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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:folate metabolic pathway
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Accession:PW:0000140 term browser browse the term
Definition:Folate metabolism represents the various aspects of the folate cycle and the folate-mediated transfer reactions essential for several biosynthetic pathways. The folate cycle and the folate-mediated one-carbon pathways are part of folate metabolism. Folate compounds are water-soluble forms of vitamin B9.
Synonyms:related_synonym: folic acid metabolic process;   vitamin B9 metabolic pathway


show annotations for term's descendants           Sort by:
folate metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akp3 alkaline phosphatase 3, intestine, not Mn requiring IEA KEGG rno:00790 NCBI chr 9:87,804,680...87,808,715
Ensembl chr 9:87,804,749...87,807,913 		JBrowse link
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 TAS
ISO		 SMPDB
RGD		 PMID:14729668 SMP:00053, RGD:1547843 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465 		JBrowse link
G Alpi alkaline phosphatase, intestinal IEA KEGG rno:00790 NCBI chr 9:87,773,411...87,776,877
Ensembl chr 9:87,773,411...87,776,877 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated IEA KEGG rno:00790 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Dhfr dihydrofolate reductase IDA
ISO
IEA		 SMPDB
KEGG
RGD		 PMID:11502523 SMP:00053 rno:00790, RGD:1298877 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Dmgdh dimethylglycine dehydrogenase TAS RGD PMID:15358367 RGD:1547831 NCBI chr 2:24,912,600...24,987,533
Ensembl chr 2:24,912,578...24,987,528 		JBrowse link
G Folh1 folate hydrolase 1 ISO RGD PMID:9816319 RGD:151347637 NCBI chr 1:140,428,101...140,501,563
Ensembl chr 1:140,428,101...140,501,379 		JBrowse link
G Folr2 folate receptor beta ISO RGD PMID:8445646 RGD:1540379 NCBI chr 1:156,200,044...156,218,380
Ensembl chr 1:156,200,060...156,205,724 		JBrowse link
G Fpgs folylpolyglutamate synthase IEA
ISO		 KEGG
SMPDB		 SMP:00053 rno:00790 NCBI chr 3:15,972,800...15,993,592
Ensembl chr 3:15,972,800...15,993,563 		JBrowse link
G Ftcd formimidoyltransferase cyclodeaminase ISO SMPDB SMP:00053 NCBI chr20:12,055,203...12,068,717
Ensembl chr20:12,055,208...12,068,735 		JBrowse link
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase ISO RGD PMID:12450384 RGD:1547842 NCBI chr11:30,864,896...30,891,125
Ensembl chr11:30,865,889...30,891,125 		JBrowse link
G Gch1 GTP cyclohydrolase 1 IEA KEGG rno:00790 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Ggh gamma-glutamyl hydrolase IEA
ISO		 KEGG
SMPDB		 SMP:00053 rno:00790 NCBI chr 5:33,529,880...33,552,790
Ensembl chr 5:33,529,880...33,552,787 		JBrowse link
G Gnmt glycine N-methyltransferase TAS RGD PMID:15347642 RGD:1359070 NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434 		JBrowse link
G Mocs1 molybdenum cofactor synthesis 1 IEA KEGG rno:00790 NCBI chr 9:11,547,533...11,573,935
Ensembl chr 9:11,547,531...11,567,790 		JBrowse link
G Mocs2 molybdenum cofactor synthesis 2 IEA KEGG rno:00790 NCBI chr 2:46,504,588...46,516,327
Ensembl chr 2:46,504,588...46,516,324 		JBrowse link
G Mtfmt mitochondrial methionyl-tRNA formyltransferase ISO SMPDB SMP:00053 NCBI chr 8:65,953,787...65,971,841
Ensembl chr 8:65,953,767...65,971,841 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 TAS
ISO		 SMPDB
RGD		 PMID:2186031 SMP:00053, RGD:1299513 NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372 		JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like ISO SMPDB SMP:00053 NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase ISO SMPDB
