CXCL6 (C-X-C motif chemokine ligand 6)

Gene: CXCL6 (C-X-C motif chemokine ligand 6) Pan paniscus

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Symbol:

CXCL6

Name:

C-X-C motif chemokine ligand 6

RGD ID:

11779933

Description:

ENCODES a protein that exhibits chemokine activity (ortholog); INVOLVED IN animal organ regeneration (ortholog); cellular response to lipopolysaccharide (ortholog); cytokine production (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); Alcoholic Liver Diseases (ortholog); asthma (ortholog); FOUND IN extracellular space (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

C-X-C motif chemokine 6; chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	56,225,837 - 56,227,789 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	56,414,925 - 56,416,877 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	50,357,643 - 50,359,822 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	56,190,130 - 56,192,402 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	56,189,961 - 56,192,402 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Lung Injury (ISO)

Alcoholic Liver Diseases (ISO)

asthma (ISO)

bacterial pneumonia (ISO)

colon carcinoma (ISO)

COVID-19 (ISO)

Endotoxemia (ISO)

Experimental Arthritis (ISO)

Helicobacter Infections (ISO)

Legionnaires' disease (ISO)

Liver Reperfusion Injury (ISO)

Myocardial Reperfusion Injury (ISO)

obstructive sleep apnea (ISO)

osteoarthritis (ISO)

prostatitis (ISO)

pulmonary emphysema (ISO)

pulmonary tuberculosis (ISO)

Reperfusion Injury (ISO)

respiratory allergy (ISO)

rheumatoid arthritis (ISO)

rhinitis (ISO)

Sepsis (ISO)

severe acute respiratory syndrome (ISO)

Venous Thrombosis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

animal organ regeneration (ISO)

antimicrobial humoral immune response mediated by antimicrobial peptide (IEA)

cellular response to lipopolysaccharide (IEA,ISO)

chemotaxis (IEA)

cytokine production (ISO)

defense response (IEA)

immune response (IEA)

leukocyte homeostasis (ISO)

midbrain development (ISO)

neutrophil activation (IEA)

neutrophil chemotaxis (IEA)

positive regulation of neuron projection development (ISO)

positive regulation of receptor signaling pathway via JAK-STAT (ISO)

regulation of chemokine production (ISO)

regulation of neutrophil mediated killing of gram-negative bacterium (ISO)

response to gamma radiation (ISO)

response to lipopolysaccharide (ISO)

signal transduction (IEA)

Cellular Component

extracellular region (IEA)

extracellular space (IEA,ISO)

Molecular Function

chemokine activity (IEA,ISO)

cytokine activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

CXCL6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	56,225,837 - 56,227,789 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	56,414,925 - 56,416,877 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	50,357,643 - 50,359,822 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	56,190,130 - 56,192,402 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	56,189,961 - 56,192,402 (-)	Ensembl	panpan1.1		panPan2

CXCL6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	73,836,678 - 73,838,760 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	73,836,640 - 73,849,064 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	74,702,395 - 74,704,477 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	74,921,277 - 74,923,341 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	75,067,447 - 75,069,511	NCBI
Celera	4	72,062,419 - 72,064,623 (+)	NCBI		Celera
Cytogenetic Map	4	q13.3	NCBI
HuRef	4	70,513,410 - 70,515,614 (+)	NCBI		HuRef
CHM1_1	4	74,738,258 - 74,740,462 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	77,180,324 - 77,182,406 (+)	NCBI		T2T-CHM13v2.0

Cxcl5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	90,907,157 - 90,909,484 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	90,907,219 - 90,909,483 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	90,759,298 - 90,761,625 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	90,759,360 - 90,761,624 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	91,188,325 - 91,190,651 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	91,834,578 - 91,836,824 (+)	NCBI		MGSCv36	mm8
Celera	5	88,910,984 - 88,913,251 (+)	NCBI		Celera
Cytogenetic Map	5	E1	NCBI
cM Map	5	44.78	NCBI

Cxcl6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	17,594,959 - 17,596,417 (-)	NCBI		GRCr8
mRatBN7.2	14	17,310,790 - 17,312,250 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	17,310,426 - 17,313,093 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	17,310,917 - 17,312,359 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	18,629,838 - 18,631,280 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	17,322,143 - 17,323,623 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	18,860,201 - 18,920,839 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	18,860,264 - 18,862,407 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	18,770,999 - 18,771,910 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	18,825,357 - 18,826,269 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	18,825,357 - 18,826,269 (-)	NCBI
Celera	14	16,687,262 - 16,688,187 (-)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

AMCF-II
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	70,008,162 - 70,010,358 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	70,008,225 - 70,010,360 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	74,160,033 - 74,162,170 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CXCL6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	22,291,949 - 22,294,191 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	22,292,045 - 22,294,207 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666084	497,366 - 499,651 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003832334	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000051275 ⟹ ENSPPAP00000028428

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	4	56,189,961 - 56,192,402 (-)	Ensembl

RefSeq Acc Id:

XM_003832334 ⟹ XP_003832382

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	3	56,225,837 - 56,227,789 (-)	NCBI
NHGRI_mPanPan1	4	56,414,925 - 56,416,877 (-)	NCBI
Mhudiblu_PPA_v0	4	50,357,643 - 50,359,822 (-)	NCBI
PanPan1.1	4	56,190,130 - 56,192,402 (-)	NCBI

