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ONTOLOGY REPORT - ANNOTATIONS

Term:chemokine activity
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Accession:GO:0008009 term browser browse the term
Definition:The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.


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chemokine activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL1 C-C motif chemokine ligand 1 enables IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr17:22,425,022...22,430,243
Ensembl chr17:22,719,425...22,722,341 		JBrowse link
G CCL13 C-C motif chemokine ligand 13 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr17:22,430,633...22,432,893
Ensembl chr17:22,723,888...22,726,381 		JBrowse link
G CCL14 C-C motif chemokine ligand 14 enables IEA InterPro GO_REF:0000002 NCBI chr17:20,809,234...20,812,370
Ensembl chr17:21,104,695...21,107,844 		JBrowse link
G CCL15 C-C motif chemokine ligand 15 enables IEA InterPro GO_REF:0000002 NCBI chr17:20,793,702...20,809,383
Ensembl chr17:21,089,791...21,095,047 		JBrowse link
G CCL16 C-C motif chemokine ligand 16 enables IEA InterPro GO_REF:0000002 NCBI chr17:20,814,498...20,818,756
Ensembl chr17:21,109,973...21,114,054 		JBrowse link
G CCL17 C-C motif chemokine ligand 17 enables IEA InterPro GO_REF:0000002 NCBI chr16:37,678,518...37,689,350
Ensembl chr16:56,819,949...56,822,131 		JBrowse link
G CCL18 C-C motif chemokine ligand 18 enables IEA InterPro GO_REF:0000002 NCBI chr17:20,723,413...20,730,633
Ensembl chr17:21,019,868...21,027,070 		JBrowse link
G CCL19 C-C motif chemokine ligand 19 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 9:34,525,820...34,527,628
Ensembl chr 9:35,334,353...35,336,108 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 enables ISO
IEA		 RGD
InterPro		 PMID:11104723 PMID:12953273 PMID:16127145 GO_REF:0000002 RGD:2303089 RGD:2303093 RGD:2303114 NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384 		JBrowse link
G CCL20 C-C motif chemokine ligand 20 enables ISO
IEA		 RGD
InterPro		 PMID:9916893 GO_REF:0000002 RGD:69987 NCBI chr2B:115,052,768...115,056,479
Ensembl chr2B:233,862,505...233,866,225 		JBrowse link
G CCL21 C-C motif chemokine ligand 21 enables IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr 9:34,545,248...34,546,801
Ensembl chr 9:35,353,768...35,354,924 		JBrowse link
G CCL22 C-C motif chemokine ligand 22 enables IEA InterPro GO_REF:0000002 NCBI chr16:37,631,861...37,640,208
Ensembl chr16:56,765,367...56,771,213 		JBrowse link
G CCL23 C-C motif chemokine ligand 23 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr17:20,778,008...20,782,929
Ensembl chr17:21,073,882...21,078,794 		JBrowse link
G CCL24 C-C motif chemokine ligand 24 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 7:68,206,688...68,210,343
Ensembl chr 7:82,263,310...82,265,480 		JBrowse link
G CCL25 C-C motif chemokine ligand 25 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr19:7,307,109...7,363,983
Ensembl chr19:8,208,273...8,217,780 		JBrowse link
G CCL26 C-C motif chemokine ligand 26 enables IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr 7:68,230,804...68,251,369
Ensembl chr 7:82,221,846...82,242,874 		JBrowse link
G CCL27 C-C motif chemokine ligand 27 enables IEA InterPro GO_REF:0000002 NCBI chr 9:34,498,478...34,501,475
Ensembl chr 9:35,307,175...35,308,146 		JBrowse link
G CCL28 C-C motif chemokine ligand 28 enables IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr 5:66,977,643...66,998,420
Ensembl chr 5:72,012,579...72,046,031 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 enables ISO
IEA		 RGD
Ensembl
InterPro		 PMID:11069838 PMID:11104723 GO_REF:0000002 GO_REF:0000107 RGD:2303112 RGD:2303114 NCBI chr17:20,915,198...20,923,530
Ensembl chr17:21,210,798...21,219,172 		JBrowse link
G CCL8 C-C motif chemokine ligand 8 enables IEA InterPro GO_REF:0000002 NCBI chr17:22,468,080...22,470,443
Ensembl chr17:22,761,064...22,763,933 		JBrowse link
G CKLF chemokine like factor enables ISO (PMID:11415443) UniProt PMID:11415443 NCBI chr16:46,870,637...46,884,165
Ensembl chr16:65,972,218...65,998,677 		JBrowse link
G CX3CL1 C-X3-C motif chemokine ligand 1 enables ISO
IEA		 RGD
InterPro
Ensembl		 PMID:9724801 GO_REF:0000002 GO_REF:0000107 RGD:727628 NCBI chr16:37,646,447...37,659,078
Ensembl chr16:56,779,065...56,791,760 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 enables ISO
IEA		 RGD
InterPro
Ensembl		 PMID:9288136 GO_REF:0000002 GO_REF:0000107 RGD:2311389 NCBI chr 4:48,182,355...48,184,733