RGD		 PMID:9454603 SMP:00053, RGD:1540378 NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO SMPDB
RGD		 PMID:11933257 SMP:00053, RGD:1535021 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Mthfs methenyltetrahydrofolate synthetase ISO SMPDB SMP:00053 NCBI chr 8:89,729,498...89,801,998
Ensembl chr 8:89,729,508...89,799,089 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase IDA RGD PMID:15845641 RGD:1359026 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:15979034 RGD:1359037 NCBI chr 1:34,866,991...34,899,425
Ensembl chr 1:34,867,089...34,899,425 		JBrowse link
G Pts 6-pyruvoyl-tetrahydropterin synthase IEA KEGG rno:00790 NCBI chr 8:50,870,838...50,877,869
Ensembl chr 8:50,870,841...50,877,869 		JBrowse link
G Qdpr quinoid dihydropteridine reductase IEA KEGG rno:00790 NCBI chr14:65,670,251...65,683,853
Ensembl chr14:65,670,131...65,683,854 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 TAS RGD PMID:15671219 RGD:1359815 NCBI chr10:45,468,698...45,490,833
Ensembl chr10:45,468,700...45,497,820 		JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 TAS RGD PMID:15671219 RGD:1359815 NCBI chr 7:63,358,961...63,364,293
Ensembl chr 7:63,358,961...63,364,236 		JBrowse link
G Slc19a1 solute carrier family 19 member 1 TAS RGD PMID:11600421 RGD:735239 NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972 		JBrowse link
G Slc46a1 solute carrier family 46 member 1 ISO SMPDB SMP:00053 NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848 		JBrowse link
G Spr sepiapterin reductase IEA KEGG rno:00790 NCBI chr 4:117,671,948...117,676,292
Ensembl chr 4:117,671,949...117,675,678 		JBrowse link
G Tyms thymidylate synthetase IDA RGD PMID:9894005 RGD:1545055 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
altered folate cycle metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 ISO RGD PMID:22353665 RGD:7242562 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465 		JBrowse link
G Dhfr dihydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Folr1 folate receptor alpha ISO RGD PMID:22108709 RGD:7242557 NCBI chr 1:156,219,460...156,238,436
Ensembl chr 1:156,219,460...156,230,667 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:22108709 PMID:22108709 RGD:7242557, RGD:7242557 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 1:34,866,991...34,899,425
Ensembl chr 1:34,867,089...34,899,425 		JBrowse link
G Slc46a1 solute carrier family 46 member 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848 		JBrowse link
altered folate mediated one-carbon metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO RGD PMID:22353665 RGD:7242562 NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO RGD PMID:22353665 RGD:7242562 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:22353665 RGD:7242562 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822 		JBrowse link
folate cycle metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 ISO RGD PMID:22353665 RGD:7242562 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465 		JBrowse link
G Amt aminomethyltransferase ISO RGD PMID:20645850 RGD:7242560 NCBI chr 8:108,981,620...108,988,127
Ensembl chr 8:108,976,472...108,988,126 		JBrowse link
G Dhfr dihydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Dld dihydrolipoamide dehydrogenase ISO RGD PMID:20645850 RGD:7242560 NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795 		JBrowse link
G Dmgdh dimethylglycine dehydrogenase ISO RGD PMID:20645850 RGD:7242560 NCBI chr 2:24,912,600...24,987,533
Ensembl chr 2:24,912,578...24,987,528 		JBrowse link
G Folh1 folate hydrolase 1 ISO RGD PMID:20814827 PMID:16859665 RGD:7242426, RGD:7242559 NCBI chr 1:140,428,101...140,501,563
