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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:folate mediated one-carbon metabolic pathway
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Accession:PW:0000189 term browser browse the term
Definition:Folate mediated one-carbon metabolism represents the one-carbon transfer reactions important for de novo purine and thymidylate biosynthesis and for the remethylation of methionine in the methionine cycle and homocysteine metabolism. The methionine cycle also produces the major methyl donor for proteins, nucleic acids, lipids and other small molecules. The folate mediated one-carbon transfer and the folate cycle pathways are part of folate metabolism.
Synonyms:related_synonym: KEGG:00670
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folate mediated one-carbon metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 IEA
TAS		 KEGG
RGD		 PMID:14729668 rno:00670, RGD:1547843 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465 		JBrowse link
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 IEA KEGG rno:00670 NCBI chr 7:20,254,246...20,305,793
Ensembl chr 7:20,254,233...20,305,776 		JBrowse link
G Amt aminomethyltransferase IEA KEGG rno:00670 NCBI chr 8:108,981,620...108,988,127
Ensembl chr 8:108,976,472...108,988,126 		JBrowse link
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase IEA
IDA
ISO		 KEGG
RGD		 PMID:9332377 PMID:22332074 rno:00670, RGD:70804, RGD:7242561 NCBI chr 9:73,164,846...73,184,897
Ensembl chr 9:73,164,846...73,184,889 		JBrowse link
G Dhfr dihydrofolate reductase IDA
IEA
ISO		 KEGG
RGD		 PMID:11502523 PMID:22332074 rno:00670, RGD:1298877, RGD:7242561 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Dmgdh dimethylglycine dehydrogenase TAS RGD PMID:15358367 RGD:1547831 NCBI chr 2:24,912,600...24,987,533
Ensembl chr 2:24,912,578...24,987,528 		JBrowse link
G Folh1 folate hydrolase 1 TAS RGD PMID:9501243 RGD:728645 NCBI chr 1:140,428,101...140,501,563
Ensembl chr 1:140,428,101...140,501,379 		JBrowse link
G Ftcd formimidoyltransferase cyclodeaminase IEA KEGG rno:00670 NCBI chr20:12,055,203...12,068,717
Ensembl chr20:12,055,208...12,068,735 		JBrowse link
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase ISO
IEA		 KEGG
RGD		 PMID:12450384 PMID:22332074 rno:00670, RGD:1547842, RGD:7242561 NCBI chr11:30,864,896...30,891,125
Ensembl chr11:30,865,889...30,891,125 		JBrowse link
G Gnmt glycine N-methyltransferase TAS RGD PMID:8278367 RGD:1545057 NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434 		JBrowse link
G Mtfmt mitochondrial methionyl-tRNA formyltransferase IEA KEGG rno:00670 NCBI chr 8:65,953,787...65,971,841
Ensembl chr 8:65,953,767...65,971,841 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 IEA
ISO
TAS		 KEGG
RGD		 PMID:22332074 PMID:2186031 rno:00670, RGD:7242561, RGD:1299513 NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372 		JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like IEA KEGG rno:00670 NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase ISO
IEA		 KEGG
RGD		 PMID:9454603 rno:00670, RGD:1540378 NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608 		JBrowse link
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like IEA KEGG rno:00670 NCBI chr14:17,089,947...17,170,036
Ensembl chr14:17,089,952...17,170,112 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO
IEA		 KEGG
RGD		 PMID:11933257 PMID:22332074 rno:00670, RGD:1535021, RGD:7242561 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Mthfs methenyltetrahydrofolate synthetase IEA KEGG rno:00670 NCBI chr 8:89,729,498...89,801,998
Ensembl chr 8:89,729,508...89,799,089 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase IEA
ISO
IDA		 KEGG
RGD		 PMID:20814827 PMID:15845641 rno:00670, RGD:7242426, RGD:1359026 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO RGD PMID:20814827 RGD:7242426 NCBI chr 1:34,866,991...34,899,425
Ensembl chr 1:34,867,089...34,899,425 		JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 TAS
ISO
IEA
IDA		 KEGG
RGD		 PMID:15671219 PMID:22332074 PMID:3110140 rno:00670, RGD:1359815, RGD:7242561, RGD:2300383 NCBI chr10:45,468,698...45,490,833
Ensembl chr10:45,468,700...45,497,820 		JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 TAS
ISO
IEA
IDA		 KEGG
RGD		 PMID:15671219 PMID:22332074 PMID:3110140 rno:00670, RGD:1359815, RGD:7242561, RGD:2300383 NCBI chr 7:63,358,961...63,364,293
Ensembl chr 7:63,358,961...63,364,236 		JBrowse link
G Tyms thymidylate synthetase IEA
IDA
ISO		 KEGG
RGD		 PMID:9894005 PMID:22332074 rno:00670, RGD:1545055, RGD:7242561 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
altered folate mediated one-carbon metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO RGD PMID:22353665 RGD:7242562 NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO RGD PMID:22353665 RGD:7242562 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:22353665 RGD:7242562 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    classic metabolic pathway 1854
      metabolic pathway of cofactors, vitamins, nutrients 367
        folate metabolic pathway 42
          folate mediated one-carbon metabolic pathway 22
            altered folate mediated one-carbon metabolic pathway 3
Path 2
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3871
      homeostasis pathway 1773
        organic chemical homeostasis pathway 438
          S-adenosylmethionine homeostasis pathway 289
            folate metabolic pathway 42
              folate mediated one-carbon metabolic pathway 22
                altered folate mediated one-carbon metabolic pathway 3
paths to the root