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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:paracetamol drug pathway
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Accession:PW:0001524 term browser browse the term
Definition:The pharmacokinetics/pharmacodynamics of paracetamol, a widely used analgesic, known as acetaminophen (APAP). The analgesic effect is believed to be due to the inhibition of prostaglandins biosynthesis. Paracetamol overdose is associated with hepatic toxicity and a leading cause of liver failure. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.
Synonyms:exact_synonym: acetaminophen drug pathway
 related_synonym: SMP:00710
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paracetamol drug pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 ISO SMPDB SMP:00710 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type ISO SMPDB SMP:00710 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542 		JBrowse link
G Alox12b arachidonate 12-lipoxygenase, 12R type ISO SMPDB SMP:00710 NCBI chr10:53,863,060...53,874,938
Ensembl chr10:53,863,060...53,874,938 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase ISO SMPDB SMP:00710 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874 		JBrowse link
G Alox15b arachidonate 15-lipoxygenase, type B ISO SMPDB SMP:00710 NCBI chr10:53,892,496...53,901,812
Ensembl chr10:53,892,466...53,901,812 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO SMPDB SMP:00710 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Cbr1 carbonyl reductase 1 ISO SMPDB SMP:00710 NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 ISO SMPDB SMP:00710 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 ISO SMPDB SMP:00710
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 ISO SMPDB SMP:00710 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 ISO SMPDB SMP:00710 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794 		JBrowse link
G Cyp2u1 cytochrome P450, family 2, subfamily u, polypeptide 1 ISO SMPDB SMP:00710 NCBI chr 2:219,849,403...219,866,959
Ensembl chr 2:219,849,407...219,866,882 		JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 ISO SMPDB SMP:00710 NCBI chr16:17,763,543...17,804,944
Ensembl chr16:17,707,317...17,804,940 		JBrowse link
G Cyp4f6 cytochrome P450, family 4, subfamily f, polypeptide 6 ISO SMPDB SMP:00710 NCBI chr 7:12,030,276...12,058,020
Ensembl chr 7:12,030,301...12,057,782 		JBrowse link
G Ephx2 epoxide hydrolase 2 ISO SMPDB SMP:00710 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO SMPDB SMP:00710 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Gpx1 glutathione peroxidase 1 ISO SMPDB SMP:00710 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Lta4h leukotriene A4 hydrolase ISO SMPDB SMP:00710 NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600 		JBrowse link
G Ltc4s leukotriene C4 synthase ISO SMPDB SMP:00710 NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651 		JBrowse link
G Pla2g4b phospholipase A2 group IVB ISO SMPDB SMP:00710 NCBI chr 3:107,004,238...107,013,853
Ensembl chr 3:107,005,489...107,013,853 		JBrowse link
G Prxl2b peroxiredoxin like 2B ISO SMPDB SMP:00710 NCBI chr 5:165,462,610...165,465,213 JBrowse link
G Ptgds prostaglandin D2 synthase ISO SMPDB SMP:00710 NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833 		JBrowse link
G Ptges prostaglandin E synthase ISO SMPDB SMP:00710 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Ptgis prostaglandin I2 synthase ISO SMPDB SMP:00710 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO SMPDB
RGD		 PMID:23719833 SMP:00710, RGD:8552695 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO SMPDB
RGD		 PMID:23719833 SMP:00710, RGD:8552695 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Tbxas1 thromboxane A synthase 1 ISO SMPDB SMP:00710 NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096 		JBrowse link
paracetamol pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A ISO SMPDB SMP:00640 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 ISO SMPDB SMP:00640 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 TAS RGD PMID:23462933 RGD:8552693 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 TAS RGD PMID:23462933 RGD:8552693 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 TAS
ISO		 SMPDB
RGD		 PMID:23462933 SMP:00640, RGD:8552693 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 ISO SMPDB SMP:00640 NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 TAS
ISO		 SMPDB
RGD		 PMID:23462933 SMP:00640, RGD:8552693 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 ISO SMPDB SMP:00640 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 ISO SMPDB SMP:00640 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 ISO SMPDB
RGD		 PMID:23462933 SMP:00640, RGD:8552693 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 ISO SMPDB SMP:00640 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 ISO SMPDB SMP:00640 NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 ISO SMPDB SMP:00640 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO SMPDB SMP:00640 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 ISO SMPDB SMP:00640 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 ISO SMPDB SMP:00640 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 ISO SMPDB SMP:00640 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hyou1 hypoxia up-regulated 1 ISO SMPDB SMP:00640 NCBI chr 8:44,706,073...44,718,189
Ensembl chr 8:44,706,263...44,718,186 		JBrowse link
G Pdia2 protein disulfide isomerase family A, member 2 ISO SMPDB SMP:00640 NCBI chr10:15,215,824...15,218,937
Ensembl chr10:15,215,824...15,220,931 		JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 ISO SMPDB SMP:00640 NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107 		JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 ISO SMPDB SMP:00640 NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613 		JBrowse link
G Ppib peptidylprolyl isomerase B ISO SMPDB SMP:00640 NCBI chr 8:66,603,877...66,609,734
Ensembl chr 8:66,603,861...66,630,428 		JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 ISO SMPDB SMP:00640 NCBI chr11:83,872,659...83,874,902
Ensembl chr11:83,872,659...83,874,902 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 ISO SMPDB SMP:00640 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 ISO SMPDB
RGD		 PMID:23462933 SMP:00640, RGD:8552693 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 ISO SMPDB SMP:00640 NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 ISO SMPDB
RGD		 PMID:23462933 SMP:00640, RGD:8552693 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 ISO SMPDB
RGD		 PMID:23462933 SMP:00640, RGD:8552693 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 ISO SMPDB SMP:00640 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    drug pathway 397
      nervous system drug pathway 183
        analgesic and/or antipyretic drug pathway 97
          paracetamol drug pathway 55
            paracetamol pharmacokinetics pathway 29
paths to the root