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ONTOLOGY REPORT - ANNOTATIONS

Term:phosphatidylethanolamine metabolic process
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Accession:GO:0046337 term browser browse the term
Definition:The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes.
Synonyms:exact_synonym: phosphatidylethanolamine metabolism


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phosphatidylethanolamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipc lipase C, hepatic type IDA RGD PMID:2223857 RGD:1600650 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464 		JBrowse link
G Lpin1 lipin 1 involved_in ISO (PMID:23426360), (PMID:31695197) RGD PMID:23426360 PMID:31695197 NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097 		JBrowse link
G Pla2g10 phospholipase A2, group X involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:2446974|PMID:12359733), (MGI:4947921|PMID:21266583)
(PMID:12359733)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:12359733 PMID:21266583 GO_REF:0000024 GO_REF:0000107 MGI:2446974 MGI:4947921 NCBI chr10:1,597,761...1,610,822
Ensembl chr10:1,597,761...1,609,000 		JBrowse link
G Pla2g2a phospholipase A2 group IIA involved_in ISS
ISO		 GO_REF:0000024
(PMID:25082876)		 UniProt
RGD		 PMID:25082876 GO_REF:0000024 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014 		JBrowse link
G Pla2g2d phospholipase A2, group IID involved_in ISO (MGI:5510633|PMID:23690440) RGD PMID:23690440 MGI:5510633 NCBI chr 5:151,016,010...151,022,531
Ensembl chr 5:151,018,870...151,022,525 		JBrowse link
G Pla2g3 phospholipase A2, group III involved_in ISO (PMID:28947740) RGD PMID:28947740 NCBI chr14:78,367,625...78,373,913
Ensembl chr14:78,368,105...78,373,913 		JBrowse link
N-acylphosphatidylethanolamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd4 abhydrolase domain containing 4, N-acyl phospholipase B involved_in ISO (MGI:6316590|PMID:25853435) RGD PMID:25853435 MGI:6316590 NCBI chr15:27,697,384...27,716,013
Ensembl chr15:27,704,113...27,716,966 		JBrowse link
G Naaa N-acylethanolamine acid amidase involved_in ISS
ISO		 GO_REF:0000024
(PMID:22825852)		 UniProt
RGD		 PMID:22825852 GO_REF:0000024 NCBI chr14:15,777,306...15,796,411
Ensembl chr14:15,777,306...15,796,410 		JBrowse link
G Napepld N-acyl phosphatidylethanolamine phospholipase D involved_in ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000107
(MGI:3623664|PMID:16605240), (MGI:3696625|PMID:15760304), (MGI:5641800|PMID:25757720)
(PMID:25684574)		 UniProt
GO_Central
Ensembl
RGD		 PMID:15760304 PMID:16605240 PMID:25684574 PMID:25757720 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 MGI:3623664 MGI:3696625 MGI:5641800 NCBI chr 4:13,360,532...13,398,815
Ensembl chr 4:13,361,006...13,398,748 		JBrowse link
G Pla2g4e phospholipase A2, group IVE involved_in ISO (PMID:29447909)
(MGI:6161105|PMID:29447909), (MGI:6414734|PMID:27399000)		 RGD PMID:27399000 PMID:29447909 MGI:6161105 MGI:6414734 NCBI chr 3:107,132,540...107,198,609
Ensembl chr 3:107,132,541...107,198,233 		JBrowse link
G Plaat1 phospholipase A and acyltransferase 1 involved_in ISO
IBA		 (PMID:22825852), (PMID:27623847)
GO_REF:0000033		 RGD
GO_Central		 PMID:22825852 PMID:27623847 GO_REF:0000033 NCBI chr11:71,517,492...71,537,142
Ensembl chr11:71,517,493...71,527,020 		JBrowse link
G Plaat3 phospholipase A and acyltransferase 3 involved_in ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000107
(PMID:22825852)		 UniProt
GO_Central
Ensembl
RGD		 PMID:22825852 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:204,782,608...204,816,397
Ensembl chr 1:204,782,729...204,817,667 		JBrowse link
G Plaat5 phospholipase A and acyltransferase 5 involved_in
acts_upstream_of_or_within		 ISO
IBA
IEA
IDA		 (PMID:22825852)
(PMID:19000777)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:19000777 PMID:22825852 PMID:19000777 GO_REF:0000033 GO_REF:0000107, RGD:10400866 NCBI chr 1:204,847,600...204,878,456
Ensembl chr 1:204,847,600...204,878,184 		JBrowse link
phosphatidylethanolamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox15 arachidonate 15-lipoxygenase involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:5436199|PMID:22503541)		 UniProt
Ensembl
RGD		 PMID:22503541 GO_REF:0000024 GO_REF:0000107 MGI:5436199 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874 		JBrowse link
G Cept1 choline/ethanolamine phosphotransferase 1 involved_in IEA
IBA		 GO_REF:0000041
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000041 NCBI chr 2:193,994,220...194,036,141
Ensembl chr 2:193,993,447...194,035,578 		JBrowse link
G Chka choline kinase alpha involved_in ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000107
(PMID:19915674)
GO_REF:0000041		 UniProt
GO_Central
Ensembl
RGD		 PMID:19915674 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107 NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516 		JBrowse link
G Chkb choline kinase beta involved_in ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000041