Sequence:

show sequence

AGGCAGCTCCTCCCAGCCACCCACCCCACCAATTCCCATCCTCCCGCCCCCCTCCACCAACCCC
TTCTTTCCACACTGCCCCCTGAGTTCAGGGAATTTCCCCAGCATCCCAAAGCTTGAGTTTCCTG
CCAGTCGGGAGGGATGAATGCAGATAAAGGGAGTGCAGAAGGCACGAGGAAACCAAAGTGCTCT
GTATCCTCCAGTCTCCGCGCCTCCACCCAGCTCAGGAACCCGCGAACCCTCTCTTGACCACTAT
GAGCCTCCGGTCCAGCTGCGCTGCCCGTGTCCCGGGTCCTTCGGGCTCCTTGTGCGCGCTGCTC
GCGCTGCTGCTCCTGCTGACGCCGCCGGGGCCCCTCGCCAGCGCTGGTCCTGTCTCTGCTGTGC
TGACAGAGCTGCGTTGCACTTGTTTACTCGTTACGCTGAGAGTAAACCCCAAAACGATTGGTAA
ACTGCAGGTGTTCCCCGCAGGCCCGCAGTGCTCCAAGGTGGAAGTGGTAGCCTCCCTGAAGAAC
GGGAAGCAAGTTTGTCTGGACCCGGAAGCCCCTTTTCTAAAGAAAGTCATCCAGAAAATTTTGG
ACAGTGGAAACAAGAAAAACTGAGTAACAAAAAAGACCATGCATCATAAAATTGCCCAGTCTTC
AGCGGAGCAGTTTTCTGGAGATCCCTGGACCCAGTAAGAATAAGAAGGAAGGCTTGGTTTTTTT
CCAGCAGTCCATTTTCTACATGGATTCCCTACTTTGAAGAGTGTGGGGAAAGCCTACGCTTGTC
CCTGAAGTTTACAGCTCAGCTAATGAAGTATTAATATAGTATTTCCACTATTTACTGTTATTTT
ACCTGATAAGTTATTGAACCCTTTGGCAATTGACCATATTGTGAGCAAAGAATCACTGGTTATT
AGTTTTTCAATGAATATTGAATTGAAGATAACTATTGTATTTCTATCATACATTCCTTAAAGTC
TTACAGAAAAGGCTGTGGATTTCATATGGAAATAATGTTTTATTAGTGTGCTGTTGAGGGAGGT
ATCCTGTTGTTCTCACTCACTCTTCTCATAAAATAGGAAATATTTTAGTTCTGTTTCTTGGGGA
ATATGTTACTCTTTACCCTAGGATGCTATTTAAGTTGTACTGTATTAGAACACTGGGTGTGTCA
TACCGTTATCTGTGCAGAATATATTTCCTTATTCAGAATTTCTAAAAATTTAAGTTCTGTAAGG
GCTAATATATTCTCTTCCTATGGTTTTAGACGTTTGATGTCTTCTTAGTATGGCATAATGTCAT
GATTTACTCATTAAACTTTGATTTTGTATGCTATTTTTTCACTATAGGATGACTATAATTCTGG
TCACTAAATATACACTTTAGATAGATGAAGAAGCCCAAAAACATAAATTCCTGATTGCTAATTT
ACATAGAAATGTATTCTCTTGGTTTTTTAAATAAAAGCAAAATTAACAATGATCTGTGCTCTGA
AAGTTTTGAAAATATATTTGAACAATTTGAATATAAATTCATCATTTAGTCATCAAAATATATA
CAGCATTGCTAAGATTTTCAGATATCTATTGTGGATCTTTTAAAGGTTTTGACCATTTTGTTAT
GAGGAATTATACATGTATCACATTCACTATATTAAAATTGCACTTTTATTTTTTCCTGTGTGTC
ACGTTGGTTTTTGGTACTTGTATTGTCATTTGGAGAAACAATAAAAGATTTCTAAACCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003832382	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000028428
	ENSPPAP00000028428.1

RefSeq Acc Id:	XP_003832382 ⟸ XM_003832334
- UniProtKB:	A0A2R9BGM4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSLRSSCAARVPGPSGSLCALLALLLLLTPPGPLASAGPVSAVLTELRCTCLLVTLRVNPKTIG KLQVFPAGPQCSKVEVVASLKNGKQVCLDPEAPFLKKVIQKILDSGNKKN hide sequence

RefSeq Acc Id:

ENSPPAP00000028428 ⟸ ENSPPAT00000051275

Protein Domains

Chemokine interleukin-8-like

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000037250	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000051275.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.50.40	UniProtKB/TrEMBL
InterPro	Chemokine_b/g/d	UniProtKB/TrEMBL
	Chemokine_CXC	UniProtKB/TrEMBL
	Chemokine_CXC_CS	UniProtKB/TrEMBL
	Chemokine_IL8-like_dom	UniProtKB/TrEMBL
	CXC_Chemokine_domain	UniProtKB/TrEMBL
	Interleukin_8-like_sf	UniProtKB/TrEMBL
KEGG Report	pps:100977683	UniProtKB/TrEMBL
NCBI Gene	CXCL6	ENTREZGENE
PANTHER	C-X-C MOTIF CHEMOKINE 6	UniProtKB/TrEMBL
	SMALL INDUCIBLE CYTOKINE A	UniProtKB/TrEMBL
Pfam	IL8	UniProtKB/TrEMBL
PRINTS	INTERLEUKIN8	UniProtKB/TrEMBL
	SMALLCYTKCXC	UniProtKB/TrEMBL
PROSITE	SMALL_CYTOKINES_CXC	UniProtKB/TrEMBL
SMART	SCY	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54117	UniProtKB/TrEMBL
UniProt	A0A2R9BGM4	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD