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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of release of cytochrome c from mitochondria
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Accession:GO:0090200 term browser browse the term
Definition:Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
Comment:The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that directly and positively regulate this process.

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positive regulation of release of cytochrome c from mitochondria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2 associated agonist of cell death involved_in ISO (PMID:17289999) UniProt PMID:17289999 NCBI chrNW_004624767:22,025,721...22,037,283
Ensembl chrNW_004624767:22,026,133...22,037,277 		JBrowse link
G Bak1 BCL2 antagonist/killer 1 ISO RGD PMID:12485416 RGD:2317097 NCBI chrNW_004624754:23,297,077...23,302,366
Ensembl chrNW_004624754:23,296,800...23,301,223 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in ISS UniProt GO_REF:0000024 NCBI chrNW_004624832:5,050,222...5,068,565
Ensembl chrNW_004624832:5,050,222...5,055,506 		JBrowse link
G Bbc3 BCL2 binding component 3 involved_in ISO (PMID:21041309) BHF-UCL PMID:21041309 NCBI chrNW_004624832:6,467,716...6,476,754
Ensembl chrNW_004624832:6,470,475...6,476,754 		JBrowse link
G Bcl2l11 BCL2 like 11 involved_in ISO (PMID:17289999)
(PMID:21041309)		 UniProt
BHF-UCL		 PMID:17289999 PMID:21041309 NCBI chrNW_004624749:1,033,824...1,130,099
Ensembl chrNW_004624749:1,091,096...1,125,341 		JBrowse link
G Bid BH3 interacting domain death agonist involved_in ISO (MGI:5009775|PMID:21041309)
(PMID:21041309)
(MGI:5009197|PMID:10950869)
(PMID:17289999), (PMID:21262771)
(PMID:32029622)		 BHF-UCL
UniProt		 PMID:10950869 PMID:17289999 PMID:21041309 PMID:21262771 PMID:32029622 MGI:5009197 MGI:5009775 NCBI chrNW_004624735:9,557,732...9,590,862
Ensembl chrNW_004624735:9,579,979...9,589,260 		JBrowse link
G Bik BCL2 interacting killer involved_in ISO (PMID:21041309) BHF-UCL PMID:21041309 NCBI chrNW_004624752:5,839,422...5,856,350 JBrowse link
G Bmf Bcl2 modifying factor involved_in ISO (MGI:5009775|PMID:21041309) BHF-UCL PMID:21041309 MGI:5009775 NCBI chrNW_004624804:7,420,003...7,440,012
Ensembl chrNW_004624804:7,423,547...7,440,014 		JBrowse link
G Bnip3 BCL2 interacting protein 3 involved_in ISO (PMID:20436456) BHF-UCL PMID:20436456 NCBI chrNW_004624737:14,848,355...14,863,731
Ensembl chrNW_004624737:14,848,350...14,862,965 		JBrowse link
G Dnm1l dynamin 1 like involved_in ISO (PMID:21149567) UniProt PMID:21149567 NCBI chrNW_004624778:3,391,690...3,475,548 JBrowse link
G Fam162a family with sequence similarity 162 member A involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624912:739,804...763,149
Ensembl chrNW_004624912:739,917...762,939 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 involved_in ISO PMID:23907461 UniProt PMID:23907461 RGD:8553942 NCBI chrNW_004624740:26,627,560...26,632,483
Ensembl chrNW_004624740:26,627,473...26,632,027 		JBrowse link
G Hrk harakiri, BCL2 interacting protein involved_in ISO (PMID:21041309) BHF-UCL PMID:21041309 NCBI chrNW_004624747:16,365,938...16,387,841
Ensembl chrNW_004624747:16,366,080...16,387,840 		JBrowse link
G LOC101704728 protein AF1q involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624731:39,307,512...39,307,956 JBrowse link
G Mff mitochondrial fission factor involved_in ISO (PMID:21149567) UniProt PMID:21149567 NCBI chrNW_004624843:1,626,800...1,664,906 JBrowse link
G Mllt11 MLLT11 transcription factor 7 cofactor involved_in ISS
IEA		 UniProt
TreeGrafter		 GO_REF:0000024 GO_REF:0000118 NCBI chrNW_004624772:18,762,099...18,768,629 JBrowse link
G Mmp9 matrix metallopeptidase 9 involved_in ISO (PMID:22984561) CACAO PMID:22984561 NCBI chrNW_004624790:8,584,399...8,591,763
Ensembl chrNW_004624790:8,583,457...8,591,713 		JBrowse link
G Pdcd5 programmed cell death 5 involved_in ISO (PMID:16374546) UniProt PMID:16374546 NCBI chrNW_004624794:7,482,401...7,491,561 JBrowse link
G Pink1 PTEN induced kinase 1 involved_in ISO (PMID:19880420) BHF-UCL PMID:19880420 NCBI chrNW_004624764:5,656,207...5,671,260
Ensembl chrNW_004624764:5,656,229...5,671,260 		JBrowse link
G Pla2g6 phospholipase A2 group VI ISO RGD PMID:18936091 RGD:6482750 NCBI chrNW_004624752:9,792,778...9,841,817
Ensembl chrNW_004624752:9,792,807...9,843,457 		JBrowse link
G Plaur plasminogen activator, urokinase receptor involved_in ISO (PMID:22984561) CACAO PMID:22984561 NCBI chrNW_004624907:1,174,648...1,188,919
Ensembl chrNW_004624907:1,174,448...1,189,377 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 involved_in ISO (PMID:14500711), (PMID:14699081), (PMID:15705586)
(PMID:15705586), (PMID:17289999)		 UniProt
BHF-UCL		 PMID:14500711 PMID:14699081 PMID:15705586 PMID:17289999 NCBI chrNW_004624792:5,330,289...5,338,067 JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO (PMID:14730312) UniProt PMID:14730312 NCBI chrNW_004624782:14,247,333...14,249,861
Ensembl chrNW_004624782:14,247,864...14,249,000 		JBrowse link
G Tnfsf10 TNF superfamily member 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624730:50,534,284...50,550,279
Ensembl chrNW_004624730:50,531,915...50,550,528 		JBrowse link
G Tp53 tumor protein p53 involved_in ISO (PMID:14963330) UniProt PMID:14963330 NCBI chrNW_004624786:10,266,316...10,282,664
Ensembl chrNW_004624786:10,263,518...10,271,218 		JBrowse link
G Wdr35 WD repeat domain 35 ISO RGD PMID:23289926 RGD:11553920 NCBI chrNW_004624738:2,618,464...2,720,567
Ensembl chrNW_004624738:2,618,738...2,623,166
Ensembl chrNW_004624738:2,618,738...2,623,166 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15093
    positive regulation of biological process 5901
      positive regulation of cellular process 5397
        positive regulation of cellular component organization 1240
          positive regulation of organelle organization 531
            positive regulation of release of cytochrome c from mitochondria 26
Path 2
Term Annotations click to browse term
  biological_process 15093
    cellular process 14253
      cellular component organization or biogenesis 6217
        cellular component organization 6020
          organelle organization 3386
            mitochondrion organization 517
              apoptotic mitochondrial changes 113
                release of cytochrome c from mitochondria 60
                  regulation of release of cytochrome c from mitochondria 48
                    positive regulation of release of cytochrome c from mitochondria 26
paths to the root