in increased chemical synthesis of Testosterone | CTD | PMID:12783697 | tris(2-chloroethyl) phosphate | increases expression | EXP | | 6480464 | tris(chloroethyl)phosphate results in increased expression of CYP11B2 mRNA | CTD | PMID:22446829 | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of CYP11B2 mRNA | CTD | PMID:19566492 | valsartan | decreases expression | ISO | RGD:2454 | 6480464 | valsartan results in decreased expression of CYP11B2 mRNA; more ... | CTD | PMID:16043663 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Metabolic pathways |
| Steroid hormone biosynthesis | |
Phenotype AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| 24. |
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RGD automated import pipeline for gene-chemical interactions |
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RGD Automated Pipelines |
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RGD Disease Portals| CYP11B2 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| CYP11B2 (Homo sapiens) |
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| Cyp11b2 (Rattus norvegicus) |
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Position Markers| RH121974 |
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QTLs in Region (Human Genome Assembly GRCh37)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NG_008374 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_000498 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | ABBA01005284 | (Get FASTA) | Search GEO for Microarray Profiles |
| AC073385 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AMYH01019094 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH471162 | (Get FASTA) | Search GEO for Microarray Profiles | |
| D10170 | (Get FASTA) | Search GEO for Microarray Profiles | |
| D13752 | (Get FASTA) | Search GEO for Microarray Profiles | |
| EU326306 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M32881 | (Get FASTA) | Search GEO for Microarray Profiles | |
| S77397 | (Get FASTA) | Search GEO for Microarray Profiles | |
| S77409 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X54741 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_000498 | |||||||||||||||||||||||||
| RefSeq Status: | REVIEWED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_000489 | |||||||||||||||||||||||||
| Peptide Label: | precursor | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_000489 | (Get FASTA) |
| GenBank Protein | AAA35741 | (Get FASTA) |
| AAB34642 | (Get FASTA) | |
| AAB34643 | (Get FASTA) | |
| AAI11459 | (Get FASTA) | |
| ACA05912 | (Get FASTA) | |
| BAA01040 | (Get FASTA) | |
| BAA02899 | (Get FASTA) | |
| CAA38539 | (Get FASTA) | |
| EAW82292 | (Get FASTA) | |
| P19099 | (Get FASTA) |
External Database Links| Database | Acc Id | Source(s) |
| COSMIC | CYP11B2 | COSMIC |
| Ensembl Genes | ENSG00000179142 | ENTREZGENE |
| Ensembl Protein | ENSP00000325822 | ENTREZGENE |
| Ensembl Transcript | ENST00000323110 | ENTREZGENE |
| Entrez Gene | 1585 | ENTREZGENE |
| Gene3D-CATH | Cyt_P450 | UniProtKB/Swiss-Prot |
| Germonline | ENSG00000179142 | |
| HGNC ID | 2592 | ENTREZGENE |
| HomoloGene Group ID | 106948 | ENTREZGENE |
| HPRD ID | 00492 | ENTREZGENE |
| InterPro | Cyt_P450 | UniProtKB/Swiss-Prot |
| Cyt_P450_CS | UniProtKB/Swiss-Prot | |
| Cyt_P450_mitochondrial | UniProtKB/Swiss-Prot | |
| IPI | IPI00290116 | UniProtKB/Swiss-Prot |
| IPI01024713 | UniProtKB/TrEMBL | |
| KEGG Report | hsa:1585 | ENTREZGENE, UniProtKB/Swiss-Prot |
| OMIM | 124080 | OMIM |
| 203400 | OMIM | |
| 610600 | OMIM | |
| Pfam | p450 | UniProtKB/Swiss-Prot |
| PharmGKB | CYP11B2 | RGD, PharmGKB |
| PRINTS | MITP450 | UniProtKB/Swiss-Prot |
| P450 | UniProtKB/Swiss-Prot | |
| PROSITE | CYTOCHROME_P450 | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | Cytochrome_P450 | UniProtKB/Swiss-Prot |
| UniGene | Hs.632054 | ENTREZGENE |
| UniProt | C11B2_HUMAN | UniProtKB/Swiss-Prot |
| Q16316_HUMAN | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2011-08-16 | CYP11B2 | cytochrome P450, family 11, subfamily B, polypeptide 2 | CYP11B2 | cytochrome P450, family 11, subfamily B, polypeptide 2 | Symbol and/or name change | 39860 | APPROVED |
| More on CYP11B2 | |||
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Entrez Gene | ||
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Ensembl Gene | ||
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HGNC Report | ||
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NCBI Map Viewer | ||
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Vista | ||
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Vista + UCSC | ||
| RGD Object Information | |
| RGD ID: | 736494 |
| Created: | 2004-02-06 |
| Species: | Homo sapiens |
| Last Modified: | 2013-05-14 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.