Ensembl chr 4:54,020,204...54,022,606 		JBrowse link
G CXCL11 C-X-C motif chemokine ligand 11 enables ISO
IEA		 RGD
InterPro
Ensembl		 PMID:15322564 GO_REF:0000002 GO_REF:0000107 RGD:1302904 NCBI chr 4:48,169,954...48,172,455
Ensembl chr 4:54,007,818...54,010,336 		JBrowse link
G CXCL12 C-X-C motif chemokine ligand 12 enables IEA InterPro GO_REF:0000002 NCBI chr10:41,296,975...41,384,864
Ensembl chr10:44,552,480...44,564,231 		JBrowse link
G CXCL13 C-X-C motif chemokine ligand 13 enables IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr 4:46,583,759...46,589,865
Ensembl chr 4:52,428,702...52,434,803 		JBrowse link
G CXCL14 C-X-C motif chemokine ligand 14 enables IEA InterPro GO_REF:0000002 NCBI chr 5:130,960,143...130,967,365
Ensembl chr 5:137,100,019...137,108,336 		JBrowse link
G CXCL16 C-X-C motif chemokine ligand 16 enables IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr17:4,789,280...4,795,656
Ensembl chr17:4,778,717...4,785,639 		JBrowse link
G CXCL3 C-X-C motif chemokine ligand 3 enables IEA InterPro GO_REF:0000002 NCBI chr 4:50,152,730...50,154,974
Ensembl chr 4:55,925,562...55,986,555 		JBrowse link
G CXCL5 C-X-C motif chemokine ligand 5 enables IEA InterPro GO_REF:0000002 NCBI chr 4:50,192,665...50,195,642
Ensembl chr 4:56,024,848...56,027,989 		JBrowse link
G CXCL6 C-X-C motif chemokine ligand 6 enables ISO
IEA		 RGD
InterPro
Ensembl		 PMID:12468547 GO_REF:0000002 GO_REF:0000107 RGD:629532 NCBI chr 4:50,357,643...50,359,822
Ensembl chr 4:56,189,961...56,192,402 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 enables IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr 4:50,452,857...50,456,015
Ensembl chr 4:56,286,708...56,288,083 		JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 enables IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr 4:48,198,478...48,204,658
Ensembl chr 4:54,036,342...54,042,502 		JBrowse link
G GPR15LG G protein-coupled receptor 15 ligand enables IEA Ensembl GO_REF:0000107 NCBI chr10:80,589,270...80,600,894
Ensembl chr10:84,159,041...84,170,624 		JBrowse link
G LOC100967628 C-C motif chemokine 3-like 1 enables IEA InterPro GO_REF:0000002 NCBI chr17:19,094,247...19,096,128 JBrowse link
G LOC100974886 uncharacterized LOC100974886 enables ISO
IEA		 RGD
InterPro		 PMID:10975996 GO_REF:0000002 RGD:5135014 NCBI chr 4:50,092,989...50,095,541
Ensembl chr 4:55,925,562...55,986,555 		JBrowse link
G LOC100976904 growth-regulated alpha protein enables ISO
IEA		 RGD
InterPro		 PMID:10975996 GO_REF:0000002 RGD:5135014 NCBI chr 4:50,325,248...50,327,165
Ensembl chr 4:56,153,899...56,159,474 		JBrowse link
G LOC100977215 uncharacterized LOC100977215 enables ISO (MGI:5897759|PMID:12538707) UniProt PMID:12538707 MGI:5897759 NCBI chr 9:34,501,614...34,502,680 JBrowse link
G LOC100978630 lymphotactin-like enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 1:144,027,642...144,030,976
Ensembl chr 1:147,750,001...147,753,369 		JBrowse link
G LOC100978961 lymphotactin enables IEA InterPro GO_REF:0000002 NCBI chr 1:143,837,578...144,068,261
Ensembl chr 1:147,785,654...147,790,587 		JBrowse link
G LOC100980531 eotaxin enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr17:22,495,737...22,515,144
Ensembl chr17:22,806,076...22,808,345
Ensembl chr17:22,806,076...22,808,345 		JBrowse link
G LOC100991964 C-C motif chemokine 4 enables IEA InterPro GO_REF:0000002 NCBI chr17:19,109,618...19,112,193
Ensembl chr17:20,984,988...20,987,572 		JBrowse link
G LOC100992309 C-C motif chemokine 3 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr17:20,704,738...20,706,641
Ensembl chr17:21,000,709...21,002,610 		JBrowse link
G LOC117974322 C-C motif chemokine 4 enables IEA InterPro GO_REF:0000002 NCBI chr17:20,689,341...20,691,921 JBrowse link
G PF4 platelet factor 4 enables IEA InterPro GO_REF:0000002 NCBI chr 4:50,208,806...50,210,570
Ensembl chr 4:56,041,833...56,043,750 		JBrowse link
G PF4V1 platelet factor 4 variant 1 enables IEA InterPro GO_REF:0000002 NCBI chr 4:50,341,931...50,343,220
Ensembl chr 4:56,173,293...56,175,607 		JBrowse link
G PPBP pro-platelet basic protein enables IEA InterPro GO_REF:0000002 NCBI chr 4:50,203,168...50,204,303
Ensembl chr 4:56,035,060...56,037,702 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17492
    binding 16141
      protein binding 14561
        signaling receptor binding 1468
          receptor ligand activity 437
            cytokine activity 193
              chemokine activity 47
paths to the root