Ensembl chr 1:140,428,101...140,501,379 		JBrowse link
G Folr1 folate receptor alpha ISO RGD PMID:22108709 RGD:7242557 NCBI chr 1:156,219,460...156,238,436
Ensembl chr 1:156,219,460...156,230,667 		JBrowse link
G Folr2 folate receptor beta ISO RGD PMID:22108709 RGD:7242557 NCBI chr 1:156,200,044...156,218,380
Ensembl chr 1:156,200,060...156,205,724 		JBrowse link
G Fpgs folylpolyglutamate synthase ISO RGD PMID:16859665 RGD:7242559 NCBI chr 3:15,972,800...15,993,592
Ensembl chr 3:15,972,800...15,993,563 		JBrowse link
G Gcsh glycine cleavage system protein H ISO RGD PMID:20645850 RGD:7242560 NCBI chr19:45,036,013...45,046,770
Ensembl chr19:45,036,011...45,046,792 		JBrowse link
G Ggh gamma-glutamyl hydrolase TAS RGD PMID:16859665 RGD:7242559 NCBI chr 5:33,529,880...33,552,790
Ensembl chr 5:33,529,880...33,552,787 		JBrowse link
G Gldc glycine decarboxylase ISO RGD PMID:20645850 RGD:7242560 NCBI chr 1:227,883,249...227,962,119
Ensembl chr 1:227,883,249...227,962,097 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372 		JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like ISO RGD PMID:22108709 RGD:7242557 NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase ISO RGD PMID:20645850 PMID:22108709 RGD:7242560, RGD:7242557 NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608 		JBrowse link
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like ISO RGD PMID:22108709 RGD:7242557 NCBI chr14:17,089,947...17,170,036
Ensembl chr14:17,089,952...17,170,112 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:22108709 RGD:7242557 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:22108709 RGD:7242557 NCBI chr 1:34,866,991...34,899,425
Ensembl chr 1:34,867,089...34,899,425 		JBrowse link
G Sardh sarcosine dehydrogenase ISO RGD PMID:20645850 RGD:7242560 NCBI chr 3:10,510,553...10,575,342
Ensembl chr 3:10,510,553...10,573,874 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 ISO RGD PMID:22108709 RGD:7242557 NCBI chr10:45,468,698...45,490,833
Ensembl chr10:45,468,700...45,497,820 		JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 ISO RGD PMID:20645850 PMID:22108709 RGD:7242560, RGD:7242557 NCBI chr 7:63,358,961...63,364,293
Ensembl chr 7:63,358,961...63,364,236 		JBrowse link
G Slc19a1 solute carrier family 19 member 1 ISO RGD PMID:22108709 PMID:20814827 RGD:7242557, RGD:7242426 NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972 		JBrowse link
G Slc25a32 solute carrier family 25 member 32 ISO RGD PMID:22332074 RGD:7242561 NCBI chr 7:70,142,958...70,160,726
Ensembl chr 7:70,142,964...70,160,770 		JBrowse link
G Slc46a1 solute carrier family 46 member 1 ISO RGD PMID:22108709 PMID:20814827 RGD:7242557, RGD:7242426 NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848 		JBrowse link
folate mediated one-carbon metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 IEA
TAS		 KEGG
RGD		 PMID:14729668 rno:00670, RGD:1547843 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465 		JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 IEA KEGG rno:00670 NCBI chr 7:20,254,246...20,305,793
Ensembl chr 7:20,254,233...20,305,776 		JBrowse link
G Amt aminomethyltransferase IEA KEGG rno:00670 NCBI chr 8:108,981,620...108,988,127
Ensembl chr 8:108,976,472...108,988,126 		JBrowse link
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase IEA
ISO
IDA		 KEGG
RGD		 PMID:22332074 PMID:9332377 rno:00670, RGD:7242561, RGD:70804 NCBI chr 9:73,164,846...73,184,897
Ensembl chr 9:73,164,846...73,184,889 		JBrowse link
G Dhfr dihydrofolate reductase IDA
ISO
IEA		 KEGG