(PMID:19915674)		 UniProt
GO_Central
RGD		 PMID:19915674 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 NCBI chr 7:120,500,960...120,504,359
Ensembl chr 7:120,500,984...120,504,461 		JBrowse link
G Etnk1 ethanolamine kinase 1 involved_in ISO
IBA		 (PMID:11044454)
GO_REF:0000033		 RGD
GO_Central		 PMID:11044454 GO_REF:0000033 NCBI chr 4:176,126,056...176,170,325
Ensembl chr 4:176,126,180...176,193,770 		JBrowse link
G Etnk2 ethanolamine kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000041
MGI:3526407 (PMID:16861741)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:16861741 GO_REF:0000033 GO_REF:0000041 NCBI chr13:44,811,012...44,829,052
Ensembl chr13:44,811,015...44,829,037 		JBrowse link
G Pcyt2 phosphate cytidylyltransferase 2, ethanolamine involved_in TAS
IBA
ISO
IEA
ISS		 GO_REF:0000033
(MGI:3709941|PMID:17325045)
GO_REF:0000041
GO_REF:0000024
(PMID:31637422)		 GO_Central
RGD
UniProt		 PMID:17325045 PMID:31637422 PMID:10493918 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 MGI:3709941, RGD:633525 NCBI chr10:105,888,769...105,896,182
Ensembl chr10:105,888,775...105,896,172 		JBrowse link
G Pisd phosphatidylserine decarboxylase involved_in ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000041
(PMID:30488656), (PMID:30858161)		 UniProt
GO_Central
RGD		 PMID:30488656 PMID:30858161 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 NCBI chr14:77,941,927...77,991,021
Ensembl chr14:77,941,948...77,991,003 		JBrowse link
G Selenoi selenoprotein I involved_in ISO
IBA		 (PMID:17132865), (PMID:28052917), (PMID:29500230)
GO_REF:0000033		 RGD
GO_Central		 PMID:17132865 PMID:28052917 PMID:29500230 GO_REF:0000033 NCBI chr 6:26,073,127...26,111,326
Ensembl chr 6:26,072,648...26,111,314 		JBrowse link
G Slc27a1 solute carrier family 27 member 1 involved_in ISO
IEA		 (PMID:19523918)
GO_REF:0000107		 RGD
Ensembl		 PMID:19523918 GO_REF:0000107 NCBI chr16:18,278,984...18,300,173
Ensembl chr16:18,278,984...18,296,063 		JBrowse link
phosphatidylethanolamine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pla2g15 phospholipase A2, group XV involved_in ISS
ISO		 GO_REF:0000024
(MGI:3654404|PMID:16880524), (MGI:3694368|PMID:16837646)		 UniProt
RGD		 PMID:16837646 PMID:16880524 GO_REF:0000024 MGI:3654404 MGI:3694368 NCBI chr19:34,050,685...34,068,070
Ensembl chr19:34,050,694...34,068,063 		JBrowse link
G Pla2g6 phospholipase A2 group VI involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 7:110,851,378...110,891,557
Ensembl chr 7:110,851,378...110,891,114 		JBrowse link
G Plb1 phospholipase B1 involved_in IDA PMID:9442064 UniProt PMID:9442064 RGD:30309923 NCBI chr 6:24,087,051...24,227,167
Ensembl chr 6:24,089,214...24,210,117 		JBrowse link
G Pnpla8 patatin-like phospholipase domain containing 8 involved_in ISO (PMID:15695510) RGD PMID:15695510 NCBI chr 6:61,329,810...61,391,736
Ensembl chr 6:61,329,810...61,391,734 		JBrowse link
regulation of phosphatidylethanolamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mfsd2a MFSD2 lysolipid transporter A, lysophospholipid acts_upstream_of ISO (MGI:6196220|PMID:30074985) RGD PMID:30074985 MGI:6196220 NCBI chr 5:135,225,801...135,240,744
Ensembl chr 5:135,225,816...135,240,690 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19694
    metabolic process 11456
      cellular metabolic process 9553
        cellular lipid metabolic process 1074
          glycerolipid metabolic process 393
            glycerophospholipid metabolic process 287
              phosphatidylethanolamine metabolic process 28
                N-acylphosphatidylethanolamine metabolic process 7
                negative regulation of phosphatidylethanolamine metabolic process 0
                phosphatidyl-N-monomethylethanolamine metabolic process + 0
                phosphatidylethanolamine biosynthetic process + 10
                phosphatidylethanolamine catabolic process 4
                positive regulation of phosphatidylethanolamine metabolic process 0
                regulation of phosphatidylethanolamine metabolic process + 1
Path 2
Term Annotations click to browse term
  biological_process 19694
    metabolic process 11456
      cellular metabolic process 9553
        phosphorus metabolic process 1877
          phosphate-containing compound metabolic process 1845
            phospholipid metabolic process 382
              glycerophospholipid metabolic process 287
                phosphatidylethanolamine metabolic process 28
                  N-acylphosphatidylethanolamine metabolic process 7
                  negative regulation of phosphatidylethanolamine metabolic process 0
                  phosphatidyl-N-monomethylethanolamine metabolic process + 0
                  phosphatidylethanolamine biosynthetic process + 10
                  phosphatidylethanolamine catabolic process 4
                  positive regulation of phosphatidylethanolamine metabolic process 0
                  regulation of phosphatidylethanolamine metabolic process + 1
paths to the root