RGD		 PMID:11502523 PMID:22332074 rno:00670, RGD:1298877, RGD:7242561 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Dmgdh dimethylglycine dehydrogenase TAS RGD PMID:15358367 RGD:1547831 NCBI chr 2:24,912,600...24,987,533
Ensembl chr 2:24,912,578...24,987,528 		JBrowse link
G Folh1 folate hydrolase 1 TAS RGD PMID:9501243 RGD:728645 NCBI chr 1:140,428,101...140,501,563
Ensembl chr 1:140,428,101...140,501,379 		JBrowse link
G Ftcd formimidoyltransferase cyclodeaminase IEA KEGG rno:00670 NCBI chr20:12,055,203...12,068,717
Ensembl chr20:12,055,208...12,068,735 		JBrowse link
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase ISO
IEA		 KEGG
RGD		 PMID:12450384 PMID:22332074 rno:00670, RGD:1547842, RGD:7242561 NCBI chr11:30,864,896...30,891,125
Ensembl chr11:30,865,889...30,891,125 		JBrowse link
G Gnmt glycine N-methyltransferase TAS RGD PMID:8278367 RGD:1545057 NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434 		JBrowse link
G Mtfmt mitochondrial methionyl-tRNA formyltransferase IEA KEGG rno:00670 NCBI chr 8:65,953,787...65,971,841
Ensembl chr 8:65,953,767...65,971,841 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 IEA
ISO
TAS		 KEGG
RGD		 PMID:22332074 PMID:2186031 rno:00670, RGD:7242561, RGD:1299513 NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372 		JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like IEA KEGG rno:00670 NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase ISO
IEA		 KEGG
RGD		 PMID:9454603 rno:00670, RGD:1540378 NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608 		JBrowse link
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like IEA KEGG rno:00670 NCBI chr14:17,089,947...17,170,036
Ensembl chr14:17,089,952...17,170,112 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO
IEA		 KEGG
RGD		 PMID:11933257 PMID:22332074 rno:00670, RGD:1535021, RGD:7242561 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Mthfs methenyltetrahydrofolate synthetase IEA KEGG rno:00670 NCBI chr 8:89,729,498...89,801,998
Ensembl chr 8:89,729,508...89,799,089 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase IEA
ISO
IDA		 KEGG
RGD		 PMID:20814827 PMID:15845641 rno:00670, RGD:7242426, RGD:1359026 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:20814827 RGD:7242426 NCBI chr 1:34,866,991...34,899,425
Ensembl chr 1:34,867,089...34,899,425 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 TAS
ISO
IEA
IDA		 KEGG
RGD		 PMID:15671219 PMID:22332074 PMID:3110140 rno:00670, RGD:1359815, RGD:7242561, RGD:2300383 NCBI chr10:45,468,698...45,490,833
Ensembl chr10:45,468,700...45,497,820 		JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 TAS
ISO
IEA
IDA		 KEGG
RGD		 PMID:15671219 PMID:22332074 PMID:3110140 rno:00670, RGD:1359815, RGD:7242561, RGD:2300383 NCBI chr 7:63,358,961...63,364,293
Ensembl chr 7:63,358,961...63,364,236 		JBrowse link
G Tyms thymidylate synthetase IEA
ISO
IDA		 KEGG
RGD		 PMID:22332074 PMID:9894005 rno:00670, RGD:7242561, RGD:1545055 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    classic metabolic pathway 1854
      metabolic pathway of cofactors, vitamins, nutrients 367
        folate metabolic pathway 42
          altered folate metabolic pathway + 8
          folate cycle metabolic pathway + 25
          folate mediated one-carbon metabolic pathway + 22
Path 2
Term Annotations click to browse term
  pathway 6091
    regulatory pathway 3867
      homeostasis pathway 1773
        organic chemical homeostasis pathway 438
          S-adenosylmethionine homeostasis pathway 289
            folate metabolic pathway 42
              altered folate metabolic pathway + 8
              folate cycle metabolic pathway + 25
              folate mediated one-carbon metabolic pathway + 22
paths to the root